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Aliases for TAOK1 Gene

Aliases for TAOK1 Gene

  • TAO Kinase 1 2 3
  • MARKK 3 4 6
  • PSK2 3 4 6
  • Thousand And One Amino Acid Protein Kinase 1 3 4
  • Prostate-Derived Sterile 20-Like Kinase 2 3 4
  • Prostate-Derived STE20-Like Kinase 2 3 4
  • Kinase From Chicken Homolog B 3 4
  • MARK Kinase 3 4
  • EC 2.7.11.1 4 63
  • MAP3K16 3 4
  • HKFC-B 3 4
  • HTAOK1 3 4
  • PSK-2 3 4
  • TAO1 3 6
  • Microtubule Affinity Regulating Kinase Kinase 3
  • Serine/Threonine Protein Kinase TAO1 Homolog 3
  • Thousand And One Amino Acid Protein 1 3
  • Serine/Threonine-Protein Kinase TAO1 3
  • STE20-Like Kinase PSK2 3
  • EC 2.7.11 63
  • KIAA1361 4
  • KFC-B 3

External Ids for TAOK1 Gene

Previous GeneCards Identifiers for TAOK1 Gene

  • GC17P024742
  • GC17P027717
  • GC17P023926

Summaries for TAOK1 Gene

GeneCards Summary for TAOK1 Gene

TAOK1 (TAO Kinase 1) is a Protein Coding gene. Among its related pathways are MAPK signaling pathway and Cell Cycle, Mitotic. GO annotations related to this gene include protein serine/threonine kinase activity and kinase activity. An important paralog of this gene is MAP4K3.

UniProtKB/Swiss-Prot for TAOK1 Gene

  • Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating Thr-208 of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade.

Gene Wiki entry for TAOK1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAOK1 Gene

Genomics for TAOK1 Gene

Regulatory Elements for TAOK1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TAOK1 Gene

Start:
29,390,464 bp from pter
End:
29,551,904 bp from pter
Size:
161,441 bases
Orientation:
Plus strand

Genomic View for TAOK1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TAOK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAOK1 Gene

Proteins for TAOK1 Gene

  • Protein details for TAOK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L7X3-TAOK1_HUMAN
    Recommended name:
    Serine/threonine-protein kinase TAO1
    Protein Accession:
    Q7L7X3
    Secondary Accessions:
    • A2RUT8
    • B7ZLV6
    • Q96L75
    • Q9H2K7
    • Q9H7S5
    • Q9P2I6

    Protein attributes for TAOK1 Gene

    Size:
    1001 amino acids
    Molecular mass:
    116070 Da
    Quaternary structure:
    • Self-associates. Interacts with MAP2K3 (By similarity). Interacts with SPRED1 and TESK1. Interacts with MAP3K7.
    SequenceCaution:
    • Sequence=BAA92599.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TAOK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAOK1 Gene

Proteomics data for TAOK1 Gene at MOPED

Post-translational modifications for TAOK1 Gene

  • Autophosphorylated (By similarity). Phosphorylated by ATM in response to DNA damage. Phosphorylated by LRRK2.
  • Proteolytically processed by caspase-3 (CASP3).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TAOK1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for TAOK1 Gene

Gene Families for TAOK1 Gene

Suggested Antigen Peptide Sequences for TAOK1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7L7X3

UniProtKB/Swiss-Prot:

TAOK1_HUMAN :
  • Q7L7X3
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
genes like me logo Genes that share domains with TAOK1: view

Function for TAOK1 Gene

Molecular function for TAOK1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation: Serine/threonine-protein kinase activity is inhibited by SPRED1
UniProtKB/Swiss-Prot Function: Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating Thr-208 of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade.
UniProtKB/Swiss-Prot Induction: In response to DNA damage.

Enzyme Numbers (IUBMB) for TAOK1 Gene

Gene Ontology (GO) - Molecular Function for TAOK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0004672 protein kinase activity NAS 14517247
GO:0004674 protein serine/threonine kinase activity NAS 14517247
GO:0004709 MAP kinase kinase kinase activity IBA --
GO:0004713 protein tyrosine kinase activity --
genes like me logo Genes that share ontologies with TAOK1: view
genes like me logo Genes that share phenotypes with TAOK1: view

Animal Model Products

CRISPR Products

miRNA for TAOK1 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TAOK1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for TAOK1 Gene

Localization for TAOK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAOK1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAOK1 Gene COMPARTMENTS Subcellular localization image for TAOK1 gene
Compartment Confidence
cytosol 4
nucleus 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for TAOK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with TAOK1: view

Pathways for TAOK1 Gene

genes like me logo Genes that share pathways with TAOK1: view

Pathways by source for TAOK1 Gene

Gene Ontology (GO) - Biological Process for TAOK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IBA --
GO:0000186 activation of MAPKK activity IBA --
GO:0000278 mitotic cell cycle TAS --
GO:0006281 DNA repair IEA --
GO:0006468 protein phosphorylation NAS 14517247
genes like me logo Genes that share ontologies with TAOK1: view

Compounds for TAOK1 Gene

(2) HMDB Compounds for TAOK1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
genes like me logo Genes that share compounds with TAOK1: view

Transcripts for TAOK1 Gene

Unigene Clusters for TAOK1 Gene

TAO kinase 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TAOK1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TAOK1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAOK1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: - - -
SP2: - - -
SP3:
SP4: -

ExUns: 22
SP1:
SP2:
SP3:
SP4:

Relevant External Links for TAOK1 Gene

GeneLoc Exon Structure for
TAOK1
ECgene alternative splicing isoforms for
TAOK1

Expression for TAOK1 Gene

mRNA expression in normal human tissues for TAOK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TAOK1 Gene

SOURCE GeneReport for Unigene cluster for TAOK1 Gene Hs.597434

mRNA Expression by UniProt/SwissProt for TAOK1 Gene

Q7L7X3-TAOK1_HUMAN
Tissue specificity: Highly expressed in the testis, and to a lower extent also expressed in brain, placenta, colon and skeletal muscle.
genes like me logo Genes that share expressions with TAOK1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TAOK1 Gene

Orthologs for TAOK1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TAOK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAOK1 35
  • 99.83 (n)
  • 100 (a)
TAOK1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TAOK1 35
  • 95.24 (n)
  • 99.7 (a)
TAOK1 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TAOK1 35
  • 95.6 (n)
  • 99.7 (a)
TAOK1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Taok1 35
  • 93.27 (n)
  • 99.4 (a)
Taok1 16
Taok1 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TAOK1 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TAOK1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Taok1 35
  • 93.54 (n)
  • 98.9 (a)
chicken
(Gallus gallus)
Aves TAOK1 35
  • 87.15 (n)
  • 98.3 (a)
TAOK1 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TAOK1 36
  • 95 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC52943 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6620 35
taok1 35
  • 83.15 (n)
  • 95.4 (a)
zebrafish
(Danio rerio)
Actinopterygii CU929119.2 36
  • 81 (a)
OneToMany
LOC100004576 35
  • 73.57 (n)
  • 85.59 (a)
taok1 36
  • 84 (a)
OneToMany
TAOK1 (2 of 3) 36
  • 88 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003202 35
  • 57.78 (n)
  • 59.44 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tao 35
  • 57.93 (n)
  • 58.13 (a)
Tao 36
  • 49 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea kin-18 35
  • 51.42 (n)
  • 44.06 (a)
kin-18 36
  • 38 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8830 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
OneToMany
Species with no ortholog for TAOK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TAOK1 Gene

ENSEMBL:
Gene Tree for TAOK1 (if available)
TreeFam:
Gene Tree for TAOK1 (if available)

Paralogs for TAOK1 Gene

Paralogs for TAOK1 Gene

Selected SIMAP similar genes for TAOK1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TAOK1: view

Variants for TAOK1 Gene

Sequence variations from dbSNP and Humsavar for TAOK1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs179331 -- 29,513,923(+) tgggt(C/G)acaga intron-variant
rs179332 -- 29,536,532(-) acctc(C/T)gcctc intron-variant
rs179333 -- 29,532,095(-) atcac(A/G)aggtc intron-variant
rs186658 -- 29,536,486(-) agtag(C/T)tggga intron-variant
rs189085 -- 29,532,112(-) gaggc(C/T)gaggc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TAOK1 Gene

Variant ID Type Subtype PubMed ID
esv2715797 CNV Deletion 23290073
esv2335781 CNV Deletion 18987734
esv2658989 CNV Deletion 23128226
esv994280 OTHER Inversion 20482838
esv2673792 CNV Deletion 23128226
esv22895 CNV Loss 19812545
nsv833409 CNV Gain 17160897
esv2474903 CNV Deletion 19546169
nsv819892 CNV Loss 19587683
esv260002 OTHER Complex 20981092
nsv821292 CNV Duplication 20802225
nsv827940 CNV Gain 20364138

Relevant External Links for TAOK1 Gene

HapMap Linkage Disequilibrium report
TAOK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAOK1 Gene

Disorders for TAOK1 Gene

Relevant External Links for TAOK1

Genetic Association Database (GAD)
TAOK1
Human Genome Epidemiology (HuGE) Navigator
TAOK1
genes like me logo Genes that share disorders with TAOK1: view

No data available for UniProtKB/Swiss-Prot for TAOK1 Gene

Publications for TAOK1 Gene

  1. MARKK, a Ste20-like kinase, activates the polarity-inducing kinase MARK/PAR-1. (PMID: 14517247) Timm T. … Mandelkow E.M. (EMBO J. 2003) 2 3 23
  2. A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling. (PMID: 17417629) Draviam V.M. … Elledge S.J. (Nat. Cell Biol. 2007) 3 4 23
  3. Human TAO kinase 1 induces apoptosis in SH-SY5Y cells. (PMID: 17900936) Wu M.F. … Wang S.G. (Cell Biol. Int. 2008) 3 4 23
  4. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  5. Comparative studies of a new subfamily of human Ste20-like kinases: homodimerization, subcellular localization, and selective activation of MKK3 and p38. (PMID: 13679851) Yustein J.T. … Kung H.-J. (Oncogene 2003) 3 4

Products for TAOK1 Gene

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