Aliases for PTGIR Gene
External Ids for PTGIR Gene
Previous GeneCards Identifiers for PTGIR Gene
The protein encoded by this gene is a member of the G-protein coupled receptor family 1 and has been shown to be a receptor for prostacyclin. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent vasodilation and inhibition of platelet aggregation through binding to this receptor. [provided by RefSeq, Jul 2008]
GeneCards Summary for PTGIR Gene
PTGIR (Prostaglandin I2 (Prostacyclin) Receptor (IP)) is a Protein Coding gene. Diseases associated with PTGIR include Acute Erythroid Leukemia and Kidney Papillary Necrosis. Among its related pathways are Platelet homeostasis and Vascular smooth muscle contraction. GO annotations related to this gene include G-protein coupled receptor activity and guanyl-nucleotide exchange factor activity. An important paralog of this gene is PTGER2.
UniProtKB/Swiss-Prot for PTGIR Gene
Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase.
Prostanoid receptors are activated by the endogenous ligands prostaglandin (PG) D2, PGE2, PGF2alpha, PGH2, prostacyclin (PGI2) and thromboxane A2. Cyclooxygenase (COX) converts arachidonic acid to PGH2, from which the other prostaglandins are synthesized.