Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SH3RF1 Gene

Aliases for SH3RF1 Gene

  • SH3 Domain Containing Ring Finger 1 2 3 5
  • SH3 Domain-Containing RING Finger Protein 1 3 4
  • SH3 Multiple Domains Protein 2 3 4
  • SH3 Multiple Domains 2 2 3
  • Plenty Of SH3 Domains 2 3
  • Plenty Of SH3s 3 4
  • SH3MD2 3 4
  • RNF142 3 4
  • POSH 3 4
  • Putative E3 Ubiquitin-Protein Ligase SH3RF1 3
  • Ring Finger Protein 142 3
  • RING Finger Protein 142 4
  • Protein POSH 4
  • EC 6.3.2.- 4
  • KIAA1494 4
  • EC 6.3.2 63

External Ids for SH3RF1 Gene

Previous HGNC Symbols for SH3RF1 Gene

  • SH3MD2

Previous GeneCards Identifiers for SH3RF1 Gene

  • GC04M170251
  • GC04M170015
  • GC04M165769

Summaries for SH3RF1 Gene

Entrez Gene Summary for SH3RF1 Gene

  • This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been shown to function as an ubiquitin-protein ligase involved in protein sorting at the trans-Golgi network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling pathway, facilitating the formation of a functional signaling module. [provided by RefSeq, Jul 2008]

GeneCards Summary for SH3RF1 Gene

SH3RF1 (SH3 Domain Containing Ring Finger 1) is a Protein Coding gene. Among its related pathways are Antigen processing- Ubiquitination and Proteasome degradation and Immune System. GO annotations related to this gene include ligase activity. An important paralog of this gene is SORBS3.

UniProtKB/Swiss-Prot for SH3RF1 Gene

  • Acts as a scaffold protein, contributes to Rac-induced signal transduction such as JNKs (MAPK8 and MAPK9) activation and induces apoptosis. Within a signaling complex, it probably recruits protein kinases such as MAP3K10 or MAP3K11 which are in turn activated leading to the sequential activation of MAP2K4, MAP2K7 and JNKs (MAPK8 and MAPK9) (By similarity). May be involved in targeting of HIV-1 GAG and GAG-POL polyproteins to the plasma membrane.

  • Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes such as UBE2D1 or UBE2N and then transfers it to substrates. In the absence of an external substrate, it can catalyze self-ubiquitination. Stimulates ubiquitination of potassium channel KCNJ1, enhancing its dynamin-dependent and clathrin-independent endocytosis.

  • Plays an essential role in the targeting of HIV-1 Gag to the plasma membrane, this function is dependent on its RING domain, and hence its E3 ligase activity.

Gene Wiki entry for SH3RF1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SH3RF1 Gene

Genomics for SH3RF1 Gene

Regulatory Elements for SH3RF1 Gene

Enhancers for SH3RF1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SH3RF1 on UCSC Golden Path with GeneCards custom track

Promoters for SH3RF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SH3RF1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SH3RF1 Gene

Chromosome:
4
Start:
169,094,256 bp from pter
End:
169,271,105 bp from pter
Size:
176,850 bases
Orientation:
Minus strand

Genomic View for SH3RF1 Gene

Genes around SH3RF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SH3RF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SH3RF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH3RF1 Gene

Proteins for SH3RF1 Gene

  • Protein details for SH3RF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z6J0-SH3R1_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase SH3RF1
    Protein Accession:
    Q7Z6J0
    Secondary Accessions:
    • Q05BT2
    • Q8IW46
    • Q9HAM2
    • Q9P234

    Protein attributes for SH3RF1 Gene

    Size:
    888 amino acids
    Molecular mass:
    93129 Da
    Quaternary structure:
    • Interacts with Rac; in a GTP-dependent manner (By similarity). Interacts with MAP3K10 and MAP3K11. Interacts with MAPK8IP; this interaction leads to the PJAC complex (POSH-JIP or SH3RF1/MAPK8IP apoptotic complex) with a 1:1 ratio. Interacts with SIAH1. Interacts with HERP1. Probably part of a signaling complex that may contain SH3RF1, MAPK8IP, DLK1, MAP2K4, MAP2K7, MAPK8, MAPK9, AKT1 and AKT2.
    SequenceCaution:
    • Sequence=AAH33203.1; Type=Frameshift; Positions=182; Evidence={ECO:0000305}; Sequence=AAH33203.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH53671.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the middle of the protein.; Evidence={ECO:0000305};

    Alternative splice isoforms for SH3RF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SH3RF1 Gene

Proteomics data for SH3RF1 Gene at MOPED

Post-translational modifications for SH3RF1 Gene

  • Phosphorylated at Ser-304 by AKT1 and AKT2. When phosphorylated, it has reduced ability to bind Rac.
  • Subject to ubiquitination and proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SH3RF1 Gene

Domains & Families for SH3RF1 Gene

Gene Families for SH3RF1 Gene

Protein Domains for SH3RF1 Gene

Suggested Antigen Peptide Sequences for SH3RF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z6J0

UniProtKB/Swiss-Prot:

SH3R1_HUMAN :
  • The RING finger domain is responsible of ubiquitination and proteasomal degradation.
  • Belongs to the SH3RF family.
  • Contains 1 RING-type zinc finger.
Domain:
  • The RING finger domain is responsible of ubiquitination and proteasomal degradation.
  • Contains 4 SH3 domains.
Family:
  • Belongs to the SH3RF family.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with SH3RF1: view

Function for SH3RF1 Gene

Molecular function for SH3RF1 Gene

UniProtKB/Swiss-Prot Function:
Acts as a scaffold protein, contributes to Rac-induced signal transduction such as JNKs (MAPK8 and MAPK9) activation and induces apoptosis. Within a signaling complex, it probably recruits protein kinases such as MAP3K10 or MAP3K11 which are in turn activated leading to the sequential activation of MAP2K4, MAP2K7 and JNKs (MAPK8 and MAPK9) (By similarity). May be involved in targeting of HIV-1 GAG and GAG-POL polyproteins to the plasma membrane.
UniProtKB/Swiss-Prot Function:
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes such as UBE2D1 or UBE2N and then transfers it to substrates. In the absence of an external substrate, it can catalyze self-ubiquitination. Stimulates ubiquitination of potassium channel KCNJ1, enhancing its dynamin-dependent and clathrin-independent endocytosis.
UniProtKB/Swiss-Prot Function:
Plays an essential role in the targeting of HIV-1 Gag to the plasma membrane, this function is dependent on its RING domain, and hence its E3 ligase activity.

Enzyme Numbers (IUBMB) for SH3RF1 Gene

Gene Ontology (GO) - Molecular Function for SH3RF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with SH3RF1: view

Phenotypes for SH3RF1 Gene

genes like me logo Genes that share phenotypes with SH3RF1: view

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SH3RF1 Gene

Localization for SH3RF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SH3RF1 Gene

Cytoplasm, perinuclear region. Cell projection, lamellipodium. Cytoplasm. Golgi apparatus, trans-Golgi network. Note=Colocalizes, with AKT2, in lamellipodia (By similarity). Colocalizes, with HERP1, in trans-Golgi network. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SH3RF1 Gene COMPARTMENTS Subcellular localization image for SH3RF1 gene
Compartment Confidence
cytosol 5
golgi apparatus 5
nucleus 3
cytoskeleton 1
endosome 1

No data available for Gene Ontology (GO) - Cellular Components for SH3RF1 Gene

Pathways & Interactions for SH3RF1 Gene

genes like me logo Genes that share pathways with SH3RF1: view

Pathways by source for SH3RF1 Gene

UniProtKB/Swiss-Prot Q7Z6J0-SH3R1_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for SH3RF1 Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for SH3RF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with SH3RF1: view

Drugs & Compounds for SH3RF1 Gene

(1) Drugs for SH3RF1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with SH3RF1: view

Transcripts for SH3RF1 Gene

Unigene Clusters for SH3RF1 Gene

SH3 domain containing ring finger 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SH3RF1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15
SP1: - - -
SP2: -
SP3:
SP4:
SP5:
SP6: -
SP7:

Relevant External Links for SH3RF1 Gene

GeneLoc Exon Structure for
SH3RF1
ECgene alternative splicing isoforms for
SH3RF1

Expression for SH3RF1 Gene

mRNA expression in normal human tissues for SH3RF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SH3RF1 Gene

This gene is overexpressed in Platelet (58.6) and Placenta (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SH3RF1 Gene



SOURCE GeneReport for Unigene cluster for SH3RF1 Gene Hs.301804

genes like me logo Genes that share expression patterns with SH3RF1: view

Protein tissue co-expression partners for SH3RF1 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SH3RF1 Gene

Orthologs for SH3RF1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SH3RF1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SH3RF1 35
  • 77.46 (n)
  • 81.55 (a)
SH3RF1 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SH3RF1 35
  • 89.19 (n)
  • 92.38 (a)
SH3RF1 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sh3rf1 35
  • 85.95 (n)
  • 90.73 (a)
Sh3rf1 16
Sh3rf1 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SH3RF1 35
  • 99.59 (n)
  • 99.55 (a)
SH3RF1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sh3rf1 35
  • 86.44 (n)
  • 90.51 (a)
oppossum
(Monodelphis domestica)
Mammalia SH3RF1 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SH3RF1 36
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves SH3RF1 35
  • 76.15 (n)
  • 80.81 (a)
SH3RF1 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SH3RF1 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sh3rf1 35
  • 70.56 (n)
  • 75.03 (a)
zebrafish
(Danio rerio)
Actinopterygii sh3rf1 35
  • 63.83 (n)
  • 66.71 (a)
sh3rf1 36
  • 63 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta POSH 36
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sorb-1 36
  • 12 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NBP2 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
OneToMany
Species with no ortholog for SH3RF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SH3RF1 Gene

ENSEMBL:
Gene Tree for SH3RF1 (if available)
TreeFam:
Gene Tree for SH3RF1 (if available)

Paralogs for SH3RF1 Gene

Paralogs for SH3RF1 Gene

(16) SIMAP similar genes for SH3RF1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SH3RF1: view

Variants for SH3RF1 Gene

Sequence variations from dbSNP and Humsavar for SH3RF1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs3811813 - 169,116,421(+) CAGTG(A/G)AGCAG reference, missense
rs2068 -- 169,124,912(-) ACCTC(A/C/T)GGGTA intron-variant
rs2069 -- 169,124,915(-) GTCAC(C/G)TCCGG intron-variant
rs906321 -- 169,177,713(-) AGCAT(G/T)ATAGA intron-variant
rs963991 -- 169,105,889(-) tcttt(C/T)tttga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SH3RF1 Gene

Variant ID Type Subtype PubMed ID
nsv880897 CNV Gain 21882294
nsv4599 CNV Insertion 18451855
esv2728720 CNV Deletion 23290073
esv2728721 CNV Deletion 23290073
esv1236515 CNV Deletion 17803354
nsv290567 CNV Insertion 16902084
esv1943131 CNV Deletion 18987734
esv2728722 CNV Deletion 23290073
esv2728723 CNV Deletion 23290073

Variation tolerance for SH3RF1 Gene

Residual Variation Intolerance Score: 15.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.94; 59.61% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SH3RF1 Gene

Disorders for SH3RF1 Gene

Relevant External Links for SH3RF1

Genetic Association Database (GAD)
SH3RF1
Human Genome Epidemiology (HuGE) Navigator
SH3RF1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SH3RF1

No disorders were found for SH3RF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SH3RF1 Gene

Publications for SH3RF1 Gene

  1. Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex. (PMID: 14504284) Figueroa C. … Vojtek A.B. (J. Biol. Chem. 2003) 3 4 23 67
  2. A new rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-kappaB signalling pathways. (PMID: 9482736) Tapon N. … Hall A. (EMBO J. 1998) 2 3
  3. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3
  4. Imputation-based association analyses identify new lung cancer susceptibility variants in CDK6 and SH3RF1 and their interactions with smoking in Chinese populations. (PMID: 23644744) Deng Q. … Wu T. (Carcinogenesis 2013) 3
  5. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PMID: 24255178) Couzens A.L. … Gingras A.C. (Sci Signal 2013) 3

Products for SH3RF1 Gene

Sources for SH3RF1 Gene

Content