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Aliases for PCDH10 Gene

Aliases for PCDH10 Gene

  • Protocadherin 10 2 3
  • KIAA1400 4
  • OL-PCDH 3
  • PCDH19 3

External Ids for PCDH10 Gene

Previous GeneCards Identifiers for PCDH10 Gene

  • GC04P135012
  • GC04P134373
  • GC04P134463
  • GC04P134529
  • GC04P134428
  • GC04P134070
  • GC04P129800

Summaries for PCDH10 Gene

Entrez Gene Summary for PCDH10 Gene

  • This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. This family member contains 6 extracellular cadherin domains, a transmembrane domain and a cytoplasmic tail differing from those of the classical cadherins. The encoded protein is a cadherin-related neuronal receptor thought to function in the establishment of specific cell-cell connections in the brain. This gene plays a role in inhibiting cancer cell motility and cell migration. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2015]

GeneCards Summary for PCDH10 Gene

PCDH10 (Protocadherin 10) is a Protein Coding gene. Diseases associated with PCDH10 include bladder transitional cell carcinoma and dravet syndrome. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is PCDH7.

UniProtKB/Swiss-Prot for PCDH10 Gene

  • Potential calcium-dependent cell-adhesion protein

Gene Wiki entry for PCDH10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCDH10 Gene

Genomics for PCDH10 Gene

Regulatory Elements for PCDH10 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PCDH10 Gene

133,149,290 bp from pter
133,208,606 bp from pter
59,317 bases
Plus strand

Genomic View for PCDH10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PCDH10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCDH10 Gene

Proteins for PCDH10 Gene

  • Protein details for PCDH10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q4W5F6
    • Q96SF0

    Protein attributes for PCDH10 Gene

    1040 amino acids
    Molecular mass:
    112936 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA92638.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PCDH10 Gene


neXtProt entry for PCDH10 Gene

Proteomics data for PCDH10 Gene at MOPED

Post-translational modifications for PCDH10 Gene

  • Glycosylation at Asn 273 and Asn 557
  • Modification sites at PhosphoSitePlus

Other Protein References for PCDH10 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for PCDH10 Gene

Domains & Families for PCDH10 Gene

Gene Families for PCDH10 Gene

Protein Domains for PCDH10 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 6 cadherin domains.
  • Contains 6 cadherin domains.
genes like me logo Genes that share domains with PCDH10: view

Function for PCDH10 Gene

Molecular function for PCDH10 Gene

UniProtKB/Swiss-Prot Function:
Potential calcium-dependent cell-adhesion protein

Gene Ontology (GO) - Molecular Function for PCDH10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with PCDH10: view
genes like me logo Genes that share phenotypes with PCDH10: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PCDH10

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for PCDH10 Gene

Localization for PCDH10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCDH10 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for PCDH10 Gene COMPARTMENTS Subcellular localization image for PCDH10 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for PCDH10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PCDH10: view

Pathways & Interactions for PCDH10 Gene

SuperPathways for PCDH10 Gene

No Data Available

Interacting Proteins for PCDH10 Gene

Gene Ontology (GO) - Biological Process for PCDH10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion --
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
genes like me logo Genes that share ontologies with PCDH10: view

No data available for Pathways by source and SIGNOR curated interactions for PCDH10 Gene

Drugs & Compounds for PCDH10 Gene

(1) Drugs for PCDH10 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Nutra 0
genes like me logo Genes that share compounds with PCDH10: view

Transcripts for PCDH10 Gene

Unigene Clusters for PCDH10 Gene

Protocadherin 10:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PCDH10

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PCDH10 Gene

No ASD Table

Relevant External Links for PCDH10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PCDH10 Gene

mRNA expression in normal human tissues for PCDH10 Gene

mRNA differential expression in normal tissues according to GTEx for PCDH10 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x5.3), Brain - Caudate (basal ganglia) (x4.7), and Artery - Aorta (x4.4).

Protein differential expression in normal tissues from HIPED for PCDH10 Gene

This gene is overexpressed in Amniocyte (40.2) and Fetal Brain (26.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PCDH10 Gene

SOURCE GeneReport for Unigene cluster for PCDH10 Gene Hs.192859

mRNA Expression by UniProt/SwissProt for PCDH10 Gene

Tissue specificity: Moderately expressed in all regions of the brain examined, as well as in testis and ovary, and low expression in all other tissues tested.
genes like me logo Genes that share expression patterns with PCDH10: view

Protein tissue co-expression partners for PCDH10 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

Orthologs for PCDH10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PCDH10 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PCDH10 35
  • 92.29 (n)
  • 98.55 (a)
(Canis familiaris)
Mammalia LOC102156925 35
  • 91.68 (n)
  • 97.77 (a)
(Mus musculus)
Mammalia Pcdh10 35
  • 89.72 (n)
  • 97.39 (a)
Pcdh10 16
Pcdh10 36
  • 95 (a)
(Pan troglodytes)
Mammalia PCDH10 35
  • 99.46 (n)
  • 99.9 (a)
(Monodelphis domestica)
Mammalia PCDH10 36
  • 96 (a)
(Gallus gallus)
Aves PCDH10 35
  • 85.2 (n)
  • 92.22 (a)
(Anolis carolinensis)
Reptilia PCDH10 36
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pcdh10 35
  • 74.91 (n)
  • 82.85 (a)
(Danio rerio)
Actinopterygii pcdh10a 35
  • 73.37 (n)
  • 79.06 (a)
pcdh10b 35
pcdh10a 36
  • 77 (a)
pcdh10b 36
  • 76 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
CSA.7308 36
  • 19 (a)
Species with no ortholog for PCDH10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PCDH10 Gene

Gene Tree for PCDH10 (if available)
Gene Tree for PCDH10 (if available)

Paralogs for PCDH10 Gene

genes like me logo Genes that share paralogs with PCDH10: view

Variants for PCDH10 Gene

Structural Variations from Database of Genomic Variants (DGV) for PCDH10 Gene

Variant ID Type Subtype PubMed ID
esv274926 CNV Gain+Loss 21479260
nsv470078 CNV Gain 18288195

Variation tolerance for PCDH10 Gene

Residual Variation Intolerance Score: 1.65% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.11; 38.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PCDH10 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for PCDH10 Gene

Disorders for PCDH10 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PCDH10 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
bladder transitional cell carcinoma
  • urothelial bladder carcinoma
dravet syndrome
  • dravet syndrome, modifier of
- elite association

Relevant External Links for PCDH10

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PCDH10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PCDH10 Gene

Publications for PCDH10 Gene

  1. High-resolution melting analysis of PCDH10 methylation levels in gastric, colorectal and pancreatic cancers. (PMID: 20353276) Yu B. … Zhang W. (Neoplasma 2010) 23 67
  2. Inhibition of apoptosis by downregulation of hBex1, a novel mechanism, contributes to the chemoresistance of Bcr/Abl+ leukemic cells. (PMID: 19028701) Ding K. … Zhu Y. (Carcinogenesis 2009) 23 67
  3. Methylation of protocadherin 10, a novel tumor suppressor, is associated with poor prognosis in patients with gastric cancer. (PMID: 19084528) Yu J. … Sung J.J. (Gastroenterology 2009) 23 67
  4. X-linked protocadherin 19 mutations cause female-limited epilepsy and cognitive impairment. (PMID: 18469813) Dibbens L.M. … Gecz J. (Nat. Genet. 2008) 23 67
  5. Identifying autism loci and genes by tracing recent shared ancestry. (PMID: 18621663) Morrow E.M. … Walsh C.A. (Science 2008) 23 67

Products for PCDH10 Gene

Sources for PCDH10 Gene

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