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Aliases for CSRP2BP Gene

Aliases for CSRP2BP Gene

  • CSRP2 Binding Protein 2 3
  • ADA2A-Containing Complex Subunit 2 3 4
  • CSRP2-Binding Protein 3 4
  • CRP2BP 3 4
  • ATAC2 3 4
  • Cysteine Rich Protein 2 Binding Protein 2
  • Cysteine-Rich Protein 2-Binding Protein 3
  • ATAC Component 2 Homolog (Drosophila) 2
  • ATAC Component 2 Homolog 3
  • CRP2 Binding Partner 3
  • CRP2 Binding Protein 3
  • CRP2-Binding Partner 4
  • DJ717M23.1 3
  • PRO1194 3
  • KAT14 3

External Ids for CSRP2BP Gene

Previous GeneCards Identifiers for CSRP2BP Gene

  • GC20P018106
  • GC20P018113

Summaries for CSRP2BP Gene

Entrez Gene Summary for CSRP2BP Gene

  • CSRP2 is a protein containing two LIM domains, which are double zinc finger motifs found in proteins of diverse function. CSRP2 and some related proteins are thought to act as protein adapters, bridging two or more proteins to form a larger protein complex. The protein encoded by this gene binds to one of the LIM domains of CSRP2 and contains an acetyltransferase domain. Although the encoded protein has been detected in the cytoplasm, it is predominantly a nuclear protein. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2011]

GeneCards Summary for CSRP2BP Gene

CSRP2BP (CSRP2 Binding Protein) is a Protein Coding gene. Among its related pathways are RNA Polymerase I Promoter Opening and RNA Polymerase I Promoter Opening. GO annotations related to this gene include histone acetyltransferase activity and LIM domain binding.

UniProtKB/Swiss-Prot for CSRP2BP Gene

  • Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. May function as a scaffold for the ATAC complex to promote ATAC complex stability. Has also weak histone acetyltransferase activity toward histone H4. Required for the normal progression through G1 and G2/M phases of the cell cycle.

Gene Wiki entry for CSRP2BP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSRP2BP Gene

Genomics for CSRP2BP Gene

Regulatory Elements for CSRP2BP Gene

Genomic Location for CSRP2BP Gene

Start:
18,138,118 bp from pter
End:
18,188,387 bp from pter
Size:
50,270 bases
Orientation:
Plus strand

Genomic View for CSRP2BP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CSRP2BP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSRP2BP Gene

Proteins for CSRP2BP Gene

  • Protein details for CSRP2BP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H8E8-CSR2B_HUMAN
    Recommended name:
    Cysteine-rich protein 2-binding protein
    Protein Accession:
    Q9H8E8
    Secondary Accessions:
    • A2A2I5
    • Q96GW6
    • Q96IH3
    • Q9HBF0
    • Q9UIY5

    Protein attributes for CSRP2BP Gene

    Size:
    782 amino acids
    Molecular mass:
    88844 Da
    Quaternary structure:
    • Interacts with the LIM 1 domain of CSRP2. Component of the ADA2A-containing complex (ATAC), composed of CSRP2BP, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1. In the complex, it probably interacts directly with KAT2A, MBIP and WDR5.
    SequenceCaution:
    • Sequence=CAB56651.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for CSRP2BP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CSRP2BP Gene

Proteomics data for CSRP2BP Gene at MOPED

Post-translational modifications for CSRP2BP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CSRP2BP Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CSRP2BP Gene

Domains for CSRP2BP Gene

Protein Domains for CSRP2BP Gene

Suggested Antigen Peptide Sequences for CSRP2BP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H8E8

UniProtKB/Swiss-Prot:

CSR2B_HUMAN :
  • Q9H8E8
Domain:
  • Contains 1 N-acetyltransferase domain.
genes like me logo Genes that share domains with CSRP2BP: view

No data available for Gene Families for CSRP2BP Gene

Function for CSRP2BP Gene

Molecular function for CSRP2BP Gene

UniProtKB/Swiss-Prot Function: Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. May function as a scaffold for the ATAC complex to promote ATAC complex stability. Has also weak histone acetyltransferase activity toward histone H4. Required for the normal progression through G1 and G2/M phases of the cell cycle.

Gene Ontology (GO) - Molecular Function for CSRP2BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004402 histone acetyltransferase activity IDA 19103755
GO:0005515 protein binding IPI 16189514
GO:0008080 N-acetyltransferase activity --
GO:0030274 LIM domain binding NAS 10924333
genes like me logo Genes that share ontologies with CSRP2BP: view
genes like me logo Genes that share phenotypes with CSRP2BP: view

Animal Model Products

CRISPR Products

miRNA for CSRP2BP Gene

miRTarBase miRNAs that target CSRP2BP

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CSRP2BP

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CSRP2BP Gene

Localization for CSRP2BP Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSRP2BP Gene

Nucleus. Cytoplasm. Note=Mainly nuclear.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CSRP2BP Gene COMPARTMENTS Subcellular localization image for CSRP2BP gene
Compartment Confidence
nucleus 5
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for CSRP2BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IPI 10924333
GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex IDA 18838386
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CSRP2BP: view

Pathways for CSRP2BP Gene

genes like me logo Genes that share pathways with CSRP2BP: view

Pathways by source for CSRP2BP Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Epigenetic Chromatin Modification Enzymes in human,mouse,rat

Interacting Proteins for CSRP2BP Gene

Gene Ontology (GO) - Biological Process for CSRP2BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle IEA --
GO:0006325 chromatin organization TAS --
GO:0016573 histone acetylation --
GO:0043966 histone H3 acetylation IDA 18838386
genes like me logo Genes that share ontologies with CSRP2BP: view

Transcripts for CSRP2BP Gene

Unigene Clusters for CSRP2BP Gene

CSRP2 binding protein:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CSRP2BP

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CSRP2BP Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12 ^ 13
SP1: -
SP2: - -
SP3: -
SP4:
SP5:
SP6: - - - - - -
SP7: -
SP8: - - -
SP9: - -
SP10:

Relevant External Links for CSRP2BP Gene

GeneLoc Exon Structure for
CSRP2BP
ECgene alternative splicing isoforms for
CSRP2BP

Expression for CSRP2BP Gene

mRNA expression in normal human tissues for CSRP2BP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for CSRP2BP Gene

SOURCE GeneReport for Unigene cluster for CSRP2BP Gene Hs.728790

mRNA Expression by UniProt/SwissProt for CSRP2BP Gene

Q9H8E8-CSR2B_HUMAN
Tissue specificity: Expressed in skeletal muscle, heart, lung, placenta, brain, liver, pancreas and kidney. High expression in skeletal muscle and heart. Lower expression in lung
genes like me logo Genes that share expressions with CSRP2BP: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CSRP2BP Gene

Orthologs for CSRP2BP Gene

This gene was present in the common ancestor of animals.

Orthologs for CSRP2BP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CSRP2BP 35
  • 99.45 (n)
  • 99.74 (a)
CSRP2BP 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CSRP2BP 35
  • 85.29 (n)
  • 95.52 (a)
CSRP2BP 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CSRP2BP 35
  • 91.89 (n)
  • 97.31 (a)
CSRP2BP 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Csrp2bp 35
  • 87.55 (n)
  • 95.38 (a)
Csrp2bp 16
Csrp2bp 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CSRP2BP 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CSRP2BP 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Csrp2bp 35
  • 88.28 (n)
  • 95.76 (a)
chicken
(Gallus gallus)
Aves CSRP2BP 35
  • 79.56 (n)
  • 88.93 (a)
CSRP2BP 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CSRP2BP 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia csrp2bp 35
  • 70.03 (n)
  • 77.33 (a)
Str.13779 35
zebrafish
(Danio rerio)
Actinopterygii csrp2bp 35
  • 68.41 (n)
  • 75.39 (a)
csrp2bp 36
  • 74 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Atac2 36
  • 32 (a)
OneToOne
CG10414 37
  • 41 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13011 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5283 36
  • 42 (a)
OneToOne
Species with no ortholog for CSRP2BP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CSRP2BP Gene

ENSEMBL:
Gene Tree for CSRP2BP (if available)
TreeFam:
Gene Tree for CSRP2BP (if available)

Paralogs for CSRP2BP Gene

Selected SIMAP similar genes for CSRP2BP Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for CSRP2BP Gene

genes like me logo Genes that share paralogs with CSRP2BP: view

No data available for Paralogs for CSRP2BP Gene

Variants for CSRP2BP Gene

Sequence variations from dbSNP and Humsavar for CSRP2BP Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs8517 -- 18,187,709(+) ATGAA(C/T)GATGT utr-variant-3-prime, nc-transcript-variant
rs742918 -- 18,168,469(+) gttac(A/G)gtgag intron-variant
rs742919 -- 18,166,747(-) cctat(A/C)acaag intron-variant
rs1009545 -- 18,150,976(+) TCAAG(A/G)AATAT intron-variant
rs1009546 -- 18,153,782(+) GTCAC(C/T)TGAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CSRP2BP Gene

Variant ID Type Subtype PubMed ID
nsv833933 CNV Gain 17160897

Relevant External Links for CSRP2BP Gene

HapMap Linkage Disequilibrium report
CSRP2BP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSRP2BP Gene

Disorders for CSRP2BP Gene

Relevant External Links for CSRP2BP

Genetic Association Database (GAD)
CSRP2BP
Human Genome Epidemiology (HuGE) Navigator
CSRP2BP
genes like me logo Genes that share disorders with CSRP2BP: view

No data available for UniProtKB/Swiss-Prot for CSRP2BP Gene

Publications for CSRP2BP Gene

  1. The cysteine- and glycine-rich LIM domain protein CRP2 specifically interacts with a novel human protein. (PMID: 10924333) Weiskirchen R. … Gressner A.M. (Biochem. Biophys. Res. Commun. 2000) 2 3 4 23
  2. The double-histone-acetyltransferase complex ATAC is essential for mammalian development. (PMID: 19103755) Guelman S. … Zha J. (Mol. Cell. Biol. 2009) 2 3 4
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for CSRP2BP Gene

Sources for CSRP2BP Gene

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