Aliases for ADGRB1 Gene
Aliases for ADGRB1 Gene
External Ids for ADGRB1 Gene
- HGNC: 943
- Entrez Gene: 575
- Ensembl: ENSG00000181790
- OMIM: 602682
- UniProtKB: O14514
Previous HGNC Symbols for ADGRB1 Gene
- BAI1
Summaries for ADGRB1 Gene
-
Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas [provided by RefSeq, Jul 2008]
GeneCards Summary for ADGRB1 Gene
ADGRB1 (Adhesion G Protein-Coupled Receptor B1) is a Protein Coding gene. Diseases associated with ADGRB1 include Glioblastoma. Among its related pathways are DNA Damage Response and p53 Signaling. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is ADGRB3.
UniProtKB/Swiss-Prot for ADGRB1 Gene
-
Phosphatidylserine receptor which enhances the engulfment of apoptotic cells (PubMed:24509909). Also mediates the binding and engulfment of Gram-negative bacteria (PubMed:26838550). Stimulates production of reactive oxygen species by macrophages in response to Gram-negative bacteria, resulting in enhanced microbicidal macrophage activity (PubMed:26838550). In the gastric mucosa, required for recognition and engulfment of apoptotic gastric epithelial cells (PubMed:24509909). Promotes myoblast fusion (By similarity). Activates the Rho pathway in a G-protein-dependent manner (PubMed:23782696). Inhibits MDM2-mediated ubiquitination and degradation of DLG4/PSD95, promoting DLG4 stability and regulating synaptic plasticity (By similarity). Required for the formation of dendritic spines by ensuring the correct localization of PARD3 and TIAM1 (By similarity). Potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53/TP53 signal in suppression of glioblastoma (PubMed:11875720).
-
Vasculostatin-120: Inhibits angiogenesis in a CD36-dependent manner.
-
Vasculostatin-40: Inhibits angiogenesis.
Additional gene information for ADGRB1 Gene
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRB1 Gene
Genomics for ADGRB1 Gene
GeneHancer (GH) Regulatory Elements for ADGRB1 Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH08I142447 | Enhancer | 1 | FANTOM5 ENCODE | 550.8 | -1.7 | -1681 | 0.4 | CTCF RB1 ARID4B SIN3A ZIC2 RAD21 GLIS2 SMC3 ZNF143 ZNF444 | ADGRB1 TSNARE1 ENSG00000261693 | |
GH08I142451 | Enhancer | 0.8 | FANTOM5 dbSUPER | 555.1 | +1.8 | 1769 | 0.3 | SP3 SUZ12 ZBTB8A ZNF335 GLIS1 CTBP2 ZBTB26 EZH2 ZBTB20 | ADGRB1 LYNX1 TSNARE1 MROH4P | |
GH08I142450 | Enhancer | 0.5 | dbSUPER | 550.8 | +1.3 | 1293 | 0.1 | GLIS1 ZBTB26 ZBTB20 EZH2 | ADGRB1 MROH4P | |
GH08I142454 | Enhancer | 0.5 | dbSUPER | 550.8 | +1.2 | 1152 | 0.1 | GLIS2 GLIS1 PATZ1 EZH2 | ADGRB1 MROH4P | |
GH08I142463 | Promoter | 0.5 | EPDnew | 550.4 | +14.5 | 14514 | 0.1 | ADGRB1 MROH4P |
Regulatory Element Products
Genomic Locations for ADGRB1 Gene
- chr8:142,449,430-142,545,009
- (GRCh38/hg38)
- Size:
- 95,580 bases
- Orientation:
- Plus strand
- chr8:143,530,791-143,626,370
- (GRCh37/hg19)
Genomic View for ADGRB1 Gene
- Cytogenetic band:
-
- 8q24.3 by Ensembl
- 8q24.3 by Entrez Gene
- 8q24.3 by HGNC


RefSeq DNA sequence for ADGRB1 Gene
Proteins for ADGRB1 Gene
-
Protein details for ADGRB1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O14514-AGRB1_HUMAN
- Recommended name:
- Adhesion G protein-coupled receptor B1
- Protein Accession:
- O14514
Protein attributes for ADGRB1 Gene
- Size:
- 1584 amino acids
- Molecular mass:
- 173501 Da
- Quaternary structure:
-
- Interacts with ELMO1 and DOCK (By similarity). When bound to ELMO1 and DOCK1, acts as a module to promote apoptotic cell engulfment (By similarity). Interacts with MDM2; the interaction results in inhibition of MDM2-mediated ubiquitination and degradation of DLG4/PSD95 (By similarity). Interacts with PARD3 and TIAM1; the interaction is required for correct dendritic. localization of PARD3 and TIAM1 and for dendritic spine formation (PubMed:23595754). Interacts with MAGI1 (PubMed:9647739). Interacts with MAGI3 (PubMed:10748157). Interacts with BAIAP2 (PubMed:10343108). Interacts with PHYHIP (By similarity). Interacts with DLG4 (via PDZ domain) (PubMed:23782696). Vasculostatin-120: Interacts with CD36 (PubMed:19176395). Vasculostatin-120: Interacts with ARRB2 (PubMed:23782696).
Protein Expression for ADGRB1 Gene
Post-translational modifications for ADGRB1 Gene
- Proteolytically cleaved to produce vasculostatin-40 and vasculostatin-120 (PubMed:15782143, PubMed:22333914, PubMed:22330140). Vasculostatin-40 is the major form and is produced through proteolytic cleavage by MMP14 between residues 321 and 329 with cleavage likely to be between Ser-326 and Leu-327 (PubMed:22330140).
- Ubiquitinated.
Other Protein References for ADGRB1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
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Domains & Families for ADGRB1 Gene
Gene Families for ADGRB1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- G-protein coupled receptors
- Plasma proteins
- Predicted membrane proteins
Protein Domains for ADGRB1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ADGRB1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O14514UniProtKB/Swiss-Prot:
AGRB1_HUMAN :- The TSP type-1 repeats in the extracellular domain mediate binding to phosphatidylserine. They are also required for bacterial recognition and binding to bacterial outer membrane lipopolysaccharide.
- Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
- Domain:
-
- The TSP type-1 repeats in the extracellular domain mediate binding to phosphatidylserine. They are also required for bacterial recognition and binding to bacterial outer membrane lipopolysaccharide.
- Family:
-
- Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
Function for ADGRB1 Gene
Molecular function for ADGRB1 Gene
- UniProtKB/Swiss-Prot Function:
- Phosphatidylserine receptor which enhances the engulfment of apoptotic cells (PubMed:24509909). Also mediates the binding and engulfment of Gram-negative bacteria (PubMed:26838550). Stimulates production of reactive oxygen species by macrophages in response to Gram-negative bacteria, resulting in enhanced microbicidal macrophage activity (PubMed:26838550). In the gastric mucosa, required for recognition and engulfment of apoptotic gastric epithelial cells (PubMed:24509909). Promotes myoblast fusion (By similarity). Activates the Rho pathway in a G-protein-dependent manner (PubMed:23782696). Inhibits MDM2-mediated ubiquitination and degradation of DLG4/PSD95, promoting DLG4 stability and regulating synaptic plasticity (By similarity). Required for the formation of dendritic spines by ensuring the correct localization of PARD3 and TIAM1 (By similarity). Potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53/TP53 signal in suppression of glioblastoma (PubMed:11875720).
- UniProtKB/Swiss-Prot Function:
- Vasculostatin-120: Inhibits angiogenesis in a CD36-dependent manner.
- UniProtKB/Swiss-Prot Function:
- Vasculostatin-40: Inhibits angiogenesis.
- UniProtKB/Swiss-Prot Induction:
- By p53/TP53.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001530 | lipopolysaccharide binding | ISS | -- |
GO:0001786 | phosphatidylserine binding | ISS | -- |
GO:0004871 | signal transducer activity | IEA | -- |
GO:0004872 | receptor activity | IEA | -- |
GO:0004888 | transmembrane signaling receptor activity | IEA | -- |
Phenotypes for ADGRB1 Gene
- MGI mutant phenotypes for ADGRB1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ADGRB1:
-
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased viability in esophageal squamous lineage
- Dynamic nuclei (hole, folded or small irregular)
- Increased transferrin (TF) endocytosis
- Synthetic lethal with MLN4924 (a NAE inhibitor)
Animal Models for ADGRB1 Gene
- MGI Knock Outs for ADGRB1:
-
- Adgrb1 tm2a(EUCOMM)Wtsi
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- Yeast expression
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No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ADGRB1 Gene
Localization for ADGRB1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ADGRB1 Gene
- Cell membrane; Multi-pass membrane protein. Cell projection, phagocytic cup. Cell junction, focal adhesion. Cell projection, dendritic spine. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density.
- Vasculostatin-120: Secreted.
- Vasculostatin-40: Secreted.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001891 | phagocytic cup | ISS | -- |
GO:0005576 | extracellular region | IEA | -- |
GO:0005615 | extracellular space | IDA | 15782143 |
GO:0005886 | plasma membrane | ISS,TAS | -- |
GO:0005887 | integral component of plasma membrane | TAS | 9647739 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADGRB1 Gene
Pathways & Interactions for ADGRB1 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | DNA Damage Response | ||
2 | p53 Signaling |
.44
|
Pathways by source for ADGRB1 Gene
1 KEGG pathway for ADGRB1 Gene
1 Qiagen pathway for ADGRB1 Gene
Interacting Proteins for ADGRB1 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002376 | immune system process | IEA | -- |
GO:0006909 | phagocytosis | IEA | -- |
GO:0006910 | phagocytosis, recognition | ISS | -- |
GO:0006911 | phagocytosis, engulfment | IEA | -- |
GO:0007155 | cell adhesion | TAS | 9647739 |
No data available for SIGNOR curated interactions for ADGRB1 Gene
Drugs & Compounds for ADGRB1 Gene
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
PHOSPHATIDYLSERINE | Pharma | 0 |
Transcripts for ADGRB1 Gene
mRNA/cDNA for ADGRB1 Gene
- (10) REFSEQ mRNAs :
- (32) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
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-
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Expression for ADGRB1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Hair (Integumentary System)
- Zigzag Dermal Papilla Cells Dermal Papilla
- Guard Dermal Papilla Cells Dermal Papilla
-
Dermis (Integumentary System)
- Zigzag Dermal Papilla Cells Dermal Papilla
- Guard Dermal Papilla Cells Dermal Papilla
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADGRB1 Gene
NURSA nuclear receptor signaling pathways regulating expression of ADGRB1 Gene:
ADGRB1mRNA Expression by UniProt/SwissProt for ADGRB1 Gene:
O14514-AGRB1_HUMANEvidence on tissue expression from TISSUES for ADGRB1 Gene
- Nervous system(4.5)
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No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADGRB1 Gene
Orthologs for ADGRB1 Gene
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | BAI1 34 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | BAI1 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | BAI1 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Bai1 33 34 |
|
||
Adgrb1 16 |
|
||||
rat (Rattus norvegicus) |
Mammalia | Bai1 33 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | BAI1 34 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | BAI1 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | BAI1 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
-- 34 |
|
OneToMany | |||
tropical clawed frog (Silurana tropicalis) |
Amphibia | bai1 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | bai1a 34 |
|
OneToMany | |
BAI1 (1 of 3) 34 |
|
OneToMany | |||
bai1b 34 |
|
OneToMany | |||
Dr.15237 33 |
|
||||
fruit fly (Drosophila melanogaster) |
Insecta | unc-5 34 |
|
OneToMany | |
worm (Caenorhabditis elegans) |
Secernentea | C36B7.5 34 |
|
ManyToMany | |
sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
ManyToMany |
- Species where no ortholog for ADGRB1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for ADGRB1 Gene
Variants for ADGRB1 Gene
SNP ID | Clin | Chr 08 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000032621 | -- | 142,506,458(+) | G/A | intron_variant | |
rs1000036960 | -- | 142,526,324(+) | G/C | intron_variant | |
rs1000047385 | -- | 142,491,235(+) | G/A | intron_variant | |
rs1000061678 | -- | 142,478,528(+) | G/A | intron_variant | |
rs1000073848 | -- | 142,515,236(+) | C/T | intron_variant |
Additional Variant Information for ADGRB1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ADGRB1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADGRB1 Gene
Disorders for ADGRB1 Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
glioblastoma |
|
Additional Disease Information for ADGRB1
No data available for UniProtKB/Swiss-Prot and Genatlas for ADGRB1 Gene
Publications for ADGRB1 Gene
- Vasculostatin inhibits intracranial glioma growth and negatively regulates in vivo angiogenesis through a CD36-dependent mechanism. (PMID: 19176395) Kaur B … Van Meir EG (Cancer research 2009) 3 4 22 58
- Brain angiogenesis inhibitor 1 is differentially expressed in normal brain and glioblastoma independently of p53 expression. (PMID: 12507886) Kaur B … Van Meir EG (The American journal of pathology 2003) 3 4 22 58
- Identification of BAIAP2 (BAI-associated protein 2), a novel human homologue of hamster IRSp53, whose SH3 domain interacts with the cytoplasmic domain of BAI1. (PMID: 10343108) Oda K … Tokino T (Cytogenetics and cell genetics 1999) 3 4 22 58
- Cloning and characterization of BAI-associated protein 1: a PDZ domain-containing protein that interacts with BAI1. (PMID: 9647739) Shiratsuchi T … Tokino T (Biochemical and biophysical research communications 1998) 3 4 22 58
- Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1). (PMID: 9533023) Shiratsuchi T … Tokino T (Cytogenetics and cell genetics 1997) 2 3 22 58
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for ADGRB1
- VectorBuilder custom plasmid, inducible vectors for ADGRB1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ADGRB1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 86 available BAI1 Antibodies ranked by validation data
- Compare Top BAI1 Antibodies
- Recommended
- 30 WB Antibodies (anti-human)
- 24 IHC (p) Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 5 IHC Antibodies (anti-human)
- 30 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 12 IHC (p) Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-rat)
- 8 WB Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- antibodies-online: Search results for 4 available BAI1 Elisa Kits ranked by validation data
- Compare Top BAI1 Elisa Kits
- Recommended
- antibodies-online: Search results for 6 available BAI1 Proteins ranked by validation data
- Compare Top BAI1 Proteins
- Search GeneTex for Antibodies for ADGRB1
- Search GeneTex for Proteins for ADGRB1
- ViGene Biosciences adenoviral particle packaged cDNA for ADGRB1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for ADGRB1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for ADGRB1 gene
- Search ViGene Biosciences for ADGRB1
- Horizon Cell Lines for ADGRB1
- genomics-online: cdna clones - Search results for 68 available BAI1 gene related products
- Overview of 68 available BAI1 gene related products
- orf clones - Search results for 68 available BAI1 gene related products
- Overview of 68 available BAI1 gene related products
- genomics-online: gRNA clones - Search results for 68 available BAI1 gene related products
- Overview of 68 available BAI1 gene related products
- genomics-online: primer clones - Search results for 68 available BAI1 gene related products
- Overview of 68 available BAI1 gene related products
- genomics-online: shRNA clones - Search results for 68 available BAI1 gene related products
- Overview of 68 available BAI1 gene related products
Sources for ADGRB1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew