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Aliases for PTPRJ Gene

Aliases for PTPRJ Gene

  • Protein Tyrosine Phosphatase, Receptor Type J 2 3
  • Protein-Tyrosine Phosphatase Receptor Type J 3 4
  • Protein-Tyrosine Phosphatase Eta 3 4
  • Density-Enhanced Phosphatase 1 3 4
  • CD148 Antigen 3 4
  • EC 3.1.3.48 4 63
  • R-PTP-ETA 3 4
  • HPTP Eta 3 4
  • R-PTP-J 3 4
  • DEP-1 3 4
  • DEP1 3 4
  • Protein Tyrosine Phosphatase, Receptor Type, J Polypeptide 3
  • Susceptibility To Colon Cancer 1, Mouse, Homolog Of 3
  • Protein Tyrosine Phosphatase, Receptor Type, J 5
  • Human Density Enhanced Phosphatase-1 3
  • HPTPeta 3
  • CD148 3
  • SCC1 3

External Ids for PTPRJ Gene

Previous GeneCards Identifiers for PTPRJ Gene

  • GC11P049914
  • GC11P048896
  • GC11P048033
  • GC11P047966
  • GC11P047958
  • GC11P047712

Summaries for PTPRJ Gene

Entrez Gene Summary for PTPRJ Gene

  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for PTPRJ Gene

PTPRJ (Protein Tyrosine Phosphatase, Receptor Type J) is a Protein Coding gene. Diseases associated with PTPRJ include cornelia de lange syndrome 4 and colorectal cancer. Among its related pathways are Adherens junction and PAK Pathway. GO annotations related to this gene include protein kinase binding and protein tyrosine phosphatase activity. An important paralog of this gene is PTPRO.

UniProtKB/Swiss-Prot for PTPRJ Gene

  • Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, RET (variant MEN2A), KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2. Plays a role in cell adhesion, migration, proliferation and differentiation. Involved in vascular development. Regulator of macrophage adhesion and spreading. Positively affects cell-matrix adhesion. Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation. Negative regulator of PDGF-stimulated cell migration; through dephosphorylation of PDGFR. Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dephosphorylation. Negative regulator of EGFR signaling pathway; through EGFR dephosphorylation. Enhances the barrier function of epithelial junctions during reassembly. Negatively regulates T-cell receptor (TCR) signaling. Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling.

Gene Wiki entry for PTPRJ Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPRJ Gene

Genomics for PTPRJ Gene

Regulatory Elements for PTPRJ Gene

Enhancers for PTPRJ Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PTPRJ on UCSC Golden Path with GeneCards custom track

Promoters for PTPRJ Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PTPRJ on UCSC Golden Path with GeneCards custom track

Genomic Location for PTPRJ Gene

Chromosome:
11
Start:
47,980,558 bp from pter
End:
48,170,842 bp from pter
Size:
190,285 bases
Orientation:
Plus strand

Genomic View for PTPRJ Gene

Genes around PTPRJ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTPRJ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTPRJ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPRJ Gene

Proteins for PTPRJ Gene

  • Protein details for PTPRJ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12913-PTPRJ_HUMAN
    Recommended name:
    Receptor-type tyrosine-protein phosphatase eta
    Protein Accession:
    Q12913
    Secondary Accessions:
    • Q15255
    • Q6P4H4
    • Q8NHM2
    • Q9UDA9

    Protein attributes for PTPRJ Gene

    Size:
    1337 amino acids
    Molecular mass:
    145941 Da
    Quaternary structure:
    • Monomer. Interacts with CTNNB1 (phosphorylated) and JUP (phosphorylated). Interacts with FLT3 (phosphorylated). Interacts with GAB1 and GRB2.

    Three dimensional structures from OCA and Proteopedia for PTPRJ Gene

    Alternative splice isoforms for PTPRJ Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTPRJ Gene

Proteomics data for PTPRJ Gene at MOPED

Selected DME Specific Peptides for PTPRJ Gene

Post-translational modifications for PTPRJ Gene

  • N- and O-glycosylated.
  • Glycosylation at Asn 72, Asn 82, Asn 93, Asn 104, Asn 142, Asn 172, Asn 192, Asn 231, Asn 258, Asn 278, Asn 342, Asn 351, Asn 376, Asn 391, Asn 396, Asn 413, Asn 431, Asn 501, Asn 525, Asn 536, Asn 582, Asn 603, Asn 618, Asn 628, Asn 637, Asn 666, Asn 669, Asn 761, Asn 772, Asn 784, Asn 790, Asn 824, Asn 910, and Asn 937
  • Modification sites at PhosphoSitePlus

Other Protein References for PTPRJ Gene

Antibody Products

Domains & Families for PTPRJ Gene

Suggested Antigen Peptide Sequences for PTPRJ Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q12913

UniProtKB/Swiss-Prot:

PTPRJ_HUMAN :
  • Contains 9 fibronectin type-III domains.
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.
Domain:
  • Contains 9 fibronectin type-III domains.
  • Contains 1 tyrosine-protein phosphatase domain.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.
genes like me logo Genes that share domains with PTPRJ: view

Function for PTPRJ Gene

Molecular function for PTPRJ Gene

GENATLAS Biochemistry:
protein tyrosine kinase,receptor type,J polypeptide
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot Function:
Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, RET (variant MEN2A), KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2. Plays a role in cell adhesion, migration, proliferation and differentiation. Involved in vascular development. Regulator of macrophage adhesion and spreading. Positively affects cell-matrix adhesion. Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation. Negative regulator of PDGF-stimulated cell migration; through dephosphorylation of PDGFR. Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dephosphorylation. Negative regulator of EGFR signaling pathway; through EGFR dephosphorylation. Enhances the barrier function of epithelial junctions during reassembly. Negatively regulates T-cell receptor (TCR) signaling. Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling.

Enzyme Numbers (IUBMB) for PTPRJ Gene

Gene Ontology (GO) - Molecular Function for PTPRJ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005161 platelet-derived growth factor receptor binding IPI 10821867
GO:0005515 protein binding IEA,IPI 10821867
GO:0008013 beta-catenin binding IPI 12370829
GO:0045295 gamma-catenin binding IPI 12370829
genes like me logo Genes that share ontologies with PTPRJ: view
genes like me logo Genes that share phenotypes with PTPRJ: view

Human Phenotype Ontology for PTPRJ Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PTPRJ Gene

MGI Knock Outs for PTPRJ:

Animal Model Products

  • Taconic Biosciences Mouse Models for PTPRJ

No data available for Transcription Factor Targets and HOMER Transcription for PTPRJ Gene

Localization for PTPRJ Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPRJ Gene

Cell membrane; Single-pass type I membrane protein. Cell projection, ruffle membrane. Cell junction. Note=After T-cell stimulation, it is temporarily excluded from immunological synapses.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTPRJ Gene COMPARTMENTS Subcellular localization image for PTPRJ gene
Compartment Confidence
extracellular 5
plasma membrane 5
nucleus 2
endoplasmic reticulum 1

No data available for Gene Ontology (GO) - Cellular Components for PTPRJ Gene

Pathways & Interactions for PTPRJ Gene

genes like me logo Genes that share pathways with PTPRJ: view

Pathways by source for PTPRJ Gene

1 GeneGo (Thomson Reuters) pathway for PTPRJ Gene
1 Qiagen pathway for PTPRJ Gene

SIGNOR curated interactions for PTPRJ Gene

Gene Ontology (GO) - Biological Process for PTPRJ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
GO:0016311 dephosphorylation IEA --
GO:0030155 regulation of cell adhesion IMP 12370829
GO:0035335 peptidyl-tyrosine dephosphorylation IEA,IMP 9780142
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway IMP 19836242
genes like me logo Genes that share ontologies with PTPRJ: view

Drugs & Compounds for PTPRJ Gene

(4) Drugs for PTPRJ Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for PTPRJ Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with PTPRJ: view

Transcripts for PTPRJ Gene

Unigene Clusters for PTPRJ Gene

Protein tyrosine phosphatase, receptor type, J:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PTPRJ Gene

No ASD Table

Relevant External Links for PTPRJ Gene

GeneLoc Exon Structure for
PTPRJ
ECgene alternative splicing isoforms for
PTPRJ

Expression for PTPRJ Gene

mRNA expression in normal human tissues for PTPRJ Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTPRJ Gene

This gene is overexpressed in Whole Blood (x9.3).

Protein differential expression in normal tissues from HIPED for PTPRJ Gene

This gene is overexpressed in Serum (15.2), Peripheral blood mononuclear cells (14.1), Neutrophil (11.5), and Nasal epithelium (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PTPRJ Gene



SOURCE GeneReport for Unigene cluster for PTPRJ Gene Hs.318547

mRNA Expression by UniProt/SwissProt for PTPRJ Gene

Q12913-PTPRJ_HUMAN
Tissue specificity: Expressed in the promyelocytic cell line HL-60, the granulocyte-macrophage colony-stimulating factor-dependent leukemic cell line F-36P, and the IL3 and erythropoietin-dependent leukemic cell line F-36E. Expressed predominantly in epithelial cells and lymphocytes. Enhanced expression at high cell density.
genes like me logo Genes that share expression patterns with PTPRJ: view

Primer Products

No data available for Protein tissue co-expression partners for PTPRJ Gene

Orthologs for PTPRJ Gene

This gene was present in the common ancestor of animals.

Orthologs for PTPRJ Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PTPRJ 35
  • 78.67 (n)
  • 71.54 (a)
PTPRJ 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTPRJ 35
  • 79.56 (n)
  • 72.17 (a)
PTPRJ 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptprj 35
  • 77.71 (n)
  • 72.7 (a)
Ptprj 16
Ptprj 36
  • 67 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PTPRJ 35
  • 99.32 (n)
  • 98.7 (a)
PTPRJ 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptprj 35
  • 77.48 (n)
  • 73.38 (a)
oppossum
(Monodelphis domestica)
Mammalia PTPRJ 36
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PTPRJ 36
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves PTPRJ 35
  • 56.22 (n)
  • 49.79 (a)
PTPRJ 36
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTPRJ 36
  • 42 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ptprja 35
  • 49.65 (n)
  • 39.77 (a)
PTPRJ (2 of 3) 36
  • 25 (a)
OneToMany
ptprja 36
  • 24 (a)
OneToMany
ptprjb 36
  • 62 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Ptp52F 37
  • 38 (a)
Ptp52F 36
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F36H1.3 37
  • 36 (a)
F47B3.1 37
  • 35 (a)
F47B3.6 37
  • 35 (a)
T22C1.8 37
  • 32 (a)
Y41D4A.5 37
  • 29 (a)
Y48G9A.9 37
  • 33 (a)
ZK354.8 37
  • 32 (a)
Y71G12B.31 36
  • 30 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3156 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
ManyToMany
Species with no ortholog for PTPRJ:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PTPRJ Gene

ENSEMBL:
Gene Tree for PTPRJ (if available)
TreeFam:
Gene Tree for PTPRJ (if available)

Paralogs for PTPRJ Gene

Pseudogenes.org Pseudogenes for PTPRJ Gene

genes like me logo Genes that share paralogs with PTPRJ: view

Variants for PTPRJ Gene

Sequence variations from dbSNP and Humsavar for PTPRJ Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_015905 A colon cancer sample
rs1566734 A colon cancer sample 48,123,823(-) TTGAT(G/T)GTAGA nc-transcript-variant, reference, missense
rs1503185 - 48,125,070(-) TGTCT(C/T)GGGAC nc-transcript-variant, reference, missense
rs2229701 - 48,124,970(+) CAGAT(A/G)CCAGC nc-transcript-variant, reference, missense
rs2229703 - 48,127,800(+) TTGAC(A/G)TCACC nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PTPRJ Gene

Variant ID Type Subtype PubMed ID
nsv897326 CNV Gain 21882294
nsv317 CNV Loss 18451855
nsv528641 CNV Loss 19592680
dgv1091n71 CNV Gain 21882294
nsv39746 CNV Loss 16902084
nsv897329 CNV Gain 21882294
esv2657950 CNV Deletion 23128226
nsv467871 CNV Gain 19166990
esv2458591 CNV Deletion 19546169
esv2380235 CNV Deletion 18987734
esv3499 CNV Deletion 18987735
esv2744445 CNV Deletion 23290073
esv1002186 CNV Deletion 20482838
esv990562 CNV Deletion 20482838
esv7637 CNV Loss 19470904
esv2674478 CNV Deletion 23128226
nsv428253 CNV Loss 18775914

Variation tolerance for PTPRJ Gene

Residual Variation Intolerance Score: 62.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.82; 67.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTPRJ Gene

HapMap Linkage Disequilibrium report
PTPRJ
Human Gene Mutation Database (HGMD)
PTPRJ

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPRJ Gene

Disorders for PTPRJ Gene

MalaCards: The human disease database

(13) MalaCards diseases for PTPRJ Gene - From: OMIM, ClinVar, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
cornelia de lange syndrome 4
  • cdls4
colorectal cancer
  • colorectal cancer, somatic
precursor b lymphoblastic lymphoma/leukemia
  • b lymphoblastic leukemia/lymphoma
precursor lymphoblastic lymphoma/leukemia
  • precursor lymphoid neoplasm
cogan syndrome
  • cogan's syndrome
- elite association - COSMIC cancer census association via MalaCards
Search PTPRJ in MalaCards View complete list of genes associated with diseases

Relevant External Links for PTPRJ

Genetic Association Database (GAD)
PTPRJ
Human Genome Epidemiology (HuGE) Navigator
PTPRJ
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTPRJ
genes like me logo Genes that share disorders with PTPRJ: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTPRJ Gene

Publications for PTPRJ Gene

  1. Expression of DEP-1, a receptor-like protein-tyrosine-phosphatase, is enhanced with increasing cell density. (PMID: 7937872) Oestman A. … Tonks N.K. (Proc. Natl. Acad. Sci. U.S.A. 1994) 2 3 4 23 67
  2. Molecular cloning, characterization, and chromosomal localization of a novel protein-tyrosine phosphatase, HPTP eta. (PMID: 7994032) Honda H. … Hirai H. (Blood 1994) 2 3 23
  3. Missense polymorphisms of PTPRJ and PTPN13 genes affect susceptibility to a variety of human cancers. (PMID: 19672627) Mita Y. … Shimizu K. (J. Cancer Res. Clin. Oncol. 2010) 3 23
  4. Phosphatome profiling reveals PTPN2, PTPRJ and PTEN as potent negative regulators of PKB/Akt activation in Ras-mutated cancer cells. (PMID: 19922411) Omerovic J. … Prior I.A. (Biochem. J. 2010) 3 23
  5. The eighth fibronectin type III domain of protein tyrosine phosphatase receptor J influences the formation of protein complexes and cell localization. (PMID: 19122201) Iuliano R. … Fusco A. (J. Biochem. 2009) 3 23

Products for PTPRJ Gene

Sources for PTPRJ Gene

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