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Aliases for PTGIR Gene

Aliases for PTGIR Gene

  • Prostaglandin I2 (Prostacyclin) Receptor (IP) 2 3 5
  • Prostaglandin I2 Receptor 3 4
  • Prostanoid IP Receptor 3 4
  • PGI2 Receptor 3 4
  • PGI Receptor 3 4
  • PRIPR 3 4
  • IP 3

External Ids for PTGIR Gene

Previous GeneCards Identifiers for PTGIR Gene

  • GC19M047767
  • GC19M047514
  • GC19M051799
  • GC19M051815
  • GC19M047123
  • GC19M043548

Summaries for PTGIR Gene

Entrez Gene Summary for PTGIR Gene

  • The protein encoded by this gene is a member of the G-protein coupled receptor family 1 and has been shown to be a receptor for prostacyclin. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent vasodilation and inhibition of platelet aggregation through binding to this receptor. [provided by RefSeq, Jul 2008]

GeneCards Summary for PTGIR Gene

PTGIR (Prostaglandin I2 (Prostacyclin) Receptor (IP)) is a Protein Coding gene. Diseases associated with PTGIR include acute erythroid leukemia and chemical colitis. Among its related pathways are Peptide ligand-binding receptors and Platelet activation. GO annotations related to this gene include G-protein coupled receptor activity and guanyl-nucleotide exchange factor activity. An important paralog of this gene is TBXA2R.

UniProtKB/Swiss-Prot for PTGIR Gene

  • Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase.

Tocris Summary for PTGIR Gene

  • Prostanoid receptors are activated by the endogenous ligands prostaglandin (PG) D2, PGE2, PGF2alpha, PGH2, prostacyclin (PGI2) and thromboxane A2. Cyclooxygenase (COX) converts arachidonic acid to PGH2, from which the other prostaglandins are synthesized.

Gene Wiki entry for PTGIR Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTGIR Gene

Genomics for PTGIR Gene

Regulatory Elements for PTGIR Gene

Enhancers for PTGIR Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PTGIR on UCSC Golden Path with GeneCards custom track

Promoters for PTGIR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PTGIR on UCSC Golden Path with GeneCards custom track

Genomic Location for PTGIR Gene

Chromosome:
19
Start:
46,610,040 bp from pter
End:
46,625,118 bp from pter
Size:
15,079 bases
Orientation:
Minus strand

Genomic View for PTGIR Gene

Genes around PTGIR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTGIR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTGIR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTGIR Gene

Proteins for PTGIR Gene

  • Protein details for PTGIR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43119-PI2R_HUMAN
    Recommended name:
    Prostacyclin receptor
    Protein Accession:
    P43119

    Protein attributes for PTGIR Gene

    Size:
    386 amino acids
    Molecular mass:
    40956 Da
    Quaternary structure:
    • Interacts (non-isoprenylated C-terminus) with PDZK1.

neXtProt entry for PTGIR Gene

Proteomics data for PTGIR Gene at MOPED

Post-translational modifications for PTGIR Gene

  • Isoprenylation does not influence ligand binding but is required for efficient coupling to the effectors adenylyl cyclase and phospholipase C.
  • Palmitoylation of either Cys-308 or Cys-311 is sufficient to maintain functional coupling to G(s) and signaling.
  • Glycosylation at Asn 7
  • Modification sites at PhosphoSitePlus

Other Protein References for PTGIR Gene

Antibody Products

No data available for DME Specific Peptides for PTGIR Gene

Domains & Families for PTGIR Gene

Gene Families for PTGIR Gene

Suggested Antigen Peptide Sequences for PTGIR Gene

Graphical View of Domain Structure for InterPro Entry

P43119

UniProtKB/Swiss-Prot:

PI2R_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with PTGIR: view

Function for PTGIR Gene

Molecular function for PTGIR Gene

GENATLAS Biochemistry:
protaglandin 12 (prostacyclin) receptor,subtype IP,expressed in the cardiovascular system,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase.
genes like me logo Genes that share phenotypes with PTGIR: view

Animal Models for PTGIR Gene

MGI Knock Outs for PTGIR:

Animal Model Products

  • Taconic Biosciences Mouse Models for PTGIR

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PTGIR Gene

Localization for PTGIR Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTGIR Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTGIR Gene COMPARTMENTS Subcellular localization image for PTGIR gene
Compartment Confidence
cytosol 5
plasma membrane 5
extracellular 2
lysosome 1
nucleus 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for PTGIR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA 20622039
genes like me logo Genes that share ontologies with PTGIR: view

Pathways & Interactions for PTGIR Gene

genes like me logo Genes that share pathways with PTGIR: view

Gene Ontology (GO) - Biological Process for PTGIR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007267 cell-cell signaling TAS 7512962
GO:0030819 positive regulation of cAMP biosynthetic process IEA,IMP 20622039
GO:0043547 positive regulation of GTPase activity TAS --
GO:0043950 positive regulation of cAMP-mediated signaling IEA,IMP 20622039
GO:0048662 negative regulation of smooth muscle cell proliferation IEA,IDA 20622039
genes like me logo Genes that share ontologies with PTGIR: view

No data available for SIGNOR curated interactions for PTGIR Gene

Drugs & Compounds for PTGIR Gene

(39) Drugs for PTGIR Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Iloprost Approved, Investigational Pharma Full agonist, Agonist, agonist, Target Others, Prostacyclin (PGI2) analog 77
Treprostinil Approved, Investigational Pharma Full agonist, Agonist, agonist, Target 77
Dinoprost Tromethamine Approved Pharma antagonist, Target 11
Epoprostenol Approved Pharma agonist, Target 53
Aspirin Approved Pharma Channel blocker 1059

(17) Additional Compounds for PTGIR Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(+-)-Cloprostenol sodium salt
55028-72-3
U 46619
56985-40-1

(5) Tocris Compounds for PTGIR Gene

Compound Action Cas Number
(+-)-Cloprostenol sodium salt Water-soluble PGF2alpha analog and potent FP receptor agonist 55028-72-3
BMY 45778 Non-prostanoid prostacyclin IP receptor partial agonist 152575-66-1
Iloprost Prostacyclin (PGI2) analog 78919-13-8
Prostaglandin E2 Major endogenous prostanoid 363-24-6
U 46619 Potent, stable thromboxane A2 (TP) receptor agonist 56985-40-1

(2) ApexBio Compounds for PTGIR Gene

Compound Action Cas Number
Alprostadil 745-65-3
Bimatoprost 155206-00-1
genes like me logo Genes that share compounds with PTGIR: view

Transcripts for PTGIR Gene

Unigene Clusters for PTGIR Gene

Prostaglandin I2 (prostacyclin) receptor (IP):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PTGIR Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c
SP1: - -
SP2: - - -
SP3: - - - -
SP4: - - -

Relevant External Links for PTGIR Gene

GeneLoc Exon Structure for
PTGIR
ECgene alternative splicing isoforms for
PTGIR

Expression for PTGIR Gene

mRNA expression in normal human tissues for PTGIR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTGIR Gene

This gene is overexpressed in Artery - Aorta (x10.1) and Artery - Coronary (x5.0).

Protein differential expression in normal tissues from HIPED for PTGIR Gene

This gene is overexpressed in Peripheral blood mononuclear cells (55.5) and Adipocyte (12.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PTGIR Gene



SOURCE GeneReport for Unigene cluster for PTGIR Gene Hs.458324

genes like me logo Genes that share expression patterns with PTGIR: view

Protein tissue co-expression partners for PTGIR Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for PTGIR Gene

Orthologs for PTGIR Gene

This gene was present in the common ancestor of chordates.

Orthologs for PTGIR Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PTGIR 35
  • 86.37 (n)
  • 84.37 (a)
PTGIR 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTGIR 35
  • 86.89 (n)
  • 83.85 (a)
PTGIR 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptgir 35
  • 80.09 (n)
  • 79.48 (a)
Ptgir 16
Ptgir 36
  • 73 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PTGIR 35
  • 98.79 (n)
  • 98.95 (a)
PTGIR 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptgir 35
  • 78.61 (n)
  • 79.48 (a)
oppossum
(Monodelphis domestica)
Mammalia PTGIR 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTGIR 36
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ptgir 35
  • 55.81 (n)
  • 56.74 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC561406 35
  • 59.43 (n)
  • 52.49 (a)
ptgir 36
  • 48 (a)
OneToOne
Species with no ortholog for PTGIR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PTGIR Gene

ENSEMBL:
Gene Tree for PTGIR (if available)
TreeFam:
Gene Tree for PTGIR (if available)

Paralogs for PTGIR Gene

Paralogs for PTGIR Gene

(4) SIMAP similar genes for PTGIR Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with PTGIR: view

Variants for PTGIR Gene

Sequence variations from dbSNP and Humsavar for PTGIR Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs2229127 - 46,624,153(-) TGTTC(A/G)TGGCC nc-transcript-variant, reference, missense
rs28590598 - 46,621,485(+) TCTGC(A/C/G)AGTCT intron-variant, downstream-variant-500B, reference, missense, utr-variant-3-prime
rs7259655 -- 46,616,289(+) CATCA(A/G)ATGCC intron-variant
rs12979494 -- 46,619,257(+) ggagg(C/T)tgagg intron-variant
rs12979905 -- 46,619,256(+) gggag(C/G)ctgag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTGIR Gene

Variant ID Type Subtype PubMed ID
nsv833849 CNV Loss 17160897
dgv3961n71 CNV Loss 21882294

Variation tolerance for PTGIR Gene

Residual Variation Intolerance Score: 52.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.08; 60.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTGIR Gene

HapMap Linkage Disequilibrium report
PTGIR
Human Gene Mutation Database (HGMD)
PTGIR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTGIR Gene

Disorders for PTGIR Gene

MalaCards: The human disease database

(5) MalaCards diseases for PTGIR Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
acute erythroid leukemia
  • acute erythroleukemia
chemical colitis
chronic pulmonary heart disease
acute endometritis
pulmonary hypertension
  • primary pulmonary hypertension
- elite association - COSMIC cancer census association via MalaCards
Search PTGIR in MalaCards View complete list of genes associated with diseases

Relevant External Links for PTGIR

Genetic Association Database (GAD)
PTGIR
Human Genome Epidemiology (HuGE) Navigator
PTGIR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTGIR
genes like me logo Genes that share disorders with PTGIR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTGIR Gene

Publications for PTGIR Gene

  1. Role of extracellular cysteine residues in dimerization/oligomerization of the human prostacyclin receptor. (PMID: 15194446) Giguere V. … Parent J.-L. (Eur. J. Pharmacol. 2004) 3 4 23 67
  2. Smooth muscle proliferation and role of the prostacyclin (IP) receptor in idiopathic pulmonary arterial hypertension. (PMID: 20622039) Falcetti E. … Clapp L.H. (Am. J. Respir. Crit. Care Med. 2010) 3 25 26
  3. Iloprost-induced desensitization of the prostacyclin receptor in isolated rabbit lungs. (PMID: 17257398) Schermuly R.T. … Rose F. (Respir. Res. 2007) 23 25 26
  4. Chromosomal localization of the human prostanoid receptor gene family. (PMID: 7759114) Duncan A.M. … Adam M. (Genomics 1995) 2 3 23
  5. Estrogen increases expression of the human prostacyclin receptor within the vasculature through an ERalpha-dependent mechanism. (PMID: 20070947) Turner E.C. … Kinsella B.T. (J. Mol. Biol. 2010) 3 23

Products for PTGIR Gene

Sources for PTGIR Gene

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