Free for academic non-profit institutions. Other users need a Commercial license

ADGRB1 Gene(Protein Coding)

Adhesion G Protein-Coupled Receptor B1

GCID:
GC08P142449
GIFtS:
45
Genes Participants
UDN Logo

Aliases for ADGRB1 Gene

Aliases for ADGRB1 Gene

  • Adhesion G Protein-Coupled Receptor B1 2 3 5
  • BAI1 3 4
  • Brain-Specific Angiogenesis Inhibitor 1 2
  • GDAIF 3

External Ids for ADGRB1 Gene

Previous HGNC Symbols for ADGRB1 Gene

  • BAI1

Summaries for ADGRB1 Gene

Entrez Gene Summary for ADGRB1 Gene

  • Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas [provided by RefSeq, Jul 2008]

GeneCards Summary for ADGRB1 Gene

ADGRB1 (Adhesion G Protein-Coupled Receptor B1) is a Protein Coding gene. Diseases associated with ADGRB1 include Glioblastoma. Among its related pathways are p53 Pathway (RnD) and p53 signaling pathway. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is THBS4.

UniProtKB/Swiss-Prot for ADGRB1 Gene

  • Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Likely to be a potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53 signal in suppression of glioblastoma. May function in cell adhesion and signal transduction in the brain.

Gene Wiki entry for ADGRB1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRB1 Gene

Genomics for ADGRB1 Gene

Products:

  1. Regulatory Element

Regulatory Elements for ADGRB1 Gene

Enhancers for ADGRB1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ADGRB1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADGRB1 Gene

Chromosome:
8
Start:
142,449,430 bp from pter
End:
142,545,009 bp from pter
Size:
95,580 bases
Orientation:
Plus strand

Genomic View for ADGRB1 Gene

Genes around ADGRB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADGRB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADGRB1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ADGRB1 Gene

Proteins for ADGRB1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for ADGRB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14514-BAI1_HUMAN
    Recommended name:
    Brain-specific angiogenesis inhibitor 1
    Protein Accession:
    O14514

    Protein attributes for ADGRB1 Gene

    Size:
    1584 amino acids
    Molecular mass:
    173501 Da
    Quaternary structure:
    • Interacts with ELMO1 and DOCK1. When bound to ELMO1 and DOCK1, it may act as a module to promote the engulfment (By similarity). Interacts with MAGI1, MAGI3, BAIAP2 and PHYHIP.

neXtProt entry for ADGRB1 Gene

Proteomics data for ADGRB1 Gene at MOPED

Protein Expression for ADGRB1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ADGRB1 Gene

  • The endogenous protein is proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADGRB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ADGRB1 Gene

Domains & Families for ADGRB1 Gene

Gene Families for ADGRB1 Gene

HGNC:

Protein Domains for ADGRB1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ADGRB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O14514

UniProtKB/Swiss-Prot:

BAI1_HUMAN :
  • The TSP1 repeats inhibit in vivo angiogenesis in rat cornea induced by BFGF.
  • Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
Domain:
  • The TSP1 repeats inhibit in vivo angiogenesis in rat cornea induced by BFGF.
  • Contains 1 GPS domain.
  • Contains 5 TSP type-1 domains.
Family:
  • Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
genes like me logo Genes that share domains with ADGRB1: view

Function for ADGRB1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for ADGRB1 Gene

UniProtKB/Swiss-Prot Function:
Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Likely to be a potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53 signal in suppression of glioblastoma. May function in cell adhesion and signal transduction in the brain.
UniProtKB/Swiss-Prot Induction:
By p53/TP53.

Phenotypes for ADGRB1 Gene

MGI mutant phenotypes for ADGRB1:
inferred from 1 alleles
GenomeRNAi human phenotypes for ADGRB1:
genes like me logo Genes that share phenotypes with ADGRB1: view

Animal Models for ADGRB1 Gene

MGI Knock Outs for ADGRB1:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ADGRB1 Gene

Localization for ADGRB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRB1 Gene

Cell membrane; Multi-pass membrane protein. Note=Likely to be concentrated at cell-cell adhesion sites.

Gene Ontology (GO) - Cellular Components for ADGRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ADGRB1: view

No data available for Subcellular locations from COMPARTMENTS for ADGRB1 Gene

Pathways & Interactions for ADGRB1 Gene

genes like me logo Genes that share pathways with ADGRB1: view

Pathways by source for ADGRB1 Gene

1 KEGG pathway for ADGRB1 Gene
1 R&D Systems pathway for ADGRB1 Gene
1 Qiagen pathway for ADGRB1 Gene

Gene Ontology (GO) - Biological Process for ADGRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0008285 negative regulation of cell proliferation TAS 7531056
genes like me logo Genes that share ontologies with ADGRB1: view

No data available for SIGNOR curated interactions for ADGRB1 Gene

Drugs & Compounds for ADGRB1 Gene

Products:

  1. Drug

(1) Drugs for ADGRB1 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphatidylserine Approved Nutra 0
genes like me logo Genes that share compounds with ADGRB1: view

Transcripts for ADGRB1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for ADGRB1 Gene

(5) REFSEQ mRNAs :
(32) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRB1 Gene

No ASD Table

Relevant External Links for ADGRB1 Gene

GeneLoc Exon Structure for
ADGRB1
ECgene alternative splicing isoforms for
ADGRB1

Expression for ADGRB1 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for ADGRB1 Gene

mRNA expression in normal human tissues for ADGRB1 Gene
mRNA expression by GTEx for ADGRB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ADGRB1 Gene

This gene is overexpressed in Fetal Brain (68.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADGRB1 Gene



mRNA Expression by UniProt/SwissProt for ADGRB1 Gene

O14514-BAI1_HUMAN
Tissue specificity: Specifically expressed in brain. Reduced or no expression is observed in some glioblastoma cell lines and cancer tissues. No expression in astrocytes.
genes like me logo Genes that share expression patterns with ADGRB1: view

Protein tissue co-expression partners for ADGRB1 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for ADGRB1 Gene

Orthologs for ADGRB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADGRB1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia BAI1 35
  • 91.1 (n)
  • 94.23 (a)
BAI1 36
  • 94 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia BAI1 35
  • 90.51 (n)
  • 93.56 (a)
BAI1 36
  • 86 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Bai1 35
  • 88.33 (n)
  • 94.18 (a)
Adgrb1 16
Bai1 36
  • 94 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Bai1 35
  • 87.93 (n)
  • 94.29 (a)
oppossum
(Monodelphis domestica)
 Mammalia BAI1 36
  • 80 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia BAI1 36
  • 76 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia BAI1 36
  • 99 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves BAI1 35
  • 73.71 (n)
  • 78.66 (a)
BAI1 36
  • 76 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia -- 36
  • 72 (a)
 OneToMany
-- 36
  • 80 (a)
 OneToMany
tropical clawed frog
(Silurana tropicalis)
 Amphibia bai1 35
  • 69.48 (n)
  • 74.3 (a)
zebrafish
(Danio rerio)
 Actinopterygii Dr.15237 35
BAI1 (1 of 3) 36
  • 61 (a)
 OneToMany
bai1a 36
  • 70 (a)
 OneToMany
bai1b 36
  • 59 (a)
 OneToMany
fruit fly
(Drosophila melanogaster)
 Insecta unc-5 36
  • 15 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea C36B7.5 36
  • 16 (a)
 ManyToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 36
  • 36 (a)
 ManyToMany
Species with no ortholog for ADGRB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADGRB1 Gene

ENSEMBL:
Gene Tree for ADGRB1 (if available)
TreeFam:
Gene Tree for ADGRB1 (if available)

Paralogs for ADGRB1 Gene

Paralogs for ADGRB1 Gene

genes like me logo Genes that share paralogs with ADGRB1: view

Variants for ADGRB1 Gene

Sequence variations from dbSNP and Humsavar for ADGRB1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs7837059 -- 142,533,117(+) GGCAG(C/T)GGTGG intron-variant
rs7838992 -- 142,528,552(+) AGCCG(C/T)CCCCG intron-variant
rs7839199 -- 142,521,433(+) GCAGG(C/G/T)GCAGC intron-variant
rs7843913 -- 142,492,197(+) CCACC(C/T)TCTAC intron-variant
rs7846567 -- 142,530,788(+) CTTTG(A/C)AGTCA intron-variant

Variation tolerance for ADGRB1 Gene

Residual Variation Intolerance Score: 3.73% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.30; 41.06% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for ADGRB1 Gene

Disorders for ADGRB1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ADGRB1 Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
glioblastoma
  • glioblastoma multiforme
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ADGRB1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADGRB1
genes like me logo Genes that share disorders with ADGRB1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADGRB1 Gene

Publications for ADGRB1 Gene

  1. Identification of BAIAP2 (BAI-associated protein 2), a novel human homologue of hamster IRSp53, whose SH3 domain interacts with the cytoplasmic domain of BAI1. (PMID: 10343108) Oda K. … Tokino T. (Cytogenet. Cell Genet. 1999) 3 4 23 67
  2. Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1). (PMID: 9533023) Shiratsuchi T. … Tokino T. (Cytogenet. Cell Genet. 1997) 2 3 23
  3. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J. … SchiAPth H.B. (Pharmacol. Rev. 2015) 2 3
  4. Extracellular fragment of brain-specific angiogenesis inhibitor 1 suppresses endothelial cell proliferation by blocking alphavbeta5 integrin. (PMID: 14980512) Koh J.T. … Kim K.K. (Exp. Cell Res. 2004) 3 23
  5. Brain angiogenesis inhibitor 1 is differentially expressed in normal brain and glioblastoma independently of p53 expression. (PMID: 12507886) Kaur B. … Van Meir E.G. (Am. J. Pathol. 2003) 3 23

Products for ADGRB1 Gene

Sources for ADGRB1 Gene

Content