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Aliases for PTMA Gene

Aliases for PTMA Gene

  • Prothymosin, Alpha 2 3 5
  • Gene Sequence 28 2 3
  • TMSA 3 4
  • Prothymosin, Alpha (Gene Sequence 28) 2
  • Prothymosin Alpha Protein 3

External Ids for PTMA Gene

Previous HGNC Symbols for PTMA Gene

  • TMSA

Previous GeneCards Identifiers for PTMA Gene

  • GC02P230632
  • GC02P231306
  • GC02P232536
  • GC02P232775
  • GC02P232398
  • GC02P232281
  • GC02P232571

Summaries for PTMA Gene

GeneCards Summary for PTMA Gene

PTMA (Prothymosin, Alpha) is a Protein Coding gene. Diseases associated with PTMA include Hepatitis B and Thymus Cancer. Among its related pathways are Epstein-Barr virus infection and Validated targets of C-MYC transcriptional activation.

UniProtKB/Swiss-Prot for PTMA Gene

  • Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.

Gene Wiki entry for PTMA Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTMA Gene

Genomics for PTMA Gene

Regulatory Elements for PTMA Gene

Enhancers for PTMA Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PTMA on UCSC Golden Path with GeneCards custom track

Genomic Location for PTMA Gene

Chromosome:
2
Start:
231,706,895 bp from pter
End:
231,713,541 bp from pter
Size:
6,647 bases
Orientation:
Plus strand

Genomic View for PTMA Gene

Genes around PTMA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTMA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTMA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTMA Gene

Proteins for PTMA Gene

  • Protein details for PTMA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P06454-PTMA_HUMAN
    Recommended name:
    Prothymosin alpha
    Protein Accession:
    P06454
    Secondary Accessions:
    • Q15249
    • Q15592

    Protein attributes for PTMA Gene

    Size:
    111 amino acids
    Molecular mass:
    12203 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PTMA Gene

    Alternative splice isoforms for PTMA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTMA Gene

Proteomics data for PTMA Gene at MOPED

Post-translational modifications for PTMA Gene

Antibody Products

No data available for DME Specific Peptides for PTMA Gene

Domains & Families for PTMA Gene

Protein Domains for PTMA Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P06454

UniProtKB/Swiss-Prot:

PTMA_HUMAN :
  • Belongs to the pro/parathymosin family.
Family:
  • Belongs to the pro/parathymosin family.
genes like me logo Genes that share domains with PTMA: view

No data available for Gene Families for PTMA Gene

Function for PTMA Gene

Molecular function for PTMA Gene

GENATLAS Biochemistry:
prothymosin alpha,widely expressed,abundant audic nuclear protein potential modulator of the interaction of histone 1 with chromatin
UniProtKB/Swiss-Prot Function:
Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.
genes like me logo Genes that share phenotypes with PTMA: view

Animal Model Products

CRISPR Products

miRNA for PTMA Gene

miRTarBase miRNAs that target PTMA

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PTMA Gene

Localization for PTMA Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTMA Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTMA Gene COMPARTMENTS Subcellular localization image for PTMA gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for PTMA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with PTMA: view

Pathways & Interactions for PTMA Gene

genes like me logo Genes that share pathways with PTMA: view

Pathways by source for PTMA Gene

1 BioSystems pathway for PTMA Gene
1 KEGG pathway for PTMA Gene

Gene Ontology (GO) - Biological Process for PTMA Gene

None

No data available for SIGNOR curated interactions for PTMA Gene

Drugs & Compounds for PTMA Gene

(19) Drugs for PTMA Gene - From: DGIdb and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Thymalfasin Approved, Investigational Pharma 22

(3) Additional Compounds for PTMA Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PTMA: view

Transcripts for PTMA Gene

Unigene Clusters for PTMA Gene

Prothymosin, alpha:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PTMA Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7
SP1: - - -
SP2:
SP3: -
SP4: - -

Relevant External Links for PTMA Gene

GeneLoc Exon Structure for
PTMA
ECgene alternative splicing isoforms for
PTMA

Expression for PTMA Gene

mRNA expression in normal human tissues for PTMA Gene

Protein differential expression in normal tissues from HIPED for PTMA Gene

This gene is overexpressed in Oral epithelium (12.7), Fetal Brain (11.4), and Nasal epithelium (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PTMA Gene



SOURCE GeneReport for Unigene cluster for PTMA Gene Hs.459927

genes like me logo Genes that share expression patterns with PTMA: view

Protein tissue co-expression partners for PTMA Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PTMA Gene

Orthologs for PTMA Gene

This gene was present in the common ancestor of chordates.

Orthologs for PTMA Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia PTMA 35
  • 92.42 (n)
  • 98.18 (a)
-- 36
  • 64 (a)
OneToMany
-- 36
  • 88 (a)
OneToMany
PTMA 36
  • 99 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia PTMA 35
  • 99.09 (n)
  • 99.09 (a)
cow
(Bos Taurus)
Mammalia PTMA 36
  • 98 (a)
OneToMany
PTMA 36
  • 95 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Gm6625 36
  • 53 (a)
OneToMany
Ptma 36
  • 95 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia PTMA 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTMA 36
  • 91 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia ptma-prov 35
zebrafish
(Danio rerio)
Actinopterygii ptma 35
Species with no ortholog for PTMA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PTMA Gene

ENSEMBL:
Gene Tree for PTMA (if available)
TreeFam:
Gene Tree for PTMA (if available)

Paralogs for PTMA Gene

genes like me logo Genes that share paralogs with PTMA: view

No data available for Paralogs for PTMA Gene

Variants for PTMA Gene

Sequence variations from dbSNP and Humsavar for PTMA Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs838440 -- 231,707,301(-) CACTT(A/C)GCTGT upstream-variant-2KB
rs3087853 -- 231,709,070(+) AGAGC(C/G)TGGCT intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1058315 -- 231,709,234(+) GGCCG(C/G)CGGTT intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1058316 -- 231,709,410(+) GTGCG(C/T)CGGGA intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs2060412 -- 231,709,794(-) AGAAA(A/G)AGCCA intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for PTMA Gene

Variant ID Type Subtype PubMed ID
nsv834568 CNV Loss 17160897
dgv1291e1 CNV Complex 17122850
dgv1292e1 CNV Complex 17122850
nsv428408 CNV Gain+Loss 18775914
dgv1293e1 CNV Complex 17122850
nsv3204 CNV Loss 18451855

Variation tolerance for PTMA Gene

Residual Variation Intolerance Score: 54.5% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PTMA Gene

Disorders for PTMA Gene

MalaCards: The human disease database

(5) MalaCards diseases for PTMA Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hepatitis b
  • chronic hepatitis b
thymus cancer
  • neoplasm of thymus
invasive malignant thymoma
  • infiltrating thymoma
hepatocellular carcinoma
  • hepatocellular carcinoma, somatic
spindle cell thymoma
  • medullary thymoma
- elite association - COSMIC cancer census association via MalaCards
Search PTMA in MalaCards View complete list of genes associated with diseases

Relevant External Links for PTMA

Genetic Association Database (GAD)
PTMA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTMA
genes like me logo Genes that share disorders with PTMA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTMA Gene

Publications for PTMA Gene

  1. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson D.F. … Stefansson K. (Nat. Genet. 2008) 3 48 67
  2. Effects of zinc binding on the structure and dynamics of the intrinsically disordered protein prothymosin alpha: evidence for metalation as an entropic switch. (PMID: 17929838) Yi S. … Choy W.Y. (Biochemistry 2007) 3 23
  3. The human prothymosin alpha gene family contains several processed pseudogenes lacking deleterious lesions. (PMID: 1612591) Manrow R.E. … Berger S.L. (Genomics 1992) 2 3
  4. Prothymosin I+ variants isolated from CD8+ T cells and cervicovaginal fluid suppress HIV-1 replication through type I interferon induction. (PMID: 25404520) Teixeira A. … Mosoian A. (J. Infect. Dis. 2015) 3
  5. New host factors important for respiratory syncytial virus (RSV) replication revealed by a novel microfluidics screen for interactors of matrix (M) protein. (PMID: 25556234) Kipper S. … Bajorek M. (Mol. Cell Proteomics 2015) 3

Products for PTMA Gene

Sources for PTMA Gene

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