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Aliases for PTGIS Gene

Aliases for PTGIS Gene

  • Prostaglandin I2 (Prostacyclin) Synthase 2 3 5
  • Prostaglandin I2 Synthase 3 4
  • CYP8A1 3 4
  • CYP8 3 4
  • Cytochrome P450, Family 8, Subfamily A, Polypeptide 1 3
  • Cytochrome P450 2
  • Polypeptide 1 2
  • Subfamily A 2
  • EC 5.3.99.4 4
  • Family 8 2
  • PGIS 3
  • PTGI 3

External Ids for PTGIS Gene

Previous GeneCards Identifiers for PTGIS Gene

  • GC20M047848
  • GC20M048758
  • GC20M048805
  • GC20M047553
  • GC20M048120
  • GC20M044868

Summaries for PTGIS Gene

Entrez Gene Summary for PTGIS Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis. [provided by RefSeq, Jul 2008]

GeneCards Summary for PTGIS Gene

PTGIS (Prostaglandin I2 (Prostacyclin) Synthase) is a Protein Coding gene. Diseases associated with PTGIS include hypertension, essential and stroke, ischemic. Among its related pathways are Linoleic acid metabolism and Metabolism. GO annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP8B1.

UniProtKB/Swiss-Prot for PTGIS Gene

  • Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2).

Gene Wiki entry for PTGIS Gene

PharmGKB "VIP" Summary for PTGIS Gene

No data available for Tocris Summary , fRNAdb sequence ontologies and piRNA Summary for PTGIS Gene

Genomics for PTGIS Gene

Regulatory Elements for PTGIS Gene

Enhancers for PTGIS Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PTGIS on UCSC Golden Path with GeneCards custom track

Promoters for PTGIS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PTGIS on UCSC Golden Path with GeneCards custom track

Genomic Location for PTGIS Gene

Chromosome:
20
Start:
49,503,874 bp from pter
End:
49,568,170 bp from pter
Size:
64,297 bases
Orientation:
Minus strand

Genomic View for PTGIS Gene

Genes around PTGIS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTGIS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTGIS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTGIS Gene

Proteins for PTGIS Gene

  • Protein details for PTGIS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16647-PTGIS_HUMAN
    Recommended name:
    Prostacyclin synthase
    Protein Accession:
    Q16647
    Secondary Accessions:
    • Q3MII8
    • Q9HAX2
    • Q9HAX3
    • Q9HAX4

    Protein attributes for PTGIS Gene

    Size:
    500 amino acids
    Molecular mass:
    57104 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PTGIS Gene

neXtProt entry for PTGIS Gene

Proteomics data for PTGIS Gene at MOPED

Post-translational modifications for PTGIS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PTGIS Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for PTGIS (Prostaglandin I2 Synthase)

No data available for DME Specific Peptides for PTGIS Gene

Domains & Families for PTGIS Gene

Gene Families for PTGIS Gene

Protein Domains for PTGIS Gene

Suggested Antigen Peptide Sequences for PTGIS Gene

Graphical View of Domain Structure for InterPro Entry

Q16647

UniProtKB/Swiss-Prot:

PTGIS_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with PTGIS: view

Function for PTGIS Gene

Molecular function for PTGIS Gene

GENATLAS Biochemistry:
prostaglandin 12 synthase
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=9.55 uM for 6-keto-PGF1alpha {ECO:0000269 PubMed:25623425}; Vmax=534 mmol/min/pg enzyme {ECO:0000269 PubMed:25623425};
UniProtKB/Swiss-Prot CatalyticActivity:
(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-6,9-alpha-epoxy-11-alpha,15-dihydroxyprosta-5,13-dienoate.
UniProtKB/Swiss-Prot Function:
Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2).

Enzyme Numbers (IUBMB) for PTGIS Gene

genes like me logo Genes that share phenotypes with PTGIS: view

Human Phenotype Ontology for PTGIS Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PTGIS Gene

MGI Knock Outs for PTGIS:

Animal Model Products

  • Taconic Biosciences Mouse Models for PTGIS

miRNA for PTGIS Gene

miRTarBase miRNAs that target PTGIS

No data available for Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for PTGIS Gene

Localization for PTGIS Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTGIS Gene

Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTGIS Gene COMPARTMENTS Subcellular localization image for PTGIS gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
nucleus 5
plasma membrane 5
golgi apparatus 2
peroxisome 2
cytosol 1
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for PTGIS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 21035466
genes like me logo Genes that share ontologies with PTGIS: view

Pathways & Interactions for PTGIS Gene

genes like me logo Genes that share pathways with PTGIS: view

Interacting Proteins for PTGIS Gene

Gene Ontology (GO) - Biological Process for PTGIS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001516 prostaglandin biosynthetic process IDA 20122998
GO:0006766 vitamin metabolic process TAS --
GO:0006767 water-soluble vitamin metabolic process TAS --
GO:0007566 embryo implantation IEA --
GO:0019369 arachidonic acid metabolic process TAS --
genes like me logo Genes that share ontologies with PTGIS: view

No data available for SIGNOR curated interactions for PTGIS Gene

Drugs & Compounds for PTGIS Gene

(11) Drugs for PTGIS Gene - From: DrugBank, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phenylbutazone Approved Pharma inhibitor, Target 0
Epoprostenol Approved Pharma Target, inducer 53
(6E)-7-{6-[(1E)-OCT-1-ENYL]-2,3-DIAZABICYCLO[2.2.1]HEPT-2-EN-5-YL}HEPT-6-ENOIC ACID Experimental Pharma Target 0
heme Pharma Agonist 0

(23) Additional Compounds for PTGIS Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Prostaglandin H2
  • (15S)Hydroxy-9alpha,11alpha-(epoxymethano)prosta-5,13-dienoate
  • (15S)Hydroxy-9alpha,11alpha-(epoxymethano)prosta-5,13-dienoic acid
  • (5Z)-7-{(1R,4S,5R,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2,3-dioxabicyclo[2.2.1]hept-5-yl}hept-5-enoate
  • (5Z)-7-{(1R,4S,5R,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2,3-dioxabicyclo[2.2.1]hept-5-yl}hept-5-enoic acid
  • (5Z,13E)-(15S)-9,11-epidioxy-15-hydroxyprosta-5,13-dienoate
42935-17-1
genes like me logo Genes that share compounds with PTGIS: view

Transcripts for PTGIS Gene

mRNA/cDNA for PTGIS Gene

Unigene Clusters for PTGIS Gene

Prostaglandin I2 (prostacyclin) synthase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PTGIS Gene

No ASD Table

Relevant External Links for PTGIS Gene

GeneLoc Exon Structure for
PTGIS
ECgene alternative splicing isoforms for
PTGIS

Expression for PTGIS Gene

mRNA expression in normal human tissues for PTGIS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTGIS Gene

This gene is overexpressed in Artery - Coronary (x5.8), Artery - Aorta (x5.8), and Artery - Tibial (x4.0).

Protein differential expression in normal tissues from HIPED for PTGIS Gene

This gene is overexpressed in Urinary Bladder (12.9), Testis (11.5), and Uterus (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PTGIS Gene



SOURCE GeneReport for Unigene cluster for PTGIS Gene Hs.302085

mRNA Expression by UniProt/SwissProt for PTGIS Gene

Q16647-PTGIS_HUMAN
Tissue specificity: Widely expressed; particularly abundant in ovary, heart, skeletal muscle, lung and prostate.
genes like me logo Genes that share expression patterns with PTGIS: view

Protein tissue co-expression partners for PTGIS Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for PTGIS Gene

This gene was present in the common ancestor of chordates.

Orthologs for PTGIS Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PTGIS 35
  • 87.2 (n)
  • 87.6 (a)
PTGIS 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTGIS 35
  • 86.85 (n)
  • 87.76 (a)
PTGIS 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptgis 35
  • 84.31 (n)
  • 86.04 (a)
Ptgis 16
Ptgis 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PTGIS 35
  • 98.68 (n)
  • 98.96 (a)
PTGIS 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptgis 35
  • 82.43 (n)
  • 83.96 (a)
oppossum
(Monodelphis domestica)
Mammalia PTGIS 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PTGIS 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTGIS 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ptgis 35
  • 59.86 (n)
  • 56.84 (a)
zebrafish
(Danio rerio)
Actinopterygii ptgis 35
  • 55.41 (n)
  • 49.78 (a)
ptgis 36
  • 48 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
ManyToMany
CSA.4049 36
  • 34 (a)
ManyToMany
Species with no ortholog for PTGIS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PTGIS Gene

ENSEMBL:
Gene Tree for PTGIS (if available)
TreeFam:
Gene Tree for PTGIS (if available)

Paralogs for PTGIS Gene

Paralogs for PTGIS Gene

(4) SIMAP similar genes for PTGIS Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PTGIS: view

Variants for PTGIS Gene

Sequence variations from dbSNP and Humsavar for PTGIS Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
VAR_010915 -
rs5622 - 49,547,864(+) TCATC(A/T)CTGGG reference, missense
rs56195291 - 49,513,151(+) ACCAC(A/C/G/T)TCGCA reference, missense
rs5623 - 49,544,365(-) TACAG(A/C)AGCAG reference, missense
rs5624 - 49,544,315(-) ACAGC(C/T)TCCTG reference, missense

Variation tolerance for PTGIS Gene

Residual Variation Intolerance Score: 94.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.95; 49.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTGIS Gene

HapMap Linkage Disequilibrium report
PTGIS
Human Gene Mutation Database (HGMD)
PTGIS
The Human Cytochrome P450 Allele Nomenclature Database
PTGIS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PTGIS Gene

Disorders for PTGIS Gene

MalaCards: The human disease database

(10) MalaCards diseases for PTGIS Gene - From: OMIM, ClinVar, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hypertension, essential
  • hypertension, essential 3
stroke, ischemic
  • ischemic stroke
myocardial infarction
  • myocardial infarction, protection against
acute endometritis
chronic thromboembolic pulmonary hypertension
  • cteph
- elite association - COSMIC cancer census association via MalaCards
Search PTGIS in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

PTGIS_HUMAN
  • Essential hypertension (EHT) [MIM:145500]: A condition in which blood pressure is consistently higher than normal with no identifiable cause. {ECO:0000269 PubMed:12372404}. Note=The disease may be caused by mutations affecting the gene represented in this entry.

Relevant External Links for PTGIS

Genetic Association Database (GAD)
PTGIS
Human Genome Epidemiology (HuGE) Navigator
PTGIS
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTGIS
genes like me logo Genes that share disorders with PTGIS: view

No data available for Genatlas for PTGIS Gene

Publications for PTGIS Gene

  1. Splicing mutation of the prostacyclin synthase gene in a family associated with hypertension. (PMID: 12372404) Nakayama T. … Oates J.A. (Biochem. Biophys. Res. Commun. 2002) 3 4 23 48 67
  2. Genetic polymorphisms of prostacyclin synthase gene and cardiovascular disease. (PMID: 20357747) Nakayama T. (Int Angiol 2010) 3 23 25
  3. Characterization of the substrate mimic bound to engineered prostacyclin synthase in solution using high-resolution NMR spectroscopy and mutagenesis: implication of the molecular mechanism in biosynthesis of prostacyclin. (PMID: 18081314) Ruan K.H. … Cervantes V. (Biochemistry 2008) 3 23 25
  4. Human gene encoding prostacyclin synthase (PTGIS): genomic organization, chromosomal localization, and promoter activity. (PMID: 8812456) Yokoyama C. … Tanabe T. (Genomics 1996) 2 3 23
  5. Protection against cytokine toxicity through endoplasmic reticulum and mitochondrial stress prevention by prostacyclin synthase overexpression in insulin-producing cells. (PMID: 20159982) Gurgul-Convey E. … Lenzen S. (J. Biol. Chem. 2010) 3 23

Products for PTGIS Gene

Sources for PTGIS Gene

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