Aliases for MKL1 Gene
External Ids for MKL1 Gene
Previous GeneCards Identifiers for MKL1 Gene
The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
GeneCards Summary for MKL1 Gene
MKL1 (Megakaryoblastic Leukemia (Translocation) 1) is a Protein Coding gene. Diseases associated with MKL1 include 'megakaryoblastic acute myeloid leukemia with t(1;22)(p13;q13)' and acute leukemia. Among its related pathways are RhoA signaling pathway. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription regulatory region sequence-specific DNA binding. An important paralog of this gene is MKL2.
UniProtKB/Swiss-Prot for MKL1 Gene
Transcriptional coactivator of serum response factor (SRF) with the potential to modulate SRF target genes. Suppresses TNF-induced cell death by inhibiting activation of caspases; its transcriptional activity is indispensable for the antiapoptotic function. It may up-regulate antiapoptotic molecules, which in turn inhibit caspase activation (By similarity).