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Aliases for PTMA Gene

Aliases for PTMA Gene

  • Prothymosin, Alpha 2 3
  • TMSA 3 4 6
  • Gene Sequence 28 2 3
  • Prothymosin, Alpha (Gene Sequence 28) 2
  • Prothymosin Alpha Protein 3
  • Prothymosin Alpha 3

External Ids for PTMA Gene

Previous HGNC Symbols for PTMA Gene

  • TMSA

Previous GeneCards Identifiers for PTMA Gene

  • GC02P230632
  • GC02P231306
  • GC02P232536
  • GC02P232775
  • GC02P232398
  • GC02P232281
  • GC02P232571

Summaries for PTMA Gene

GeneCards Summary for PTMA Gene

PTMA (Prothymosin, Alpha) is a Protein Coding gene. Diseases associated with PTMA include hepatitis b. Among its related pathways are Epstein-Barr virus infection and Validated targets of C-MYC transcriptional activation.

UniProtKB/Swiss-Prot for PTMA Gene

  • Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections

Gene Wiki entry for PTMA Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTMA Gene

Genomics for PTMA Gene

Regulatory Elements for PTMA Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PTMA Gene

231,706,895 bp from pter
231,713,541 bp from pter
6,647 bases
Plus strand

Genomic View for PTMA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PTMA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTMA Gene

Proteins for PTMA Gene

  • Protein details for PTMA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Prothymosin alpha
    Protein Accession:
    Secondary Accessions:
    • Q15249
    • Q15592

    Protein attributes for PTMA Gene

    111 amino acids
    Molecular mass:
    12203 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PTMA Gene

    Alternative splice isoforms for PTMA Gene


neXtProt entry for PTMA Gene

Proteomics data for PTMA Gene at MOPED

Post-translational modifications for PTMA Gene

  • Covalently linked to a small RNA of about 20 nucleotides.
  • Ubiquitination at Lys15 and Lys103
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PTMA Gene

Domains for PTMA Gene

Protein Domains for PTMA Gene


Graphical View of Domain Structure for InterPro Entry



  • P06454
  • Belongs to the pro/parathymosin family.
genes like me logo Genes that share domains with PTMA: view

No data available for Gene Families for PTMA Gene

Function for PTMA Gene

Molecular function for PTMA Gene

GENATLAS Biochemistry: prothymosin alpha,widely expressed,abundant audic nuclear protein potential modulator of the interaction of histone 1 with chromatin
UniProtKB/Swiss-Prot Function: Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections

Gene Ontology (GO) - Molecular Function for PTMA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15607035
genes like me logo Genes that share ontologies with PTMA: view

Phenotypes for PTMA Gene

genes like me logo Genes that share phenotypes with PTMA: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for PTMA Gene

Localization for PTMA Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTMA Gene

Subcellular locations from

Jensen Localization Image for PTMA Gene COMPARTMENTS Subcellular localization image for PTMA gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for PTMA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 10854063
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with PTMA: view

Pathways for PTMA Gene

genes like me logo Genes that share pathways with PTMA: view

Pathways by source for PTMA Gene

1 BioSystems pathway for PTMA Gene
1 KEGG pathway for PTMA Gene

Gene Ontology (GO) - Biological Process for PTMA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated TAS 10854063
genes like me logo Genes that share ontologies with PTMA: view

Compounds for PTMA Gene

(22) Novoseek inferred chemical compound relationships for PTMA Gene

Compound -log(P) Hits PubMed IDs
thymalfasin 95.1 13
lamivudine 65.9 22
ifn-alpha 61.8 2
entecavir 59.5 2
adefovir 56.9 3
genes like me logo Genes that share compounds with PTMA: view

Transcripts for PTMA Gene

Unigene Clusters for PTMA Gene

Prothymosin, alpha:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PTMA

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTMA Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7
SP1: - - -
SP3: -
SP4: - -

Relevant External Links for PTMA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PTMA Gene

mRNA expression in normal human tissues for PTMA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PTMA Gene

SOURCE GeneReport for Unigene cluster for PTMA Gene Hs.459927

genes like me logo Genes that share expressions with PTMA: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PTMA Gene

Orthologs for PTMA Gene

This gene was present in the common ancestor of chordates.

Orthologs for PTMA Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PTMA 35
  • 99.09 (n)
  • 99.09 (a)
(Bos Taurus)
Mammalia PTMA 36
  • 98 (a)
  • 95 (a)
(Canis familiaris)
Mammalia -- 36
  • 64 (a)
-- 36
  • 88 (a)
  • 92.42 (n)
  • 98.18 (a)
  • 99 (a)
(Mus musculus)
Mammalia Gm6625 36
  • 53 (a)
Ptma 16
Ptma 36
  • 95 (a)
(Ornithorhynchus anatinus)
Mammalia PTMA 36
  • 72 (a)
(Anolis carolinensis)
Reptilia PTMA 36
  • 91 (a)
African clawed frog
(Xenopus laevis)
Amphibia ptma-prov 35
(Danio rerio)
Actinopterygii ptma 35
Species with no ortholog for PTMA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PTMA Gene

Gene Tree for PTMA (if available)
Gene Tree for PTMA (if available)

Paralogs for PTMA Gene

genes like me logo Genes that share paralogs with PTMA: view

No data available for Paralogs for PTMA Gene

Variants for PTMA Gene

Sequence variations from dbSNP and Humsavar for PTMA Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs8868 -- 231,708,591(+) CGCAG(C/T)CGCCT utr-variant-5-prime
rs12415 -- 231,708,582(+) CTTGC(C/T)CGCCG utr-variant-5-prime
rs13370 -- 231,708,644(+) ATCGC(C/T)AGAGT utr-variant-5-prime
rs838440 -- 231,707,301(-) CACTT(A/C)GCTGT upstream-variant-2KB
rs1058315 -- 231,709,234(+) GGCCG(C/G)CGGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTMA Gene

Variant ID Type Subtype PubMed ID
nsv834568 CNV Loss 17160897
dgv1291e1 CNV Complex 17122850
dgv1292e1 CNV Complex 17122850
nsv428408 CNV Gain+Loss 18775914
dgv1293e1 CNV Complex 17122850
nsv3204 CNV Loss 18451855

Relevant External Links for PTMA Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTMA Gene

Disorders for PTMA Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for PTMA Gene including...

Search for PTMA Gene in MalaCards »

(30) Novoseek inferred disease relationships for PTMA Gene

Disease -log(P) Hits PubMed IDs
hepatitis b chronic 78.3 40
radiation sickness 60.7 1
hepatitis b 60 14
hepatitis c chronic 58.4 21
hepatitis c 45.5 6

Relevant External Links for PTMA

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with PTMA: view

No data available for UniProtKB/Swiss-Prot for PTMA Gene

Publications for PTMA Gene

  1. Effects of zinc binding on the structure and dynamics of the intrinsically disordered protein prothymosin alpha: evidence for metalation as an entropic switch. (PMID: 17929838) Yi S. … Choy W.Y. (Biochemistry 2007) 3 23
  2. Phosphorylation of human and bovine prothymosin alpha in vivo. (PMID: 8485135) Sburlati A.R. … Berger S.L. (Biochemistry 1993) 3 4
  3. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson D.F. … Stefansson K. (Nat. Genet. 2008) 3 48
  4. The human prothymosin alpha gene family contains several processed pseudogenes lacking deleterious lesions. (PMID: 1612591) Manrow R.E. … Berger S.L. (Genomics 1992) 2 3
  5. Isolation and partial sequencing of the human prothymosin alpha gene family. Evidence against export of the gene products. (PMID: 2708378) Eschenfeldt W.H. … Berger S.L. (J. Biol. Chem. 1989) 3 4

Products for PTMA Gene

Sources for PTMA Gene

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