Aliases for PTGIS Gene
External Ids for PTGIS Gene
Previous GeneCards Identifiers for PTGIS Gene
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis. [provided by RefSeq, Jul 2008]
GeneCards Summary for PTGIS Gene
PTGIS (Prostaglandin I2 (Prostacyclin) Synthase) is a Protein Coding gene. Diseases associated with PTGIS include Hypertension, Essential and Stroke, Ischemic. Among its related pathways are Development Ligand-independent activation of ESR1 and ESR2 and Arachidonic acid metabolism. GO annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP8B1.
UniProtKB/Swiss-Prot for PTGIS Gene
Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2).