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Aliases for PTPRN2 Gene

Aliases for PTPRN2 Gene

  • Protein Tyrosine Phosphatase, Receptor Type, N Polypeptide 2 2 3
  • ICAAR 3 4 6
  • IAR 3 4 6
  • Islet Cell Autoantigen-Related Protein 3 4
  • EC 3.1.3.48 4 63
  • R-PTP-N2 3 4
  • Phogrin 3 4
  • IAR/Receptor-Like Protein-Tyrosine Phosphatase 3
  • Receptor-Type Tyrosine-Protein Phosphatase N2 3
  • Protein Tyrosine Phosphatase Receptor Pi 3
  • Tyrosine Phosphatase IA-2 Beta 3
  • IAR PTPRP 2
  • IA-2beta 3
  • KIAA0387 4
  • PTPRP 3

External Ids for PTPRN2 Gene

Previous GeneCards Identifiers for PTPRN2 Gene

  • GC07M155562
  • GC07M156175
  • GC07M156634
  • GC07M156748
  • GC07M156831
  • GC07M157024
  • GC07M157331
  • GC07M151062

Summaries for PTPRN2 Gene

Entrez Gene Summary for PTPRN2 Gene

  • This gene encodes a protein with sequence similarity to receptor-like protein tyrosine phosphatases. However, tyrosine phosphatase activity has not been experimentally validated for this protein. Studies of the rat ortholog suggest that the encoded protein may instead function as a phosphatidylinositol phosphatase with the ability to dephosphorylate phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-diphosphate, and this function may be involved in the regulation of insulin secretion. This protein has been identified as an autoantigen in insulin-dependent diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

GeneCards Summary for PTPRN2 Gene

PTPRN2 (Protein Tyrosine Phosphatase, Receptor Type, N Polypeptide 2) is a Protein Coding gene. Diseases associated with PTPRN2 include spondylolysis. Among its related pathways are PAK Pathway and Allograft rejection. GO annotations related to this gene include transmembrane receptor protein tyrosine phosphatase activity. An important paralog of this gene is PTPN6.

UniProtKB/Swiss-Prot for PTPRN2 Gene

  • Implicated in development of nervous system and pancreatic endocrine cells.

Gene Wiki entry for PTPRN2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPRN2 Gene

Genomics for PTPRN2 Gene

Regulatory Elements for PTPRN2 Gene

Genomic Location for PTPRN2 Gene

Start:
157,539,056 bp from pter
End:
158,587,796 bp from pter
Size:
1,048,741 bases
Orientation:
Minus strand

Genomic View for PTPRN2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PTPRN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPRN2 Gene

Proteins for PTPRN2 Gene

  • Protein details for PTPRN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92932-PTPR2_HUMAN
    Recommended name:
    Receptor-type tyrosine-protein phosphatase N2
    Protein Accession:
    Q92932
    Secondary Accessions:
    • E9PC57
    • Q8N4I5
    • Q92662
    • Q9Y4F8
    • Q9Y4I6

    Protein attributes for PTPRN2 Gene

    Size:
    1015 amino acids
    Molecular mass:
    111271 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Autoantigen in insulin-dependent diabetes mellitus (IDDM)
    SequenceCaution:
    • Sequence=BAA20841.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PTPRN2 Gene

    Alternative splice isoforms for PTPRN2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTPRN2 Gene

Proteomics data for PTPRN2 Gene at MOPED

Selected DME Specific Peptides for PTPRN2 Gene

Post-translational modifications for PTPRN2 Gene

  • Appears to undergo multiple proteolytic cleavage at consecutive basic residues
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PTPRN2 Gene

Antibody Products

Domains for PTPRN2 Gene

Gene Families for PTPRN2 Gene

HGNC:
  • PTPR :Protein tyrosine phosphatases / Class I Cys-based PTPs : Transmembrane receptor-like
IUPHAR :

Suggested Antigen Peptide Sequences for PTPRN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92932

UniProtKB/Swiss-Prot:

PTPR2_HUMAN :
  • Q92932
Domain:
  • The cytoplasmic domain appears to contain the autoantigenic epitopes
  • Contains 1 tyrosine-protein phosphatase domain.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily.
genes like me logo Genes that share domains with PTPRN2: view

Function for PTPRN2 Gene

Molecular function for PTPRN2 Gene

GENATLAS Biochemistry:
phogrin,protein tyrosine phosphatase,receptor-type,N,polypeptide 2,homolog of mouse IA2B/ICAR gene,encoding an autoantigen in insulin-dependent diabetes
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 4.5.;
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot Function:
Implicated in development of nervous system and pancreatic endocrine cells.

Enzyme Numbers (IUBMB) for PTPRN2 Gene

Gene Ontology (GO) - Molecular Function for PTPRN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity --
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity TAS 8798755
GO:0005515 protein binding --
GO:0016791 phosphatase activity --
genes like me logo Genes that share ontologies with PTPRN2: view

Phenotypes for PTPRN2 Gene

genes like me logo Genes that share phenotypes with PTPRN2: view

Animal Models for PTPRN2 Gene

MGI Knock Outs for PTPRN2:

Animal Model Products

miRNA for PTPRN2 Gene

miRTarBase miRNAs that target PTPRN2

No data available for Transcription Factor Targeting and HOMER Transcription for PTPRN2 Gene

Localization for PTPRN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPRN2 Gene

Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTPRN2 Gene COMPARTMENTS Subcellular localization image for PTPRN2 gene
Compartment Confidence
plasma membrane 4
cytoskeleton 2
endoplasmic reticulum 2
extracellular 2
golgi apparatus 1
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PTPRN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005788 endoplasmic reticulum lumen IEA --
GO:0005887 integral component of plasma membrane TAS 8798755
GO:0030141 secretory granule IEA --
GO:0030658 transport vesicle membrane IEA --
genes like me logo Genes that share ontologies with PTPRN2: view

Pathways for PTPRN2 Gene

genes like me logo Genes that share pathways with PTPRN2: view

Pathways by source for PTPRN2 Gene

1 Qiagen pathway for PTPRN2 Gene
1 KEGG pathway for PTPRN2 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PTPRN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation TAS 8798755
GO:0016311 dephosphorylation --
GO:0034260 negative regulation of GTPase activity IEA --
GO:0035335 peptidyl-tyrosine dephosphorylation TAS 8798755
genes like me logo Genes that share ontologies with PTPRN2: view

Compounds for PTPRN2 Gene

(2) HMDB Compounds for PTPRN2 Gene

Compound Synonyms Cas Number PubMed IDs
Phosphate
  • NFB Orthophosphate
14265-44-2
Water
  • Dihydrogen oxide
7732-18-5

(6) Novoseek inferred chemical compound relationships for PTPRN2 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 58.7 27
glucose 19.1 3
glutamate 18.4 5
forskolin 15 1
alanine 10.9 1
genes like me logo Genes that share compounds with PTPRN2: view

Transcripts for PTPRN2 Gene

mRNA/cDNA for PTPRN2 Gene

(2) Selected AceView cDNA sequences:
(8) Additional mRNA sequences :
(8) REFSEQ mRNAs :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PTPRN2 Gene

Protein tyrosine phosphatase, receptor type, N polypeptide 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PTPRN2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTPRN2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - - -
SP6:
SP7:
SP8: -
SP9: - -
SP10:
SP11:
SP12: -
SP13:

ExUns: 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29 ^ 30 ^ 31a · 31b · 31c · 31d · 31e
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - -
SP5: - - -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for PTPRN2 Gene

GeneLoc Exon Structure for
PTPRN2
ECgene alternative splicing isoforms for
PTPRN2

Expression for PTPRN2 Gene

mRNA expression in normal human tissues for PTPRN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTPRN2 Gene

This gene is overexpressed in Brain - Cortex (4.7), Brain - Anterior cingulate cortex (BA24) (4.6), Brain - Frontal Cortex (BA9) (4.3), Brain - Nucleus accumbens (basal ganglia) (4.2), and Brain - Putamen (basal ganglia) (4.1).

Protein differential expression in normal tissues for PTPRN2 Gene

This gene is overexpressed in Cerebrospinal fluid (50.4) and Frontal cortex (13.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PTPRN2 Gene

SOURCE GeneReport for Unigene cluster for PTPRN2 Gene Hs.490789

mRNA Expression by UniProt/SwissProt for PTPRN2 Gene

Q92932-PTPR2_HUMAN
Tissue specificity: Highest levels in brain and pancreas. Lower levels in trachea, prostate, stomach and spinal chord
genes like me logo Genes that share expressions with PTPRN2: view

Expression partners for PTPRN2 Gene

In Situ Assay Products

Orthologs for PTPRN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PTPRN2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PTPRN2 35
  • 76.27 (n)
  • 69.49 (a)
PTPRN2 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTPRN2 35
  • 75.41 (n)
  • 69.91 (a)
PTPRN2 36
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptprn2 35
  • 75.8 (n)
  • 70.47 (a)
Ptprn2 16
Ptprn2 36
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptprn2 35
  • 75.94 (n)
  • 71.57 (a)
oppossum
(Monodelphis domestica)
Mammalia PTPRN2 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PTPRN2 36
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves PTPRN2 35
  • 62.58 (n)
  • 58.26 (a)
PTPRN2 36
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTPRN2 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ptprn2 35
  • 61.19 (n)
  • 57.86 (a)
zebrafish
(Danio rerio)
Actinopterygii ptprn2 35
  • 45.61 (n)
  • 35.79 (a)
ptprn2 36
  • 45 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta ia2 37
  • 63 (a)
IA-2 36
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ida-1 37
  • 32 (a)
ida-1 36
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToMany
Species with no ortholog for PTPRN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PTPRN2 Gene

ENSEMBL:
Gene Tree for PTPRN2 (if available)
TreeFam:
Gene Tree for PTPRN2 (if available)

Paralogs for PTPRN2 Gene

Selected SIMAP similar genes for PTPRN2 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for PTPRN2 Gene

genes like me logo Genes that share paralogs with PTPRN2: view

Variants for PTPRN2 Gene

Sequence variations from dbSNP and Humsavar for PTPRN2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs4104 -- 158,154,341(-) CCATT(C/T)GAGTG intron-variant
rs9931 -- 157,539,158(-) AAGCA(C/T)ATGCC utr-variant-3-prime
rs104685 -- 157,541,896(+) TCTTC(C/T)GCCCT intron-variant
rs122004 -- 157,577,996(+) TCCTG(C/G)CCTGG intron-variant
rs123776 -- 157,546,895(+) ATACA(C/T)ACAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTPRN2 Gene

Variant ID Type Subtype PubMed ID
dgv7564n71 CNV Loss 21882294
nsv889589 CNV Loss 21882294
nsv8242 CNV Loss 18304495
dgv7565n71 CNV Loss 21882294
esv270515 CNV Insertion 20981092
nsv442286 CNV CNV 18776908
dgv2167e1 CNV Complex 17122850
nsv428191 CNV Gain 18775914
esv273957 CNV Insertion 20981092
esv268250 CNV Insertion 20981092
esv2663923 CNV Deletion 23128226
esv2202859 CNV Deletion 18987734
nsv365287 CNV Loss 16902084
esv2657371 CNV Deletion 23128226
esv2735700 CNV Deletion 23290073
esv2735701 CNV Deletion 23290073
esv2735702 CNV Deletion 23290073
esv2735703 CNV Deletion 23290073
esv1458869 CNV Insertion 17803354
nsv435851 CNV Deletion 17901297
dgv7566n71 CNV Loss 21882294
nsv8243 CNV Gain+Loss 18304495
nsv512009 CNV Loss 21212237
esv22807 CNV Loss 19812545
nsv821230 CNV Deletion 20802225
esv1627187 CNV Deletion 17803354
esv2735704 CNV Deletion 23290073
esv1351690 CNV Deletion 17803354
esv2735705 CNV Deletion 23290073
esv2735707 CNV Deletion 23290073
esv268629 CNV Insertion 20981092
esv272948 CNV Insertion 20981092
esv33068 CNV Gain 17666407
esv1159588 CNV Insertion 17803354
esv2735708 CNV Deletion 23290073
esv2735709 CNV Deletion 23290073
esv2735710 CNV Deletion 23290073
esv1129897 CNV Insertion 17803354
dgv1151n67 CNV Gain 20364138
nsv889595 CNV Loss 21882294
esv2752150 CNV Gain 17911159
nsv523513 CNV Loss 19592680
esv2422331 CNV Duplication 17116639
esv2735711 CNV Deletion 23290073
esv2735712 CNV Deletion 23290073
esv989590 CNV Deletion 20482838
esv2677537 CNV Deletion 23128226
esv1002942 CNV Deletion 20482838
esv2735713 CNV Deletion 23290073
dgv1152n67 CNV Gain 20364138
nsv8244 CNV Gain+Loss 18304495
nsv509230 CNV Insertion 20534489
nsv8245 CNV Gain 18304495
essv14331 CNV CNV 17122850
esv33838 CNV Gain 17666407
esv2735714 CNV Deletion 23290073
esv2675545 CNV Deletion 23128226
dgv1194e201 CNV Deletion 23290073
nsv365377 CNV Loss 16902084
dgv1195e201 CNV Deletion 23290073
esv2735721 CNV Deletion 23290073
esv2735722 CNV Deletion 23290073
esv2735723 CNV Deletion 23290073
esv2735724 CNV Deletion 23290073
nsv889596 CNV Loss 21882294
nsv366775 CNV Loss 16902084
nsv6023 CNV Insertion 18451855
nsv8246 CNV Gain 18304495
dgv1196e201 CNV Deletion 23290073
esv23204 CNV Gain+Loss 19812545
esv1387349 CNV Insertion 17803354
esv1148504 CNV Insertion 17803354
esv1692507 CNV Insertion 17803354
nsv8248 CNV Gain 18304495
nsv820728 CNV Deletion 20802225
esv26337 CNV Gain+Loss 19812545
esv2129126 CNV Deletion 18987734
esv1973415 CNV Deletion 18987734
nsv512010 CNV Loss 21212237
dgv1197e201 CNV Deletion 23290073
dgv1198e201 CNV Deletion 23290073
esv1175009 CNV Deletion 17803354
nsv366707 CNV Loss 16902084
esv1493660 CNV Deletion 17803354
esv1591253 CNV Deletion 17803354
esv1220750 CNV Deletion 17803354
esv2735733 CNV Deletion 23290073
nsv889597 CNV Loss 21882294
nsv365867 CNV Loss 16902084
esv2735734 CNV Deletion 23290073
esv2735735 CNV Deletion 23290073
dgv1199e201 CNV Deletion 23290073
esv2735738 CNV Deletion 23290073
esv22520 CNV Gain 19812545
esv2735740 CNV Deletion 23290073
esv2735741 CNV Deletion 23290073
dgv7567n71 CNV Loss 21882294
nsv366306 CNV Loss 16902084
esv2735742 CNV Deletion 23290073
esv2674334 CNV Deletion 23128226
esv2735743 CNV Deletion 23290073
esv2735744 CNV Deletion 23290073
nsv889599 CNV Loss 21882294
nsv889602 CNV Loss 21882294
esv2735745 CNV Deletion 23290073
nsv522408 CNV Loss 19592680
nsv521980 CNV Loss 19592680
esv2735746 CNV Deletion 23290073
esv2675563 CNV Deletion 23128226
esv2735747 CNV Deletion 23290073
esv2735748 CNV Deletion 23290073
esv2735749 CNV Deletion 23290073
esv2735751 CNV Deletion 23290073
esv2735752 CNV Deletion 23290073
esv2735753 CNV Deletion 23290073
nsv509231 CNV Insertion 20534489
nsv8249 CNV Gain 18304495
esv2657822 CNV Deletion 23128226
nsv465252 CNV Loss 19166990
nsv831199 CNV Gain 17160897
nsv518635 CNV Loss 19592680
esv2735754 CNV Deletion 23290073
esv2735755 CNV Deletion 23290073
esv2735756 CNV Deletion 23290073
esv2735757 CNV Deletion 23290073
esv2597859 CNV Insertion 19546169
esv1165452 CNV Insertion 17803354
esv1600304 CNV Insertion 17803354
nsv889603 CNV Loss 21882294
nsv889604 CNV Loss 21882294
esv2735758 CNV Deletion 23290073
esv2735759 CNV Deletion 23290073
esv2735760 CNV Deletion 23290073
esv2735762 CNV Deletion 23290073
esv270958 CNV Insertion 20981092
esv21952 CNV Gain+Loss 19812545
esv2473924 CNV Deletion 19546169
esv2735763 CNV Deletion 23290073
esv1585173 CNV Insertion 17803354
esv996958 CNV Gain 20482838
esv1455252 CNV Deletion 17803354
esv1095072 CNV Deletion 17803354
esv2735764 CNV Deletion 23290073
esv1652062 CNV Insertion 17803354
esv2735765 CNV Deletion 23290073
esv2119297 CNV Deletion 18987734
esv2735766 CNV Deletion 23290073
esv2735767 CNV Deletion 23290073
esv2735768 CNV Deletion 23290073
esv2735769 CNV Deletion 23290073
esv2182751 CNV Deletion 18987734
esv2676129 CNV Deletion 23128226
esv987843 CNV Insertion 20482838
esv1767698 CNV Insertion 17803354
esv1073346 CNV Insertion 17803354
dgv7568n71 CNV Loss 21882294
esv2735770 CNV Deletion 23290073
esv1951528 CNV Deletion 18987734
nsv889607 CNV Loss 21882294
nsv889608 CNV Loss 21882294
esv2735771 CNV Deletion 23290073
dgv1200e201 CNV Deletion 23290073
dgv1201e201 CNV Deletion 23290073
esv2735775 CNV Deletion 23290073
esv2188727 CNV Deletion 18987734
esv3409 CNV Deletion 18987735
esv2667714 CNV Deletion 23128226
esv2735780 CNV Deletion 23290073
esv2735781 CNV Deletion 23290073
nsv889609 CNV Loss 21882294
esv4996 CNV Deletion 18987735
esv2735782 CNV Deletion 23290073
esv2735784 CNV Deletion 23290073
esv1000700 CNV Insertion 20482838
esv2735785 CNV Deletion 23290073
esv29721 CNV Loss 19812545
esv2735786 CNV Deletion 23290073
esv2663824 CNV Deletion 23128226
esv2735787 CNV Deletion 23290073
esv2735788 CNV Deletion 23290073
dgv849n27 CNV Gain 19166990
esv2735789 CNV Deletion 23290073
esv2735790 CNV Deletion 23290073
nsv507431 CNV Insertion 20534489
esv2735791 CNV Deletion 23290073
nsv512011 CNV Loss 21212237
esv2752151 CNV Gain 17911159
esv26772 CNV Loss 19812545
dgv1202e201 CNV Deletion 23290073
esv8571 CNV Loss 19470904
dgv1203e201 CNV Deletion 23290073
nsv365835 CNV Loss 16902084
esv2735802 CNV Deletion 23290073
nsv470401 CNV Gain 18288195
nsv519942 CNV Gain+Loss 19592680
esv2735803 CNV Deletion 23290073
dgv1255e199 CNV Deletion 23128226
esv2735804 CNV Deletion 23290073
esv2735807 CNV Deletion 23290073
esv2735808 CNV Deletion 23290073
esv2735809 CNV Deletion 23290073
esv2735810 CNV Deletion 23290073
esv2735811 CNV Deletion 23290073
esv2675632 CNV Deletion 23128226
esv1281811 CNV Deletion 17803354
esv1544675 CNV Insertion 17803354
esv2735812 CNV Deletion 23290073
nsv889610 CNV Loss 21882294
esv1140766 CNV Insertion 17803354
esv2735813 CNV Deletion 23290073
esv2656695 CNV Deletion 23128226
esv2735814 CNV Deletion 23290073
esv2675691 CNV Deletion 23128226
esv2735815 CNV Deletion 23290073
esv2735816 CNV Deletion 23290073
esv1005454 CNV Deletion 20482838
esv1643403 CNV Deletion 17803354
dgv1204e201 CNV Deletion 23290073
esv2735819 CNV Deletion 23290073
esv1099856 CNV Insertion 17803354
esv1390782 CNV Insertion 17803354
nsv889611 CNV Loss 21882294
esv26619 CNV Gain 19812545
esv2735821 CNV Deletion 23290073
esv1482349 CNV Deletion 17803354
esv2735822 CNV Deletion 23290073
esv1524117 CNV Insertion 17803354
esv2735823 CNV Deletion 23290073
esv2735824 CNV Deletion 23290073
esv2735825 CNV Deletion 23290073
esv2370566 CNV Deletion 18987734
esv2735826 CNV Deletion 23290073
esv1006616 CNV Insertion 20482838
esv1186905 CNV Insertion 17803354
esv1482011 CNV Insertion 17803354
esv1538186 CNV Insertion 17803354
esv2570529 CNV Insertion 19546169
nsv509232 CNV Insertion 20534489
esv2735827 CNV Deletion 23290073
esv2648813 CNV Deletion 19546169
nsv820523 CNV Deletion 20802225
esv28985 CNV Loss 19812545
esv1537965 CNV Insertion 17803354
esv1094778 CNV Insertion 17803354
esv2735829 CNV Deletion 23290073
esv3684 CNV Deletion 18987735
dgv1205e201 CNV Deletion 23290073
esv1777704 CNV Deletion 17803354
dgv1206e201 CNV Deletion 23290073
esv2735834 CNV Deletion 23290073
esv2735835 CNV Deletion 23290073
esv1253259 CNV Insertion 17803354
esv1668845 CNV Insertion 17803354
esv2741038 CNV Deletion 23290073
esv2735837 CNV Deletion 23290073
esv2735838 CNV Deletion 23290073
esv2735840 CNV Deletion 23290073
esv2735841 CNV Deletion 23290073
esv2735842 CNV Deletion 23290073
esv2735843 CNV Deletion 23290073
nsv6024 CNV Insertion 18451855
esv28020 CNV Gain+Loss 19812545
esv2735844 CNV Deletion 23290073
esv2602791 CNV Loss 19546169
nsv821081 CNV Deletion 20802225
esv994490 CNV Loss 20482838
esv2735845 CNV Deletion 23290073
esv2735846 CNV Deletion 23290073
esv2678153 CNV Deletion 23128226
esv2735847 CNV Deletion 23290073
esv2735848 CNV Deletion 23290073
esv1501716 CNV Insertion 17803354
esv2020339 CNV Deletion 18987734
esv2735849 CNV Deletion 23290073
esv2735851 CNV Deletion 23290073
esv26534 CNV Gain+Loss 19812545
esv1007316 CNV Loss 20482838
esv24570 CNV Loss 19812545
esv2735852 CNV Deletion 23290073
esv2735853 CNV Deletion 23290073
esv2735854 CNV Deletion 23290073
esv2735855 CNV Deletion 23290073
esv999497 CNV Deletion 20482838
esv1154072 CNV Deletion 17803354
esv2735856 CNV Deletion 23290073
nsv510972 CNV Complex 20534489
esv2735857 CNV Deletion 23290073
esv2735858 CNV Deletion 23290073
esv2665883 CNV Deletion 23128226
esv991166 CNV Deletion 20482838
nsv831200 CNV Loss 17160897
esv2472439 CNV Deletion 19546169
esv2735859 CNV Deletion 23290073
nsv509233 CNV Insertion 20534489
esv995097 CNV Insertion 20482838
nsv821497 CNV Duplication 20802225
esv23469 CNV Gain+Loss 19812545
esv2669347 CNV Deletion 23128226
esv2735860 CNV Deletion 23290073
esv2669610 CNV Deletion 23128226
nsv889612 CNV Gain 21882294
esv2674169 CNV Deletion 23128226
esv2735863 CNV Deletion 23290073
esv2735862 CNV Deletion 23290073
esv1617552 CNV Insertion 17803354
esv1434953 CNV Deletion 17803354
esv2735864 CNV Deletion 23290073
esv2735865 CNV Deletion 23290073
nsv6025 CNV Insertion 18451855
esv1001058 CNV Insertion 20482838
esv2735866 CNV Deletion 23290073
esv1663585 CNV Insertion 17803354
esv1420305 CNV Deletion 17803354
esv2634564 CNV Insertion 19546169
esv1478003 CNV Insertion 17803354
esv28090 CNV Loss 19812545
esv2735867 CNV Deletion 23290073
esv2662026 CNV Deletion 23128226
esv2735868 CNV Deletion 23290073
nsv365303 CNV Loss 16902084
esv2735869 CNV Deletion 23290073
esv1552639 CNV Deletion 17803354
esv1185910 CNV Insertion 17803354
esv2735870 CNV Deletion 23290073
esv2735871 CNV Deletion 23290073
nsv512931 CNV Insertion 21212237
esv2160851 CNV Deletion 18987734
esv2735873 CNV Deletion 23290073
esv2735874 CNV Deletion 23290073
esv28383 CNV Loss 19812545
esv2735875 CNV Deletion 23290073
nsv6026 CNV Loss 18451855
esv2735876 CNV Deletion 23290073
esv2668650 CNV Deletion 23128226
esv2430415 CNV Deletion 19546169
dgv7569n71 CNV Loss 21882294
nsv512012 CNV Loss 21212237
esv990979 CNV Deletion 20482838
esv2093583 CNV Deletion 18987734
esv5015 CNV Deletion 18987735
esv2735877 CNV Deletion 23290073
esv996959 CNV Deletion 20482838
esv1787465 CNV Deletion 17803354
esv5555 CNV Loss 19470904
dgv7570n71 CNV Loss 21882294
dgv7571n71 CNV Loss 21882294
esv2735878 CNV Deletion 23290073
esv2735879 CNV Deletion 23290073
esv2374779 CNV Deletion 18987734
esv2735880 CNV Deletion 23290073
esv26603 CNV Loss 19812545
esv2735881 CNV Deletion 23290073
esv2658800 CNV Deletion 23128226
esv3956 CNV Deletion 18987735
esv2735882 CNV Deletion 23290073
esv2735884 CNV Deletion 23290073
esv2735885 CNV Deletion 23290073
dgv7572n71 CNV Loss 21882294
esv2429042 CNV Deletion 19546169
esv2735886 CNV Deletion 23290073
nsv512013 CNV Loss 21212237
esv2193160 CNV Deletion 18987734
esv4239 CNV Deletion 18987735
esv8654 CNV Loss 19470904
esv1008117 CNV Gain 20482838
esv26693 CNV Gain 19812545
nsv820686 CNV Deletion 20802225
esv2735887 CNV Deletion 23290073
esv2735888 CNV Deletion 23290073
esv2735889 CNV Deletion 23290073
esv2657574 CNV Deletion 23128226
esv2735891 CNV Deletion 23290073
esv2735890 CNV Deletion 23290073
esv4672 CNV Deletion 18987735
esv2662419 CNV Deletion 23128226
esv1001208 CNV Deletion 20482838
esv1512306 CNV Deletion 17803354
esv2735892 CNV Deletion 23290073
dgv7573n71 CNV Loss 21882294
esv991402 CNV Deletion 20482838
esv2735893 CNV Deletion 23290073
esv2657567 CNV Deletion 23128226
esv2735895 CNV Deletion 23290073
nsv366062 CNV Insertion 16902084
esv2735896 CNV Deletion 23290073
nsv889625 CNV Loss 21882294
esv2735897 CNV Deletion 23290073
esv2735898 CNV Deletion 23290073
esv1071067 CNV Deletion 17803354
esv21963 CNV Loss 19812545
esv2735899 CNV Deletion 23290073
dgv1207e201 CNV Deletion 23290073
esv2735900 CNV Deletion 23290073
esv2735902 CNV Deletion 23290073
esv2735903 CNV Deletion 23290073
esv2225406 CNV Deletion 18987734
esv2735904 CNV Deletion 23290073
esv1032734 CNV Deletion 17803354
esv2678502 CNV Deletion 23128226
esv997534 CNV Deletion 20482838
esv2735906 CNV Deletion 23290073
esv2735907 CNV Deletion 23290073
nsv831201 CNV Loss 17160897
esv2735908 CNV Deletion 23290073
esv2164228 CNV Deletion 18987734
esv2672761 CNV Deletion 23128226
esv2735909 CNV Deletion 23290073
esv998111 CNV Deletion 20482838
esv1259869 CNV Deletion 17803354
dgv7574n71 CNV Loss 21882294
esv2735910 CNV Deletion 23290073
nsv6027 CNV Loss 18451855
nsv889630 CNV Loss 21882294
esv2735911 CNV Deletion 23290073
esv2658937 CNV Deletion 23128226
dgv1208e201 CNV Deletion 23290073
esv2735913 CNV Deletion 23290073
esv1244297 CNV Deletion 17803354
nsv509234 CNV Insertion 20534489
esv29708 CNV Gain 19812545
esv1558426 CNV Insertion 17803354
esv2735915 CNV Deletion 23290073
esv2735918 CNV Deletion 23290073
dgv1209e201 CNV Deletion 23290073
esv1951434 CNV Deletion 18987734
esv5043 CNV Deletion 18987735
esv6030 CNV Loss 19470904
esv2665903 CNV Deletion 23128226
esv2735921 CNV Deletion 23290073
nsv442294 CNV CNV 18776908
esv33849 CNV Gain 17666407
nsv515043 CNV Complex 21397061
esv26378 CNV Gain+Loss 19812545
esv2594488 CNV Deletion 19546169
esv2735922 CNV Deletion 23290073
esv2742233 CNV Deletion 23290073
dgv1210e201 CNV Deletion 23290073
esv997326 CNV Insertion 20482838
esv2735924 CNV Deletion 23290073
esv2735926 CNV Deletion 23290073
esv1550816 CNV Insertion 17803354
esv2735927 CNV Deletion 23290073
esv2735930 CNV Deletion 23290073
esv2735931 CNV Deletion 23290073
dgv1211e201 CNV Deletion 23290073
dgv1212e201 CNV Deletion 23290073
esv2735935 CNV Deletion 23290073
esv2735938 CNV Deletion 23290073
nsv366744 CNV Loss 16902084
esv2735943 CNV Deletion 23290073
dgv7575n71 CNV Loss 21882294
esv2735944 CNV Deletion 23290073
esv990816 CNV Deletion 20482838
esv1621516 CNV Deletion 17803354
esv1064724 CNV Deletion 17803354
esv1526404 CNV Deletion 17803354
esv1609406 CNV Deletion 17803354
nsv366337 CNV Loss 16902084
esv2735945 CNV Deletion 23290073
esv2735946 CNV Deletion 23290073
dgv7576n71 CNV Loss 21882294
nsv889636 CNV Gain 21882294
esv1680668 CNV Insertion 17803354
esv1401307 CNV Insertion 17803354
esv2436240 CNV Deletion 19546169
esv987957 CNV Deletion 20482838
esv1682665 CNV Deletion 17803354
esv1566857 CNV Deletion 17803354
esv1438946 CNV Insertion 17803354
esv23833 CNV Loss 19812545
nsv821219 CNV Duplication 20802225
esv2325675 CNV Deletion 18987734
esv993502 CNV Insertion 20482838
esv2735947 CNV Deletion 23290073
esv1762513 CNV Deletion 17803354
esv2735948 CNV Deletion 23290073
esv1341538 CNV Deletion 17803354
nsv520895 CNV Loss 19592680
esv2735949 CNV Deletion 23290073
esv2735951 CNV Deletion 23290073
esv2735952 CNV Deletion 23290073
esv2735953 CNV Deletion 23290073
esv2735954 CNV Deletion 23290073
esv2742325 CNV Deletion 23290073
esv2735955 CNV Deletion 23290073
esv2735956 CNV Deletion 23290073
esv988181 CNV Insertion 20482838
esv1742476 CNV Insertion 17803354
esv25551 CNV Gain 19812545
nsv512932 CNV Insertion 21212237
esv990226 CNV Deletion 20482838
esv2735957 CNV Deletion 23290073
esv25118 CNV Loss 19812545
dgv7577n71 CNV Gain 21882294
esv7545 CNV Gain 19470904
esv1617560 CNV Insertion 17803354
esv5759 CNV Gain 19470904
esv2735958 CNV Deletion 23290073
esv2569223 CNV Deletion 19546169
esv8193 CNV Loss 19470904
esv2735959 CNV Deletion 23290073
esv2735960 CNV Deletion 23290073
esv2735962 CNV Deletion 23290073
esv2735963 CNV Deletion 23290073
esv2735964 CNV Deletion 23290073
esv2225893 CNV Deletion 18987734
esv25476 CNV Loss 19812545
nsv366114 CNV Loss 16902084
esv1376066 CNV Deletion 17803354
esv2735965 CNV Deletion 23290073
nsv366641 CNV Loss 16902084
esv1071922 CNV Deletion 17803354
esv2735966 CNV Deletion 23290073
esv1286519 CNV Deletion 17803354
esv2032123 CNV Deletion 18987734
esv2670399 CNV Deletion 23128226
dgv1256e199 CNV Deletion 23128226
esv2735967 CNV Deletion 23290073
esv2667381 CNV Deletion 23128226
esv2735968 CNV Deletion 23290073
esv2608856 CNV Insertion 19546169
dgv1213e201 CNV Deletion 23290073
esv2735970 CNV Deletion 23290073
esv2735973 CNV Deletion 23290073
esv4054 CNV Deletion 18987735
esv2735974 CNV Deletion 23290073
esv1469445 CNV Deletion 17803354
esv2735975 CNV Deletion 23290073
esv1557291 CNV Insertion 17803354
esv2735976 CNV Deletion 23290073
esv2735977 CNV Deletion 23290073
esv2735978 CNV Deletion 23290073
esv2735979 CNV Deletion 23290073
esv1380040 CNV Insertion 17803354
esv1403668 CNV Insertion 17803354
esv2735980 CNV Deletion 23290073
esv3560 CNV Deletion 18987735
esv2735981 CNV Deletion 23290073
esv2735982 CNV Deletion 23290073
esv1003874 CNV Deletion 20482838
esv2675958 CNV Deletion 23128226
esv2735984 CNV Deletion 23290073
esv1917131 CNV Deletion 18987734
esv2735985 CNV Deletion 23290073
esv2735986 CNV Deletion 23290073
esv2735987 CNV Deletion 23290073
esv1134346 CNV Deletion 17803354
esv2735988 CNV Deletion 23290073
esv7374 CNV Gain 19470904
esv7955 CNV Gain 19470904
esv1207597 CNV Insertion 17803354
esv2735989 CNV Deletion 23290073
esv1450913 CNV Deletion 17803354
esv2735990 CNV Deletion 23290073
esv2735991 CNV Deletion 23290073
esv1782223 CNV Insertion 17803354
esv2735992 CNV Deletion 23290073
esv2735993 CNV Deletion 23290073
nsv889639 CNV Loss 21882294
dgv7578n71 CNV Gain 21882294
esv2735995 CNV Deletion 23290073
esv2735996 CNV Deletion 23290073
esv1587341 CNV Insertion 17803354
nsv889641 CNV Loss 21882294
esv2735997 CNV Deletion 23290073
nsv511365 CNV Loss 21212237
esv23376 CNV Gain 19812545
esv2735998 CNV Deletion 23290073
esv2735999 CNV Deletion 23290073
nsv509236 CNV Insertion 20534489
esv2736000 CNV Deletion 23290073
esv27556 CNV Loss 19812545
dgv1214e201 CNV Deletion 23290073
esv2736002 CNV Deletion 23290073
esv4791 CNV Deletion 18987735
dgv1215e201 CNV Deletion 23290073
esv1435366 CNV Deletion 17803354
esv1313788 CNV Deletion 17803354
esv1189905 CNV Insertion 17803354
esv1212288 CNV Insertion 17803354
esv2736008 CNV Deletion 23290073
esv2736009 CNV Deletion 23290073
esv1539719 CNV Insertion 17803354
esv2736010 CNV Deletion 23290073
esv2736011 CNV Deletion 23290073
dgv7579n71 CNV Loss 21882294
nsv889644 CNV Gain 21882294
nsv510974 CNV Complex 20534489
esv991388 CNV Insertion 20482838
esv2736012 CNV Deletion 23290073
nsv509237 CNV Insertion 20534489

Relevant External Links for PTPRN2 Gene

HapMap Linkage Disequilibrium report
PTPRN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPRN2 Gene

Disorders for PTPRN2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for PTPRN2 Gene in MalaCards »

(1) Diseases for PTPRN2 Gene including...

(2) University of Copenhagen DISEASES for PTPRN2 Gene

(4) Novoseek inferred disease relationships for PTPRN2 Gene

Disease -log(P) Hits PubMed IDs
insulinoma 69.5 8
autoimmunity 48.2 3
autoimmune response 46.6 1
diabetes mellitus insulin-dependent 41.2 3

Relevant External Links for PTPRN2

Genetic Association Database (GAD)
PTPRN2
Human Genome Epidemiology (HuGE) Navigator
PTPRN2
genes like me logo Genes that share disorders with PTPRN2: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for PTPRN2 Gene

Publications for PTPRN2 Gene

  1. ICAAR, a novel member of a new family of transmembrane, tyrosine phosphatase-like proteins. (PMID: 8954911) Smith P.D. … Crompton M.R. (Biochem. Biophys. Res. Commun. 1996) 2 3 4 23
  2. Cloning and characterization of islet cell antigen-related protein- tyrosine phosphatase (PTP), a novel receptor-like PTP and autoantigen in insulin-dependent diabetes. (PMID: 8798755) Cui L. … Pallen C.J. (J. Biol. Chem. 1996) 3 4 23
  3. Molecular cloning and characterization of the human transmembrane protein tyrosine phosphatase homologue, phogrin, an autoantigen of type 1 diabetes. (PMID: 8878534) Kawasaki E. … Eisenbarth G.S. (Biochem. Biophys. Res. Commun. 1996) 3 4 23
  4. The neurosecretory vesicle protein phogrin functions as a phosphatidylinositol phosphatase to regulate insulin secretion. (PMID: 20097759) Caromile L.A. … Bowen-Pope D.F. (J. Biol. Chem. 2010) 3 23
  5. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T. … Ohara O. (DNA Res. 1997) 3 4

Products for PTPRN2 Gene

Sources for PTPRN2 Gene

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