Aliases for SLC12A5 Gene
Aliases for SLC12A5 Gene
External Ids for SLC12A5 Gene
- HGNC: 13818
- Entrez Gene: 57468
- Ensembl: ENSG00000124140
- OMIM: 606726
- UniProtKB: Q9H2X9
Previous GeneCards Identifiers for SLC12A5 Gene
- GC20P044386
- GC20P045296
- GC20P045343
- GC20P044091
- GC20P044651
- GC20P041391
Summaries for SLC12A5 Gene
-
K-Cl cotransporters are proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The protein encoded by this gene is an integral membrane K-Cl cotransporter that can function in either a net efflux or influx pathway, depending on the chemical concentration gradients of potassium and chloride. The encoded protein can act as a homomultimer, or as a heteromultimer with other K-Cl cotransporters, to maintain chloride homeostasis in neurons. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Sep 2008]
GeneCards Summary for SLC12A5 Gene
SLC12A5 (Solute Carrier Family 12 Member 5) is a Protein Coding gene. Diseases associated with SLC12A5 include Epileptic Encephalopathy, Early Infantile, 34 and Hypothalamic Hamartomas. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Circadian entrainment. GO annotations related to this gene include protein kinase binding and potassium:chloride symporter activity. An important paralog of this gene is SLC12A2.
UniProtKB/Swiss-Prot for SLC12A5 Gene
-
Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis. As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition (By similarity). Involved in the regulation of dendritic spine formation and maturation (PubMed:24668262).
No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC12A5 Gene
Genomics for SLC12A5 Gene
Regulatory Elements for SLC12A5 Gene
Enhancers for SLC12A5 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around SLC12A5 on UCSC Golden Path with GeneCards custom track
Promoters for SLC12A5 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around SLC12A5 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the SLC12A5 gene promoter:
Regulatory Element Products
Genomic Location for SLC12A5 Gene
- Chromosome:
- 20
- Start:
- 46,021,690 bp from pter
- End:
- 46,060,152 bp from pter
- Size:
- 38,463 bases
- Orientation:
- Plus strand
Genomic View for SLC12A5 Gene
Genes around SLC12A5 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20q13.12 by Ensembl
- 20q13.12 by Entrez Gene
- 20q13.12 by HGNC
SLC12A5 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SLC12A5 Gene
Proteins for SLC12A5 Gene
-
Protein details for SLC12A5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9H2X9-S12A5_HUMAN
- Recommended name:
- Solute carrier family 12 member 5
- Protein Accession:
- Q9H2X9
- A2RTX2
- Q5VZ41
- Q9H4Z0
- Q9ULP4
Protein attributes for SLC12A5 Gene
- Size:
- 1139 amino acids
- Molecular mass:
- 126184 Da
- Quaternary structure:
-
- Homomultimer and heteromultimer with other K-Cl cotransporters. Interacts with AP2A1 (By similarity).
- Miscellaneous:
-
- Inhibited by furosemide and bumetanide.
Protein Expression for SLC12A5 Gene
Post-translational modifications for SLC12A5 Gene
Other Protein References for SLC12A5 Gene
Antibody Products
- EMD Millipore top SLC12A5 Antibody
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-
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-
Santa Cruz Biotechnology (SCBT) Antibodies for SLC12A5
Protein Products
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Assay Products
- antibodies-online Kits for SLC12A5: See all 1
No data available for DME Specific Peptides for SLC12A5 Gene
Domains & Families for SLC12A5 Gene
Gene Families for SLC12A5 Gene
- HGNC:
- IUPHAR :
Protein Domains for SLC12A5 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for SLC12A5 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9H2X9- Family:
-
- Belongs to the SLC12A transporter family.
Function for SLC12A5 Gene
Molecular function for SLC12A5 Gene
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Inhibited by WNK3.
- UniProtKB/Swiss-Prot Function:
- Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis. As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition (By similarity). Involved in the regulation of dendritic spine formation and maturation (PubMed:24668262).
Phenotypes for SLC12A5 Gene
- MGI mutant phenotypes for SLC12A5:
- inferred from 5 alleles
- GenomeRNAi human phenotypes for SLC12A5:
Animal Model Products
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-
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CRISPR Products
-
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-
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- GenScript: Design CRISPR guide RNA sequences for SLC12A5
miRNA for SLC12A5 Gene
- miRTarBase miRNAs that target SLC12A5
-
- hsa-mir-25-3p (MIRT296110)
- hsa-mir-32-5p (MIRT296111)
- hsa-mir-92a-3p (MIRT296112)
- hsa-mir-363-3p (MIRT296113)
- hsa-mir-367-3p (MIRT296114)
- hsa-mir-92b-3p (MIRT296116)
- hsa-mir-7703 (MIRT296117)
- hsa-mir-542-3p (MIRT491363)
- hsa-mir-6885-5p (MIRT491364)
- hsa-mir-328-5p (MIRT491365)
- hsa-mir-4697-5p (MIRT491366)
- hsa-mir-1237-5p (MIRT491367)
- hsa-mir-4488 (MIRT491368)
- hsa-mir-3178 (MIRT491369)
- hsa-mir-4479 (MIRT491370)
- hsa-mir-2277-3p (MIRT491371)
- hsa-mir-4285 (MIRT491372)
- hsa-mir-433-5p (MIRT491373)
- hsa-mir-4325 (MIRT501138)
- hsa-mir-203a-3p (MIRT501139)
- hsa-mir-6500-3p (MIRT501140)
- hsa-mir-3614-5p (MIRT501141)
- hsa-mir-548t-5p (MIRT501142)
- hsa-mir-548az-5p (MIRT501143)
- hsa-mir-548n (MIRT501144)
- hsa-mir-224-5p (MIRT501145)
- hsa-mir-4646-3p (MIRT653747)
- hsa-mir-4433b-5p (MIRT653748)
- hsa-mir-6749-3p (MIRT653749)
- hsa-mir-4433a-5p (MIRT653750)
- hsa-mir-4313 (MIRT653751)
- hsa-mir-4469 (MIRT653752)
- hsa-mir-6075 (MIRT653753)
- hsa-mir-5193 (MIRT653754)
- hsa-mir-4667-3p (MIRT653755)
- hsa-mir-6887-3p (MIRT653756)
- hsa-mir-4726-3p (MIRT653757)
- hsa-mir-6840-3p (MIRT653758)
miRNA Products
- Search ViGene Biosciences for SLC12A5
Clone Products
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for SLC12A5 Gene
Localization for SLC12A5 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SLC12A5 Gene
- Membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytoskeleton | 1 |
| extracellular | 1 |
| nucleus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for SLC12A5 Gene
More details on SuperPathways for SLC12A5| Superpath | Contained pathways | ||
|---|---|---|---|
| 1 | Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | ||
| 2 | Circadian entrainment | ||
| 3 | Neuroscience |
Pathways by source for SLC12A5 Gene
1 Cell Signaling Technology pathway for SLC12A5 Gene
1 KEGG pathway for SLC12A5 Gene
Interacting Proteins for SLC12A5 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006810 | transport | IEA,NAS | 12106695 |
| GO:0006811 | ion transport | IEA,TAS | -- |
| GO:0006821 | chloride transport | IEA | -- |
| GO:0006873 | cellular ion homeostasis | NAS | 12106695 |
| GO:0035264 | multicellular organism growth | IEA | -- |
No data available for SIGNOR curated interactions for SLC12A5 Gene
Drugs & Compounds for SLC12A5 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Bumetanide | Approved | Pharma | Agonist, blocker, Target, inhibitor | NKCC cotransporter inhibitor, Na+/2Cl-/K+ (NKCC) symporter inhibitor | 15 | |
| Potassium Chloride | Approved, Withdrawn | Pharma | Target, Transporter, substrate | 0 | ||
| Furosemide | Approved | Pharma | Agonist | GABAA receptors antagonist, Na+/2Cl-/K+ (NKCC) symporter inhibitor. Also antagonizes GABAA | 177 | |
| DIOA | Pharma | Inhibition, Inhibitor | 0 | |||
| VU0240551 | Pharma | Inhibition, Inhibitor | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Chloride ion |
|
16887-00-6 |
|
Transcripts for SLC12A5 Gene
mRNA/cDNA for SLC12A5 Gene
- (2) REFSEQ mRNAs :
- (12) Additional mRNA sequences :
- (104) Selected AceView cDNA sequences:
- (21) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for SLC12A5 Gene
CRISPR Products
-
OriGene CRISPR knockouts for SLC12A5
-
Santa Cruz Biotechnology (SCBT) CRISPR for SLC12A5
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miRNA Products
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Clone Products
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Flow Cytometry Products
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: |
| ExUns: | 23a | · | 23b | ^ | 24a | · | 24b | ^ | 25 | ^ | 26 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||
| SP2: | |||||||||||
| SP3: | |||||||||||
| SP4: | |||||||||||
| SP5: | |||||||||||
| SP6: |
Expression for SLC12A5 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for SLC12A5 Gene
This gene is overexpressed in Brain - Cerebellum (x7.3), Brain - Cerebellar Hemisphere (x7.3), Brain - Frontal Cortex (BA9) (x6.5), Brain - Cortex (x5.3), and Brain - Anterior cingulate cortex (BA24) (x5.0).
This gene is overexpressed in Frontal cortex (39.0) and Retina (21.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC12A5 Gene
SOURCE GeneReport for Unigene cluster for SLC12A5 Gene Hs.21413
mRNA Expression by UniProt/SwissProt for SLC12A5 Gene
Q9H2X9-S12A5_HUMAN
Tissue specificity:
Brain specific. Detected in neuronal cells.
- Elite partner
Primer Products
-
OriGene qPCR primer pairs for SLC12A5
Orthologs for SLC12A5 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | SLC12A5 35 |
|
||
| SLC12A5 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | SLC12A5 35 |
|
||
| SLC12A5 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Slc12a5 35 |
|
||
| Slc12a5 16 |
|
||||
| Slc12a5 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | SLC12A5 35 |
|
||
| SLC12A5 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Slc12a5 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | SLC12A5 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | SLC12A5 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | SLC12A5 35 |
|
||
| SLC12A5 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | SLC12A5 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | slc12a5 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC572215 35 |
|
||
| slc12a5a 36 |
|
OneToMany | |||
| slc12a5b 36 |
|
OneToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | kcc 36 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | H16O14.1 37 |
|
|
|
| K02A2.3 37 |
|
|
|||
| R13A1.2 37 |
|
|
|||
| kcc-2 36 |
|
OneToMany | |||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | CCC1 35 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os08g0323700 35 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.2084 36 |
|
OneToMany |
- Species with no ortholog for SLC12A5:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for SLC12A5 Gene
Paralogs for SLC12A5 Gene
(9) SIMAP similar genes for SLC12A5 Gene using alignment to 13 proteins:
Variants for SLC12A5 Gene
| SNP ID | Clin | Chr 20 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs17297532 | - | 46,057,274(+) | TGGGC(C/T)TCCCC | reference, missense | |
| rs16985442 | - | 46,043,236(+) | GCACT(C/G)CTATC | reference, missense | |
| VAR_036557 | A colorectal cancer sample | ||||
| VAR_075078 | Epileptic encephalopathy, early infantile, 34 (EIEE34) | ||||
| VAR_075079 | Epileptic encephalopathy, early infantile, 34 (EIEE34) |
Residual Variation Intolerance Score:
2.35% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.95;
49.30% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for SLC12A5 Gene
- Human Gene Mutation Database (HGMD)
- SLC12A5
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC12A5 Gene
Disorders for SLC12A5 Gene
(5) MalaCards diseases for SLC12A5 Gene - From: ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| epileptic encephalopathy, early infantile, 34 |
|
|
| hypothalamic hamartomas |
|
|
| malignant migrating partial seizures of infancy |
|
|
| epilepsy syndrome |
|
|
| rett syndrome |
|
|
Search SLC12A5 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
S12A5_HUMAN- Epileptic encephalopathy, early infantile, 34 (EIEE34) [MIM:616645]: A form of epileptic encephalopathy, a heterogeneous group of severe childhood onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. EIEE34 is characterized by onset of refractory migrating focal seizures in infancy. Affected children show developmental regression and are severely impaired globally. {ECO:0000269 PubMed:26333769}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Relevant External Links for SLC12A5
No data available for Genatlas for SLC12A5 Gene
Publications for SLC12A5 Gene
- Heterogeneity in gene loci associated with type 2 diabetes on human chromosome 20q13.1. (PMID: 18602983) Bento J.L. … Mychaleckyj J.C. (Genomics 2008) 3 23 48 67
- Opposite effect of membrane raft perturbation on transport activity of KCC2 and NKCC1. (PMID: 19686239) Hartmann A.M. … Nothwang H.G. (J. Neurochem. 2009) 3 23
- A novel N-terminal isoform of the neuron-specific K-Cl cotransporter KCC2. (PMID: 17715129) Uvarov P. … Airaksinen M.S. (J. Biol. Chem. 2007) 3 23
- Functional and molecular characterization of multiple K-Cl cotransporter isoforms in corneal epithelial cells. (PMID: 17418819) CapA^-Aponte J.E. … Reinach P.S. (Exp. Eye Res. 2007) 23 25
- A C-terminal domain in KCC2 confers constitutive K+-Cl- cotransport. (PMID: 16291749) Mercado A. … Mount D.B. (J. Biol. Chem. 2006) 3 23
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- ViGene Biosciences ready-to-package AAV shRNAs for SLC12A5 gene
- ViGene Biosciences ready-to-package AAV shRNAs for SLC12A5 gene
- ViGene Biosciences ready-to-package AAV shRNAs for SLC12A5 gene
- Search ViGene Biosciences for SLC12A5
- Search ViGene Biosciences for SLC12A5
- Santa Cruz Biotechnology (SCBT) Antibodies for SLC12A5
- Search Santa Cruz Biotechnology (SCBT) for SLC12A5 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for SLC12A5
Sources for SLC12A5 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon