Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TSHZ3 Gene

Aliases for TSHZ3 Gene

  • Teashirt Zinc Finger Homeobox 3 2 3 5
  • Zinc Finger Protein 537 2 3 4
  • Teashirt Family Zinc Finger 3 2 3
  • Teashirt 3 2 3
  • ZNF537 3 4
  • TSH3 3 4
  • KIAA1474 4

External Ids for TSHZ3 Gene

Previous HGNC Symbols for TSHZ3 Gene

  • ZNF537

Previous GeneCards Identifiers for TSHZ3 Gene

  • GC19M036458
  • GC19M031765
  • GC19M028269

Summaries for TSHZ3 Gene

GeneCards Summary for TSHZ3 Gene

TSHZ3 (Teashirt Zinc Finger Homeobox 3) is a Protein Coding gene. GO annotations related to this gene include chromatin binding. An important paralog of this gene is TSHZ2.

UniProtKB/Swiss-Prot for TSHZ3 Gene

  • Transcriptional regulator involved in developmental processes. Function in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter.

Gene Wiki entry for TSHZ3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSHZ3 Gene

Genomics for TSHZ3 Gene

Regulatory Elements for TSHZ3 Gene

Promoters for TSHZ3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TSHZ3 on UCSC Golden Path with GeneCards custom track

Genomic Location for TSHZ3 Gene

Chromosome:
19
Start:
31,274,945 bp from pter
End:
31,349,547 bp from pter
Size:
74,603 bases
Orientation:
Minus strand

Genomic View for TSHZ3 Gene

Genes around TSHZ3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSHZ3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSHZ3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSHZ3 Gene

Proteins for TSHZ3 Gene

  • Protein details for TSHZ3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q63HK5-TSH3_HUMAN
    Recommended name:
    Teashirt homolog 3
    Protein Accession:
    Q63HK5
    Secondary Accessions:
    • Q9H0G6
    • Q9P254

    Protein attributes for TSHZ3 Gene

    Size:
    1081 amino acids
    Molecular mass:
    118566 Da
    Quaternary structure:
    • Interacts (via homeobox domain) with APBB1 (via PID domain 1). Interacts (via N-terminus) with HDAC1 and HDAC2; the interaction is direct. Found in a trimeric complex with APBB1 and HDAC1; the interaction between HDAC1 and APBB1 is mediated by TSHZ3.
    SequenceCaution:
    • Sequence=CAB66739.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TSHZ3 Gene

neXtProt entry for TSHZ3 Gene

Proteomics data for TSHZ3 Gene at MOPED

Post-translational modifications for TSHZ3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TSHZ3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TSHZ3 Gene

Domains & Families for TSHZ3 Gene

Protein Domains for TSHZ3 Gene

Suggested Antigen Peptide Sequences for TSHZ3 Gene

Graphical View of Domain Structure for InterPro Entry

Q63HK5

UniProtKB/Swiss-Prot:

TSH3_HUMAN :
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the teashirt C2H2-type zinc-finger protein family.
  • Contains 5 C2H2-type zinc fingers.
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the teashirt C2H2-type zinc-finger protein family.
Similarity:
  • Contains 5 C2H2-type zinc fingers.
genes like me logo Genes that share domains with TSHZ3: view

Function for TSHZ3 Gene

Molecular function for TSHZ3 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional regulator involved in developmental processes. Function in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter.

Gene Ontology (GO) - Molecular Function for TSHZ3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with TSHZ3: view
genes like me logo Genes that share phenotypes with TSHZ3: view

Animal Models for TSHZ3 Gene

MGI Knock Outs for TSHZ3:

Animal Model Products

miRNA for TSHZ3 Gene

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TSHZ3 Gene

Localization for TSHZ3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSHZ3 Gene

Nucleus. Cell projection, growth cone. Note=Colocalizes with APBB1 in axonal growth cone (By similarity). Colocalizes with APBB1 in the nucleus. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TSHZ3 Gene COMPARTMENTS Subcellular localization image for TSHZ3 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for TSHZ3 Gene

Pathways & Interactions for TSHZ3 Gene

SuperPathways for TSHZ3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TSHZ3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002087 regulation of respiratory gaseous exchange by neurological system process ISS --
GO:0007275 multicellular organism development IEA --
GO:0045892 negative regulation of transcription, DNA-templated IDA 19343227
genes like me logo Genes that share ontologies with TSHZ3: view

No data available for Pathways by source and SIGNOR curated interactions for TSHZ3 Gene

Drugs & Compounds for TSHZ3 Gene

No Compound Related Data Available

Transcripts for TSHZ3 Gene

mRNA/cDNA for TSHZ3 Gene

Unigene Clusters for TSHZ3 Gene

Teashirt zinc finger homeobox 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TSHZ3 Gene

No ASD Table

Relevant External Links for TSHZ3 Gene

GeneLoc Exon Structure for
TSHZ3
ECgene alternative splicing isoforms for
TSHZ3

Expression for TSHZ3 Gene

mRNA expression in normal human tissues for TSHZ3 Gene

mRNA differential expression in normal tissues according to GTEx for TSHZ3 Gene

This gene is overexpressed in Ovary (x4.7).

Protein differential expression in normal tissues from HIPED for TSHZ3 Gene

This gene is overexpressed in Liver, secretome (46.5) and Cardia (18.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TSHZ3 Gene



SOURCE GeneReport for Unigene cluster for TSHZ3 Gene Hs.278436

mRNA Expression by UniProt/SwissProt for TSHZ3 Gene

Q63HK5-TSH3_HUMAN
Tissue specificity: Expressed in brain; strongly reduced in post-mortem elderly subjects with Alzheimer disease.
genes like me logo Genes that share expression patterns with TSHZ3: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for TSHZ3 Gene

Orthologs for TSHZ3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TSHZ3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TSHZ3 35
  • 99.33 (n)
  • 100 (a)
TSHZ3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TSHZ3 36
  • 94 (a)
OneToOne
TSHZ3 35
  • 90.44 (n)
  • 95.65 (a)
dog
(Canis familiaris)
Mammalia TSHZ3 35
  • 89.64 (n)
  • 94.36 (a)
TSHZ3 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tshz3 36
  • 95 (a)
OneToOne
Tshz3 16
Tshz3 35
  • 88.5 (n)
  • 95.1 (a)
oppossum
(Monodelphis domestica)
Mammalia TSHZ3 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TSHZ3 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tshz3 35
  • 88.51 (n)
  • 95.66 (a)
chicken
(Gallus gallus)
Aves TSHZ3 36
  • 90 (a)
OneToOne
TSHZ3 35
  • 79.3 (n)
  • 92.12 (a)
lizard
(Anolis carolinensis)
Reptilia TSHZ3 36
  • 90 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.9022 35
tropical clawed frog
(Silurana tropicalis)
Amphibia tshz3 35
  • 75.74 (n)
  • 87.28 (a)
zebrafish
(Danio rerio)
Actinopterygii TSHZ3 (1 of 2) 36
  • 72 (a)
OneToMany
TSHZ3 (2 of 2) 36
  • 50 (a)
OneToMany
tshz3b 35
  • 71.05 (n)
  • 75.9 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5824 36
  • 17 (a)
OneToMany
Species with no ortholog for TSHZ3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TSHZ3 Gene

ENSEMBL:
Gene Tree for TSHZ3 (if available)
TreeFam:
Gene Tree for TSHZ3 (if available)

Paralogs for TSHZ3 Gene

Paralogs for TSHZ3 Gene

(2) SIMAP similar genes for TSHZ3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TSHZ3: view

Variants for TSHZ3 Gene

Sequence variations from dbSNP and Humsavar for TSHZ3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs4805664 - 31,277,733(+) CCACC(A/G)GCTCA reference, missense
rs143453460 - 31,278,387(+) TGACC(C/T)CCACA reference, missense
rs2909 -- 31,336,792(-) AACTT(C/T)TTGTT intron-variant
rs1078373 -- 31,310,224(+) GTAAT(A/G)AGCCT intron-variant
rs3745784 -- 31,277,510(-) AAGGC(C/T)GCTGT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for TSHZ3 Gene

Variant ID Type Subtype PubMed ID
nsv510764 CNV Loss 20534489
esv25402 CNV Loss 19812545
esv2718454 CNV Deletion 23290073
nsv911571 CNV Loss 21882294
nsv828522 CNV Gain 20364138

Variation tolerance for TSHZ3 Gene

Residual Variation Intolerance Score: 13.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.03; 50.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TSHZ3 Gene

HapMap Linkage Disequilibrium report
TSHZ3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSHZ3 Gene

Disorders for TSHZ3 Gene

Relevant External Links for TSHZ3

Genetic Association Database (GAD)
TSHZ3
Human Genome Epidemiology (HuGE) Navigator
TSHZ3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TSHZ3

No disorders were found for TSHZ3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSHZ3 Gene

Publications for TSHZ3 Gene

  1. Analysis of TSHZ2 and TSHZ3 genes in congenital pelvi-ureteric junction obstruction. (PMID: 19745106) Jenkins D. … Woolf A.S. (Nephrol. Dial. Transplant. 2010) 3 4 48 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants. (PMID: 24315451) van der Valk R.J. … de Jongste J.C. (J. Allergy Clin. Immunol. 2014) 3
  5. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PMID: 23667531) Cox J.L. … Rizzino A. (PLoS ONE 2013) 3

Products for TSHZ3 Gene

Sources for TSHZ3 Gene

Back to Top

Content