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Aliases for BAK1 Gene

Aliases for BAK1 Gene

  • BCL2 Antagonist/Killer 1 2 3
  • BCL2-Antagonist/Killer 1 2 3 5
  • Apoptosis Regulator BAK 3 4
  • Bcl-2-Like Protein 7 3 4
  • Bcl2-L-7 3 4
  • BCL2L7 3 4
  • CDN1 3 4
  • BAK 3 4
  • Pro-Apoptotic Protein BAK 3
  • BCL2-Like 7 Protein 3
  • BAK-LIKE 3

External Ids for BAK1 Gene

Previous HGNC Symbols for BAK1 Gene

  • CDN1

Previous GeneCards Identifiers for BAK1 Gene

  • GC06M033542
  • GC06M033588
  • GC06M033489
  • GC06M033648
  • GC06M033281
  • GC06M033541

Summaries for BAK1 Gene

Entrez Gene Summary for BAK1 Gene

  • The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress. [provided by RefSeq, Jul 2008]

GeneCards Summary for BAK1 Gene

BAK1 (BCL2 Antagonist/Killer 1) is a Protein Coding gene. Diseases associated with BAK1 include benign mammary dysplasia and chronic gonococcal salpingitis. Among its related pathways are MicroRNAs in cancer and Gemtuzumab ozogamicin Pathway, Pharmacokinetics/Pharmacodynamics. GO annotations related to this gene include protein homodimerization activity and protein heterodimerization activity. An important paralog of this gene is BCL2.

UniProtKB/Swiss-Prot for BAK1 Gene

  • In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti-apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis.

Gene Wiki entry for BAK1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BAK1 Gene

Genomics for BAK1 Gene

Regulatory Elements for BAK1 Gene

Promoters for BAK1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BAK1 on UCSC Golden Path with GeneCards custom track

Genomic Location for BAK1 Gene

Chromosome:
6
Start:
33,572,546 bp from pter
End:
33,580,299 bp from pter
Size:
7,754 bases
Orientation:
Minus strand

Genomic View for BAK1 Gene

Genes around BAK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BAK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BAK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BAK1 Gene

Proteins for BAK1 Gene

  • Protein details for BAK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16611-BAK_HUMAN
    Recommended name:
    Bcl-2 homologous antagonist/killer
    Protein Accession:
    Q16611
    Secondary Accessions:
    • C0H5Y7
    • Q6I9T6
    • Q92533

    Protein attributes for BAK1 Gene

    Size:
    211 amino acids
    Molecular mass:
    23409 Da
    Quaternary structure:
    • Interacts with BCL2A1 (By similarity). Homodimer. Formation of the homodimer is zinc-dependent. Forms heterodimers with BCL2, E1B 19k protein, and BCL2L1 isoform Bcl-X(L). Interacts with myxoma virus protein M11L. Interacts with BOP/C22orf29. Interacts with VDAC1 (PubMed:25296756).

    Three dimensional structures from OCA and Proteopedia for BAK1 Gene

    Alternative splice isoforms for BAK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BAK1 Gene

Proteomics data for BAK1 Gene at MOPED

Post-translational modifications for BAK1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BAK1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for BAK1 (BAK1)

No data available for DME Specific Peptides for BAK1 Gene

Domains & Families for BAK1 Gene

Gene Families for BAK1 Gene

Suggested Antigen Peptide Sequences for BAK1 Gene

Graphical View of Domain Structure for InterPro Entry

Q16611

UniProtKB/Swiss-Prot:

BAK_HUMAN :
  • Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.
  • Belongs to the Bcl-2 family.
Domain:
  • Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.
Family:
  • Belongs to the Bcl-2 family.
genes like me logo Genes that share domains with BAK1: view

Function for BAK1 Gene

Molecular function for BAK1 Gene

GENATLAS Biochemistry:
BCL2-antagonist/killer 1,BAX subfamily
UniProtKB/Swiss-Prot Function:
In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti-apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis.

Gene Ontology (GO) - Molecular Function for BAK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031072 heat shock protein binding IEA --
genes like me logo Genes that share ontologies with BAK1: view
genes like me logo Genes that share phenotypes with BAK1: view

Animal Models for BAK1 Gene

MGI Knock Outs for BAK1:

Animal Model Products

miRNA for BAK1 Gene

miRTarBase miRNAs that target BAK1

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BAK1 Gene

Localization for BAK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BAK1 Gene

Mitochondrion membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BAK1 Gene COMPARTMENTS Subcellular localization image for BAK1 gene
Compartment Confidence
mitochondrion 5
cytosol 4
endoplasmic reticulum 2
plasma membrane 2
extracellular 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for BAK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA --
GO:0031966 mitochondrial membrane IEA --
genes like me logo Genes that share ontologies with BAK1: view

Pathways & Interactions for BAK1 Gene

genes like me logo Genes that share pathways with BAK1: view

SIGNOR curated interactions for BAK1 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for BAK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001782 B cell homeostasis IEA --
GO:0001836 release of cytochrome c from mitochondria IGI 21041309
GO:0001974 blood vessel remodeling IEA --
GO:0002262 myeloid cell homeostasis IEA --
GO:0002352 B cell negative selection IEA --
genes like me logo Genes that share ontologies with BAK1: view

Drugs & Compounds for BAK1 Gene

(30) Drugs for BAK1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(23) Additional Compounds for BAK1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with BAK1: view

Transcripts for BAK1 Gene

Unigene Clusters for BAK1 Gene

BCL2-antagonist/killer 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BAK1 Gene

No ASD Table

Relevant External Links for BAK1 Gene

GeneLoc Exon Structure for
BAK1
ECgene alternative splicing isoforms for
BAK1

Expression for BAK1 Gene

mRNA expression in normal human tissues for BAK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BAK1 Gene

This gene is overexpressed in Nasal epithelium (45.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for BAK1 Gene



SOURCE GeneReport for Unigene cluster for BAK1 Gene Hs.485139

mRNA Expression by UniProt/SwissProt for BAK1 Gene

Q16611-BAK_HUMAN
Tissue specificity: Expressed in a wide variety of tissues, with highest levels in the heart and skeletal muscle.
genes like me logo Genes that share expression patterns with BAK1: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for BAK1 Gene

Orthologs for BAK1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BAK1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BAK1 35
  • 86.73 (n)
  • 86.26 (a)
BAK1 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC481744 35
  • 89.73 (n)
  • 91.94 (a)
BAK1 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bak1 35
  • 80.22 (n)
  • 77.51 (a)
Bak1 16
Bak1 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BAK1 35
  • 99.37 (n)
  • 99.53 (a)
BAK1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bak1 35
  • 79.43 (n)
  • 77.03 (a)
oppossum
(Monodelphis domestica)
Mammalia BAK1 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves BAK1 35
  • 69.08 (n)
  • 61.84 (a)
lizard
(Anolis carolinensis)
Reptilia BAK1 36
  • 62 (a)
OneToOne
Species with no ortholog for BAK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BAK1 Gene

ENSEMBL:
Gene Tree for BAK1 (if available)
TreeFam:
Gene Tree for BAK1 (if available)

Paralogs for BAK1 Gene

Paralogs for BAK1 Gene

(2) SIMAP similar genes for BAK1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for BAK1 Gene

genes like me logo Genes that share paralogs with BAK1: view

Variants for BAK1 Gene

Sequence variations from dbSNP and Humsavar for BAK1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs4987115 - 33,575,916(-) GGTAG(C/T)CCAGG intron-variant, reference, missense
rs5745592 - 33,575,441(-) TACAG(A/C)ACCAT reference, missense
rs1051911 - 33,575,874(-) TTACC(A/G)CCATC intron-variant, reference, missense
rs210134 -- 33,572,432(+) ATTCT(A/G)GAGGC downstream-variant-500B
rs210135 -- 33,572,915(+) CCTGA(A/T)ATAAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for BAK1 Gene

Variant ID Type Subtype PubMed ID
nsv519079 CNV Loss 19592680
nsv885770 CNV Loss 21882294

Variation tolerance for BAK1 Gene

Residual Variation Intolerance Score: 65.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.48; 28.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BAK1 Gene

HapMap Linkage Disequilibrium report
BAK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BAK1 Gene

Disorders for BAK1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for BAK1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
benign mammary dysplasia
chronic gonococcal salpingitis
  • gonococcal salpingitis
retinal drusen
  • basal laminar drusen
acute salpingitis
chronic salpingitis
- elite association - COSMIC cancer census association via MalaCards
Search BAK1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for BAK1

Genetic Association Database (GAD)
BAK1
Human Genome Epidemiology (HuGE) Navigator
BAK1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BAK1
genes like me logo Genes that share disorders with BAK1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BAK1 Gene

Publications for BAK1 Gene

  1. Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak. (PMID: 7715731) Kiefer M.C. … Barr P.J. (Nature 1995) 2 3 4 23 67
  2. BAK, BAX, and NBK/BIK proapoptotic gene alterations in Iranian patients with ataxia telangiectasia. (PMID: 19898928) Isaian A. … Sanati M.H. (J. Clin. Immunol. 2010) 3 23
  3. Endogenous Bak inhibitors Mcl-1 and Bcl-xL: differential impact on TRAIL resistance in Bax-deficient carcinoma. (PMID: 20308427) Gillissen B. … Daniel P.T. (J. Cell Biol. 2010) 3 23
  4. The additional loss of Bak and not the lack of the protein tyrosine kinase p56/Lck in one JCaM1.6 subclone caused pronounced apoptosis resistance in response to stimuli of the intrinsic pathway. (PMID: 19343496) Rudner J. … Jendrossek V. (Apoptosis 2009) 3 23
  5. Context-dependent Bcl-2/Bak interactions regulate lymphoid cell apoptosis. (PMID: 19351886) Dai H. … Kaufmann S.H. (J. Biol. Chem. 2009) 3 23

Products for BAK1 Gene

Sources for BAK1 Gene

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