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Aliases for NUFIP2 Gene

Aliases for NUFIP2 Gene

  • Nuclear Fragile X Mental Retardation Protein Interacting Protein 2 2 3 5
  • Cell Proliferation-Inducing Gene 1 Protein 3 4
  • 82 KDa FMRP-Interacting Protein 3 4
  • FMRP-Interacting Protein 2 3 4
  • 82-FIP 3 4
  • Fragile X Mental Retardation Protein 3
  • 82-KD FMRP Interacting Protein 3
  • Proliferation-Inducing Gene 1 3
  • KIAA1321 4
  • 182-FIP 3
  • FIP-82 3
  • PIG1 3

External Ids for NUFIP2 Gene

Previous GeneCards Identifiers for NUFIP2 Gene

  • GC17M024613
  • GC17M027582
  • GC17M023791

Summaries for NUFIP2 Gene

GeneCards Summary for NUFIP2 Gene

NUFIP2 (Nuclear Fragile X Mental Retardation Protein Interacting Protein 2) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and RNA binding.

UniProtKB/Swiss-Prot for NUFIP2 Gene

  • Binds RNA.

Gene Wiki entry for NUFIP2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUFIP2 Gene

Genomics for NUFIP2 Gene

Regulatory Elements for NUFIP2 Gene

Enhancers for NUFIP2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NUFIP2 on UCSC Golden Path with GeneCards custom track

Promoters for NUFIP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NUFIP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for NUFIP2 Gene

Chromosome:
17
Start:
29,255,836 bp from pter
End:
29,294,148 bp from pter
Size:
38,313 bases
Orientation:
Minus strand

Genomic View for NUFIP2 Gene

Genes around NUFIP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUFIP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUFIP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUFIP2 Gene

Proteins for NUFIP2 Gene

  • Protein details for NUFIP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z417-NUFP2_HUMAN
    Recommended name:
    Nuclear fragile X mental retardation-interacting protein 2
    Protein Accession:
    Q7Z417
    Secondary Accessions:
    • A1L3A6
    • Q9P2M5

    Protein attributes for NUFIP2 Gene

    Size:
    695 amino acids
    Molecular mass:
    76121 Da
    Quaternary structure:
    • Interacts with FMRP.
    SequenceCaution:
    • Sequence=BAA92559.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NUFIP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUFIP2 Gene

Proteomics data for NUFIP2 Gene at MOPED

Post-translational modifications for NUFIP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NUFIP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NUFIP2 Gene

Domains & Families for NUFIP2 Gene

Protein Domains for NUFIP2 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NUFIP2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for NUFIP2 Gene

Function for NUFIP2 Gene

Molecular function for NUFIP2 Gene

UniProtKB/Swiss-Prot Function:
Binds RNA.

Gene Ontology (GO) - Molecular Function for NUFIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with NUFIP2: view
genes like me logo Genes that share phenotypes with NUFIP2: view

Animal Model Products

miRNA for NUFIP2 Gene

miRTarBase miRNAs that target NUFIP2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUFIP2 Gene

Localization for NUFIP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUFIP2 Gene

Nucleus. Cytoplasm. Note=Distribution is cell cycle-modulated, being cytoplasmic in the G2/M phase and accumulating in nucleus during the G1 phase.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUFIP2 Gene COMPARTMENTS Subcellular localization image for NUFIP2 gene
Compartment Confidence
nucleus 5
cytosol 3
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for NUFIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 12837692
genes like me logo Genes that share ontologies with NUFIP2: view

Pathways & Interactions for NUFIP2 Gene

SuperPathways for NUFIP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NUFIP2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NUFIP2 Gene

Drugs & Compounds for NUFIP2 Gene

No Compound Related Data Available

Transcripts for NUFIP2 Gene

mRNA/cDNA for NUFIP2 Gene

Unigene Clusters for NUFIP2 Gene

Nuclear fragile X mental retardation protein interacting protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NUFIP2 Gene

No ASD Table

Relevant External Links for NUFIP2 Gene

GeneLoc Exon Structure for
NUFIP2
ECgene alternative splicing isoforms for
NUFIP2

Expression for NUFIP2 Gene

mRNA expression in normal human tissues for NUFIP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NUFIP2 Gene

This gene is overexpressed in Lung (58.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NUFIP2 Gene



SOURCE GeneReport for Unigene cluster for NUFIP2 Gene Hs.462598

genes like me logo Genes that share expression patterns with NUFIP2: view

Protein tissue co-expression partners for NUFIP2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NUFIP2 Gene

Orthologs for NUFIP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NUFIP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NUFIP2 35
  • 95.81 (n)
  • 95.45 (a)
NUFIP2 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NUFIP2 35
  • 95.55 (n)
  • 95.14 (a)
NUFIP2 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nufip2 35
  • 93.55 (n)
  • 93.9 (a)
Nufip2 16
Nufip2 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NUFIP2 35
  • 99.76 (n)
  • 99.71 (a)
NUFIP2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nufip2 35
  • 94.11 (n)
  • 94.07 (a)
oppossum
(Monodelphis domestica)
Mammalia NUFIP2 36
  • 30 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUFIP2 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves NUFIP2 35
  • 72.07 (n)
  • 70.23 (a)
NUFIP2 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NUFIP2 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nufip2 35
  • 68.25 (n)
  • 59.44 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.29769 35
zebrafish
(Danio rerio)
Actinopterygii nufip2 35
  • 56.06 (n)
  • 47.74 (a)
nufip2 36
  • 44 (a)
OneToOne
Species with no ortholog for NUFIP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUFIP2 Gene

ENSEMBL:
Gene Tree for NUFIP2 (if available)
TreeFam:
Gene Tree for NUFIP2 (if available)

Paralogs for NUFIP2 Gene

No data available for Paralogs for NUFIP2 Gene

Variants for NUFIP2 Gene

Sequence variations from dbSNP and Humsavar for NUFIP2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs2661 -- 29,258,284(-) GCACA(A/T)ACCCA utr-variant-3-prime
rs8614 -- 29,261,788(-) TGGGG(G/T)CATTA utr-variant-3-prime
rs16731 -- 29,261,962(+) ACAGA(A/C)AGAGA utr-variant-3-prime
rs708101 -- 29,267,315(-) ACACT(G/T)TGGGA intron-variant
rs708102 -- 29,283,362(-) AGACC(C/G)TGTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUFIP2 Gene

Variant ID Type Subtype PubMed ID
nsv908029 CNV Loss 21882294
nsv908031 CNV Loss 21882294
nsv908032 CNV Loss 21882294
esv2658759 CNV Deletion 23128226
esv2671407 CNV Deletion 23128226
esv2715796 CNV Deletion 23290073

Variation tolerance for NUFIP2 Gene

Residual Variation Intolerance Score: 17.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.31; 53.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUFIP2 Gene

HapMap Linkage Disequilibrium report
NUFIP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUFIP2 Gene

Disorders for NUFIP2 Gene

Relevant External Links for NUFIP2

Genetic Association Database (GAD)
NUFIP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NUFIP2

No disorders were found for NUFIP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUFIP2 Gene

Publications for NUFIP2 Gene

  1. 82-FIP, a novel FMRP (fragile X mental retardation protein) interacting protein, shows a cell cycle-dependent intracellular localization. (PMID: 12837692) Bardoni B. … Mandel J.-L. (Hum. Mol. Genet. 2003) 2 3 4 23 67
  2. The structure of the N-terminal domain of the fragile X mental retardation protein: a platform for protein-protein interaction. (PMID: 16407062) Ramos A. … Pastore A. (Structure 2006) 2 3
  3. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  4. Analysis of HIV-1 Gag protein interactions via biotin ligase tagging. (PMID: 25631074) Ritchie C. … Barklis E. (J. Virol. 2015) 3
  5. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. (PMID: 25737280) Murn J. … Shi Y. (Genes Dev. 2015) 3

Products for NUFIP2 Gene

Sources for NUFIP2 Gene

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