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Aliases for GPAM Gene

Aliases for GPAM Gene

  • Glycerol-3-Phosphate Acyltransferase, Mitochondrial 2 3 5
  • EC 2.3.1.15 4 63
  • GPAT-1 3 4
  • GPAT1 3 4
  • Glycerol 3-Phosphate Acyltransferase, Mitochondrial 3
  • Glycerol-3-Phosphate Acyltransferase 1 2
  • Mitochondrial 2
  • KIAA1560 4
  • EC 2.3.1 63
  • GPAT 3

External Ids for GPAM Gene

Previous GeneCards Identifiers for GPAM Gene

  • GC10U990097
  • GC10M113575
  • GC10M113899
  • GC10M107537

Summaries for GPAM Gene

Entrez Gene Summary for GPAM Gene

  • This gene encodes a mitochondrial enzyme which prefers saturated fatty acids as its substrate for the synthesis of glycerolipids. This metabolic pathway's first step is catalyzed by the encoded enzyme. Two forms for this enzyme exist, one in the mitochondria and one in the endoplasmic reticulum. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for GPAM Gene

GPAM (Glycerol-3-Phosphate Acyltransferase, Mitochondrial) is a Protein Coding gene. Among its related pathways are triacylglycerol biosynthesis and Glycerophospholipid biosynthesis. GO annotations related to this gene include transferase activity, transferring acyl groups and glycerol-3-phosphate O-acyltransferase activity. An important paralog of this gene is GPAT2.

UniProtKB/Swiss-Prot for GPAM Gene

  • Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis.

Gene Wiki entry for GPAM Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPAM Gene

Genomics for GPAM Gene

Regulatory Elements for GPAM Gene

Enhancers for GPAM Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GPAM on UCSC Golden Path with GeneCards custom track

Genomic Location for GPAM Gene

Chromosome:
10
Start:
112,149,864 bp from pter
End:
112,215,395 bp from pter
Size:
65,532 bases
Orientation:
Minus strand

Genomic View for GPAM Gene

Genes around GPAM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPAM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPAM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPAM Gene

Proteins for GPAM Gene

  • Protein details for GPAM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCL2-GPAT1_HUMAN
    Recommended name:
    Glycerol-3-phosphate acyltransferase 1, mitochondrial
    Protein Accession:
    Q9HCL2
    Secondary Accessions:
    • Q5VW51
    • Q86TA3

    Protein attributes for GPAM Gene

    Size:
    828 amino acids
    Molecular mass:
    93795 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPAM Gene

Proteomics data for GPAM Gene at MOPED

Post-translational modifications for GPAM Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPAM Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for GPAM Gene

Gene Families for GPAM Gene

Protein Domains for GPAM Gene

Suggested Antigen Peptide Sequences for GPAM Gene

Graphical View of Domain Structure for InterPro Entry

Q9HCL2

UniProtKB/Swiss-Prot:

GPAT1_HUMAN :
  • The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
  • Belongs to the GPAT/DAPAT family.
Domain:
  • The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
Family:
  • Belongs to the GPAT/DAPAT family.
genes like me logo Genes that share domains with GPAM: view

Function for GPAM Gene

Molecular function for GPAM Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate.
UniProtKB/Swiss-Prot Function:
Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis.

Enzyme Numbers (IUBMB) for GPAM Gene

Gene Ontology (GO) - Molecular Function for GPAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004366 glycerol-3-phosphate O-acyltransferase activity IMP 18238778
genes like me logo Genes that share ontologies with GPAM: view
genes like me logo Genes that share phenotypes with GPAM: view

Animal Models for GPAM Gene

MGI Knock Outs for GPAM:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPAM

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPAM Gene

Localization for GPAM Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPAM Gene

Mitochondrion outer membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPAM Gene COMPARTMENTS Subcellular localization image for GPAM gene
Compartment Confidence
mitochondrion 5
cytosol 2
endoplasmic reticulum 2
plasma membrane 2
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GPAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005741 mitochondrial outer membrane IEA,TAS --
genes like me logo Genes that share ontologies with GPAM: view

Pathways & Interactions for GPAM Gene

genes like me logo Genes that share pathways with GPAM: view

UniProtKB/Swiss-Prot Q9HCL2-GPAT1_HUMAN

  • Pathway: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 1/3.

Interacting Proteins for GPAM Gene

Gene Ontology (GO) - Biological Process for GPAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006631 fatty acid metabolic process IEA --
GO:0006637 acyl-CoA metabolic process IEA --
GO:0006641 triglyceride metabolic process IEA --
GO:0006644 phospholipid metabolic process TAS --
GO:0006650 glycerophospholipid metabolic process IEA --
genes like me logo Genes that share ontologies with GPAM: view

No data available for SIGNOR curated interactions for GPAM Gene

Drugs & Compounds for GPAM Gene

(4) Drugs for GPAM Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Propionyl-CoA Experimental Pharma 0
Coenzyme A Nutra 0

(41) Additional Compounds for GPAM Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
acetyl-coa
  • Ac-CoA
  • Ac-Coenzyme A
  • Ac-S-CoA
  • Ac-S-Coenzyme A
  • Acetyl coenzyme-A
72-89-9
glycerol 3-phosphate
  • 1-(Dihydrogen phosphate) Glycerol
  • 1-Glycerophosphate
  • 1-Glycerophosphorate
  • 1-Glycerophosphoric acid
  • 3-Glycerophosphate
57-03-4
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
4460-95-1
genes like me logo Genes that share compounds with GPAM: view

Transcripts for GPAM Gene

Unigene Clusters for GPAM Gene

Glycerol-3-phosphate acyltransferase, mitochondrial:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPAM Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1: - - - -
SP2: - - -
SP3: - -
SP4:
SP5:
SP6: -

ExUns: 21 ^ 22a · 22b ^ 23 ^ 24
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for GPAM Gene

GeneLoc Exon Structure for
GPAM
ECgene alternative splicing isoforms for
GPAM

Expression for GPAM Gene

mRNA expression in normal human tissues for GPAM Gene

mRNA differential expression in normal tissues according to GTEx for GPAM Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x11.7), Adipose - Subcutaneous (x9.2), Breast - Mammary Tissue (x5.4), and Liver (x5.1).

Protein differential expression in normal tissues from HIPED for GPAM Gene

This gene is overexpressed in Gallbladder (22.0), Breast (12.9), Liver (12.1), and Adipocyte (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GPAM Gene



SOURCE GeneReport for Unigene cluster for GPAM Gene Hs.42586

genes like me logo Genes that share expression patterns with GPAM: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for GPAM Gene

Orthologs for GPAM Gene

This gene was present in the common ancestor of animals.

Orthologs for GPAM Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GPAM 35
  • 89.49 (n)
  • 94.18 (a)
GPAM 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPAM 35
  • 91.02 (n)
  • 95.77 (a)
GPAM 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpam 35
  • 84.64 (n)
  • 92.87 (a)
Gpam 16
Gpam 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GPAM 35
  • 99.6 (n)
  • 99.64 (a)
GPAM 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpam 35
  • 84.78 (n)
  • 91.67 (a)
oppossum
(Monodelphis domestica)
Mammalia GPAM 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPAM 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPAM 35
  • 76.18 (n)
  • 81.62 (a)
GPAM 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPAM 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC145183 35
  • 66.59 (n)
  • 70.65 (a)
Str.16265 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.15378 35
zebrafish
(Danio rerio)
Actinopterygii gpam 35
  • 65.28 (n)
  • 66.63 (a)
gpam 36
  • 63 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003687 35
  • 44.08 (n)
  • 34.32 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5508 35
  • 42.11 (n)
  • 32.24 (a)
CG5508 36
  • 23 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea acl-6 35
  • 43.31 (n)
  • 31.61 (a)
acl-6 36
  • 26 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6605 36
  • 29 (a)
OneToMany
Species with no ortholog for GPAM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPAM Gene

ENSEMBL:
Gene Tree for GPAM (if available)
TreeFam:
Gene Tree for GPAM (if available)

Paralogs for GPAM Gene

Paralogs for GPAM Gene

(5) SIMAP similar genes for GPAM Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GPAM: view

Variants for GPAM Gene

Sequence variations from dbSNP and Humsavar for GPAM Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs11549703 - 112,181,774(-) TGAAT(A/C)TGCAC reference, missense
rs2792751 - 112,180,571(-) CCACC(A/C/G)TCTTC reference, missense
rs10787428 - 112,175,621(+) CATTT(C/T)CAGTC reference, missense
rs35019520 - 112,166,466(-) TGTTA(C/T)TAGAA reference, missense
rs1807800 -- 112,153,794(+) CTGGC(A/T)TTAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPAM Gene

Variant ID Type Subtype PubMed ID
nsv7211 OTHER Inversion 18451855
nsv508608 CNV Loss 20534489
nsv831989 CNV Gain 17160897

Variation tolerance for GPAM Gene

Residual Variation Intolerance Score: 30% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.36; 53.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPAM Gene

HapMap Linkage Disequilibrium report
GPAM
Human Gene Mutation Database (HGMD)
GPAM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPAM Gene

Disorders for GPAM Gene

Relevant External Links for GPAM

Genetic Association Database (GAD)
GPAM
Human Genome Epidemiology (HuGE) Navigator
GPAM
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPAM

No disorders were found for GPAM Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPAM Gene

Publications for GPAM Gene

  1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 67
  2. AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferase. (PMID: 18238778) Chen Y.Q. … Cao G. (J. Biol. Chem. 2008) 3 23
  3. Expression and identification of p90 as the murine mitochondrial glycerol-3-phosphate acyltransferase. (PMID: 8369314) Yet S.F. … Sul H.S. (Biochemistry 1993) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for GPAM Gene

Sources for GPAM Gene

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