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Aliases for MTA3 Gene

Aliases for MTA3 Gene

  • Metastasis Associated 1 Family Member 3 2 3 5
  • Metastasis Associated Gene Family, Member 3 2
  • KIAA1266 4

External Ids for MTA3 Gene

Previous GeneCards Identifiers for MTA3 Gene

  • GC02P042783
  • GC02P042963
  • GC02P042770
  • GC02P042696
  • GC02P042633
  • GC02P042577
  • GC02P042649
  • GC02P042722

Summaries for MTA3 Gene

GeneCards Summary for MTA3 Gene

MTA3 (Metastasis Associated 1 Family Member 3) is a Protein Coding gene. Diseases associated with MTA3 include Congenital Disorder Of Glycosylation, Type Ip and Gastroesophageal Junction Adenocarcinoma. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Gene Expression. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and chromatin binding. An important paralog of this gene is RERE.

UniProtKB/Swiss-Prot for MTA3 Gene

  • Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels. Contributes to transcriptional repression by BCL6.

Gene Wiki entry for MTA3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTA3 Gene

Genomics for MTA3 Gene

Regulatory Elements for MTA3 Gene

Enhancers for MTA3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MTA3 on UCSC Golden Path with GeneCards custom track

Promoters for MTA3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MTA3 on UCSC Golden Path with GeneCards custom track

Genomic Location for MTA3 Gene

Chromosome:
2
Start:
42,494,569 bp from pter
End:
42,795,030 bp from pter
Size:
300,462 bases
Orientation:
Plus strand

Genomic View for MTA3 Gene

Genes around MTA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTA3 Gene

Proteins for MTA3 Gene

  • Protein details for MTA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BTC8-MTA3_HUMAN
    Recommended name:
    Metastasis-associated protein MTA3
    Protein Accession:
    Q9BTC8
    Secondary Accessions:
    • Q9NSP2
    • Q9ULF4

    Protein attributes for MTA3 Gene

    Size:
    594 amino acids
    Molecular mass:
    67504 Da
    Quaternary structure:
    • Component of the nucleosome-remodeling and histone-deacetylase multiprotein complex (NuRD). Interacts with BCL6. Interacts with NACC2.
    SequenceCaution:
    • Sequence=BAA86580.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MTA3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MTA3 Gene

Proteomics data for MTA3 Gene at MOPED

Post-translational modifications for MTA3 Gene

  • Ubiquitination at Lys 61 and Lys 510
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MTA3 Gene

Domains & Families for MTA3 Gene

Suggested Antigen Peptide Sequences for MTA3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BTC8

UniProtKB/Swiss-Prot:

MTA3_HUMAN :
  • Contains 1 BAH domain.
  • Contains 1 GATA-type zinc finger.
Domain:
  • Contains 1 BAH domain.
  • Contains 1 ELM2 domain.
  • Contains 1 SANT domain.
Similarity:
  • Contains 1 GATA-type zinc finger.
genes like me logo Genes that share domains with MTA3: view

Function for MTA3 Gene

Molecular function for MTA3 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels. Contributes to transcriptional repression by BCL6.
UniProtKB/Swiss-Prot Induction:
By estrogen.

Gene Ontology (GO) - Molecular Function for MTA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22926524
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with MTA3: view
genes like me logo Genes that share phenotypes with MTA3: view

Animal Models for MTA3 Gene

MGI Knock Outs for MTA3:
  • Mta3 tm3a(KOMP)Wtsi

Animal Model Products

miRNA for MTA3 Gene

miRTarBase miRNAs that target MTA3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MTA3 Gene

Localization for MTA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTA3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MTA3 Gene COMPARTMENTS Subcellular localization image for MTA3 gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for MTA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with MTA3: view

Pathways & Interactions for MTA3 Gene

genes like me logo Genes that share pathways with MTA3: view

Gene Ontology (GO) - Biological Process for MTA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016575 histone deacetylation TAS --
genes like me logo Genes that share ontologies with MTA3: view

No data available for SIGNOR curated interactions for MTA3 Gene

Drugs & Compounds for MTA3 Gene

(1) Drugs for MTA3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with MTA3: view

Transcripts for MTA3 Gene

Unigene Clusters for MTA3 Gene

Metastasis associated 1 family, member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MTA3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b · 20c · 20d ·
SP1: - - - - - - - - -
SP2: - - - - - -
SP3: - - -
SP4: - -
SP5: - - - -
SP6:
SP7:
SP8:
SP9:
SP10: -

ExUns: 20e ^ 21 ^ 22a · 22b ^ 23
SP1: - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for MTA3 Gene

GeneLoc Exon Structure for
MTA3
ECgene alternative splicing isoforms for
MTA3

Expression for MTA3 Gene

mRNA expression in normal human tissues for MTA3 Gene

Protein differential expression in normal tissues from HIPED for MTA3 Gene

This gene is overexpressed in Placenta (15.8), Lung (15.0), Peripheral blood mononuclear cells (8.7), and Testis (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MTA3 Gene



SOURCE GeneReport for Unigene cluster for MTA3 Gene Hs.435413

mRNA Expression by UniProt/SwissProt for MTA3 Gene

Q9BTC8-MTA3_HUMAN
Tissue specificity: Expressed in germinal centers of lymphoid tissues. No expression in nonepithelial cells.
genes like me logo Genes that share expression patterns with MTA3: view

Protein tissue co-expression partners for MTA3 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MTA3 Gene

Orthologs for MTA3 Gene

This gene was present in the common ancestor of animals.

Orthologs for MTA3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MTA3 35
  • 93.16 (n)
  • 97.83 (a)
MTA3 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MTA3 35
  • 93.99 (n)
  • 98.4 (a)
MTA3 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mta3 35
  • 86.36 (n)
  • 95.06 (a)
Mta3 16
Mta3 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MTA3 35
  • 99.8 (n)
  • 100 (a)
MTA3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mta3 35
  • 84.31 (n)
  • 90.77 (a)
oppossum
(Monodelphis domestica)
Mammalia MTA3 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MTA3 36
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves MTA3 35
  • 83.78 (n)
  • 88.5 (a)
MTA3 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MTA3 36
  • 68 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii mta3 35
  • 70.29 (n)
  • 80.58 (a)
mta3 36
  • 58 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea lin-40 35
  • 52.58 (n)
  • 47.89 (a)
Species with no ortholog for MTA3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MTA3 Gene

ENSEMBL:
Gene Tree for MTA3 (if available)
TreeFam:
Gene Tree for MTA3 (if available)

Paralogs for MTA3 Gene

Paralogs for MTA3 Gene

Pseudogenes.org Pseudogenes for MTA3 Gene

genes like me logo Genes that share paralogs with MTA3: view

Variants for MTA3 Gene

Sequence variations from dbSNP and Humsavar for MTA3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs731204 -- 42,694,933(-) TTGAA(C/T)AACTA intron-variant
rs731205 -- 42,694,759(-) GAGTT(A/C)TTTCA intron-variant
rs1561504 -- 42,726,070(+) ATGAG(A/C)TAGTT intron-variant
rs1561505 -- 42,726,205(+) CAGAG(G/T)GTTGA intron-variant
rs1561506 -- 42,726,242(+) AACAC(A/C)CGGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MTA3 Gene

Variant ID Type Subtype PubMed ID
nsv873970 CNV Gain 21882294
nsv524679 CNV Loss 19592680
esv2678416 CNV Deletion 23128226
esv2719982 CNV Deletion 23290073

Variation tolerance for MTA3 Gene

Residual Variation Intolerance Score: 20.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.42; 27.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MTA3 Gene

Human Gene Mutation Database (HGMD)
MTA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTA3 Gene

Disorders for MTA3 Gene

MalaCards: The human disease database

(4) MalaCards diseases for MTA3 Gene - From: OMIM, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
congenital disorder of glycosylation, type ip
  • congenital disorder of glycosylation 1p
gastroesophageal junction adenocarcinoma
  • adenocarcinoma of cardioesophageal junction
tonsil cancer
  • malignant neoplasm of faucial tonsil
nasopharyngeal disease
  • nasopharyngeal diseases
- elite association - COSMIC cancer census association via MalaCards
Search MTA3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MTA3

Genetic Association Database (GAD)
MTA3
Human Genome Epidemiology (HuGE) Navigator
MTA3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MTA3
genes like me logo Genes that share disorders with MTA3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MTA3 Gene

Publications for MTA3 Gene

  1. MTA3, a Mi-2/NuRD complex subunit, regulates an invasive growth pathway in breast cancer. (PMID: 12705869) Fujita N. … Wade P.A. (Cell 2003) 2 3 4 67
  2. Emerging roles of MTA family members in human cancers. (PMID: 14613024) Kumar R. … Bagheri-Yarmand R. (Semin. Oncol. 2003) 2 3 23
  3. The metastasis-associated genes MTA1 and MTA3 are abundantly expressed in human placenta and chorionic carcinoma cells. (PMID: 19363681) BrA1ning A. … Mylonas I. (Histochem. Cell Biol. 2009) 3 23
  4. Breast cancer risk associated with genotypic polymorphism of the genes involved in the estrogen-receptor-signaling pathway: a multigenic study on cancer susceptibility. (PMID: 16502042) Yu J.C. … Shen C.Y. (J. Biomed. Sci. 2006) 3 23
  5. Upstream determinants of estrogen receptor-alpha regulation of metastatic tumor antigen 3 pathway. (PMID: 15169784) Mishra S.K. … Kumar R. (J. Biol. Chem. 2004) 3 23

Products for MTA3 Gene

Sources for MTA3 Gene

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