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Aliases for ADGRB3 Gene

Aliases for ADGRB3 Gene

  • Adhesion G Protein-Coupled Receptor B3 2 3
  • Brain-Specific Angiogenesis Inhibitor 3 2 3 4
  • BAI3 3 4
  • DJ91B17.1 (Brain-Specific Angiogenesis Inhibitor 3) 3
  • KIAA0550 4

External Ids for ADGRB3 Gene

Previous HGNC Symbols for ADGRB3 Gene

  • BAI3

Summaries for ADGRB3 Gene

Entrez Gene Summary for ADGRB3 Gene

  • This p53-target gene encodes a brain-specific angiogenesis inhibitor, a seven-span transmembrane protein, and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities, and may also play a role in angiogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADGRB3 Gene

ADGRB3 (Adhesion G Protein-Coupled Receptor B3) is a Protein Coding gene. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is UNC5D.

UniProtKB/Swiss-Prot for ADGRB3 Gene

  • Receptor that plays a role in the regulation of synaptogenesis and dendritic spine formation at least partly via interaction with ELMO1 and RAC1 activity (By similarity). Promotes myoblast fusion through ELMO/DOCK1 (PubMed:24567399).

Gene Wiki entry for ADGRB3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRB3 Gene

Genomics for ADGRB3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ADGRB3 Gene

Chromosome:
6
Start:
68,635,282 bp from pter
End:
69,389,511 bp from pter
Size:
754,230 bases
Orientation:
Plus strand

Genomic View for ADGRB3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADGRB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRB3 Gene

No data available for Regulatory Elements for ADGRB3 Gene

Proteins for ADGRB3 Gene

  • Protein details for ADGRB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60242-AGRB3_HUMAN
    Recommended name:
    Adhesion G protein-coupled receptor B3
    Protein Accession:
    O60242
    Secondary Accessions:
    • B7Z1K0
    • O60297
    • Q2NKN6
    • Q5VY37
    • Q9BX54

    Protein attributes for ADGRB3 Gene

    Size:
    1522 amino acids
    Molecular mass:
    171518 Da
    Quaternary structure:
    • Forms a heterodimer, consisting of a large extracellular region non-covalently linked to a seven-transmembrane moiety. Interacts (via TSP N-terminal domains) with C1QL1, C1QL2, C1QL3 and C1QL4 (PubMed:21262840). Interacts with ELMO1, ELMO2 AND ELMO3 (PubMed:24567399).
    Miscellaneous:
    • Autoproteolysis appears to be cell specific, does not readily undergo proteolytic cleavage in HEK293T cells.
    SequenceCaution:
    • Sequence=BAA25476.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ADGRB3 Gene

    Alternative splice isoforms for ADGRB3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADGRB3 Gene

Proteomics data for ADGRB3 Gene at MOPED

Post-translational modifications for ADGRB3 Gene

  • The endogenous protein is proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.
  • Glycosylation at Asn 51, Asn 54, Asn 82, Asn 105, Asn 241, Asn 337, Asn 418, Asn 540, Asn 625, Asn 779, Asn 812, Asn 828, and Asn 937
  • Modification sites at PhosphoSitePlus

Other Protein References for ADGRB3 Gene

Antibody Products

No data available for DME Specific Peptides for ADGRB3 Gene

Domains & Families for ADGRB3 Gene

Gene Families for ADGRB3 Gene

Suggested Antigen Peptide Sequences for ADGRB3 Gene

Graphical View of Domain Structure for InterPro Entry

O60242

UniProtKB/Swiss-Prot:

AGRB3_HUMAN :
  • Contains 1 CUB domain.
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
Domain:
  • Contains 1 CUB domain.
  • Contains 1 GPS domain.
  • Contains 4 TSP type-1 domains.
Family:
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
genes like me logo Genes that share domains with ADGRB3: view

Function for ADGRB3 Gene

Molecular function for ADGRB3 Gene

UniProtKB/Swiss-Prot Function:
Receptor that plays a role in the regulation of synaptogenesis and dendritic spine formation at least partly via interaction with ELMO1 and RAC1 activity (By similarity). Promotes myoblast fusion through ELMO/DOCK1 (PubMed:24567399).

Gene Ontology (GO) - Molecular Function for ADGRB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0005096 GTPase activator activity ISS --
GO:0005515 protein binding IPI 21262840
genes like me logo Genes that share ontologies with ADGRB3: view
genes like me logo Genes that share phenotypes with ADGRB3: view

miRNA for ADGRB3 Gene

miRTarBase miRNAs that target ADGRB3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADGRB3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ADGRB3 Gene

Localization for ADGRB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRB3 Gene

Cell membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for ADGRB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IPI 21262840
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADGRB3: view

No data available for Subcellular locations from COMPARTMENTS for ADGRB3 Gene

Pathways & Interactions for ADGRB3 Gene

SuperPathways for ADGRB3 Gene

No Data Available

Interacting Proteins for ADGRB3 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000359630%0d%0a9606.ENSP00000386772%0d%0a9606.ENSP00000362987%0d%0a
Selected Interacting proteins: O60242-AGRB3_HUMAN ENSP00000359630 for ADGRB3 Gene via I2D UniProtKB STRING

Gene Ontology (GO) - Biological Process for ADGRB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007520 myoblast fusion IDA 24567399
GO:0016525 negative regulation of angiogenesis IEA --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with ADGRB3: view

No data available for Pathways by source and SIGNOR curated interactions for ADGRB3 Gene

Drugs & Compounds for ADGRB3 Gene

No Compound Related Data Available

Transcripts for ADGRB3 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADGRB3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRB3 Gene

No ASD Table

Relevant External Links for ADGRB3 Gene

GeneLoc Exon Structure for
ADGRB3
ECgene alternative splicing isoforms for
ADGRB3

Expression for ADGRB3 Gene

mRNA expression in normal human tissues for ADGRB3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ADGRB3 Gene

This gene is overexpressed in Frontal cortex (37.4), Fetal Brain (22.1), and Serum (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ADGRB3 Gene



mRNA Expression by UniProt/SwissProt for ADGRB3 Gene

O60242-AGRB3_HUMAN
Tissue specificity: Strongly expressed in brain. Also detected in heart. Reduced expression in some glioblastoma cell lines.
genes like me logo Genes that share expression patterns with ADGRB3: view

Protein tissue co-expression partners for ADGRB3 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ADGRB3 Gene

Orthologs for ADGRB3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADGRB3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BAI3 35
  • 94.19 (n)
  • 97.99 (a)
BAI3 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BAI3 35
  • 95.93 (n)
  • 98.55 (a)
BAI3 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bai3 35
  • 92.36 (n)
  • 98.42 (a)
Bai3 16
Bai3 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BAI3 35
  • 99.69 (n)
  • 99.87 (a)
BAI3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bai3 35
  • 91.79 (n)
  • 98.03 (a)
oppossum
(Monodelphis domestica)
Mammalia BAI3 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 93 (a)
OneToMany
-- 36
  • 83 (a)
OneToMany
-- 36
  • 92 (a)
OneToMany
chicken
(Gallus gallus)
Aves BAI3 35
  • 88.07 (n)
  • 94.87 (a)
BAI3 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BAI3 36
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bai3 35
  • 82.5 (n)
  • 88.74 (a)
zebrafish
(Danio rerio)
Actinopterygii bai3 35
  • 73.55 (n)
  • 79.15 (a)
bai3 36
  • 80 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta unc-5 36
  • 14 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F14H12.3 36
  • 33 (a)
ManyToMany
mig-21 36
  • 27 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 12 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 34 (a)
ManyToMany
CSA.10960 36
  • 13 (a)
ManyToMany
Species with no ortholog for ADGRB3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADGRB3 Gene

ENSEMBL:
Gene Tree for ADGRB3 (if available)
TreeFam:
Gene Tree for ADGRB3 (if available)

Paralogs for ADGRB3 Gene

Paralogs for ADGRB3 Gene

genes like me logo Genes that share paralogs with ADGRB3: view

Variants for ADGRB3 Gene

Sequence variations from dbSNP and Humsavar for ADGRB3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs16669 -- 68,818,946(+) TGTGT(-/AA)AACAT intron-variant
rs67807 -- 69,138,075(+) gaaac(A/G)gtacc intron-variant
rs314190 -- 69,126,706(-) taggt(A/G)tgtct intron-variant
rs314191 -- 69,090,859(+) GAAAT(A/T)AGCTT intron-variant
rs314192 -- 69,092,501(+) CACAG(A/G)AAGTT intron-variant

Variation tolerance for ADGRB3 Gene

Residual Variation Intolerance Score: 1.57% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.03; 50.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADGRB3 Gene

HapMap Linkage Disequilibrium report
ADGRB3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ADGRB3 Gene

Disorders for ADGRB3 Gene

Relevant External Links for ADGRB3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADGRB3
genes like me logo Genes that share disorders with ADGRB3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADGRB3 Gene

Publications for ADGRB3 Gene

  1. Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1). (PMID: 9533023) Shiratsuchi T. … Tokino T. (Cytogenet. Cell Genet. 1997) 2 23 67
  2. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J. … SchiAPth H.B. (Pharmacol. Rev. 2015) 2 67
  3. The genetics of symptom-based phenotypes: toward a molecular classification of schizophrenia. (PMID: 18628273) DeRosse P. … Malhotra A.K. (Schizophr Bull 2008) 23 67
  4. Brain angiogenesis inhibitor 1 is differentially expressed in normal brain and glioblastoma independently of p53 expression. (PMID: 12507886) Kaur B. … Van Meir E.G. (Am. J. Pathol. 2003) 23 67
  5. G-protein coupled receptor BAI3 promotes myoblast fusion in vertebrates. (PMID: 24567399) Hamoud N. … Cote J.F. (Proc. Natl. Acad. Sci. U.S.A. 2014) 67

Products for ADGRB3 Gene

Sources for ADGRB3 Gene

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