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Aliases for BIRC6 Gene

Aliases for BIRC6 Gene

  • Baculoviral IAP Repeat Containing 6 2 3
  • BIR Repeat-Containing Ubiquitin-Conjugating Enzyme 3 4
  • Ubiquitin-Conjugating BIR Domain Enzyme Apollon 3 4
  • Baculoviral IAP Repeat-Containing 6 2 3
  • KIAA1289 4 6
  • APOLLON 3 4
  • BRUCE 3 4
  • Ubiquitin-Conjugating BIR-Domain Enzyme Apollon 3
  • Baculoviral IAP Repeat-Containing Protein 6 3
  • EC 6.3.2.- 4
  • Apollon 2

External Ids for BIRC6 Gene

Previous GeneCards Identifiers for BIRC6 Gene

  • GC02P032525
  • GC02P032709
  • GC02P032556
  • GC02P032493
  • GC02P032435
  • GC02P032582
  • GC02P032320

Summaries for BIRC6 Gene

Entrez Gene Summary for BIRC6 Gene

  • This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation of apoptotic proteins by ubiquitination. [provided by RefSeq, Jul 2008]

GeneCards Summary for BIRC6 Gene

BIRC6 (Baculoviral IAP Repeat Containing 6) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Apoptosis Signaling Pathways. GO annotations related to this gene include ubiquitin-protein transferase activity and cysteine-type endopeptidase inhibitor activity. An important paralog of this gene is UBE2O.

UniProtKB/Swiss-Prot for BIRC6 Gene

  • Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification.

Gene Wiki entry for BIRC6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BIRC6 Gene

Genomics for BIRC6 Gene

Regulatory Elements for BIRC6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for BIRC6 Gene

Start:
32,356,667 bp from pter
End:
32,618,899 bp from pter
Size:
262,233 bases
Orientation:
Plus strand

Genomic View for BIRC6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BIRC6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BIRC6 Gene

Proteins for BIRC6 Gene

  • Protein details for BIRC6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NR09-BIRC6_HUMAN
    Recommended name:
    Baculoviral IAP repeat-containing protein 6
    Protein Accession:
    Q9NR09
    Secondary Accessions:
    • Q9ULD1

    Protein attributes for BIRC6 Gene

    Size:
    4857 amino acids
    Molecular mass:
    530255 Da
    Quaternary structure:
    • Homodimer. Binds the activated, processed forms of CASP3, CASP6, CASP7 and CASP9. Interacts with RNF41, DIABLO/SMAC, HTRA2, KIF23/MKLP1, USP8/UBPY, BIRC5/survivin, MAP2K1/MEK1, RAB8A/RAB8, RAB11A/RAB11, PLK1, EXOC3/SEC6 and EXOC4/SEC8.
    SequenceCaution:
    • Sequence=BAA86603.2; Type=Frameshift; Positions=2047; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for BIRC6 Gene

neXtProt entry for BIRC6 Gene

Proteomics data for BIRC6 Gene at MOPED

Post-translational modifications for BIRC6 Gene

  • Ubiquitinated. Ubiquitination is mediated by the RNF41 E3 ligase and leads to proteasomal degradation, impairing inhibition of apoptosis. Deubiquitinated by USP8/UBPY.
  • Ubiquitination at Lys416, Lys1643, Lys2265, Lys2270, Lys2277, Lys2511, Lys3854, and Lys4020
  • Modification sites at PhosphoSitePlus

Other Protein References for BIRC6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BIRC6 Gene

Domains for BIRC6 Gene

Gene Families for BIRC6 Gene

HGNC:
  • BIRC :Baculoviral IAP repeat containing
  • UBE2 :Ubiquitin-conjugating enzymes E2

Suggested Antigen Peptide Sequences for BIRC6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NR09

UniProtKB/Swiss-Prot:

BIRC6_HUMAN :
  • Q9NR09
Domain:
  • The BIR domain is essential for its antiapoptotic function and is important for binding to DIABLO/SMAC and CASP9.
Family:
  • In the C-terminal section; belongs to the ubiquitin-conjugating enzyme family.
Similarity:
  • Contains 1 BIR repeat.
genes like me logo Genes that share domains with BIRC6: view

Function for BIRC6 Gene

Molecular function for BIRC6 Gene

UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by DIABLO/SMAC, HTRA2, CASP3, CASP6, CASP7 and CASP9.
UniProtKB/Swiss-Prot Function: Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification.

Enzyme Numbers (IUBMB) for BIRC6 Gene

Gene Ontology (GO) - Molecular Function for BIRC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 15200957
GO:0004869 cysteine-type endopeptidase inhibitor activity IMP 15200957
GO:0005515 protein binding IPI 14765125
GO:0016874 ligase activity IEA --
GO:0016881 acid-amino acid ligase activity --
genes like me logo Genes that share ontologies with BIRC6: view
genes like me logo Genes that share phenotypes with BIRC6: view

Animal Models for BIRC6 Gene

MGI Knock Outs for BIRC6:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BIRC6

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for BIRC6 Gene

Localization for BIRC6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BIRC6 Gene

Golgi apparatus, trans-Golgi network membrane. Midbody. Endosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Concentrates in a pericentriolar compartment in interphase, moves partially to spindle poles in metaphase, and finally localizes to the spindle midzone and the midbody in telophase and during cytokinesis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BIRC6 Gene COMPARTMENTS Subcellular localization image for BIRC6 gene
Compartment Confidence
cytoskeleton 5
endosome 5
cytosol 3
golgi apparatus 3
plasma membrane 3

Gene Ontology (GO) - Cellular Components for BIRC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IDA 18329369
GO:0005768 endosome IDA 18329369
GO:0005802 trans-Golgi network IDA 18329369
GO:0005815 microtubule organizing center IDA 18329369
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with BIRC6: view

Pathways for BIRC6 Gene

genes like me logo Genes that share pathways with BIRC6: view

Pathways by source for BIRC6 Gene

1 Cell Signaling Technology pathway for BIRC6 Gene
1 BioSystems pathway for BIRC6 Gene
1 KEGG pathway for BIRC6 Gene
1 R&D Systems pathway for BIRC6 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for BIRC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001890 placenta development --
GO:0006464 cellular protein modification process --
GO:0006468 protein phosphorylation TAS 18329369
GO:0006915 apoptotic process IEA --
GO:0007067 mitotic nuclear division IEA --
genes like me logo Genes that share ontologies with BIRC6: view

Compounds for BIRC6 Gene

(4) HMDB Compounds for BIRC6 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2
Pyrophosphate
  • (4-)Diphosphoric acid ion
14000-31-8
genes like me logo Genes that share compounds with BIRC6: view

Transcripts for BIRC6 Gene

Unigene Clusters for BIRC6 Gene

Baculoviral IAP repeat containing 6:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BIRC6

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for BIRC6

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BIRC6 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1:
SP2:
SP3:
SP4: -
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:

ExUns: 24 ^ 25 ^ 26a · 26b · 26c ^ 27 ^ 28 ^ 29a · 29b ^ 30a · 30b · 30c ^ 31 ^ 32a · 32b · 32c ^ 33 ^ 34a · 34b ^ 35a · 35b · 35c ^ 36 ^ 37 ^ 38 ^ 39 ^
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10: - -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:

ExUns: 40 ^ 41 ^ 42 ^ 43 ^ 44 ^ 45 ^ 46 ^ 47 ^ 48 ^ 49 ^ 50 ^ 51 ^ 52a · 52b ^ 53 ^ 54 ^ 55a · 55b
SP1: -
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:

Relevant External Links for BIRC6 Gene

GeneLoc Exon Structure for
BIRC6
ECgene alternative splicing isoforms for
BIRC6

Expression for BIRC6 Gene

mRNA expression in normal human tissues for BIRC6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BIRC6 Gene

SOURCE GeneReport for Unigene cluster for BIRC6 Gene Hs.150107

mRNA Expression by UniProt/SwissProt for BIRC6 Gene

Q9NR09-BIRC6_HUMAN
Tissue specificity: Expressed in brain cancer cells
genes like me logo Genes that share expressions with BIRC6: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for BIRC6 Gene

Orthologs for BIRC6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for BIRC6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BIRC6 35
  • 99.65 (n)
  • 99.77 (a)
BIRC6 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BIRC6 35
  • 93.53 (n)
  • 97.74 (a)
BIRC6 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BIRC6 35
  • 93.74 (n)
  • 97.76 (a)
BIRC6 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Birc6 35
  • 89.26 (n)
  • 95.51 (a)
Birc6 16
Birc6 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BIRC6 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BIRC6 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Birc6 35
  • 89.7 (n)
  • 96.01 (a)
chicken
(Gallus gallus)
Aves BIRC6 35
  • 83.41 (n)
  • 92.78 (a)
BIRC6 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BIRC6 36
  • 90 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.32494 35
tropical clawed frog
(Silurana tropicalis)
Amphibia birc6 35
  • 76.9 (n)
  • 87.04 (a)
Str.10024 35
zebrafish
(Danio rerio)
Actinopterygii birc6 35
  • 71.06 (n)
  • 82.45 (a)
birc6 36
  • 79 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002651 35
  • 46.13 (n)
  • 40 (a)
fruit fly
(Drosophila melanogaster)
Insecta Bruce 35
  • 47.41 (n)
  • 40.28 (a)
Bruce 36
  • 32 (a)
OneToOne
Bruce 37
  • 51 (a)
worm
(Caenorhabditis elegans)
Secernentea ubc-17 36
  • 33 (a)
OneToOne
ubc-17 37
  • 52 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.9070 35
Species with no ortholog for BIRC6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for BIRC6 Gene

ENSEMBL:
Gene Tree for BIRC6 (if available)
TreeFam:
Gene Tree for BIRC6 (if available)

Paralogs for BIRC6 Gene

Paralogs for BIRC6 Gene

Selected SIMAP similar genes for BIRC6 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with BIRC6: view

Variants for BIRC6 Gene

Sequence variations from dbSNP and Humsavar for BIRC6 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs15695 -- 32,528,847(-) acatc(A/C)cttat intron-variant
rs176399 -- 32,407,470(+) AAAGA(A/T)TTAGA intron-variant
rs176400 -- 32,408,501(+) TTGCT(A/G)TGTTA intron-variant
rs176401 -- 32,411,443(+) ttttt(A/T)aattt intron-variant
rs176402 -- 32,412,769(+) AGTGG(C/T)GAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BIRC6 Gene

Variant ID Type Subtype PubMed ID
esv2422335 CNV Duplication 17116639
esv2751888 CNV Gain 17911159
nsv516173 CNV Gain+Loss 19592680
nsv873780 CNV Loss 21882294
dgv443n27 CNV Gain 19166990
nsv833681 CNV Gain+Loss 17160897
nsv470447 CNV Loss 18288195
nsv833692 CNV Loss 17160897
esv2422472 CNV Duplication 17116639
esv2719881 CNV Deletion 23290073
nsv873781 CNV Loss 21882294
nsv470448 CNV Gain 18288195
nsv456108 CNV Gain 19166990
nsv873782 CNV Loss 21882294
nsv873783 CNV Gain 21882294
nsv873784 CNV Gain 21882294
esv2464710 CNV Deletion 19546169
nsv833703 CNV Loss 17160897
esv2664912 CNV Deletion 23128226

Relevant External Links for BIRC6 Gene

HapMap Linkage Disequilibrium report
BIRC6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BIRC6 Gene

Disorders for BIRC6 Gene

Relevant External Links for BIRC6

Genetic Association Database (GAD)
BIRC6
Human Genome Epidemiology (HuGE) Navigator
BIRC6
genes like me logo Genes that share disorders with BIRC6: view

No data available for UniProtKB/Swiss-Prot for BIRC6 Gene

Publications for BIRC6 Gene

  1. A human IAP-family gene, apollon, expressed in human brain cancer cells. (PMID: 10544019) Chen Z. … Tsuruo T. (Biochem. Biophys. Res. Commun. 1999) 2 3 4 23
  2. Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis. (PMID: 14765125) Qiu X.B. … Goldberg A.L. (EMBO J. 2004) 3 4 23
  3. Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase. (PMID: 15200957) Bartke T. … Jentsch S. (Mol. Cell 2004) 3 4 23
  4. The membrane-associated inhibitor of apoptosis protein, BRUCE/Apollon, antagonizes both the precursor and mature forms of Smac and caspase-9. (PMID: 15507451) Qiu X.B. … Goldberg A.L. (J. Biol. Chem. 2005) 3 23
  5. HtrA2 cleaves Apollon and induces cell death by IAP-binding motif in Apollon-deficient cells. (PMID: 15781261) Sekine K. … Naito M. (Biochem. Biophys. Res. Commun. 2005) 3 23

Products for BIRC6 Gene

Sources for BIRC6 Gene

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