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Aliases for PTX3 Gene

Aliases for PTX3 Gene

  • Pentraxin 3 2 3 5
  • Tumor Necrosis Factor-Inducible Gene 14 Protein 3 4
  • Tumor Necrosis Factor Alpha-Induced Protein 5 3 4
  • TNF Alpha-Induced Protein 5 3 4
  • Long Pentraxin 3 2 3
  • TNFAIP5 3 4
  • TSG-14 3 4
  • Pentraxin-Related Gene, Rapidly Induced By IL-1 Beta 2
  • Pentaxin-Related Gene, Rapidly Induced By IL-1 Beta 2
  • Tumor Necrosis Factor, Alpha-Induced Protein 5 2
  • Tumor Necrosis Factor-Inducible Protein TSG-14 3
  • Pentraxin-Related Protein PTX3 3
  • Pentaxin-Related Protein PTX3 4
  • Pentraxin 3, Long 2
  • TSG14 4

External Ids for PTX3 Gene

Previous HGNC Symbols for PTX3 Gene


Previous GeneCards Identifiers for PTX3 Gene

  • GC03P154190
  • GC03P158101
  • GC03P158436
  • GC03P158475
  • GC03P158637
  • GC03P157154
  • GC03P154550

Summaries for PTX3 Gene

Entrez Gene Summary for PTX3 Gene

  • This gene encodes a member of the pentraxin protein family. The expression of this protein is induced by inflammatory cytokines in response to inflammatory stimuli in several mesenchymal and epithelial cell types, particularly endothelial cells and mononuclear phagocytes. The protein promotes fibrocyte differentiation and is involved in regulating inflammation and complement activation. It also plays a role in angiogenesis and tissue remodeling. The protein serves as a biomarker for several inflammatory conditions. [provided by RefSeq, Jun 2016]

GeneCards Summary for PTX3 Gene

PTX3 (Pentraxin 3) is a Protein Coding gene. Diseases associated with PTX3 include Infectious Myocarditis and Hyper-Igd Syndrome. Among its related pathways are Lung fibrosis and Innate Immune System. GO annotations related to this gene include virion binding and (1->3)-beta-D-glucan binding. An important paralog of this gene is NPTX2.

UniProtKB/Swiss-Prot for PTX3 Gene

  • Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility.

Gene Wiki entry for PTX3 Gene

Additional gene information for PTX3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTX3 Gene

Genomics for PTX3 Gene

Regulatory Elements for PTX3 Gene

Enhancers for PTX3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H157358 0.7 ENCODE 11.4 -76.9 -76935 2.6 JUN MAX CEBPG RAD21 BRCA1 RFX5 POLR2A RCOR1 FOS CHD2 KRT18P34 PTX3 VEPH1 ENSG00000243176 LOC105374179
GH03H157429 0.3 FANTOM5 2.4 -6.8 -6822 0.3 CCNL1 PTX3 LOC105374179
GH03H157436 1 ENCODE 0.7 +1.2 1207 3.7 ATF1 ZNF121 GLIS2 FOS SP3 REST GLIS1 MYNN WT1 PRDM4 KRT18P34 PTX3 VEPH1
GH03H157475 1.2 Ensembl ENCODE 0.3 +39.5 39450 1.2 PKNOX1 ATF1 ZSCAN4 INSM2 KLF17 FEZF1 GLI4 ZNF2 ZNF366 SCRT2 VEPH1 PTX3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PTX3 on UCSC Golden Path with GeneCards custom track

Promoters for PTX3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000160932 911 2201 ZNF121 GLIS2 FOS REST GLIS1 MYNN WT1 PRDM4 SP7 KLF1

Genomic Locations for PTX3 Gene

Genomic Locations for PTX3 Gene
6,840 bases
Plus strand

Genomic View for PTX3 Gene

Genes around PTX3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTX3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTX3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTX3 Gene

Proteins for PTX3 Gene

  • Protein details for PTX3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pentraxin-related protein PTX3
    Protein Accession:
    Secondary Accessions:
    • B2R6T6
    • Q38M82

    Protein attributes for PTX3 Gene

    381 amino acids
    Molecular mass:
    41976 Da
    Quaternary structure:
    • Homooctamer; disulfide-linked. Binds to C1q (By similarity).

neXtProt entry for PTX3 Gene

Post-translational modifications for PTX3 Gene

Other Protein References for PTX3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for PTX3 (Pentraxin 3/TSG-14)
  • Santa Cruz Biotechnology (SCBT) Antibodies for PTX3

No data available for DME Specific Peptides for PTX3 Gene

Domains & Families for PTX3 Gene

Gene Families for PTX3 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for PTX3 Gene

Suggested Antigen Peptide Sequences for PTX3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PTX3: view

No data available for UniProtKB/Swiss-Prot for PTX3 Gene

Function for PTX3 Gene

Molecular function for PTX3 Gene

GENATLAS Biochemistry:
pentaxin 3,acute phase reactant,induced by IL1B,in endothelial,hepatic,fibroblastic cells
UniProtKB/Swiss-Prot Function:
Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility.
UniProtKB/Swiss-Prot Induction:
By IL1B/interleukin-1 beta and TNF.

Gene Ontology (GO) - Molecular Function for PTX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001849 complement component C1q binding IDA 23544079
GO:0001872 (1->3)-beta-D-glucan binding IEA --
GO:0005515 protein binding IPI 19050261
GO:0042802 identical protein binding IPI 20363749
GO:0046790 virion binding IDA 23544079
genes like me logo Genes that share ontologies with PTX3: view
genes like me logo Genes that share phenotypes with PTX3: view

Animal Models for PTX3 Gene

MGI Knock Outs for PTX3:

miRNA for PTX3 Gene

miRTarBase miRNAs that target PTX3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTX3 Gene

Localization for PTX3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTX3 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTX3 gene
Compartment Confidence
extracellular 5
nucleus 2
mitochondrion 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PTX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA,IEA 23544079
GO:0035580 specific granule lumen TAS --
GO:1904724 tertiary granule lumen TAS --
genes like me logo Genes that share ontologies with PTX3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PTX3 Gene

Pathways & Interactions for PTX3 Gene

genes like me logo Genes that share pathways with PTX3: view

Pathways by source for PTX3 Gene

1 BioSystems pathway for PTX3 Gene
3 Reactome pathways for PTX3 Gene

Gene Ontology (GO) - Biological Process for PTX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001878 response to yeast IEA --
GO:0006954 inflammatory response TAS 1429570
GO:0008228 opsonization IEA --
GO:0043312 neutrophil degranulation TAS --
GO:0044869 negative regulation by host of viral exo-alpha-sialidase activity IDA 23544079
genes like me logo Genes that share ontologies with PTX3: view

No data available for SIGNOR curated interactions for PTX3 Gene

Drugs & Compounds for PTX3 Gene

(22) Drugs for PTX3 Gene - From: ClinicalTrials and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Amlodipine Approved Pharma Calcium channel blocker 507
Heparin Approved, Investigational Pharma Antagonist 874,274
Valsartan Approved, Investigational Pharma Antagonist Angiotensin II AT1 receptor antagonist 298
Angiotensin II Investigational Pharma Full agonist, Agonist Potent vasopressor and a powerful stimulus for production and release of aldosterone from the adrenal cortex. 1198
Angiotensin II Type 1 Receptor Blockers Pharma 1105

(2) Additional Compounds for PTX3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PTX3: view

Transcripts for PTX3 Gene

mRNA/cDNA for PTX3 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(126) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PTX3 Gene

Pentraxin 3, long:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTX3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b

Relevant External Links for PTX3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PTX3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PTX3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PTX3 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (18.8) and Amniocyte (18.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PTX3 Gene

NURSA nuclear receptor signaling pathways regulating expression of PTX3 Gene:


SOURCE GeneReport for Unigene cluster for PTX3 Gene:


Evidence on tissue expression from TISSUES for PTX3 Gene

  • Heart(4.4)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with PTX3: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PTX3 Gene

Orthologs for PTX3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PTX3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PTX3 33 34
  • 99.13 (n)
(Bos Taurus)
Mammalia PTX3 33 34
  • 87.37 (n)
(Mus musculus)
Mammalia Ptx3 33 16 34
  • 84.6 (n)
(Rattus norvegicus)
Mammalia Ptx3 33
  • 83.29 (n)
(Canis familiaris)
Mammalia PTX3 33 34
  • 80.91 (n)
(Monodelphis domestica)
Mammalia PTX3 34
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia PTX3 34
  • 56 (a)
(Gallus gallus)
Aves PTX3 33 34
  • 65.96 (n)
(Anolis carolinensis)
Reptilia PTX3 34
  • 48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ptx3 33
  • 59.06 (n)
(Danio rerio)
Actinopterygii ptx3b 33 34
  • 51.25 (n)
ptx3a 34
  • 33 (a)
Species where no ortholog for PTX3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PTX3 Gene

Gene Tree for PTX3 (if available)
Gene Tree for PTX3 (if available)

Paralogs for PTX3 Gene

Paralogs for PTX3 Gene

genes like me logo Genes that share paralogs with PTX3: view

Variants for PTX3 Gene

Sequence variations from dbSNP and Humsavar for PTX3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs386352354 Uncertain significance 157,437,041(+) GACAA(C/T)GGACT intron-variant, reference, synonymous-codon
rs1000074101 -- 157,437,519(+) CACGC(A/C)GTGCG intron-variant, reference, missense
rs1000807843 -- 157,436,282(+) CAAAA(A/C)AAAAA intron-variant, upstream-variant-2KB
rs1000872046 -- 157,437,831(+) CCTGG(C/G)CGCGG intron-variant, reference, missense
rs1001299836 -- 157,437,819(+) GGCGG(G/T)GCGCG intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PTX3 Gene

Variant ID Type Subtype PubMed ID
esv2759193 CNV gain 17122850

Variation tolerance for PTX3 Gene

Residual Variation Intolerance Score: 74.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.43; 63.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTX3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTX3 Gene

Disorders for PTX3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PTX3 Gene - From: GeneCards

Disorder Aliases PubMed IDs
infectious myocarditis
hyper-igd syndrome
  • hyper igd syndrome
- elite association - COSMIC cancer census association via MalaCards
Search PTX3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PTX3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PTX3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTX3 Gene

Publications for PTX3 Gene

  1. Interleukin-1-inducible genes in endothelial cells. Cloning of a new gene related to C-reactive protein and serum amyloid P component. (PMID: 1429570) Breviario F … Rocchi M (The Journal of biological chemistry 1992) 2 3 4 22 60
  2. Genetic variation in pentraxin (PTX) 3 gene associates with PTX3 production and fertility in women. (PMID: 19846603) May L … Westendorp RG (Biology of reproduction 2010) 3 22 45 60
  3. Pentraxin 3, a non-redundant soluble pattern recognition receptor involved in innate immunity. (PMID: 12763682) Mantovani A … Bottazzi B (Vaccine 2003) 3 4 22 60
  4. Relationship of TSG-14 protein to the pentraxin family of major acute phase proteins. (PMID: 7523502) Lee GW … Vilcek J (Journal of immunology (Baltimore, Md. : 1950) 1994) 3 4 22 60
  5. TSG-14, a tumor necrosis factor- and IL-1-inducible protein, is a novel member of the pentaxin family of acute phase proteins. (PMID: 7679696) Lee GW … Vilcek J (Journal of immunology (Baltimore, Md. : 1950) 1993) 3 4 22 60

Products for PTX3 Gene

Sources for PTX3 Gene

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