Aliases for SLC4A5 Gene
External Ids for SLC4A5 Gene
Previous GeneCards Identifiers for SLC4A5 Gene
This gene encodes a member of the sodium bicarbonate cotransporter (NBC) family, part of the bicarbonate transporter superfamily. Sodium bicarbonate cotransporters are involved in intracellular pH regulation and electroneural or electrogenic sodium bicarbonate transport. This protein is thought to be an integral membrane protein. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for SLC4A5 Gene
SLC4A5 (Solute Carrier Family 4 (Sodium Bicarbonate Cotransporter), Member 5) is a Protein Coding gene. Diseases associated with SLC4A5 include renal tubular acidosis, proximal, with ocular abnormalities and alstrom syndrome. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Bile secretion. GO annotations related to this gene include inorganic anion exchanger activity and sodium:bicarbonate symporter activity. An important paralog of this gene is SLC4A8.
UniProtKB/Swiss-Prot for SLC4A5 Gene
Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na(+):HCO3(-) stoichiometry of 2:1. May have a housekeeping function in regulating the pH of tissues in which it is expressed. May play a role in mediating Na(+):HCO3(-) cotransport in hepatocytes and intrahepatic cholangiocytes. Also may be important in protecting the renal paranchyma from alterations in urine pH.