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Aliases for ABHD6 Gene

Aliases for ABHD6 Gene

  • Abhydrolase Domain Containing 6 2 3
  • EC 3.1.1.23 4 64
  • Abhydrolase Domain-Containing Protein 6 4
  • 2-Arachidonoylglycerol Hydrolase 4

External Ids for ABHD6 Gene

Summaries for ABHD6 Gene

GeneCards Summary for ABHD6 Gene

ABHD6 (Abhydrolase Domain Containing 6) is a Protein Coding gene. Among its related pathways are Circadian entrainment and triacylglycerol degradation. GO annotations related to this gene include acylglycerol lipase activity.

UniProtKB/Swiss-Prot for ABHD6 Gene

  • Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol (PubMed:22969151). Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways. May also have a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids (By similarity).

Tocris Summary for ABHD6 Gene

  • ABHD6 encodes a serine hydrolase enzyme known as alpha/beta-hydrolase domain 6. This enzyme catalyzes the hydrolysis of 2-arachidonylglycerol.

No data available for Entrez Gene Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABHD6 Gene

Genomics for ABHD6 Gene

Genomic Location for ABHD6 Gene

Start:
58,237,506 bp from pter
End:
58,295,693 bp from pter
Size:
58,188 bases
Orientation:
Plus strand

Genomic View for ABHD6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ABHD6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABHD6 Gene

Regulatory Elements for ABHD6 Gene

Proteins for ABHD6 Gene

  • Protein details for ABHD6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BV23-ABHD6_HUMAN
    Recommended name:
    Monoacylglycerol lipase ABHD6
    Protein Accession:
    Q9BV23
    Secondary Accessions:
    • B2R7Y9
    • Q6ZMF7

    Protein attributes for ABHD6 Gene

    Size:
    337 amino acids
    Molecular mass:
    38331 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ABHD6 Gene

Proteomics data for ABHD6 Gene at MOPED

Post-translational modifications for ABHD6 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys223

Other Protein References for ABHD6 Gene

Domains for ABHD6 Gene

Gene Families for ABHD6 Gene

HGNC:
  • ABHD :Abhydrolase domain containing

UniProtKB/Swiss-Prot:

ABHD6_HUMAN
Family:
  • Belongs to the AB hydrolase superfamily.:
    • Q9BV23
genes like me logo Genes that share domains with ABHD6: view

Function for ABHD6 Gene

Molecular function for ABHD6 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=159 uM for 2-arachidonoyglycerol {ECO:0000269 PubMed:22969151}; Vmax=45 nmol/min/mg enzyme toward 2-arachidonoyglycerol {ECO:0000269 PubMed:22969151}; pH dependence: Optimum pH is 7.2-9 with 2-arachidonoyglycerol as substrate. {ECO:0000269 PubMed:22969151};
UniProtKB/Swiss-Prot CatalyticActivity: Hydrolyzes glycerol monoesters of long-chain fatty acids.
UniProtKB/Swiss-Prot Function: Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol (PubMed:22969151). Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways. May also have a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids (By similarity).

Enzyme Numbers (IUBMB) for ABHD6 Gene

Gene Ontology (GO) - Molecular Function for ABHD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0047372 acylglycerol lipase activity IDA 22969151
genes like me logo Genes that share ontologies with ABHD6: view

Phenotypes for ABHD6 Gene

genes like me logo Genes that share phenotypes with ABHD6: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ABHD6 Gene

Localization for ABHD6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABHD6 Gene

Membrane; Single-pass type II membrane protein. Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ABHD6 Gene COMPARTMENTS Subcellular localization image for ABHD6 gene
Compartment Confidence
extracellular 2
mitochondrion 2
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ABHD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0016021 integral component of membrane ISS --
GO:0032281 alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with ABHD6: view

Pathways for ABHD6 Gene

genes like me logo Genes that share pathways with ABHD6: view

Pathways by source for ABHD6 Gene

1 BioSystems pathway for ABHD6 Gene
1 KEGG pathway for ABHD6 Gene

Interacting Proteins for ABHD6 Gene

Gene Ontology (GO) - Biological Process for ABHD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process --
GO:0030336 negative regulation of cell migration IEA --
GO:0046464 acylglycerol catabolic process IDA 22969151
GO:0060292 long term synaptic depression IEA --
GO:2000124 regulation of endocannabinoid signaling pathway IEA --
genes like me logo Genes that share ontologies with ABHD6: view

Compounds for ABHD6 Gene

(5) Tocris Compounds for ABHD6 Gene

Compound Action Cas Number
(Z)-Pugnac O-GlcNAcase and beta-hexosaminidase inhibitor [132489-69-1]
Flurofamide Urease inhibitor [70788-28-2]
JW 480 Potent and selective inhibitor of serine hydrolase KIAA1363 (AADACL1) [1354359-53-7]
Thiamet G Potent O-GlcNAcase inhibitor [1009816-48-1]
WWL 70 Potent ABHD6 inhibitor [947669-91-2]
genes like me logo Genes that share compounds with ABHD6: view

Transcripts for ABHD6 Gene

Unigene Clusters for ABHD6 Gene

Abhydrolase domain containing 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ABHD6 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
SP1:
SP2: -
SP3:
SP4: -

Relevant External Links for ABHD6 Gene

GeneLoc Exon Structure for
ABHD6
ECgene alternative splicing isoforms for
ABHD6

Expression for ABHD6 Gene

mRNA expression in normal human tissues for ABHD6 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ABHD6 Gene

SOURCE GeneReport for Unigene cluster for ABHD6 Gene Hs.476454

genes like me logo Genes that share expressions with ABHD6: view

Orthologs for ABHD6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ABHD6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ABHD6 36
  • 99.7 (n)
  • 99.7 (a)
ABHD6 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ABHD6 36
  • 90.7 (n)
  • 94.96 (a)
ABHD6 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ABHD6 36
  • 91.3 (n)
  • 96.44 (a)
ABHD6 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Abhd6 36
  • 90.12 (n)
  • 94.01 (a)
Abhd6 16
Abhd6 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ABHD6 37
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ABHD6 37
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Abhd6 36
  • 88.33 (n)
  • 93.77 (a)
chicken
(Gallus gallus)
Aves ABHD6 36
  • 74.93 (n)
  • 80.3 (a)
ABHD6 37
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ABHD6 37
  • 69 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia abhd6-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia abhd6 36
  • 71.12 (n)
  • 75.67 (a)
zebrafish
(Danio rerio)
Actinopterygii abhd6a 36
  • 67.16 (n)
  • 69.64 (a)
abhd6a 37
  • 69 (a)
OneToMany
abhd6b 37
  • 64 (a)
OneToMany
Dr.13980 36
Species with no ortholog for ABHD6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ABHD6 Gene

ENSEMBL:
Gene Tree for ABHD6 (if available)
TreeFam:
Gene Tree for ABHD6 (if available)

Paralogs for ABHD6 Gene

No data available for Paralogs for ABHD6 Gene

Variants for ABHD6 Gene

Sequence variations from dbSNP and Humsavar for ABHD6 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs6924 -- 58,294,334(-) GGGCT(A/G)GAGCA utr-variant-3-prime
rs6925 -- 58,294,362(+) GCAGG(A/G)TACAT utr-variant-3-prime
rs8723 -- 58,294,584(+) TTTCA(A/G)TGTGC utr-variant-3-prime
rs9986 -- 58,294,679(+) TAAAC(A/G)GCTGT utr-variant-3-prime
rs14896 -- 58,294,571(-) GAAAA(A/G)AGGCC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ABHD6 Gene

Variant ID Type Subtype PubMed ID
nsv528147 CNV Gain 19592680
nsv834703 CNV Gain 17160897
esv2660248 CNV Deletion 23128226

Relevant External Links for ABHD6 Gene

HapMap Linkage Disequilibrium report
ABHD6

Disorders for ABHD6 Gene

No disorders were found for ABHD6 Gene.

No data available for UniProtKB/Swiss-Prot for ABHD6 Gene

Publications for ABHD6 Gene

  1. Biochemical and pharmacological characterization of human I+/I^-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12). (PMID: 22969151) Navia-Paldanius D. … Laitinen J.T. (J. Lipid Res. 2012) 2 3 4
  2. An unannotated alpha/beta hydrolase superfamily member, ABHD6 differentially expressed among cancer cell lines. (PMID: 18360779) Li F. … Ji C. (Mol. Biol. Rep. 2009) 3 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for ABHD6 Gene

Sources for ABHD6 Gene

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