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Aliases for SYT13 Gene

Aliases for SYT13 Gene

  • Synaptotagmin XIII 2 3 4
  • KIAA1427 4 6
  • SytXIII 3 4
  • Synaptotagmin-13 3

External Ids for SYT13 Gene

Summaries for SYT13 Gene

Entrez Gene Summary for SYT13 Gene

  • This gene encodes a member of the large synaptotagmin protein family. Family members have an extracellular N-terminal transmembrane domain and a cytoplasmic C terminus with two tandem C2 domains (C2A and C2B). Synaptotogmin family members can form homo- and heteromeric complexes with each other. They also have different biochemical properties and developmental profiles, and patterns of tissue distribution. Synaptotagmins function as membrane traffickers in multicellular organisms. Two alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for SYT13 Gene

SYT13 (Synaptotagmin XIII) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SYT13 Gene

  • May be involved in transport vesicle docking to the plasma membrane.

Gene Wiki entry for SYT13 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYT13 Gene

Genomics for SYT13 Gene

Genomic Location for SYT13 Gene

Start:
45,240,299 bp from pter
End:
45,286,333 bp from pter
Size:
46,035 bases
Orientation:
Minus strand

Genomic View for SYT13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SYT13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYT13 Gene

Regulatory Elements for SYT13 Gene

Proteins for SYT13 Gene

  • Protein details for SYT13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L8C5-SYT13_HUMAN
    Recommended name:
    Synaptotagmin-13
    Protein Accession:
    Q7L8C5
    Secondary Accessions:
    • A8K4P4
    • D3DQP1
    • Q9BQS3
    • Q9H041
    • Q9P2C0

    Protein attributes for SYT13 Gene

    Size:
    426 amino acids
    Molecular mass:
    46885 Da
    Quaternary structure:
    • Interacts with NRXN1.
    SequenceCaution:
    • Sequence=BAA92665.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SYT13 Gene

neXtProt entry for SYT13 Gene

Proteomics data for SYT13 Gene at MOPED

Post-translational modifications for SYT13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SYT13 Gene

No data available for DME Specific Peptides for SYT13 Gene

Domains for SYT13 Gene

Gene Families for SYT13 Gene

HGNC:
  • SYT :Synaptotagmins

Protein Domains for SYT13 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

SYT13_HUMAN
Domain:
  • The first C2 domain/C2A does not mediate Ca(2+)-dependent phospholipid binding.:
    • Q7L8C5
  • The second C2 domain/C2B domain binds phospholipids regardless of whether calcium is present.:
    • Q7L8C5
  • Contains 2 C2 domains.:
    • Q7L8C5
Family:
  • Belongs to the synaptotagmin family.:
    • Q7L8C5
genes like me logo Genes that share domains with SYT13: view

Function for SYT13 Gene

Molecular function for SYT13 Gene

UniProtKB/Swiss-Prot Function: May be involved in transport vesicle docking to the plasma membrane.

Gene Ontology (GO) - Molecular Function for SYT13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 NOT calcium ion binding IBA --
GO:0005515 protein binding --
GO:0005544 NOT calcium-dependent phospholipid binding IBA --
GO:0019905 syntaxin binding IBA --
GO:0030276 clathrin binding IBA --
genes like me logo Genes that share ontologies with SYT13: view

Phenotypes for SYT13 Gene

GenomeRNAi human phenotypes for SYT13:
genes like me logo Genes that share phenotypes with SYT13: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SYT13 Gene

Localization for SYT13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYT13 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SYT13 Gene COMPARTMENTS Subcellular localization image for SYT13 gene
Compartment Confidence
extracellular 2
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SYT13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA --
GO:0005887 integral component of plasma membrane IEA --
GO:0030133 transport vesicle IDA --
genes like me logo Genes that share ontologies with SYT13: view

Pathways for SYT13 Gene

SuperPathways for SYT13 Gene

No Data Available

Interacting Proteins for SYT13 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000020926%0d%0a9606.ENSP00000385142%0d%0a
Selected Interacting proteins: ENSP00000020926 Q7L8C5-SYT13_HUMAN for SYT13 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for SYT13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006906 vesicle fusion IBA --
GO:0016079 synaptic vesicle exocytosis IBA --
GO:0016192 vesicle-mediated transport --
GO:0017158 NOT regulation of calcium ion-dependent exocytosis IBA --
GO:0048791 calcium ion-dependent exocytosis of neurotransmitter IBA --
genes like me logo Genes that share ontologies with SYT13: view

No data available for Pathways by source for SYT13 Gene

Compounds for SYT13 Gene

(1) HMDB Compounds for SYT13 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with SYT13: view

Transcripts for SYT13 Gene

mRNA/cDNA for SYT13 Gene

Unigene Clusters for SYT13 Gene

Synaptotagmin XIII:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SYT13 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9
SP1: - - -
SP2: -
SP3: - -

Relevant External Links for SYT13 Gene

GeneLoc Exon Structure for
SYT13
ECgene alternative splicing isoforms for
SYT13

Expression for SYT13 Gene

mRNA expression in normal human tissues for SYT13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SYT13 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (8.0), Brain - Cortex (6.9), Brain - Anterior cingulate cortex (BA24) (6.5), Brain - Hypothalamus (4.4), and Brain - Amygdala (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SYT13 Gene

SOURCE GeneReport for Unigene cluster for SYT13 Gene Hs.436643

mRNA Expression by UniProt/SwissProt for SYT13 Gene

Q7L8C5-SYT13_HUMAN
Tissue specificity: Expressed in brain, pancreas and kidney.
genes like me logo Genes that share expressions with SYT13: view

Orthologs for SYT13 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SYT13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SYT13 36
  • 99.22 (n)
  • 99.53 (a)
SYT13 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SYT13 36
  • 89.83 (n)
  • 92.25 (a)
SYT13 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SYT13 36
  • 90.77 (n)
  • 92.02 (a)
SYT13 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Syt13 36
  • 87.17 (n)
  • 89.91 (a)
Syt13 16
Syt13 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SYT13 37
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SYT13 37
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Syt13 36
  • 86.46 (n)
  • 89.91 (a)
chicken
(Gallus gallus)
Aves SYT13 37
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SYT13 37
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia syt13 36
  • 57.01 (n)
  • 47.77 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.17253 36
syt13 36
  • 55.23 (n)
  • 46.17 (a)
syt13 37
  • 40 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 26 (a)
OneToOne
Species with no ortholog for SYT13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SYT13 Gene

ENSEMBL:
Gene Tree for SYT13 (if available)
TreeFam:
Gene Tree for SYT13 (if available)

Paralogs for SYT13 Gene

No data available for Paralogs for SYT13 Gene

Variants for SYT13 Gene

Sequence variations from dbSNP and Humsavar for SYT13 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs3793 -- 45,242,968(+) AAATT(A/G)TCTTT utr-variant-3-prime
rs8929 -- 45,240,575(-) ACAAA(A/G)CTGGG utr-variant-3-prime
rs714720 -- 45,242,250(-) GCCCA(A/G)AAAGT utr-variant-3-prime
rs751196 -- 45,260,161(-) AATAA(A/G)CAGCA intron-variant
rs751197 -- 45,259,306(+) TTTAT(A/G)TTTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SYT13 Gene

Variant ID Type Subtype PubMed ID
nsv305 CNV Insertion 18451855

Relevant External Links for SYT13 Gene

HapMap Linkage Disequilibrium report
SYT13

Disorders for SYT13 Gene

Relevant External Links for SYT13

Genetic Association Database (GAD)
SYT13
Human Genome Epidemiology (HuGE) Navigator
SYT13
genes like me logo Genes that share disorders with SYT13: view

No data available for UniProtKB/Swiss-Prot for SYT13 Gene

Publications for SYT13 Gene

  1. Characterization of KIAA1427 protein as an atypical synaptotagmin (Syt XIII). (PMID: 11171101) Fukuda M. … Mikoshiba K. (Biochem. J. 2001) 2 3 23
  2. Re-expression of tumorigenicity after attenuation of human synaptotagmin 13 in a suppressed microcell hybrid cell line. (PMID: 18202767) Jahn J.E. … Coleman W.B. (Int. J. Oncol. 2008) 3 23
  3. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  4. Genomic analysis of synaptotagmin genes. (PMID: 11543631) Craxton M.A. (Genomics 2001) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for SYT13 Gene

Sources for SYT13 Gene

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