Aliases for BAG1 Gene
External Ids for BAG1 Gene
Previous GeneCards Identifiers for BAG1 Gene
The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. Multiple protein isoforms are encoded by this mRNA through the use of a non-AUG (CUG) initiation codon, and three alternative downstream AUG initiation codons. A related pseudogene has been defined on chromosome X. [provided by RefSeq, Feb 2010]
GeneCards Summary for BAG1 Gene
BAG1 (BCL2 Associated Athanogene 1) is a Protein Coding gene. Diseases associated with BAG1 include spindle cell hemangioma and lung cancer. Among its related pathways are Cellular response to heat stress and Cellular Senescence. GO annotations related to this gene include chaperone binding and phosphoprotein binding.
UniProtKB/Swiss-Prot for BAG1 Gene
Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli.