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Aliases for NDRG2 Gene

Aliases for NDRG2 Gene

  • NDRG Family Member 2 2 3
  • N-Myc Downstream-Regulated Gene 2 Protein 3 4
  • SYLD 3 4
  • N-Myc Downstream Regulator 2 3
  • NDR1-Related Protein NDR2 3
  • Cytoplasmic Protein Ndr1 3
  • Syld709613 Protein 3
  • Protein Syld709613 4
  • Protein NDRG2 3
  • KIAA1248 4

External Ids for NDRG2 Gene

Previous GeneCards Identifiers for NDRG2 Gene

  • GC14M018857
  • GC14M015272
  • GC14M019476
  • GC14M019477
  • GC14M019478
  • GC14M020554
  • GC14M021484
  • GC14M001606

Summaries for NDRG2 Gene

Entrez Gene Summary for NDRG2 Gene

  • This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may play a role in neurite outgrowth. This gene may be involved in glioblastoma carcinogenesis. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for NDRG2 Gene

NDRG2 (NDRG Family Member 2) is a Protein Coding gene. Diseases associated with NDRG2 include glioblastoma. Among its related pathways are Angiogenesis (CST) and Apoptosis and Autophagy. An important paralog of this gene is NDRG1.

UniProtKB/Swiss-Prot for NDRG2 Gene

  • Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation.

Gene Wiki entry for NDRG2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDRG2 Gene

Genomics for NDRG2 Gene

Regulatory Elements for NDRG2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NDRG2 Gene

Start:
21,016,763 bp from pter
End:
21,070,872 bp from pter
Size:
54,110 bases
Orientation:
Minus strand

Genomic View for NDRG2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NDRG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDRG2 Gene

Proteins for NDRG2 Gene

  • Protein details for NDRG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UN36-NDRG2_HUMAN
    Recommended name:
    Protein NDRG2
    Protein Accession:
    Q9UN36
    Secondary Accessions:
    • B3KUE3
    • B4DE86
    • B7WP11
    • B7WPD5
    • D3DS07
    • D3DS10
    • Q567T1
    • Q68DW2
    • Q86U08
    • Q86U46
    • Q96FD3
    • Q96FT0
    • Q96JU0
    • Q96PN0
    • Q9BQH5
    • Q9ULH2

    Protein attributes for NDRG2 Gene

    Size:
    371 amino acids
    Molecular mass:
    40798 Da
    Quaternary structure:
    • Interacts with CTNNB1.
    SequenceCaution:
    • Sequence=BAA86562.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAD62350.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NDRG2 Gene

    Alternative splice isoforms for NDRG2 Gene

neXtProt entry for NDRG2 Gene

Proteomics data for NDRG2 Gene at MOPED

Post-translational modifications for NDRG2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for NDRG2 (NDRG2)

No data available for DME Specific Peptides for NDRG2 Gene

Domains for NDRG2 Gene

Protein Domains for NDRG2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for NDRG2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UN36

UniProtKB/Swiss-Prot:

NDRG2_HUMAN :
  • Q9UN36
Family:
  • Belongs to the NDRG family.
genes like me logo Genes that share domains with NDRG2: view

No data available for Gene Families for NDRG2 Gene

Function for NDRG2 Gene

Molecular function for NDRG2 Gene

UniProtKB/Swiss-Prot Function: Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation.

Gene Ontology (GO) - Molecular Function for NDRG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 21217774
genes like me logo Genes that share ontologies with NDRG2: view

Phenotypes for NDRG2 Gene

MGI mutant phenotypes for NDRG2:
inferred from 2 alleles
GenomeRNAi human phenotypes for NDRG2:
genes like me logo Genes that share phenotypes with NDRG2: view

Animal Models for NDRG2 Gene

MGI Knock Outs for NDRG2:

Animal Model Products

CRISPR Products

miRNA for NDRG2 Gene

miRTarBase miRNAs that target NDRG2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NDRG2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for NDRG2 Gene

Localization for NDRG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDRG2 Gene

Cytoplasm. Cytoplasm, perinuclear region. Cell projection, growth cone. Note=In neurons, seems to concentrate at axonal growth cone. Perinuclear in neurons (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NDRG2 Gene COMPARTMENTS Subcellular localization image for NDRG2 gene
Compartment Confidence
cytosol 5
cytoskeleton 4
golgi apparatus 4
nucleus 4

Gene Ontology (GO) - Cellular Components for NDRG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005794 Golgi apparatus IDA --
GO:0005813 centrosome IDA --
genes like me logo Genes that share ontologies with NDRG2: view

Pathways for NDRG2 Gene

genes like me logo Genes that share pathways with NDRG2: view

Pathways by source for NDRG2 Gene

3 Cell Signaling Technology pathways for NDRG2 Gene
1 BioSystems pathway for NDRG2 Gene

Gene Ontology (GO) - Biological Process for NDRG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001818 negative regulation of cytokine production IEA --
GO:0007165 signal transduction IBA --
GO:0010574 regulation of vascular endothelial growth factor production IEA --
GO:0016055 Wnt signaling pathway IEA --
GO:0021762 substantia nigra development IEP 22926577
genes like me logo Genes that share ontologies with NDRG2: view

Transcripts for NDRG2 Gene

Unigene Clusters for NDRG2 Gene

NDRG family member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NDRG2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NDRG2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b · 8c · 8d ^
SP1: - - - - - - - - - - - - -
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ExUns: 9a · 9b · 9c · 9d ^ 10a · 10b · 10c ^ 11a · 11b · 11c · 11d · 11e · 11f · 11g · 11h ^ 12a · 12b · 12c · 12d · 12e · 12f · 12g · 12h ^ 13a · 13b · 13c ·
SP1: - - - - - - - - - - - - - -
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SP42: - - -
SP43: -
SP44:
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ExUns: 13d · 13e ^ 14a · 14b ^ 15a · 15b · 15c · 15d ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24a · 24b · 24c
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - -
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Relevant External Links for NDRG2 Gene

GeneLoc Exon Structure for
NDRG2
ECgene alternative splicing isoforms for
NDRG2

Expression for NDRG2 Gene

mRNA expression in normal human tissues for NDRG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NDRG2 Gene

SOURCE GeneReport for Unigene cluster for NDRG2 Gene Hs.525205

mRNA Expression by UniProt/SwissProt for NDRG2 Gene

Q9UN36-NDRG2_HUMAN
Tissue specificity: Highly expressed in brain, heart, skeletal muscle and salivary gland, and moderately in kidney and liver. Expressed in dendritic cells, but not in other blood cells. Expression levels are low in pancreatic and liver cancer tissues; absent in meningioma. Expressed in low-grade gliomas but present at low levels in glioblastoma. Isoform 1 and isoform 2 are present in brain neurons and up-regulated in Alzheimer disease (at protein level).
genes like me logo Genes that share expressions with NDRG2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for NDRG2 Gene

Orthologs for NDRG2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NDRG2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NDRG2 35
  • 99.16 (n)
  • 98.32 (a)
NDRG2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NDRG2 35
  • 92.34 (n)
  • 96.08 (a)
NDRG2 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NDRG2 35
  • 91.73 (n)
  • 96.5 (a)
NDRG2 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ndrg2 35
  • 90.66 (n)
  • 95.69 (a)
Ndrg2 16
Ndrg2 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NDRG2 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NDRG2 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ndrg2 35
  • 90.66 (n)
  • 96.23 (a)
lizard
(Anolis carolinensis)
Reptilia NDRG2 36
  • 69 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia ndrg2-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ndrg2 35
  • 70.19 (n)
  • 75 (a)
Str.6843 35
zebrafish
(Danio rerio)
Actinopterygii ndrg2 35
  • 68.49 (n)
  • 70.14 (a)
ndrg2 36
  • 69 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG2082 36
  • 26 (a)
ManyToMany
MESK2 36
  • 25 (a)
ManyToMany
MESK2 37
  • 38 (a)
BcDNA:GH02439 37
  • 29 (a)
worm
(Caenorhabditis elegans)
Secernentea Y48G10A.3 36
  • 29 (a)
ManyToMany
ZK1073.1 36
  • 23 (a)
ManyToMany
Y48G10A.3 37
  • 30 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons NDL2 35
  • 45.88 (n)
  • 34.69 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7991 36
  • 35 (a)
OneToMany
Species with no ortholog for NDRG2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NDRG2 Gene

ENSEMBL:
Gene Tree for NDRG2 (if available)
TreeFam:
Gene Tree for NDRG2 (if available)

Paralogs for NDRG2 Gene

Paralogs for NDRG2 Gene

genes like me logo Genes that share paralogs with NDRG2: view

Variants for NDRG2 Gene

Sequence variations from dbSNP and Humsavar for NDRG2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs10196 -- 21,017,347(+) TAACA(C/T)CAAAA utr-variant-3-prime
rs768531 -- 21,027,974(+) CCCAT(A/G)TATTA intron-variant
rs768532 -- 21,027,908(-) TTCAT(A/G)CTCTC intron-variant
rs943999 -- 21,039,324(+) AACAG(A/C)AGTGA intron-variant
rs1052322 -- 21,016,810(-) CTCCC(A/C)CAACT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NDRG2 Gene

Variant ID Type Subtype PubMed ID
nsv428293 CNV Gain+Loss 18775914
nsv832740 CNV Gain 17160897

Relevant External Links for NDRG2 Gene

HapMap Linkage Disequilibrium report
NDRG2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NDRG2 Gene

Disorders for NDRG2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for NDRG2 Gene including...

Search for NDRG2 Gene in MalaCards »

(1) Novoseek inferred disease relationships for NDRG2 Gene

Disease -log(P) Hits PubMed IDs
tumors 33.1 22

Relevant External Links for NDRG2

Genetic Association Database (GAD)
NDRG2
genes like me logo Genes that share disorders with NDRG2: view

No data available for UniProtKB/Swiss-Prot for NDRG2 Gene

Publications for NDRG2 Gene

  1. Characterization and expression of three novel differentiation- related genes belong to the human NDRG gene family. (PMID: 11936845) Qu X. … He F. (Mol. Cell. Biochem. 2002) 3 4 23
  2. N-Myc downstream-regulated gene 2 (NDRG2) inhibits glioblastoma cell proliferation. (PMID: 12845671) Deng Y. … Lin M.C.-M. (Int. J. Cancer 2003) 3 4 23
  3. Expression and regulation of NDRG2 (N-myc downstream regulated gene 2) during the differentiation of dendritic cells. (PMID: 14572661) Choi S.-C. … Lim J.-S. (FEBS Lett. 2003) 3 4 23
  4. The repression of human differentiation-related gene NDRG2 expression by Myc via Miz-1-dependent interaction with the NDRG2 core promoter. (PMID: 17050536) Zhang J. … Yao L. (J. Biol. Chem. 2006) 3 23
  5. Expression of human NDRG2 by myeloid dendritic cells inhibits down-regulation of activated leukocyte cell adhesion molecule (ALCAM) and contributes to maintenance of T cell stimulatory activity. (PMID: 17911180) Choi S.C. … Lim J.S. (J. Leukoc. Biol. 2008) 3 23

Products for NDRG2 Gene

Sources for NDRG2 Gene

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