Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PTGIR Gene

Aliases for PTGIR Gene

  • Prostaglandin I2 (Prostacyclin) Receptor (IP) 2 3
  • Prostaglandin I2 Receptor 3 4
  • Prostanoid IP Receptor 3 4
  • PGI2 Receptor 3 4
  • PGI Receptor 3 4
  • PRIPR 3 4
  • Prostacyclin Receptor 3
  • IP 3

External Ids for PTGIR Gene

Summaries for PTGIR Gene

Entrez Gene Summary for PTGIR Gene

  • The protein encoded by this gene is a member of the G-protein coupled receptor family 1 and has been shown to be a receptor for prostacyclin. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent vasodilation and inhibition of platelet aggregation through binding to this receptor. [provided by RefSeq, Jul 2008]

GeneCards Summary for PTGIR Gene

PTGIR (Prostaglandin I2 (Prostacyclin) Receptor (IP)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and p70S6K Signaling. GO annotations related to this gene include G-protein coupled receptor activity and guanyl-nucleotide exchange factor activity. An important paralog of this gene is TBXA2R.

UniProtKB/Swiss-Prot for PTGIR Gene

  • Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase

Tocris Summary for PTGIR Gene

  • Prostanoid receptors are activated by the endogenous ligands prostaglandin (PG) D2, PGE2, PGF2alpha, PGH2, prostacyclin (PGI2) and thromboxane A2. Cyclooxygenase (COX) converts arachidonic acid to PGH2, from which the other prostaglandins are synthesized. Prostanoid receptors are a family of nine G-protein-coupled receptors that have distinct tissue distributions and actions. IP receptors are coupled to Galphas and are involved in pain mediation, relaxation of vascular smooth muscle, inhibition of platelet aggregation and they contribute to cardiovascular health.

Gene Wiki entry for PTGIR Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTGIR Gene

Genomics for PTGIR Gene

Genomic Location for PTGIR Gene

Start:
46,611,328 bp from pter
End:
46,625,118 bp from pter
Size:
13,791 bases
Orientation:
Minus strand

Genomic View for PTGIR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PTGIR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTGIR Gene

Regulatory Elements for PTGIR Gene

Proteins for PTGIR Gene

  • Protein details for PTGIR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43119-PI2R_HUMAN
    Recommended name:
    Prostacyclin receptor
    Protein Accession:
    P43119
    Secondary Accessions:

    Protein attributes for PTGIR Gene

    Size:
    386 amino acids
    Molecular mass:
    40956 Da
    Quaternary structure:
    • Interacts (non-isoprenylated C-terminus) with PDZK1.

neXtProt entry for PTGIR Gene

Proteomics data for PTGIR Gene at MOPED

Post-translational modifications for PTGIR Gene

  • Isoprenylation does not influence ligand binding but is required for efficient coupling to the effectors adenylyl cyclase and phospholipase C.
  • Palmitoylation of either Cys-308 or Cys-311 is sufficient to maintain functional coupling to G(s) and signaling.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn7

Other Protein References for PTGIR Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for PTGIR Gene

Domains for PTGIR Gene

Gene Families for PTGIR Gene

HGNC:
  • PTGR :GPCR / Class A : Prostanoid receptors
IUPHAR :

UniProtKB/Swiss-Prot:

PI2R_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • P43119
genes like me logo Genes that share domains with PTGIR: view

Function for PTGIR Gene

Molecular function for PTGIR Gene

GENATLAS Biochemistry: protaglandin 12 (prostacyclin) receptor,subtype IP,expressed in the cardiovascular system,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function: Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase

Gene Ontology (GO) - Molecular Function for PTGIR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0005085 guanyl-nucleotide exchange factor activity TAS --
genes like me logo Genes that share ontologies with PTGIR: view
genes like me logo Genes that share phenotypes with PTGIR: view

Animal Models for PTGIR Gene

MGI Knock Outs for PTGIR:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for PTGIR Gene

Localization for PTGIR Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTGIR Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTGIR Gene COMPARTMENTS Subcellular localization image for PTGIR gene
Compartment Confidence
plasma membrane 5
cytosol 4
extracellular 2
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PTGIR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA 20622039
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7512962
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with PTGIR: view

Pathways for PTGIR Gene

genes like me logo Genes that share pathways with PTGIR: view

Gene Ontology (GO) - Biological Process for PTGIR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 7512962
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IMP 20622039
GO:0007267 cell-cell signaling TAS 7512962
GO:0007596 blood coagulation TAS --
genes like me logo Genes that share ontologies with PTGIR: view

Compounds for PTGIR Gene

(5) Tocris Compounds for PTGIR Gene

Compound Action Cas Number
Iloprost Prostacyclin (PGI2) analog [78919-13-8]
L-161,982 Selective EP4 receptor antagonist [147776-06-5]
L-798,106 Potent and highly selective EP3 antagonist [244101-02-8]
Prostaglandin E2 Major endogenous prostanoid [363-24-6]
U 46619 Potent, stable thromboxane A2 (TP) receptor agonist [56985-40-1]

(1) HMDB Compounds for PTGIR Gene

Compound Synonyms Cas Number PubMed IDs
Prostaglandin I2
  • (5Z,13E)-(15S)-6,9-epoxy-11,15-dihydroxyprosta-5,13-dienoate
35121-78-9

(4) Drugbank Compounds for PTGIR Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Dinoprost Tromethamine
  • Dinoprost, trometamol salt
38562-01-5 target antagonist
Epoprostenol
  • PGI2
35121-78-9 target agonist
Iloprost
78919-13-8 target agonist
Treprostinil
81846-19-7 target agonist

(18) IUPHAR Ligand for PTGIR Gene

Ligand Type Action Affinity Pubmed IDs
BAY-73-1449 Antagonist Antagonist 10
taprostene Agonist Partial agonist 9.11
[3H]iloprost Agonist Full agonist 9
RO1138452 Antagonist Antagonist 8.7
AFP-07 Agonist Full agonist 8.5
TEI-9063 Agonist Full agonist 8.5
FK-788 Agonist Full agonist 8.05
BMY 45778 Agonist Full agonist 8
MRE-269 Agonist Full agonist 7.7
U46619 Agonist Full agonist 7.5
treprostinil Agonist Full agonist 7.49
FR-181157 Agonist Full agonist 7.27
RO3244794 Antagonist Antagonist 6.9
cicaprost Agonist Full agonist 5.9
EP 157 Agonist Full agonist 5.69
iloprost Agonist Full agonist 5.2
carbacyclin Agonist Full agonist 4.7
butaprost (free acid form) Agonist Full agonist 4.7

(28) Novoseek inferred chemical compound relationships for PTGIR Gene

Compound -log(P) Hits PubMed IDs
iloprost 94.3 27
prostacyclin 93.7 192
cicaprost 93.5 11
octimibate 90.3 8
carbacyclin 81.9 4
genes like me logo Genes that share compounds with PTGIR: view

Transcripts for PTGIR Gene

Unigene Clusters for PTGIR Gene

Prostaglandin I2 (prostacyclin) receptor (IP):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PTGIR Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c
SP1: - -
SP2: - - -
SP3: - - - -
SP4: - - -

Relevant External Links for PTGIR Gene

GeneLoc Exon Structure for
PTGIR
ECgene alternative splicing isoforms for
PTGIR

Expression for PTGIR Gene

mRNA expression in normal human tissues for PTGIR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTGIR Gene

This gene is overexpressed in Artery - Aorta (10.1) and Artery - Coronary (5.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PTGIR Gene

SOURCE GeneReport for Unigene cluster for PTGIR Gene Hs.458324

genes like me logo Genes that share expressions with PTGIR: view

Orthologs for PTGIR Gene

This gene was present in the common ancestor of chordates.

Orthologs for PTGIR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTGIR 36
  • 98.79 (n)
  • 98.95 (a)
PTGIR 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PTGIR 36
  • 86.37 (n)
  • 84.37 (a)
PTGIR 37
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTGIR 36
  • 86.89 (n)
  • 83.85 (a)
PTGIR 37
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptgir 36
  • 80.09 (n)
  • 79.48 (a)
Ptgir 16
Ptgir 37
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PTGIR 37
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptgir 36
  • 78.61 (n)
  • 79.48 (a)
lizard
(Anolis carolinensis)
Reptilia PTGIR 37
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ptgir 36
  • 55.81 (n)
  • 56.74 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC561406 36
  • 59.43 (n)
  • 52.49 (a)
ptgir 37
  • 48 (a)
OneToOne
Species with no ortholog for PTGIR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PTGIR Gene

ENSEMBL:
Gene Tree for PTGIR (if available)
TreeFam:
Gene Tree for PTGIR (if available)

Paralogs for PTGIR Gene

Paralogs for PTGIR Gene

Selected SIMAP similar genes for PTGIR Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with PTGIR: view

Variants for PTGIR Gene

Sequence variations from dbSNP and Humsavar for PTGIR Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1126510 -- 46,620,526(-) AAACC(C/T)AAGTC utr-variant-3-prime, intron-variant
rs2229127 - 46,624,153(-) TGTTC(A/G)TGGCC missense, reference, nc-transcript-variant
rs2229128 -- 46,624,067(-) CTGGT(C/G)ACCGG synonymous-codon, reference, nc-transcript-variant
rs2229129 -- 46,621,457(-) GCCTC(A/C)GGGAG reference, synonymous-codon, utr-variant-3-prime, downstream-variant-500B, intron-variant
rs2229130 -- 46,621,322(-) GGAAC(A/G)TCGTC synonymous-codon, reference, utr-variant-3-prime, downstream-variant-500B, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTGIR Gene

Variant ID Type Subtype PubMed ID
nsv833849 CNV Loss 17160897
dgv3961n71 CNV Loss 21882294

Relevant External Links for PTGIR Gene

HapMap Linkage Disequilibrium report
PTGIR
Human Gene Mutation Database (HGMD)
PTGIR

Disorders for PTGIR Gene

(2) University of Copenhagen DISEASES for PTGIR Gene

(13) Novoseek inferred disease relationships for PTGIR Gene

Disease -log(P) Hits PubMed IDs
erythroleukemia 55 2
glioma 30.4 4
acidosis 15.7 2
restenosis 14.2 1
cholera 10.3 1

Relevant External Links for PTGIR

Genetic Association Database (GAD)
PTGIR
Human Genome Epidemiology (HuGE) Navigator
PTGIR
genes like me logo Genes that share disorders with PTGIR: view

No data available for UniProtKB/Swiss-Prot for PTGIR Gene

Publications for PTGIR Gene

  1. Structural organization and chromosomal assignment of the human prostacyclin receptor gene. (PMID: 7665161) Ogawa Y. … Narumiya S. (Genomics 1995) 3 4 23
  2. Chromosomal localization of the human prostanoid receptor gene family. (PMID: 7759114) Duncan A.M. … Adam M. (Genomics 1995) 2 3 23
  3. Molecular cloning of human prostacyclin receptor cDNA and its gene expression in the cardiovascular system. (PMID: 7923647) Nakagawa O. … Nakao K. (Circulation 1994) 3 4 23
  4. Cloning and expression of a cDNA for the human prostanoid IP receptor. (PMID: 7512962) Boie Y. … Abramovitz M. (J. Biol. Chem. 1994) 3 4 23
  5. Cloning and expression of a cDNA for the human prostacyclin receptor. (PMID: 7514139) Katsuyama M. … Ichikawa A. (FEBS Lett. 1994) 3 4 23

Products for PTGIR Gene

Sources for PTGIR Gene

Back to Top

Content