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Aliases for PTGIS Gene

Aliases for PTGIS Gene

  • Prostaglandin I2 (Prostacyclin) Synthase 2 3
  • CYP8A1 3 4 6
  • CYP8 3 4 6
  • Prostaglandin I2 Synthase 3 4
  • PGIS 3 6
  • Cytochrome P450, Family 8, Subfamily A, Polypeptide 1 3
  • Prostacyclin Synthase 3
  • Cytochrome P450 2
  • Polypeptide 1 2
  • Subfamily A 2
  • EC 5.3.99.4 4
  • Family 8 2
  • PTGI 3

External Ids for PTGIS Gene

Summaries for PTGIS Gene

Entrez Gene Summary for PTGIS Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis. [provided by RefSeq, Jul 2008]

GeneCards Summary for PTGIS Gene

PTGIS (Prostaglandin I2 (Prostacyclin) Synthase) is a Protein Coding gene. Diseases associated with PTGIS include myocardial infarction and hypertension, essential. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include electron carrier activity and heme binding. An important paralog of this gene is CYP8B1.

UniProtKB/Swiss-Prot for PTGIS Gene

  • Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2)

Gene Wiki entry for PTGIS Gene

PharmGKB "VIP" Summary for PTGIS Gene

No data available for Tocris Summary , fRNAdb sequence ontologies and piRNA Summary for PTGIS Gene

Genomics for PTGIS Gene

Genomic Location for PTGIS Gene

Start:
49,503,874 bp from pter
End:
49,568,170 bp from pter
Size:
64,297 bases
Orientation:
Minus strand

Genomic View for PTGIS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PTGIS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTGIS Gene

Regulatory Elements for PTGIS Gene

Proteins for PTGIS Gene

  • Protein details for PTGIS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16647-PTGIS_HUMAN
    Recommended name:
    Prostacyclin synthase
    Protein Accession:
    Q16647
    Secondary Accessions:
    • Q3MII8
    • Q9HAX2
    • Q9HAX3
    • Q9HAX4

    Protein attributes for PTGIS Gene

    Size:
    500 amino acids
    Molecular mass:
    57104 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PTGIS Gene

neXtProt entry for PTGIS Gene

Proteomics data for PTGIS Gene at MOPED

Post-translational modifications for PTGIS Gene

No Post-translational modifications

Other Protein References for PTGIS Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for PTGIS Gene

Domains for PTGIS Gene

Gene Families for PTGIS Gene

HGNC:
  • CYP :Cytochrome P450s
IUPHAR :

Protein Domains for PTGIS Gene

UniProtKB/Swiss-Prot:

PTGIS_HUMAN
Family:
  • Belongs to the cytochrome P450 family.:
    • Q16647
genes like me logo Genes that share domains with PTGIS: view

Function for PTGIS Gene

Molecular function for PTGIS Gene

GENATLAS Biochemistry: prostaglandin 12 synthase
UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=9.55 uM for 6-keto-PGF1alpha {ECO:0000269 PubMed:25623425}; Vmax=534 mmol/min/pg enzyme {ECO:0000269 PubMed:25623425};
UniProtKB/Swiss-Prot CatalyticActivity: (5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-6,9-alpha-epoxy-11-alpha,15-dihydroxyprosta-5,13-dienoate.
UniProtKB/Swiss-Prot Function: Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2)

Enzyme Numbers (IUBMB) for PTGIS Gene

Gene Ontology (GO) - Molecular Function for PTGIS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity IEA --
GO:0005506 iron ion binding IEA --
GO:0005515 protein binding IPI 20122998
GO:0008116 prostaglandin-I synthase activity IDA 20122998
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA --
genes like me logo Genes that share ontologies with PTGIS: view

Phenotypes for PTGIS Gene

genes like me logo Genes that share phenotypes with PTGIS: view

Animal Models for PTGIS Gene

MGI Knock Outs for PTGIS:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for PTGIS Gene

Localization for PTGIS Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTGIS Gene

Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTGIS Gene COMPARTMENTS Subcellular localization image for PTGIS gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 5
plasma membrane 5
extracellular 4
golgi apparatus 2
lysosome 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PTGIS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space ISS --
GO:0005634 nucleus IDA 21035466
GO:0005783 endoplasmic reticulum IDA 21035466
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005901 caveola IDA 20122998
genes like me logo Genes that share ontologies with PTGIS: view

Pathways for PTGIS Gene

genes like me logo Genes that share pathways with PTGIS: view

Interacting Proteins for PTGIS Gene

Gene Ontology (GO) - Biological Process for PTGIS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001516 prostaglandin biosynthetic process IDA 20122998
GO:0006690 icosanoid metabolic process TAS --
GO:0006766 vitamin metabolic process TAS --
GO:0006767 water-soluble vitamin metabolic process TAS --
GO:0006769 nicotinamide metabolic process TAS --
genes like me logo Genes that share ontologies with PTGIS: view

Compounds for PTGIS Gene

(3) HMDB Compounds for PTGIS Gene

Compound Synonyms Cas Number PubMed IDs
Heme
  • (protoporphyrinato)iron
14875-96-8
Prostaglandin H2
  • Prostaglandin-H2
42935-17-1
Prostaglandin I2
  • (5Z,13E)-(15S)-6,9-epoxy-11,15-dihydroxyprosta-5,13-dienoate
35121-78-9

(3) Drugbank Compounds for PTGIS Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
(6E)-7-{6-[(1E)-OCT-1-ENYL]-2,3-DIAZABICYCLO[2.2.1]HEPT-2-EN-5-YL}HEPT-6-ENOIC ACID
target
Epoprostenol
  • PGI2
35121-78-9 target inducer
Phenylbutazone
50-33-9 target inhibitor

(29) Novoseek inferred chemical compound relationships for PTGIS Gene

Compound -log(P) Hits PubMed IDs
prostacyclin 94.4 208
prostaglandin-h2 90.7 24
pgh2 78.8 7
thromboxane a2 78 21
6-ketoprostaglandin f1alpha 77.4 8
genes like me logo Genes that share compounds with PTGIS: view

Transcripts for PTGIS Gene

mRNA/cDNA for PTGIS Gene

Unigene Clusters for PTGIS Gene

Prostaglandin I2 (prostacyclin) synthase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PTGIS Gene

No ASD Table

Relevant External Links for PTGIS Gene

GeneLoc Exon Structure for
PTGIS
ECgene alternative splicing isoforms for
PTGIS

Expression for PTGIS Gene

mRNA expression in normal human tissues for PTGIS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTGIS Gene

This gene is overexpressed in Artery - Coronary (5.8), Artery - Aorta (5.8), and Artery - Tibial (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PTGIS Gene

SOURCE GeneReport for Unigene cluster for PTGIS Gene Hs.302085

mRNA Expression by UniProt/SwissProt for PTGIS Gene

Q16647-PTGIS_HUMAN
Tissue specificity: Widely expressed; particularly abundant in ovary, heart, skeletal muscle, lung and prostate
genes like me logo Genes that share expressions with PTGIS: view

Orthologs for PTGIS Gene

This gene was present in the common ancestor of chordates.

Orthologs for PTGIS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTGIS 36
  • 98.68 (n)
  • 98.96 (a)
PTGIS 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PTGIS 36
  • 87.2 (n)
  • 87.6 (a)
PTGIS 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTGIS 36
  • 86.85 (n)
  • 87.76 (a)
PTGIS 37
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptgis 36
  • 84.31 (n)
  • 86.04 (a)
Ptgis 16
Ptgis 37
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PTGIS 37
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PTGIS 37
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptgis 36
  • 82.43 (n)
  • 83.96 (a)
lizard
(Anolis carolinensis)
Reptilia PTGIS 37
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ptgis 36
  • 59.86 (n)
  • 56.84 (a)
zebrafish
(Danio rerio)
Actinopterygii ptgis 36
  • 55.41 (n)
  • 49.78 (a)
ptgis 37
  • 48 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 30 (a)
ManyToMany
CSA.4049 37
  • 34 (a)
ManyToMany
Species with no ortholog for PTGIS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PTGIS Gene

ENSEMBL:
Gene Tree for PTGIS (if available)
TreeFam:
Gene Tree for PTGIS (if available)

Paralogs for PTGIS Gene

Paralogs for PTGIS Gene

Selected SIMAP similar genes for PTGIS Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PTGIS: view

Variants for PTGIS Gene

Sequence variations from dbSNP and Humsavar for PTGIS Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs4647 -- 49,504,240(-) CAAAA(C/T)GAGAT utr-variant-3-prime
rs5584 - 49,507,925(-) TCCGC(C/T)CATGA reference, missense
rs5585 -- 49,507,804(+) AGGGA(A/G)GTGGT utr-variant-3-prime
rs5586 -- 49,507,766(-) GGGAG(G/T)GAAAA utr-variant-3-prime
rs5587 -- 49,507,674(-) GTCTG(C/T)TCCCA utr-variant-3-prime

Relevant External Links for PTGIS Gene

HapMap Linkage Disequilibrium report
PTGIS
Human Gene Mutation Database (HGMD)
PTGIS
Locus Specific Mutation Databases (LSDB)
PTGIS
The Human Cytochrome P450 Allele Nomenclature Database
PTGIS

No data available for Structural Variations from Database of Genomic Variants (DGV) for PTGIS Gene

Disorders for PTGIS Gene

(1) OMIM Diseases for PTGIS Gene (601699)

UniProtKB/Swiss-Prot

PTGIS_HUMAN
  • Essential hypertension (EHT) [MIM:145500]: A condition in which blood pressure is consistently higher than normal with no identifiable cause. {ECO:0000269 PubMed:12372404}. Note=The disease may be caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for PTGIS Gene

(23) Novoseek inferred disease relationships for PTGIS Gene

Disease -log(P) Hits PubMed IDs
hypertension pulmonary 43.6 10
vascular diseases 32.7 2
shock endotoxic 29.7 1
cerebral infarction 28.9 1
essential hypertension 28.3 1

Relevant External Links for PTGIS

Genetic Association Database (GAD)
PTGIS
Human Genome Epidemiology (HuGE) Navigator
PTGIS
genes like me logo Genes that share disorders with PTGIS: view

Publications for PTGIS Gene

  1. Splicing mutation of the prostacyclin synthase gene in a family associated with hypertension. (PMID: 12372404) Nakayama T. … Oates J.A. (Biochem. Biophys. Res. Commun. 2002) 3 4 23 49
  2. Molecular cloning and expression of human prostacyclin synthase. (PMID: 8185632) Miyata A. … Tanabe T. (Biochem. Biophys. Res. Commun. 1994) 3 4 23
  3. Characterization of new mutations in the coding sequence and 5'- untranslated region of the human prostacyclin synthase gene (CYP8A1). (PMID: 11281454) Chevalier D. … Broly F. (Hum. Genet. 2001) 3 4 23
  4. Sequence analysis, frequency and ethnic distribution of VNTR polymorphism in the 5'-untranslated region of the human prostacyclin synthase gene (CYP8A1). (PMID: 12428676) Chevalier D. … Broly F. (Prostaglandins Other Lipid Mediat. 2002) 3 23 49
  5. Human gene encoding prostacyclin synthase (PTGIS): genomic organization, chromosomal localization, and promoter activity. (PMID: 8812456) Yokoyama C. … Tanabe T. (Genomics 1996) 2 3 23

Products for PTGIS Gene

Sources for PTGIS Gene

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