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Aliases for SH3RF1 Gene

Aliases for SH3RF1 Gene

  • SH3 Domain Containing Ring Finger 1 2 3 5
  • SH3 Domain-Containing RING Finger Protein 1 3 4
  • RING-Type E3 Ubiquitin Transferase SH3RF1 3 4
  • SH3 Multiple Domains Protein 2 3 4
  • SH3 Multiple Domains 2 2 3
  • Plenty Of SH3 Domains 2 3
  • Plenty Of SH3s 3 4
  • SH3MD2 3 4
  • RNF142 3 4
  • POSH 3 4
  • Putative E3 Ubiquitin-Protein Ligase SH3RF1 3
  • E3 Ubiquitin-Protein Ligase SH3RF1 3
  • Ring Finger Protein 142 3
  • RING Finger Protein 142 4
  • Protein POSH 4
  • EC 2.3.2.27 4
  • KIAA1494 4
  • EC 6.3.2 61

External Ids for SH3RF1 Gene

Previous HGNC Symbols for SH3RF1 Gene

  • SH3MD2

Previous GeneCards Identifiers for SH3RF1 Gene

  • GC04M170251
  • GC04M170015
  • GC04M165769

Summaries for SH3RF1 Gene

Entrez Gene Summary for SH3RF1 Gene

  • This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been shown to function as an ubiquitin-protein ligase involved in protein sorting at the trans-Golgi network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling pathway, facilitating the formation of a functional signaling module. [provided by RefSeq, Jul 2008]

GeneCards Summary for SH3RF1 Gene

SH3RF1 (SH3 Domain Containing Ring Finger 1) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ligase activity. An important paralog of this gene is SH3RF3.

UniProtKB/Swiss-Prot for SH3RF1 Gene

  • Acts as a scaffold protein, contributes to Rac-induced signal transduction such as JNKs (MAPK8 and MAPK9) activation and induces apoptosis. Within a signaling complex, it probably recruits protein kinases such as MAP3K10 or MAP3K11 which are in turn activated leading to the sequential activation of MAP2K4, MAP2K7 and JNKs (MAPK8 and MAPK9) (By similarity). May be involved in targeting of HIV-1 GAG and GAG-POL polyproteins to the plasma membrane.

  • Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes such as UBE2D1 or UBE2N and then transfers it to substrates. In the absence of an external substrate, it can catalyze self-ubiquitination. Stimulates ubiquitination of potassium channel KCNJ1, enhancing its dynamin-dependent and clathrin-independent endocytosis.

  • Plays an essential role in the targeting of HIV-1 Gag to the plasma membrane, this function is dependent on its RING domain, and hence its E3 ligase activity.

Gene Wiki entry for SH3RF1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SH3RF1 Gene

Genomics for SH3RF1 Gene

Regulatory Elements for SH3RF1 Gene

Enhancers for SH3RF1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G169266 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.4 +1.2 1207 6.2 PKNOX1 FOXA2 ARID4B SIN3A ZNF2 ZNF48 GLIS2 GATA2 ZNF143 FOS SH3RF1 HPF1 ENSG00000251171
GH04G169228 1.3 Ensembl ENCODE dbSUPER 15.6 +41.5 41535 2.0 JUN INSM2 SIN3A FEZF1 RAD21 ZEB1 ZNF324 GTF3C2 GATA2 GLI2 SH3RF1 ENSG00000251171
GH04G169220 1.3 Ensembl ENCODE dbSUPER 15.5 +47.0 46985 7.3 TAF1 JUN SIN3A MAX RAD21 YY1 GATA3 POLR2A NCOR1 HNF4G SH3RF1 ENSG00000251171 PALLD
GH04G169183 1.2 Ensembl ENCODE dbSUPER 15.4 +86.0 85959 2.3 CTCF ZNF362 MNT ZNF398 PRDM6 ZNF341 PRDM10 MAFK PRDM1 WT1 SH3RF1 ENSG00000251445 CBR4 RNY4P17 GC04P169167 ENSG00000251171
GH04G169200 1.2 Ensembl ENCODE dbSUPER 15.4 +69.3 69281 2.7 FOXA2 JUN DPF2 FOXA1 GATA3 JUND PRDM6 CTBP1 ZNF316 SMARCA4 SH3RF1 ENSG00000251171
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SH3RF1 on UCSC Golden Path with GeneCards custom track

Promoters for SH3RF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000313060 505 2801 PKNOX1 FOXA2 ARID4B SIN3A ZNF2 ZNF48 GLIS2 GATA2 ZNF143 FOS

Genomic Location for SH3RF1 Gene

Chromosome:
4
Start:
169,094,256 bp from pter
End:
169,271,105 bp from pter
Size:
176,850 bases
Orientation:
Minus strand

Genomic View for SH3RF1 Gene

Genes around SH3RF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SH3RF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SH3RF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH3RF1 Gene

Proteins for SH3RF1 Gene

  • Protein details for SH3RF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z6J0-SH3R1_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase SH3RF1
    Protein Accession:
    Q7Z6J0
    Secondary Accessions:
    • Q05BT2
    • Q8IW46
    • Q9HAM2
    • Q9P234

    Protein attributes for SH3RF1 Gene

    Size:
    888 amino acids
    Molecular mass:
    93129 Da
    Quaternary structure:
    • Interacts with Rac; in a GTP-dependent manner (By similarity). Interacts with MAP3K10 and MAP3K11. Interacts with MAPK8IP; this interaction leads to the PJAC complex (POSH-JIP or SH3RF1/MAPK8IP apoptotic complex) with a 1:1 ratio. Interacts with SIAH1. Interacts with HERP1. Probably part of a signaling complex that may contain SH3RF1, MAPK8IP, DLK1, MAP2K4, MAP2K7, MAPK8, MAPK9, AKT1 and AKT2.
    SequenceCaution:
    • Sequence=AAH33203.1; Type=Frameshift; Positions=182; Evidence={ECO:0000305}; Sequence=AAH33203.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH53671.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the middle of the protein.; Evidence={ECO:0000305};

    Alternative splice isoforms for SH3RF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SH3RF1 Gene

Selected DME Specific Peptides for SH3RF1 Gene

Q7Z6J0:
  • HGFFPTNFVQ
  • RVDENWAEG
  • AKVLPCQHTFC
  • DKIGIFPISYVEFNSAA
  • TGLFPGSFV
  • HIQTSPQ
  • PVLISSSNP
  • KKNTKKRHSFTSL
  • LLECPVC
  • IKPLPQPPPQCKALYDFE
  • PRKEDELELRKGEMFLV
  • LPSNILLVRLLDGIKQRPWKPGP
  • LRRQVDENWYHGE
  • KIGVFPGNY
  • GLSCSAPSQ
  • PQLPCAKALYNY
  • KDKEADKDCLPF
  • EKKGLLKLLS
  • RPTAAVTPIQ

Post-translational modifications for SH3RF1 Gene

  • Phosphorylated at Ser-304 by AKT1 and AKT2. When phosphorylated, it has reduced ability to bind Rac.
  • Subject to ubiquitination and proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SH3RF1 Gene

Domains & Families for SH3RF1 Gene

Gene Families for SH3RF1 Gene

Suggested Antigen Peptide Sequences for SH3RF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z6J0

UniProtKB/Swiss-Prot:

SH3R1_HUMAN :
  • The RING finger domain is responsible of ubiquitination and proteasomal degradation.
  • Belongs to the SH3RF family.
Domain:
  • The RING finger domain is responsible of ubiquitination and proteasomal degradation.
Family:
  • Belongs to the SH3RF family.
genes like me logo Genes that share domains with SH3RF1: view

Function for SH3RF1 Gene

Molecular function for SH3RF1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
Acts as a scaffold protein, contributes to Rac-induced signal transduction such as JNKs (MAPK8 and MAPK9) activation and induces apoptosis. Within a signaling complex, it probably recruits protein kinases such as MAP3K10 or MAP3K11 which are in turn activated leading to the sequential activation of MAP2K4, MAP2K7 and JNKs (MAPK8 and MAPK9) (By similarity). May be involved in targeting of HIV-1 GAG and GAG-POL polyproteins to the plasma membrane.
UniProtKB/Swiss-Prot Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes such as UBE2D1 or UBE2N and then transfers it to substrates. In the absence of an external substrate, it can catalyze self-ubiquitination. Stimulates ubiquitination of potassium channel KCNJ1, enhancing its dynamin-dependent and clathrin-independent endocytosis.
UniProtKB/Swiss-Prot Function:
Plays an essential role in the targeting of HIV-1 Gag to the plasma membrane, this function is dependent on its RING domain, and hence its E3 ligase activity.

Enzyme Numbers (IUBMB) for SH3RF1 Gene

Gene Ontology (GO) - Molecular Function for SH3RF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20696164
GO:0008270 zinc ion binding IEA --
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with SH3RF1: view

Phenotypes for SH3RF1 Gene

genes like me logo Genes that share phenotypes with SH3RF1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SH3RF1 Gene

Localization for SH3RF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SH3RF1 Gene

Cytoplasm, perinuclear region. Cell projection, lamellipodium. Cytoplasm. Golgi apparatus, trans-Golgi network. Note=Colocalizes, with AKT2, in lamellipodia (By similarity). Colocalizes, with HERP1, in trans-Golgi network. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SH3RF1 gene
Compartment Confidence
cytosol 5
golgi apparatus 5
nucleus 3

Gene Ontology (GO) - Cellular Components for SH3RF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005829 cytosol IDA 21586138
GO:0030027 lamellipodium IEA --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with SH3RF1: view

Pathways & Interactions for SH3RF1 Gene

genes like me logo Genes that share pathways with SH3RF1: view

Pathways by source for SH3RF1 Gene

UniProtKB/Swiss-Prot Q7Z6J0-SH3R1_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for SH3RF1 Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for SH3RF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0016567 protein ubiquitination IEA --
GO:0043066 negative regulation of apoptotic process IMP 21586138
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP 21586138
GO:0046328 regulation of JNK cascade IEA --
genes like me logo Genes that share ontologies with SH3RF1: view

Drugs & Compounds for SH3RF1 Gene

(1) Drugs for SH3RF1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with SH3RF1: view

Transcripts for SH3RF1 Gene

Unigene Clusters for SH3RF1 Gene

SH3 domain containing ring finger 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SH3RF1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15
SP1: - - -
SP2: -
SP3:
SP4:
SP5:
SP6: -
SP7:

Relevant External Links for SH3RF1 Gene

GeneLoc Exon Structure for
SH3RF1
ECgene alternative splicing isoforms for
SH3RF1

Expression for SH3RF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SH3RF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SH3RF1 Gene

This gene is overexpressed in Platelet (58.6) and Placenta (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SH3RF1 Gene



Protein tissue co-expression partners for SH3RF1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SH3RF1 Gene:

SH3RF1

SOURCE GeneReport for Unigene cluster for SH3RF1 Gene:

Hs.301804

Evidence on tissue expression from TISSUES for SH3RF1 Gene

  • Nervous system(4.6)
  • Liver(4.2)
  • Eye(4)
genes like me logo Genes that share expression patterns with SH3RF1: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SH3RF1 Gene

Orthologs for SH3RF1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SH3RF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SH3RF1 34 35
  • 99.59 (n)
dog
(Canis familiaris)
Mammalia SH3RF1 34 35
  • 89.19 (n)
rat
(Rattus norvegicus)
Mammalia Sh3rf1 34
  • 86.44 (n)
mouse
(Mus musculus)
Mammalia Sh3rf1 34 16 35
  • 85.95 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SH3RF1 35
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SH3RF1 35
  • 80 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SH3RF1 34 35
  • 77.46 (n)
chicken
(Gallus gallus)
Aves SH3RF1 34 35
  • 76.15 (n)
lizard
(Anolis carolinensis)
Reptilia SH3RF1 35
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sh3rf1 34
  • 70.56 (n)
zebrafish
(Danio rerio)
Actinopterygii sh3rf1 34 35
  • 63.83 (n)
fruit fly
(Drosophila melanogaster)
Insecta POSH 35
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sorb-1 35
  • 12 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NBP2 37
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 41 (a)
OneToMany
Species where no ortholog for SH3RF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SH3RF1 Gene

ENSEMBL:
Gene Tree for SH3RF1 (if available)
TreeFam:
Gene Tree for SH3RF1 (if available)

Paralogs for SH3RF1 Gene

Paralogs for SH3RF1 Gene

(16) SIMAP similar genes for SH3RF1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SH3RF1: view

Variants for SH3RF1 Gene

Sequence variations from dbSNP and Humsavar for SH3RF1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000004472 -- 169,213,702(+) TATAA(C/T)GTCTG intron-variant
rs1000033456 -- 169,227,880(+) TTTCA(A/G)TTCAG intron-variant
rs10000418 -- 169,152,535(+) GAGTT(C/T)GAGAC intron-variant
rs1000051019 -- 169,183,059(+) CCAGC(A/T)GTTTG intron-variant
rs1000075170 -- 169,114,421(+) AAGGC(A/T)ATTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SH3RF1 Gene

Variant ID Type Subtype PubMed ID
esv1236515 CNV deletion 17803354
esv1943131 CNV deletion 18987734
esv2728720 CNV deletion 23290073
esv2728721 CNV deletion 23290073
esv2728722 CNV deletion 23290073
esv2728723 CNV deletion 23290073
esv3564979 CNV deletion 23714750
esv3564980 CNV deletion 23714750
esv3603115 CNV loss 21293372
nsv1112082 CNV deletion 24896259
nsv1120843 CNV deletion 24896259
nsv1128109 CNV deletion 24896259
nsv290567 CNV insertion 16902084
nsv4599 CNV insertion 18451855
nsv964112 CNV duplication 23825009

Variation tolerance for SH3RF1 Gene

Residual Variation Intolerance Score: 15.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.94; 59.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SH3RF1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SH3RF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SH3RF1 Gene

Disorders for SH3RF1 Gene

Relevant External Links for SH3RF1

Genetic Association Database (GAD)
SH3RF1
Human Genome Epidemiology (HuGE) Navigator
SH3RF1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SH3RF1

No disorders were found for SH3RF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SH3RF1 Gene

Publications for SH3RF1 Gene

  1. Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex. (PMID: 14504284) Figueroa C. … Vojtek A.B. (J. Biol. Chem. 2003) 3 4 22 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. POSH stimulates the ubiquitination and the clathrin-independent endocytosis of ROMK1 channels. (PMID: 19710010) Lin D.H. … Wang W.H. (J. Biol. Chem. 2009) 3 4 64
  4. The ubiquitin E3 ligase POSH regulates calcium homeostasis through spatial control of Herp. (PMID: 17420289) Tuvia S. … Reiss Y. (J. Cell Biol. 2007) 3 4 64
  5. Regulation of the pro-apoptotic scaffolding protein POSH by Akt. (PMID: 17535800) Lyons T.R. … Kassenbrock C.K. (J. Biol. Chem. 2007) 3 4 64

Products for SH3RF1 Gene

Sources for SH3RF1 Gene

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