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Aliases for POLD4 Gene

Aliases for POLD4 Gene

  • Polymerase (DNA-Directed), Delta 4, Accessory Subunit 2 3
  • POLDS 3 4 6
  • DNA Polymerase Delta Smallest Subunit P12 2 3
  • P12 3 6
  • Polymerase (DNA-Directed), Delta 4 2
  • DNA Polymerase Delta Subunit P12 4
  • DNA Polymerase Delta Subunit 4 3

External Ids for POLD4 Gene

Summaries for POLD4 Gene

Entrez Gene Summary for POLD4 Gene

  • This gene encodes the smallest subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein enhances the activity of DNA polymerase delta and plays a role in fork repair and stabilization through interactions with the DNA helicase Bloom syndrome protein. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]

GeneCards Summary for POLD4 Gene

POLD4 (Polymerase (DNA-Directed), Delta 4, Accessory Subunit) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. GO annotations related to this gene include DNA-directed DNA polymerase activity.

UniProtKB/Swiss-Prot for POLD4 Gene

  • Required for optimal DNA polymerase delta activity. May contribute to PCNA-dependent activity of DNA polymerase delta.

Gene Wiki entry for POLD4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLD4 Gene

Genomics for POLD4 Gene

Genomic Location for POLD4 Gene

Start:
67,350,765 bp from pter
End:
67,356,972 bp from pter
Size:
6,208 bases
Orientation:
Minus strand

Genomic View for POLD4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for POLD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLD4 Gene

Regulatory Elements for POLD4 Gene

Proteins for POLD4 Gene

  • Protein details for POLD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCU8-DPOD4_HUMAN
    Recommended name:
    DNA polymerase delta subunit 4
    Protein Accession:
    Q9HCU8
    Secondary Accessions:
    • F5H506

    Protein attributes for POLD4 Gene

    Size:
    107 amino acids
    Molecular mass:
    12433 Da
    Quaternary structure:
    • Heterotetramer composed of subunits of 125 kDa, 50 kDa, 66 kDa and 12 kDa. Interacts with WRNIP1. Interacts with POLD4, POLD2, POLD1 and PCNA.

    Alternative splice isoforms for POLD4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for POLD4 Gene

Proteomics data for POLD4 Gene at MOPED

Post-translational modifications for POLD4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for POLD4 Gene

No data available for DME Specific Peptides for POLD4 Gene

Domains for POLD4 Gene

Gene Families for POLD4 Gene

HGNC:
  • POL :DNA polymerases

Protein Domains for POLD4 Gene

UniProtKB/Swiss-Prot:

DPOD4_HUMAN
Family:
  • Belongs to the DNA polymerase delta subunit 4 family.:
    • Q9HCU8
genes like me logo Genes that share domains with POLD4: view

Function for POLD4 Gene

Molecular function for POLD4 Gene

UniProtKB/Swiss-Prot Function: Required for optimal DNA polymerase delta activity. May contribute to PCNA-dependent activity of DNA polymerase delta.

Gene Ontology (GO) - Molecular Function for POLD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003887 DNA-directed DNA polymerase activity IEA --
GO:0005515 protein binding IPI 12403614
genes like me logo Genes that share ontologies with POLD4: view

Phenotypes for POLD4 Gene

GenomeRNAi human phenotypes for POLD4:
genes like me logo Genes that share phenotypes with POLD4: view

miRNA for POLD4 Gene

miRTarBase miRNAs that target POLD4

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for POLD4 Gene

Localization for POLD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLD4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for POLD4 Gene COMPARTMENTS Subcellular localization image for POLD4 gene
Compartment Confidence
nucleus 5
cytosol 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for POLD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 10751307
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with POLD4: view

Pathways for POLD4 Gene

genes like me logo Genes that share pathways with POLD4: view

Pathways by source for POLD4 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for POLD4 Gene
2 BioSystems pathways for POLD4 Gene

Gene Ontology (GO) - Biological Process for POLD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0000722 telomere maintenance via recombination TAS --
GO:0000723 telomere maintenance TAS --
GO:0006260 DNA replication TAS 10751307
GO:0006271 DNA strand elongation involved in DNA replication TAS --
genes like me logo Genes that share ontologies with POLD4: view

Transcripts for POLD4 Gene

Unigene Clusters for POLD4 Gene

Polymerase (DNA-directed), delta 4, accessory subunit:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for POLD4 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c · 6d · 6e
SP1: - - - - - - - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - -
SP6: - - - - - - -
SP7: - - -
SP8: - - - - - -
SP9: - - -
SP10: - -
SP11:
SP12: - - -

Relevant External Links for POLD4 Gene

GeneLoc Exon Structure for
POLD4
ECgene alternative splicing isoforms for
POLD4

Expression for POLD4 Gene

mRNA expression in normal human tissues for POLD4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for POLD4 Gene

SOURCE GeneReport for Unigene cluster for POLD4 Gene Hs.523829

genes like me logo Genes that share expressions with POLD4: view

Orthologs for POLD4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for POLD4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia POLD4 36
  • 99.69 (n)
  • 100 (a)
POLD4 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia POLD4 36
  • 88.16 (n)
  • 85.98 (a)
POLD4 37
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia POLD4 36
  • 90.03 (n)
  • 91.59 (a)
POLD4 37
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pold4 36
  • 85.67 (n)
  • 83.18 (a)
Pold4 16
Pold4 37
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia POLD4 37
  • 39 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pold4 36
  • 85.36 (n)
  • 83.18 (a)
zebrafish
(Danio rerio)
Actinopterygii POLD4 37
  • 38 (a)
OneToOne
Species with no ortholog for POLD4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for POLD4 Gene

ENSEMBL:
Gene Tree for POLD4 (if available)
TreeFam:
Gene Tree for POLD4 (if available)

Paralogs for POLD4 Gene

No data available for Paralogs for POLD4 Gene

Variants for POLD4 Gene

Sequence variations from dbSNP and Humsavar for POLD4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
VAR_022269 -
VAR_057526 -

Structural Variations from Database of Genomic Variants (DGV) for POLD4 Gene

Variant ID Type Subtype PubMed ID
nsv897796 CNV Loss 21882294
nsv897797 CNV Loss 21882294
nsv468603 CNV Loss 19166990
nsv897801 CNV Loss 21882294
nsv897804 CNV Gain 21882294
nsv367 CNV Insertion 18451855

Relevant External Links for POLD4 Gene

HapMap Linkage Disequilibrium report
POLD4

Disorders for POLD4 Gene

No disorders were found for POLD4 Gene.

No data available for UniProtKB/Swiss-Prot for POLD4 Gene

Publications for POLD4 Gene

  1. Identification of a fourth subunit of mammalian DNA polymerase delta. (PMID: 10751307) Liu L. … Lee M.Y.W.T. (J. Biol. Chem. 2000) 2 3 4
  2. Human Werner helicase interacting protein 1 (WRNIP1) functions as a novel modulator for DNA polymerase delta. (PMID: 15670210) Tsurimoto T. … Enomoto T. (Genes Cells 2005) 3 4
  3. Functional roles of p12, the fourth subunit of human DNA polymerase delta. (PMID: 16510448) Li H. … Lee M.Y. (J. Biol. Chem. 2006) 3 4
  4. The p66 and p12 subunits of DNA polymerase delta are modified by ubiquitin and ubiquitin-like proteins. (PMID: 16934752) Liu G. … Warbrick E. (Biochem. Biophys. Res. Commun. 2006) 3
  5. A novel DNA damage response: rapid degradation of the p12 subunit of dna polymerase delta. (PMID: 17317665) Zhang S. … Lee M.Y. (J. Biol. Chem. 2007) 3

Products for POLD4 Gene

Sources for POLD4 Gene

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