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Aliases for GPAM Gene

Aliases for GPAM Gene

  • Glycerol-3-Phosphate Acyltransferase, Mitochondrial 2 3
  • EC 2.3.1.15 4 63
  • GPAT-1 3 4
  • GPAT1 3 4
  • Glycerol-3-Phosphate Acyltransferase 1, Mitochondrial 3
  • Glycerol 3-Phosphate Acyltransferase, Mitochondrial 3
  • Glycerol-3-Phosphate Acyltransferase 1 2
  • Mitochondrial 2
  • KIAA1560 4
  • EC 2.3.1 63
  • GPAT 3

External Ids for GPAM Gene

Previous GeneCards Identifiers for GPAM Gene

  • GC10U990097
  • GC10M113575
  • GC10M113899
  • GC10M107537

Summaries for GPAM Gene

Entrez Gene Summary for GPAM Gene

  • This gene encodes a mitochondrial enzyme which prefers saturated fatty acids as its substrate for the synthesis of glycerolipids. This metabolic pathway's first step is catalyzed by the encoded enzyme. Two forms for this enzyme exist, one in the mitochondria and one in the endoplasmic reticulum. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for GPAM Gene

GPAM (Glycerol-3-Phosphate Acyltransferase, Mitochondrial) is a Protein Coding gene. Among its related pathways are Regulation of Cholesterol Biosynthesis by SREBP (SREBF) and Metabolism. GO annotations related to this gene include glycerol-3-phosphate O-acyltransferase activity. An important paralog of this gene is GPAT2.

UniProtKB/Swiss-Prot for GPAM Gene

  • Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis.

Gene Wiki entry for GPAM Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPAM Gene

Genomics for GPAM Gene

Regulatory Elements for GPAM Gene

Genomic Location for GPAM Gene

Start:
112,148,213 bp from pter
End:
112,215,395 bp from pter
Size:
67,183 bases
Orientation:
Minus strand

Genomic View for GPAM Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GPAM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPAM Gene

Proteins for GPAM Gene

  • Protein details for GPAM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCL2-GPAT1_HUMAN
    Recommended name:
    Glycerol-3-phosphate acyltransferase 1, mitochondrial
    Protein Accession:
    Q9HCL2
    Secondary Accessions:
    • Q5VW51
    • Q86TA3

    Protein attributes for GPAM Gene

    Size:
    828 amino acids
    Molecular mass:
    93795 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPAM Gene

Proteomics data for GPAM Gene at MOPED

Post-translational modifications for GPAM Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPAM Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for GPAM Gene

Protein Domains for GPAM Gene

Suggested Antigen Peptide Sequences for GPAM Gene

Graphical View of Domain Structure for InterPro Entry

Q9HCL2

UniProtKB/Swiss-Prot:

GPAT1_HUMAN :
  • Q9HCL2
Domain:
  • The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
Family:
  • Belongs to the GPAT/DAPAT family.
genes like me logo Genes that share domains with GPAM: view

No data available for Gene Families for GPAM Gene

Function for GPAM Gene

Molecular function for GPAM Gene

UniProtKB/Swiss-Prot CatalyticActivity: Acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate
UniProtKB/Swiss-Prot Function: Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis.

Enzyme Numbers (IUBMB) for GPAM Gene

Gene Ontology (GO) - Molecular Function for GPAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004366 glycerol-3-phosphate O-acyltransferase activity IMP 18238778
GO:0016746 transferase activity, transferring acyl groups --
genes like me logo Genes that share ontologies with GPAM: view
genes like me logo Genes that share phenotypes with GPAM: view

Animal Models for GPAM Gene

MGI Knock Outs for GPAM:

No data available for Transcription Factor Targeting and HOMER Transcription for GPAM Gene

Localization for GPAM Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPAM Gene

Mitochondrion outer membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPAM Gene COMPARTMENTS Subcellular localization image for GPAM gene
Compartment Confidence
mitochondrion 5
cytosol 2
endoplasmic reticulum 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GPAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005741 mitochondrial outer membrane TAS --
GO:0005743 mitochondrial inner membrane IEA --
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPAM: view

Pathways for GPAM Gene

genes like me logo Genes that share pathways with GPAM: view

UniProtKB/Swiss-Prot Q9HCL2-GPAT1_HUMAN

  • Pathway: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 1/3

Interacting Proteins for GPAM Gene

Gene Ontology (GO) - Biological Process for GPAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006631 fatty acid metabolic process IEA --
GO:0006637 acyl-CoA metabolic process IEA --
GO:0006641 triglyceride metabolic process --
GO:0006644 phospholipid metabolic process TAS --
GO:0006650 glycerophospholipid metabolic process --
genes like me logo Genes that share ontologies with GPAM: view

Compounds for GPAM Gene

(33) HMDB Compounds for GPAM Gene

Compound Synonyms Cas Number PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate Coenzyme A
10018-95-8
(2E)-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-CoA
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate Coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
38795-33-4

(13) Novoseek inferred chemical compound relationships for GPAM Gene

Compound -log(P) Hits PubMed IDs
glycerol 3-phosphate 94.6 59
triacylglycerol 79.7 14
phosphatidate 73.6 1
acyl-coa 71.5 3
dhap 65.8 2
genes like me logo Genes that share compounds with GPAM: view

Transcripts for GPAM Gene

Unigene Clusters for GPAM Gene

Glycerol-3-phosphate acyltransferase, mitochondrial:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPAM Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1: - - - -
SP2: - - -
SP3: - -
SP4:
SP5:
SP6: -

ExUns: 21 ^ 22a · 22b ^ 23 ^ 24
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for GPAM Gene

GeneLoc Exon Structure for
GPAM
ECgene alternative splicing isoforms for
GPAM

Expression for GPAM Gene

mRNA expression in normal human tissues for GPAM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPAM Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (11.7), Adipose - Subcutaneous (9.2), Breast - Mammary Tissue (5.4), and Liver (5.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GPAM Gene

SOURCE GeneReport for Unigene cluster for GPAM Gene Hs.42586

genes like me logo Genes that share expressions with GPAM: view

No data available for mRNA Expression by UniProt/SwissProt for GPAM Gene

Orthologs for GPAM Gene

This gene was present in the common ancestor of animals.

Orthologs for GPAM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPAM 35
  • 99.6 (n)
  • 99.64 (a)
GPAM 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GPAM 35
  • 89.49 (n)
  • 94.18 (a)
GPAM 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPAM 35
  • 91.02 (n)
  • 95.77 (a)
GPAM 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpam 35
  • 84.64 (n)
  • 92.87 (a)
Gpam 16
Gpam 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GPAM 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPAM 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpam 35
  • 84.78 (n)
  • 91.67 (a)
chicken
(Gallus gallus)
Aves GPAM 35
  • 76.18 (n)
  • 81.62 (a)
GPAM 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPAM 36
  • 79 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15378 35
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC145183 35
  • 66.59 (n)
  • 70.65 (a)
Str.16265 35
zebrafish
(Danio rerio)
Actinopterygii gpam 35
  • 65.28 (n)
  • 66.63 (a)
gpam 36
  • 63 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003687 35
  • 44.08 (n)
  • 34.32 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5508 35
  • 42.11 (n)
  • 32.24 (a)
CG5508 36
  • 23 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea acl-6 35
  • 43.31 (n)
  • 31.61 (a)
acl-6 36
  • 26 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6605 36
  • 29 (a)
OneToMany
Species with no ortholog for GPAM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPAM Gene

ENSEMBL:
Gene Tree for GPAM (if available)
TreeFam:
Gene Tree for GPAM (if available)

Paralogs for GPAM Gene

Paralogs for GPAM Gene

Selected SIMAP similar genes for GPAM Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GPAM: view

Variants for GPAM Gene

Sequence variations from dbSNP and Humsavar for GPAM Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1129555 -- 112,150,963(-) TGAGA(C/T)GGCTT utr-variant-3-prime, intron-variant
rs1807800 -- 112,153,794(+) CTGGC(A/T)TTAAG intron-variant
rs1832712 -- 112,151,532(+) TACAT(C/T)GCATT utr-variant-3-prime, intron-variant
rs1962270 -- 112,216,074(-) AAGCG(A/G)CTGAC upstream-variant-2KB
rs1962297 -- 112,214,406(+) CATCT(C/T)CAGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPAM Gene

Variant ID Type Subtype PubMed ID
nsv7211 OTHER Inversion 18451855
nsv508608 CNV Loss 20534489
nsv831989 CNV Gain 17160897

Relevant External Links for GPAM Gene

HapMap Linkage Disequilibrium report
GPAM
Human Gene Mutation Database (HGMD)
GPAM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPAM Gene

Disorders for GPAM Gene

(3) Novoseek inferred disease relationships for GPAM Gene

Disease -log(P) Hits PubMed IDs
fatty liver 42.2 1
obesity 24.4 2
insulin resistance 10.6 3

Relevant External Links for GPAM

Genetic Association Database (GAD)
GPAM
Human Genome Epidemiology (HuGE) Navigator
GPAM
genes like me logo Genes that share disorders with GPAM: view

No data available for UniProtKB/Swiss-Prot for GPAM Gene

Publications for GPAM Gene

  1. AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferase. (PMID: 18238778) Chen Y.Q. … Cao G. (J. Biol. Chem. 2008) 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4
  4. Expression and identification of p90 as the murine mitochondrial glycerol-3-phosphate acyltransferase. (PMID: 8369314) Yet S.F. … Sul H.S. (Biochemistry 1993) 2 3
  5. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 48

Products for GPAM Gene

Sources for GPAM Gene

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