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Aliases for ABHD6 Gene

Aliases for ABHD6 Gene

  • Abhydrolase Domain Containing 6 2 3
  • EC 3.1.1.23 4 63
  • Abhydrolase Domain-Containing Protein 6 4
  • 2-Arachidonoylglycerol Hydrolase 4

External Ids for ABHD6 Gene

Previous GeneCards Identifiers for ABHD6 Gene

  • GC03P058078
  • GC03P058180

Summaries for ABHD6 Gene

GeneCards Summary for ABHD6 Gene

ABHD6 (Abhydrolase Domain Containing 6) is a Protein Coding gene. Among its related pathways are Circadian entrainment and triacylglycerol degradation. GO annotations related to this gene include acylglycerol lipase activity.

UniProtKB/Swiss-Prot for ABHD6 Gene

  • Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol (PubMed:22969151). Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways. May also have a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids (By similarity).

Tocris Summary for ABHD6 Gene

  • ABHD6 encodes a serine hydrolase enzyme known as alpha/beta-hydrolase domain 6. This enzyme catalyzes the hydrolysis of 2-arachidonylglycerol.

No data available for Entrez Gene Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABHD6 Gene

Genomics for ABHD6 Gene

Regulatory Elements for ABHD6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ABHD6 Gene

Start:
58,237,506 bp from pter
End:
58,295,693 bp from pter
Size:
58,188 bases
Orientation:
Plus strand

Genomic View for ABHD6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ABHD6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABHD6 Gene

Proteins for ABHD6 Gene

  • Protein details for ABHD6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BV23-ABHD6_HUMAN
    Recommended name:
    Monoacylglycerol lipase ABHD6
    Protein Accession:
    Q9BV23
    Secondary Accessions:
    • B2R7Y9
    • Q6ZMF7

    Protein attributes for ABHD6 Gene

    Size:
    337 amino acids
    Molecular mass:
    38331 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ABHD6 Gene

Proteomics data for ABHD6 Gene at MOPED

Post-translational modifications for ABHD6 Gene

  • Ubiquitination at Lys223
  • Modification sites at PhosphoSitePlus

Other Protein References for ABHD6 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for ABHD6

Domains for ABHD6 Gene

Gene Families for ABHD6 Gene

HGNC:
  • ABHD :Abhydrolase domain containing

Suggested Antigen Peptide Sequences for ABHD6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BV23

UniProtKB/Swiss-Prot:

ABHD6_HUMAN :
  • Q9BV23
Family:
  • Belongs to the AB hydrolase superfamily.
genes like me logo Genes that share domains with ABHD6: view

Function for ABHD6 Gene

Molecular function for ABHD6 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=159 uM for 2-arachidonoyglycerol {ECO:0000269 PubMed:22969151}; Vmax=45 nmol/min/mg enzyme toward 2-arachidonoyglycerol {ECO:0000269 PubMed:22969151}; pH dependence: Optimum pH is 7.2-9 with 2-arachidonoyglycerol as substrate. {ECO:0000269 PubMed:22969151};
UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolyzes glycerol monoesters of long-chain fatty acids.
UniProtKB/Swiss-Prot Function:
Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol (PubMed:22969151). Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways. May also have a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids (By similarity).

Enzyme Numbers (IUBMB) for ABHD6 Gene

Gene Ontology (GO) - Molecular Function for ABHD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0047372 acylglycerol lipase activity IDA 22969151
genes like me logo Genes that share ontologies with ABHD6: view

Phenotypes for ABHD6 Gene

genes like me logo Genes that share phenotypes with ABHD6: view

Animal Model Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ABHD6 Gene

Localization for ABHD6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABHD6 Gene

Membrane; Single-pass type II membrane protein. Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ABHD6 Gene COMPARTMENTS Subcellular localization image for ABHD6 gene
Compartment Confidence
extracellular 2
mitochondrion 2
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ABHD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0016021 integral component of membrane ISS --
GO:0032281 alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with ABHD6: view

Pathways for ABHD6 Gene

genes like me logo Genes that share pathways with ABHD6: view

Pathways by source for ABHD6 Gene

1 BioSystems pathway for ABHD6 Gene
1 KEGG pathway for ABHD6 Gene

Interacting Proteins for ABHD6 Gene

Gene Ontology (GO) - Biological Process for ABHD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process --
GO:0030336 negative regulation of cell migration IEA --
GO:0046464 acylglycerol catabolic process IDA 22969151
GO:0060292 long term synaptic depression IEA --
GO:2000124 regulation of endocannabinoid signaling pathway IEA --
genes like me logo Genes that share ontologies with ABHD6: view

Compounds for ABHD6 Gene

(5) Tocris Compounds for ABHD6 Gene

Compound Action Cas Number
(Z)-Pugnac O-GlcNAcase and beta-hexosaminidase inhibitor [132489-69-1]
Flurofamide Urease inhibitor [70788-28-2]
ML 348 Selective and reversible lysophospholipase 1 (LYPLA1) inhibitor [899713-86-1]
SCH 51344 Potent MTH1 inhibitor [171927-40-5]
WWL 70 Potent ABHD6 inhibitor [947669-91-2]
genes like me logo Genes that share compounds with ABHD6: view

Transcripts for ABHD6 Gene

Unigene Clusters for ABHD6 Gene

Abhydrolase domain containing 6:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ABHD6

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ABHD6 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
SP1:
SP2: -
SP3:
SP4: -

Relevant External Links for ABHD6 Gene

GeneLoc Exon Structure for
ABHD6
ECgene alternative splicing isoforms for
ABHD6

Expression for ABHD6 Gene

mRNA expression in normal human tissues for ABHD6 Gene

Protein differential expression in normal tissues for ABHD6 Gene

This gene is overexpressed in Nasal epithelium (44.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ABHD6 Gene

SOURCE GeneReport for Unigene cluster for ABHD6 Gene Hs.476454

genes like me logo Genes that share expressions with ABHD6: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for ABHD6 Gene

Orthologs for ABHD6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ABHD6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ABHD6 35
  • 90.7 (n)
  • 94.96 (a)
ABHD6 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ABHD6 35
  • 91.3 (n)
  • 96.44 (a)
ABHD6 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Abhd6 35
  • 90.12 (n)
  • 94.01 (a)
Abhd6 16
Abhd6 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ABHD6 35
  • 99.7 (n)
  • 99.7 (a)
ABHD6 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Abhd6 35
  • 88.33 (n)
  • 93.77 (a)
oppossum
(Monodelphis domestica)
Mammalia ABHD6 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ABHD6 36
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves ABHD6 35
  • 74.93 (n)
  • 80.3 (a)
ABHD6 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ABHD6 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia abhd6 35
  • 71.12 (n)
  • 75.67 (a)
African clawed frog
(Xenopus laevis)
Amphibia abhd6-prov 35
zebrafish
(Danio rerio)
Actinopterygii abhd6a 35
  • 67.16 (n)
  • 69.64 (a)
Dr.13980 35
abhd6a 36
  • 69 (a)
OneToMany
abhd6b 36
  • 64 (a)
OneToMany
Species with no ortholog for ABHD6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ABHD6 Gene

ENSEMBL:
Gene Tree for ABHD6 (if available)
TreeFam:
Gene Tree for ABHD6 (if available)

Paralogs for ABHD6 Gene

No data available for Paralogs for ABHD6 Gene

Variants for ABHD6 Gene

Sequence variations from dbSNP and Humsavar for ABHD6 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs6924 -- 58,294,334(-) GGGCT(A/G)GAGCA utr-variant-3-prime
rs6925 -- 58,294,362(+) GCAGG(A/G)TACAT utr-variant-3-prime
rs8723 -- 58,294,584(+) TTTCA(A/G)TGTGC utr-variant-3-prime
rs9986 -- 58,294,679(+) TAAAC(A/G)GCTGT utr-variant-3-prime
rs14896 -- 58,294,571(-) GAAAA(A/G)AGGCC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ABHD6 Gene

Variant ID Type Subtype PubMed ID
nsv528147 CNV Gain 19592680
nsv834703 CNV Gain 17160897
esv2660248 CNV Deletion 23128226

Relevant External Links for ABHD6 Gene

HapMap Linkage Disequilibrium report
ABHD6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABHD6 Gene

Disorders for ABHD6 Gene

No disorders were found for ABHD6 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for ABHD6 Gene

Publications for ABHD6 Gene

  1. Biochemical and pharmacological characterization of human I+/I^-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12). (PMID: 22969151) Navia-Paldanius D. … Laitinen J.T. (J. Lipid Res. 2012) 2 3 4
  2. An unannotated alpha/beta hydrolase superfamily member, ABHD6 differentially expressed among cancer cell lines. (PMID: 18360779) Li F. … Ji C. (Mol. Biol. Rep. 2009) 3 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for ABHD6 Gene

Sources for ABHD6 Gene

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