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Aliases for PTPRG Gene

Aliases for PTPRG Gene

  • Protein Tyrosine Phosphatase, Receptor Type, G 2 3
  • PTPG 3 4 6
  • Protein-Tyrosine Phosphatase Gamma 3 4
  • R-PTP-GAMMA 3 4
  • EC 4 63
  • Protein Tyrosine Phosphatase, Receptor Type, Gamma Polypeptide 3
  • Receptor Type Protein Tyrosine Phosphatase Gamma 3
  • Receptor-Type Tyrosine-Protein Phosphatase Gamma 3
  • Receptor-Type Protein Phosphatase Gamma 3
  • Receptor Tyrosine Phosphatase Gamma 3
  • Protein Tyrosine Phosphatase Gamma 3
  • H_RG317H01.1 3
  • HPTPG 3
  • RPTPG 3

External Ids for PTPRG Gene

Previous HGNC Symbols for PTPRG Gene

  • PTPG

Previous GeneCards Identifiers for PTPRG Gene

  • GC03P060412
  • GC03P060949
  • GC03P061402
  • GC03P061504

Summaries for PTPRG Gene

Entrez Gene Summary for PTPRG Gene

  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. This gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for PTPRG Gene

PTPRG (Protein Tyrosine Phosphatase, Receptor Type, G) is a Protein Coding gene. Diseases associated with PTPRG include renal cell carcinoma. Among its related pathways are PAK Pathway. GO annotations related to this gene include identical protein binding and transmembrane receptor protein tyrosine phosphatase activity. An important paralog of this gene is PTPRT.

UniProtKB/Swiss-Prot for PTPRG Gene

  • Possesses tyrosine phosphatase activity.

Gene Wiki entry for PTPRG Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPRG Gene

Genomics for PTPRG Gene

Regulatory Elements for PTPRG Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PTPRG Gene

61,561,569 bp from pter
62,297,613 bp from pter
736,045 bases
Plus strand

Genomic View for PTPRG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PTPRG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPRG Gene

Proteins for PTPRG Gene

  • Protein details for PTPRG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Receptor-type tyrosine-protein phosphatase gamma
    Protein Accession:
    Secondary Accessions:
    • B2RU12
    • B7ZLX5
    • Q15623
    • Q59EE0
    • Q68DU5

    Protein attributes for PTPRG Gene

    1445 amino acids
    Molecular mass:
    162003 Da
    Quaternary structure:
    • Monomer; active form. Homodimer; inactive form (Probable). Interacts with CNTN3, CNTN4, CNTN5 and CNTN6.
    • Sequence=BAD93108.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PTPRG Gene

    Alternative splice isoforms for PTPRG Gene


neXtProt entry for PTPRG Gene

Proteomics data for PTPRG Gene at MOPED

Post-translational modifications for PTPRG Gene

  • Glycosylation at Asn109, Asn113, Asn156, Asn359, Asn444, Asn619, Asn631, Thr633, Thr640, Thr649, Thr653, Thr656, Thr715, and Asn722
  • Modification sites at PhosphoSitePlus

Other Protein References for PTPRG Gene

Domains for PTPRG Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 alpha-carbonic anhydrase domain.
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.
  • Contains 1 alpha-carbonic anhydrase domain.
  • Contains 1 fibronectin type-III domain.
  • Contains 2 tyrosine-protein phosphatase domains.
  • Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.
genes like me logo Genes that share domains with PTPRG: view

Function for PTPRG Gene

Molecular function for PTPRG Gene

GENATLAS Biochemistry:
protein tyrosine phosphatase,receptor-type,gamma polypeptide,deleted in benign proliferative breast disease,associated with familial breast cancer
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot Function:
Possesses tyrosine phosphatase activity.

Enzyme Numbers (IUBMB) for PTPRG Gene

Gene Ontology (GO) - Molecular Function for PTPRG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IDA 19167335
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity TAS 8382771
GO:0005515 protein binding IPI 19167335
GO:0016791 phosphatase activity --
GO:0042802 identical protein binding IPI 19167335
genes like me logo Genes that share ontologies with PTPRG: view
genes like me logo Genes that share phenotypes with PTPRG: view

Animal Models for PTPRG Gene

MGI Knock Outs for PTPRG:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PTPRG

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for PTPRG Gene

Localization for PTPRG Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPRG Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for PTPRG Gene COMPARTMENTS Subcellular localization image for PTPRG gene
Compartment Confidence
plasma membrane 4
cytosol 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PTPRG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0005887 integral component of plasma membrane TAS 8382771
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with PTPRG: view

Pathways for PTPRG Gene

SuperPathways for PTPRG Gene

Superpath Contained pathways
1 PAK Pathway
genes like me logo Genes that share pathways with PTPRG: view

Pathways by source for PTPRG Gene

1 Qiagen pathway for PTPRG Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PTPRG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation --
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway TAS 8382771
GO:0007420 brain development IEA --
GO:0010633 negative regulation of epithelial cell migration IMP 21724833
GO:0010977 negative regulation of neuron projection development IEA --
genes like me logo Genes that share ontologies with PTPRG: view

Drugs for PTPRG Gene

(3) HMDB Compounds for PTPRG Gene

Compound Synonyms Cas Number PubMed IDs
  • NFB Orthophosphate
Phosphoric acid
  • Acide phosphorique (FRENCH)
  • Dihydrogen oxide

(2) Novoseek inferred chemical compound relationships for PTPRG Gene

Compound -log(P) Hits PubMed IDs
tyrosine 59.8 23
estrogen 17.6 2
genes like me logo Genes that share compounds with PTPRG: view

Transcripts for PTPRG Gene

Unigene Clusters for PTPRG Gene

Protein tyrosine phosphatase, receptor type, G:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PTPRG

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTPRG Gene

No ASD Table

Relevant External Links for PTPRG Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PTPRG Gene

mRNA expression in normal human tissues for PTPRG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for PTPRG Gene

This gene is overexpressed in Serum (38.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PTPRG Gene

SOURCE GeneReport for Unigene cluster for PTPRG Gene Hs.595541

mRNA Expression by UniProt/SwissProt for PTPRG Gene

Tissue specificity: Found in a variety of tissues
genes like me logo Genes that share expressions with PTPRG: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Expression partners for PTPRG Gene

Orthologs for PTPRG Gene

This gene was present in the common ancestor of animals.

Orthologs for PTPRG Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PTPRG 35
  • 90.93 (n)
  • 95.27 (a)
  • 95 (a)
(Canis familiaris)
Mammalia PTPRG 35
  • 92.56 (n)
  • 95.15 (a)
  • 95 (a)
(Mus musculus)
Mammalia Ptprg 35
  • 89.41 (n)
  • 94.52 (a)
Ptprg 16
Ptprg 36
  • 94 (a)
(Pan troglodytes)
Mammalia PTPRG 35
  • 99.45 (n)
  • 99.45 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Ptprg 35
  • 89.89 (n)
  • 94.88 (a)
(Monodelphis domestica)
Mammalia PTPRG 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia PTPRG 36
  • 80 (a)
(Gallus gallus)
Aves PTPRG 35
  • 81.59 (n)
  • 88.03 (a)
  • 87 (a)
(Anolis carolinensis)
Reptilia PTPRG 36
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ptprg 35
  • 75.13 (n)
  • 80.19 (a)
(Danio rerio)
Actinopterygii ptprga 35
  • 69.87 (n)
  • 75 (a)
ca16b 36
  • 67 (a)
ptprga 36
  • 75 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6906 37
  • 35 (a)
Ptp69D 37
  • 32 (a)
Ptp99A 37
  • 46 (a)
Ptp99A 36
  • 27 (a)
(Caenorhabditis elegans)
Secernentea C17H12.3 37
  • 34 (a)
C55B7.3 37
  • 31 (a)
F10G8.1 37
  • 28 (a)
F47B3.1 37
  • 30 (a)
F47B3.6 37
  • 30 (a)
F47B3.7 37
  • 33 (a)
K04D7.4 37
  • 32 (a)
K07F5.8 37
  • 32 (a)
M04G7.2 37
  • 36 (a)
T27A3.5 37
  • 31 (a)
ZK484.7 37
  • 32 (a)
ZK616.7 37
  • 37 (a)
Species with no ortholog for PTPRG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PTPRG Gene

Gene Tree for PTPRG (if available)
Gene Tree for PTPRG (if available)

Paralogs for PTPRG Gene

Paralogs for PTPRG Gene

genes like me logo Genes that share paralogs with PTPRG: view

Variants for PTPRG Gene

Sequence variations from dbSNP and Humsavar for PTPRG Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1630197 -- 61,762,674(-) CTTCC(A/G)TGGGA intron-variant
rs1630840 -- 61,762,649(-) TCCTA(C/G)TAATA intron-variant
rs1713528 -- 61,870,420(+) CAATT(C/T)TCCTG intron-variant
rs1713529 -- 61,870,504(+) ttttg(G/T)atttt intron-variant
rs1713530 -- 61,738,835(-) ATGGC(A/T)CCACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTPRG Gene

Variant ID Type Subtype PubMed ID
nsv834711 CNV Loss 17160897
nsv822105 CNV Gain 20364138
esv23804 CNV Loss 19812545
dgv1462e1 CNV Complex 17122850
esv35004 CNV Gain 17911159
nsv822106 CNV Gain 20364138
esv2672277 CNV Deletion 23128226
nsv834712 CNV Gain 17160897
nsv876871 CNV Loss 21882294
nsv236686 CNV Loss 16902084
esv2554644 CNV Deletion 19546169
esv2386760 CNV Deletion 18987734
nsv471782 CNV Loss 16327809
esv2725334 CNV Deletion 23290073
esv2599998 CNV Deletion 19546169
esv2658385 CNV Deletion 23128226
esv1001407 CNV Deletion 20482838
esv1631216 CNV Deletion 17803354
esv1005605 CNV Deletion 20482838
esv1217921 CNV Deletion 17803354
dgv5151n71 CNV Gain 21882294
esv2223333 CNV Deletion 18987734
esv2673237 CNV Deletion 23128226
esv2725335 CNV Deletion 23290073
esv2725336 CNV Deletion 23290073
esv2725337 CNV Deletion 23290073
nsv516255 CNV Loss 19592680
nsv523876 CNV Loss 19592680
nsv876874 CNV Loss 21882294
esv2667638 CNV Deletion 23128226
esv2548031 CNV Insertion 19546169
esv2725338 CNV Deletion 23290073
nsv517920 CNV Loss 19592680
esv22782 CNV Loss 19812545
nsv876875 CNV Gain 21882294
esv270382 CNV Insertion 20981092
nsv460575 CNV Gain 19166990
esv259746 OTHER Complex 20981092
nsv437862 CNV Loss 16468122
nsv522606 CNV Loss 19592680

Relevant External Links for PTPRG Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPRG Gene

Disorders for PTPRG Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for PTPRG Gene in MalaCards »

(1) Disease for PTPRG Gene

(9) Novoseek inferred disease relationships for PTPRG Gene

Disease -log(P) Hits PubMed IDs
lung carcinoma 48.9 1
renal cancer 45.8 1
adenocarcinoma lung 45.6 1
carcinoma renal cell 43.4 3
cancer lung 40.9 4

Relevant External Links for PTPRG

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with PTPRG: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for PTPRG Gene

Publications for PTPRG Gene

  1. Structure of the human receptor tyrosine phosphatase gamma gene (PTPRG) and relation to the familial RCC t(3;8) chromosome translocation. (PMID: 8833149) Kastury K. … Huebner K. (Genomics 1996) 3 4 23
  2. Receptor protein-tyrosine phosphatase gamma is a candidate tumor suppressor gene at human chromosome region 3p21. (PMID: 1711217) LaForgia S. … Weston A. (Proc. Natl. Acad. Sci. U.S.A. 1991) 2 3 23
  3. The protein tyrosine phosphatases PTPRZ and PTPRG bind to distinct members of the contactin family of neural recognition molecules. (PMID: 20133774) Bouyain S. … Watkins D.J. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 4
  4. Identification of a carbonic anhydrase-like domain in the extracellular region of RPTP gamma defines a new subfamily of receptor tyrosine phosphatases. (PMID: 8382771) Barnea G. … Schlessinger J. (Mol. Cell. Biol. 1993) 3 4
  5. Estrogenic down-regulation of protein tyrosine phosphatase gamma (PTP gamma) in human breast is associated with estrogen receptor alpha. (PMID: 12553013) Liu S. … Lin Y.C. (Anticancer Res. 2002) 3 23

Products for PTPRG Gene

Sources for PTPRG Gene

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