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Aliases for PURA Gene

Aliases for PURA Gene

  • Purine-Rich Element Binding Protein A 2 3
  • PUR1 3 4 6
  • Purine-Rich Single-Stranded DNA-Binding Protein Alpha 3 4
  • Transcriptional Activator Protein Pur-Alpha 3
  • PUR-ALPHA 3
  • PURALPHA 3
  • MRD31 3

External Ids for PURA Gene

Previous GeneCards Identifiers for PURA Gene

  • GC05P139316
  • GC05P139476
  • GC05P139522
  • GC05P139473
  • GC05P134636

Summaries for PURA Gene

Entrez Gene Summary for PURA Gene

  • This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia. [provided by RefSeq, Jul 2008]

GeneCards Summary for PURA Gene

PURA (Purine-Rich Element Binding Protein A) is a Protein Coding gene. Diseases associated with PURA include mental retardation, autosomal dominant 31 and 5q31.3 microdeletion syndrome. Among its related pathways are Diurnally regulated genes with circadian orthologs. GO annotations related to this gene include transcription factor binding and single-stranded DNA binding. An important paralog of this gene is PURB.

UniProtKB/Swiss-Prot for PURA Gene

  • This is a probable transcription activator that specifically binds the purine-rich single strand of the PUR element located upstream of the MYC gene. May play a role in the initiation of DNA replication and in recombination

Gene Wiki entry for PURA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PURA Gene

Genomics for PURA Gene

Regulatory Elements for PURA Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PURA Gene

Start:
140,107,777 bp from pter
End:
140,125,619 bp from pter
Size:
17,843 bases
Orientation:
Plus strand

Genomic View for PURA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PURA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PURA Gene

Proteins for PURA Gene

  • Protein details for PURA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q00577-PURA_HUMAN
    Recommended name:
    Transcriptional activator protein Pur-alpha
    Protein Accession:
    Q00577
    Secondary Accessions:

    Protein attributes for PURA Gene

    Size:
    322 amino acids
    Molecular mass:
    34911 Da
    Quaternary structure:
    • Homodimer, heterodimer with PURB and heterotrimer with PURB and YBX1/Y-box protein 1.

neXtProt entry for PURA Gene

Proteomics data for PURA Gene at MOPED

Post-translational modifications for PURA Gene

  • Ubiquitination at Lys229, Lys239, and Lys262
  • Modification sites at PhosphoSitePlus

Other Protein References for PURA Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PURA Gene

Domains for PURA Gene

Protein Domains for PURA Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q00577

UniProtKB/Swiss-Prot:

PURA_HUMAN :
  • Q00577
Family:
  • Belongs to the PUR DNA-binding protein family.
genes like me logo Genes that share domains with PURA: view

No data available for Gene Families for PURA Gene

Function for PURA Gene

Molecular function for PURA Gene

GENATLAS Biochemistry: single-stranded DNA binding protein A with specific affinity for a purine-rich element (GGN)n
UniProtKB/Swiss-Prot Function: This is a probable transcription activator that specifically binds the purine-rich single strand of the PUR element located upstream of the MYC gene. May play a role in the initiation of DNA replication and in recombination

Gene Ontology (GO) - Molecular Function for PURA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000900 translation repressor activity, nucleic acid binding IEA --
GO:0003677 DNA binding --
GO:0003690 double-stranded DNA binding --
GO:0003691 double-stranded telomeric DNA binding IDA 15777841
GO:0003697 single-stranded DNA binding ISS --
genes like me logo Genes that share ontologies with PURA: view
genes like me logo Genes that share phenotypes with PURA: view

Animal Models for PURA Gene

MGI Knock Outs for PURA:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PURA

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PURA Gene

Localization for PURA Gene

Subcellular locations from UniProtKB/Swiss-Prot for PURA Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PURA Gene COMPARTMENTS Subcellular localization image for PURA gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PURA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000784 nuclear chromosome, telomeric region IC 15777841
GO:0005634 nucleus IDA 9716182
GO:0005662 DNA replication factor A complex ISS --
GO:0005737 cytoplasm IEA --
GO:0030425 dendrite IEA --
genes like me logo Genes that share ontologies with PURA: view

Pathways for PURA Gene

genes like me logo Genes that share pathways with PURA: view

Pathways by source for PURA Gene

1 BioSystems pathway for PURA Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Telomeres & Telomerase in human,mouse,rat

Gene Ontology (GO) - Biological Process for PURA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006268 DNA unwinding involved in DNA replication IDA 15777841
GO:0006270 DNA replication initiation TAS 1545807
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 9334258
GO:0006366 transcription from RNA polymerase II promoter TAS 9334258
GO:0007399 nervous system development IEA --
genes like me logo Genes that share ontologies with PURA: view

Compounds for PURA Gene

(1) Novoseek inferred chemical compound relationships for PURA Gene

Compound -log(P) Hits PubMed IDs
oligonucleotide 0 2
genes like me logo Genes that share compounds with PURA: view

Transcripts for PURA Gene

mRNA/cDNA for PURA Gene

(175) Selected AceView cDNA sequences:
(4) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PURA Gene

Purine-rich element binding protein A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PURA

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PURA Gene

No ASD Table

Relevant External Links for PURA Gene

GeneLoc Exon Structure for
PURA
ECgene alternative splicing isoforms for
PURA

Expression for PURA Gene

mRNA expression in normal human tissues for PURA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PURA Gene

SOURCE GeneReport for Unigene cluster for PURA Gene Hs.443121

genes like me logo Genes that share expressions with PURA: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PURA Gene

Orthologs for PURA Gene

This gene was present in the common ancestor of animals.

Orthologs for PURA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PURA 35
  • 99.9 (n)
  • 100 (a)
PURA 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PURA 35
  • 96.48 (n)
  • 99.07 (a)
PURA 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PURA 35
  • 97.83 (n)
  • 100 (a)
PURA 36
  • 59 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pura 35
  • 95.74 (n)
  • 98.72 (a)
Pura 16
Pura 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PURA 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pura 35
  • 95.85 (n)
  • 98.4 (a)
chicken
(Gallus gallus)
Aves PURA 36
  • 90 (a)
OneToOne
PURB 35
  • 92.51 (n)
  • 96.48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pura 35
  • 82.91 (n)
  • 96.64 (a)
zebrafish
(Danio rerio)
Actinopterygii pura 35
  • 84.18 (n)
  • 96.61 (a)
pura 36
  • 86 (a)
OneToMany
PURA (1 of 2) 36
  • 84 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Pur-alpha 36
  • 44 (a)
OneToMany
Pur-alpha 37
  • 48 (a)
worm
(Caenorhabditis elegans)
Secernentea plp-1 36
  • 35 (a)
ManyToMany
plp-2 36
  • 28 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
OneToMany
Species with no ortholog for PURA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PURA Gene

ENSEMBL:
Gene Tree for PURA (if available)
TreeFam:
Gene Tree for PURA (if available)

Paralogs for PURA Gene

Paralogs for PURA Gene

Selected SIMAP similar genes for PURA Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PURA: view

Variants for PURA Gene

Sequence variations from dbSNP and Humsavar for PURA Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs875575 -- 140,112,480(+) CCCCA(C/G)AGTGC upstream-variant-2KB
rs1804256 -- 140,114,928(+) GAGGT(C/G)AAGCC synonymous-codon, reference
rs2013169 -- 140,118,020(-) AAACT(A/T)GGTAA utr-variant-3-prime
rs2291877 -- 140,118,549(-) CATGT(A/G)TAATG utr-variant-3-prime
rs2337073 -- 140,113,018(-) TCCTT(C/T)TGAGA upstream-variant-2KB

Relevant External Links for PURA Gene

HapMap Linkage Disequilibrium report
PURA
Human Gene Mutation Database (HGMD)
PURA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PURA Gene

Disorders for PURA Gene

UniProtKB/Swiss-Prot

PURA_HUMAN
  • Mental retardation, autosomal dominant 31 (MRD31) [MIM:616158]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRD31 patients manifest neonatal hypotonia, encephalopathy with or without epilepsy, and severe developmental delay. {ECO:0000269 PubMed:25439098}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(4) Novoseek inferred disease relationships for PURA Gene

Disease -log(P) Hits PubMed IDs
immunodeficiency 36.3 6
myeloid leukemia 33.4 1
neurodegeneration 12.4 1
cancer 0 2

Relevant External Links for PURA

Genetic Association Database (GAD)
PURA
Human Genome Epidemiology (HuGE) Navigator
PURA
genes like me logo Genes that share disorders with PURA: view

Publications for PURA Gene

  1. Sequence of cDNA comprising the human pur gene and sequence-specific single-stranded-DNA-binding properties of the encoded protein. (PMID: 1448097) Bergemann A.D. … Johnson E.M. (Mol. Cell. Biol. 1992) 2 3 4 23
  2. Localization of PURA, the gene encoding the sequence-specific single-stranded-DNA-binding protein Pur alpha, to chromosome band 5q31. (PMID: 7606931) Ma Z.W. … Johnson E.M. (Cytogenet. Cell Genet. 1995) 3 23
  3. Cooperative action of cellular proteins YB-1 and Pur alpha with the tumor antigen of the human JC polyomavirus determines their interaction with the viral lytic control element. (PMID: 7862639) Chen N.N. … Khalili K. (Proc. Natl. Acad. Sci. U.S.A. 1995) 3 23
  4. Activation of the JC virus Tat-responsive transcriptional control element by association of the Tat protein of human immunodeficiency virus 1 with cellular protein Pur alpha. (PMID: 8943069) Krachmarov C.P. … Johnson E.M. (Proc. Natl. Acad. Sci. U.S.A. 1996) 3 23
  5. Identification of a cellular protein that binds to Tat-responsive element of TGF beta-1 promoter in glial cells. (PMID: 9383706) Thatikunta P. … Amini S. (J. Cell. Biochem. 1997) 3 23

Products for PURA Gene

Sources for PURA Gene

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