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Aliases for TSHZ3 Gene

Aliases for TSHZ3 Gene

  • Teashirt Zinc Finger Homeobox 3 2 3
  • Zinc Finger Protein 537 2 3 4
  • Teashirt Family Zinc Finger 3 2 3
  • Teashirt 3 2 3
  • KIAA1474 4 6
  • ZNF537 3 4
  • TSH3 3 4
  • Teashirt Homolog 3 3

External Ids for TSHZ3 Gene

Previous HGNC Symbols for TSHZ3 Gene

  • ZNF537

Previous GeneCards Identifiers for TSHZ3 Gene

  • GC19M036458
  • GC19M031765
  • GC19M028269

Summaries for TSHZ3 Gene

GeneCards Summary for TSHZ3 Gene

TSHZ3 (Teashirt Zinc Finger Homeobox 3) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and chromatin binding. An important paralog of this gene is TSHZ1.

UniProtKB/Swiss-Prot for TSHZ3 Gene

  • Transcriptional regulator involved in developmental processes. Function in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter.

Gene Wiki entry for TSHZ3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSHZ3 Gene

Genomics for TSHZ3 Gene

Regulatory Elements for TSHZ3 Gene

Genomic Location for TSHZ3 Gene

Start:
31,274,945 bp from pter
End:
31,349,547 bp from pter
Size:
74,603 bases
Orientation:
Minus strand

Genomic View for TSHZ3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TSHZ3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSHZ3 Gene

Proteins for TSHZ3 Gene

  • Protein details for TSHZ3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q63HK5-TSH3_HUMAN
    Recommended name:
    Teashirt homolog 3
    Protein Accession:
    Q63HK5
    Secondary Accessions:
    • Q9H0G6
    • Q9P254

    Protein attributes for TSHZ3 Gene

    Size:
    1081 amino acids
    Molecular mass:
    118566 Da
    Quaternary structure:
    • Interacts (via homeobox domain) with APBB1 (via PID domain 1). Interacts (via N-terminus) with HDAC1 and HDAC2; the interaction is direct. Found in a trimeric complex with APBB1 and HDAC1; the interaction between HDAC1 and APBB1 is mediated by TSHZ3.
    SequenceCaution:
    • Sequence=CAB66739.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TSHZ3 Gene

neXtProt entry for TSHZ3 Gene

Proteomics data for TSHZ3 Gene at MOPED

Post-translational modifications for TSHZ3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TSHZ3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TSHZ3 Gene

Domains for TSHZ3 Gene

Gene Families for TSHZ3 Gene

HGNC:
  • TSHZ :Teashirt zinc fingers
  • ZNF :Zinc fingers, C2H2-type
  • ZFHX :Homeoboxes / ZF class

Protein Domains for TSHZ3 Gene

Suggested Antigen Peptide Sequences for TSHZ3 Gene

Graphical View of Domain Structure for InterPro Entry

Q63HK5

UniProtKB/Swiss-Prot:

TSH3_HUMAN :
  • Q63HK5
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the teashirt C2H2-type zinc-finger protein family.
Similarity:
  • Contains 5 C2H2-type zinc fingers.
genes like me logo Genes that share domains with TSHZ3: view

Function for TSHZ3 Gene

Molecular function for TSHZ3 Gene

UniProtKB/Swiss-Prot Function: Transcriptional regulator involved in developmental processes. Function in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter.

Gene Ontology (GO) - Molecular Function for TSHZ3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IDA 19343227
GO:0005515 protein binding IPI 19343227
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TSHZ3: view
genes like me logo Genes that share phenotypes with TSHZ3: view

miRNA for TSHZ3 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TSHZ3 Gene

Localization for TSHZ3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSHZ3 Gene

Nucleus. Cell projection, growth cone. Note=Colocalizes with APBB1 in axonal growth cone (By similarity). Colocalizes with APBB1 in the nucleus. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TSHZ3 Gene COMPARTMENTS Subcellular localization image for TSHZ3 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for TSHZ3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 19343227
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IEA --
GO:0030426 growth cone IEA --
genes like me logo Genes that share ontologies with TSHZ3: view

Pathways for TSHZ3 Gene

SuperPathways for TSHZ3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TSHZ3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001656 metanephros development IEA --
GO:0001657 ureteric bud development IEA --
GO:0001701 in utero embryonic development IEA --
GO:0002087 regulation of respiratory gaseous exchange by neurological system process ISS --
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with TSHZ3: view

No data available for Pathways by source for TSHZ3 Gene

Transcripts for TSHZ3 Gene

mRNA/cDNA for TSHZ3 Gene

Unigene Clusters for TSHZ3 Gene

Teashirt zinc finger homeobox 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TSHZ3 Gene

No ASD Table

Relevant External Links for TSHZ3 Gene

GeneLoc Exon Structure for
TSHZ3
ECgene alternative splicing isoforms for
TSHZ3

Expression for TSHZ3 Gene

mRNA expression in normal human tissues for TSHZ3 Gene

mRNA differential expression in normal tissues according to GTEx for TSHZ3 Gene

This gene is overexpressed in Ovary (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TSHZ3 Gene

SOURCE GeneReport for Unigene cluster for TSHZ3 Gene Hs.278436

mRNA Expression by UniProt/SwissProt for TSHZ3 Gene

Q63HK5-TSH3_HUMAN
Tissue specificity: Expressed in brain; strongly reduced in post-mortem elderly subjects with Alzheimer disease.
genes like me logo Genes that share expressions with TSHZ3: view

Orthologs for TSHZ3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TSHZ3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TSHZ3 35
  • 99.33 (n)
  • 100 (a)
TSHZ3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TSHZ3 35
  • 90.44 (n)
  • 95.65 (a)
TSHZ3 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TSHZ3 35
  • 89.64 (n)
  • 94.36 (a)
TSHZ3 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tshz3 35
  • 88.5 (n)
  • 95.1 (a)
Tshz3 16
Tshz3 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TSHZ3 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TSHZ3 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tshz3 35
  • 88.51 (n)
  • 95.66 (a)
chicken
(Gallus gallus)
Aves TSHZ3 35
  • 79.3 (n)
  • 92.12 (a)
TSHZ3 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TSHZ3 36
  • 90 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.9022 35
tropical clawed frog
(Silurana tropicalis)
Amphibia tshz3 35
  • 75.74 (n)
  • 87.28 (a)
zebrafish
(Danio rerio)
Actinopterygii TSHZ3 (1 of 2) 36
  • 72 (a)
OneToMany
TSHZ3 (2 of 2) 36
  • 50 (a)
OneToMany
tshz3b 35
  • 71.05 (n)
  • 75.9 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5824 36
  • 17 (a)
OneToMany
Species with no ortholog for TSHZ3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TSHZ3 Gene

ENSEMBL:
Gene Tree for TSHZ3 (if available)
TreeFam:
Gene Tree for TSHZ3 (if available)

Paralogs for TSHZ3 Gene

Paralogs for TSHZ3 Gene

Selected SIMAP similar genes for TSHZ3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TSHZ3: view

Variants for TSHZ3 Gene

Sequence variations from dbSNP and Humsavar for TSHZ3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs2909 -- 31,336,792(-) AACTT(C/T)TTGTT intron-variant
rs8151 -- 31,275,146(+) AAATG(G/T)AGAAG utr-variant-3-prime
rs14693 -- 31,276,306(+) ATCCC(G/T)TTTAC utr-variant-3-prime
rs751156 -- 31,344,154(-) AATTG(G/T)GGTTT intron-variant
rs903931 -- 31,330,701(+) TTTAA(A/T)CCTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TSHZ3 Gene

Variant ID Type Subtype PubMed ID
nsv510764 CNV Loss 20534489
esv25402 CNV Loss 19812545
esv2718454 CNV Deletion 23290073
nsv911571 CNV Loss 21882294
nsv828522 CNV Gain 20364138

Relevant External Links for TSHZ3 Gene

HapMap Linkage Disequilibrium report
TSHZ3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSHZ3 Gene

Disorders for TSHZ3 Gene

(1) University of Copenhagen DISEASES for TSHZ3 Gene

Relevant External Links for TSHZ3

Genetic Association Database (GAD)
TSHZ3
Human Genome Epidemiology (HuGE) Navigator
TSHZ3
genes like me logo Genes that share disorders with TSHZ3: view

No data available for UniProtKB/Swiss-Prot for TSHZ3 Gene

Publications for TSHZ3 Gene

  1. Analysis of TSHZ2 and TSHZ3 genes in congenital pelvi-ureteric junction obstruction. (PMID: 19745106) Jenkins D. … Woolf A.S. (Nephrol. Dial. Transplant. 2010) 3 4 48
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  4. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  5. FE65 binds Teashirt, inhibiting expression of the primate-specific caspase-4. (PMID: 19343227) Kajiwara Y. … Buxbaum J.D. (PLoS ONE 2009) 3 4

Products for TSHZ3 Gene

Sources for TSHZ3 Gene

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