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Aliases for MTA3 Gene

Aliases for MTA3 Gene

  • Metastasis Associated 1 Family, Member 3 2 3
  • Metastasis Associated Gene Family, Member 3 2
  • KIAA1266 4

External Ids for MTA3 Gene

Summaries for MTA3 Gene

GeneCards Summary for MTA3 Gene

MTA3 (Metastasis Associated 1 Family, Member 3) is a Protein Coding gene. Diseases associated with MTA3 include gastroesophageal junction adenocarcinoma. Among its related pathways are Development NOTCH1-mediated pathway for NF-KB activity modulation and Gene Expression. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and chromatin binding. An important paralog of this gene is RERE.

UniProtKB/Swiss-Prot for MTA3 Gene

  • Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels. Contributes to transcriptional repression by BCL6.

Gene Wiki entry for MTA3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTA3 Gene

Genomics for MTA3 Gene

Genomic Location for MTA3 Gene

Start:
42,494,569 bp from pter
End:
42,756,947 bp from pter
Size:
262,379 bases
Orientation:
Plus strand

Genomic View for MTA3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MTA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTA3 Gene

Proteins for MTA3 Gene

  • Protein details for MTA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BTC8-MTA3_HUMAN
    Recommended name:
    Metastasis-associated protein MTA3
    Protein Accession:
    Q9BTC8
    Secondary Accessions:
    • Q9NSP2
    • Q9ULF4

    Protein attributes for MTA3 Gene

    Size:
    594 amino acids
    Molecular mass:
    67504 Da
    Quaternary structure:
    • Component of the nucleosome-remodeling and histone-deacetylase multiprotein complex (NuRD). Interacts with BCL6. Interacts with NACC2.
    SequenceCaution:
    • Sequence=BAA86580.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MTA3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MTA3 Gene

Proteomics data for MTA3 Gene at MOPED

Post-translational modifications for MTA3 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys61 and Lys510

No data available for DME Specific Peptides for MTA3 Gene

Domains for MTA3 Gene

Gene Families for MTA3 Gene

HGNC:
  • GATAD :GATA zinc finger domain containing

UniProtKB/Swiss-Prot:

MTA3_HUMAN
Domain:
  • Contains 1 BAH domain.:
    • Q9BTC8
  • Contains 1 ELM2 domain.:
    • Q9BTC8
  • Contains 1 SANT domain.:
    • Q9BTC8
Similarity:
  • Contains 1 GATA-type zinc finger.:
    • Q9BTC8
genes like me logo Genes that share domains with MTA3: view

Function for MTA3 Gene

Molecular function for MTA3 Gene

UniProtKB/Swiss-Prot Function: Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels. Contributes to transcriptional repression by BCL6.
UniProtKB/Swiss-Prot Induction: By estrogen.

Gene Ontology (GO) - Molecular Function for MTA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0003682 chromatin binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0005515 protein binding IPI --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with MTA3: view
genes like me logo Genes that share phenotypes with MTA3: view

miRNA for MTA3 Gene

miRTarBase miRNAs that target MTA3

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MTA3 Gene

Localization for MTA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTA3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MTA3 Gene COMPARTMENTS Subcellular localization image for MTA3 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for MTA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm --
GO:0008278 cohesin complex --
GO:0016581 NuRD complex --
genes like me logo Genes that share ontologies with MTA3: view

Pathways for MTA3 Gene

genes like me logo Genes that share pathways with MTA3: view

Gene Ontology (GO) - Biological Process for MTA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization TAS --
GO:0006355 regulation of transcription, DNA-templated --
GO:0008284 positive regulation of cell proliferation --
GO:0010971 positive regulation of G2/M transition of mitotic cell cycle --
GO:0045892 negative regulation of transcription, DNA-templated IMP 15454082
genes like me logo Genes that share ontologies with MTA3: view

Compounds for MTA3 Gene

(1) Novoseek inferred chemical compound relationships for MTA3 Gene

Compound -log(P) Hits PubMed IDs
estrogen 44.5 5
genes like me logo Genes that share compounds with MTA3: view

Transcripts for MTA3 Gene

Unigene Clusters for MTA3 Gene

Metastasis associated 1 family, member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MTA3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b · 20c · 20d ·
SP1: - - - - - - - - -
SP2: - - - - - -
SP3: - - -
SP4: - -
SP5: - - - -
SP6:
SP7:
SP8:
SP9:
SP10: -

ExUns: 20e ^ 21 ^ 22a · 22b ^ 23
SP1: - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for MTA3 Gene

GeneLoc Exon Structure for
MTA3
ECgene alternative splicing isoforms for
MTA3

Expression for MTA3 Gene

mRNA expression in normal human tissues for MTA3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MTA3 Gene

SOURCE GeneReport for Unigene cluster for MTA3 Gene Hs.435413

mRNA Expression by UniProt/SwissProt for MTA3 Gene

Q9BTC8-MTA3_HUMAN
Tissue specificity: Expressed in germinal centers of lymphoid tissues. No expression in nonepithelial cells.
genes like me logo Genes that share expressions with MTA3: view

Orthologs for MTA3 Gene

This gene was present in the common ancestor of animals.

Orthologs for MTA3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MTA3 36
  • 99.8 (n)
  • 100 (a)
MTA3 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MTA3 36
  • 93.16 (n)
  • 97.83 (a)
MTA3 37
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MTA3 36
  • 93.99 (n)
  • 98.4 (a)
MTA3 37
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mta3 36
  • 86.36 (n)
  • 95.06 (a)
Mta3 16
Mta3 37
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MTA3 37
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MTA3 37
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mta3 36
  • 84.31 (n)
  • 90.77 (a)
chicken
(Gallus gallus)
Aves MTA3 36
  • 83.78 (n)
  • 88.5 (a)
MTA3 37
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MTA3 37
  • 68 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii mta3 36
  • 70.29 (n)
  • 80.58 (a)
mta3 37
  • 58 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea lin-40 36
  • 52.58 (n)
  • 47.89 (a)
Species with no ortholog for MTA3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MTA3 Gene

ENSEMBL:
Gene Tree for MTA3 (if available)
TreeFam:
Gene Tree for MTA3 (if available)

Paralogs for MTA3 Gene

Paralogs for MTA3 Gene

Pseudogenes.org Pseudogenes for MTA3 Gene

genes like me logo Genes that share paralogs with MTA3: view

Variants for MTA3 Gene

Sequence variations from dbSNP and Humsavar for MTA3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs731204 -- 42,694,933(-) TTGAA(C/T)AACTA intron-variant
rs731205 -- 42,694,759(-) GAGTT(A/C)TTTCA intron-variant
rs752009 -- 42,576,291(-) GAAAT(A/G)ACCTG intron-variant
rs893734 -- 42,694,514(-) TCCAT(A/G)CTGGG intron-variant
rs903840 -- 42,574,909(-) ATCTA(A/C)ACTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MTA3 Gene

Variant ID Type Subtype PubMed ID
nsv873970 CNV Gain 21882294
nsv524679 CNV Loss 19592680
esv2678416 CNV Deletion 23128226
esv2719982 CNV Deletion 23290073

Relevant External Links for MTA3 Gene

HapMap Linkage Disequilibrium report
MTA3
Human Gene Mutation Database (HGMD)
MTA3

Disorders for MTA3 Gene

(5) Novoseek inferred disease relationships for MTA3 Gene

Disease -log(P) Hits PubMed IDs
breast cancer 40 6
cancer 21.9 5
carcinoma 21.8 3
tumors 20.5 3
metastasis 15.5 1

Relevant External Links for MTA3

Genetic Association Database (GAD)
MTA3
Human Genome Epidemiology (HuGE) Navigator
MTA3
genes like me logo Genes that share disorders with MTA3: view

No data available for UniProtKB/Swiss-Prot for MTA3 Gene

Publications for MTA3 Gene

  1. Breast cancer risk associated with genotypic polymorphism of the genes involved in the estrogen-receptor-signaling pathway: a multigenic study on cancer susceptibility. (PMID: 16502042) Yu J.C. … Shen C.Y. (J. Biomed. Sci. 2006) 3 23 49
  2. Emerging roles of MTA family members in human cancers. (PMID: 14613024) Kumar R. … Bagheri-Yarmand R. (Semin. Oncol. 2003) 2 3 23
  3. MTA3, a Mi-2/NuRD complex subunit, regulates an invasive growth pathway in breast cancer. (PMID: 12705869) Fujita N. … Wade P.A. (Cell 2003) 2 3 4
  4. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T. … Ohara O. (DNA Res. 1999) 3 4
  5. Differential expression and subcellular distribution of the mouse metastasis-associated proteins Mta1 and Mta3. (PMID: 11483358) Simpson A. … Mahoney M.G. (Gene 2001) 3 23

Products for MTA3 Gene

  • Addgene plasmids for MTA3

Sources for MTA3 Gene

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