Aliases for NDRG2 Gene
External Ids for NDRG2 Gene
Previous GeneCards Identifiers for NDRG2 Gene
This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may play a role in neurite outgrowth. This gene may be involved in glioblastoma carcinogenesis. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for NDRG2 Gene
NDRG2 (NDRG Family Member 2) is a Protein Coding gene. Diseases associated with NDRG2 include Glioblastoma and Charcot-Marie-Tooth Disease, Type 4D. Among its related pathways are Validated targets of C-MYC transcriptional repression and Apoptosis and Autophagy. An important paralog of this gene is NDRG4.
UniProtKB/Swiss-Prot for NDRG2 Gene
Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation.