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Aliases for PTGDR Gene

Aliases for PTGDR Gene

  • Prostaglandin D2 Receptor (DP) 2 3 5
  • PGD2 Receptor 3 4
  • Prostanoid DP Receptor 4
  • PGD Receptor 4
  • PTGDR1 3
  • ASRT1 3
  • AS1 3
  • DP1 3
  • DP 3

External Ids for PTGDR Gene

Previous GeneCards Identifiers for PTGDR Gene

  • GC14P050057
  • GC14P046530
  • GC14P050724
  • GC14P051804
  • GC14P052734
  • GC14P032895

Summaries for PTGDR Gene

Entrez Gene Summary for PTGDR Gene

  • This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein is reported to be a receptor for prostaglandin D2, which is a mediator of allergic inflammation and allergic airway inflammation in asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for PTGDR Gene

PTGDR (Prostaglandin D2 Receptor (DP)) is a Protein Coding gene. Diseases associated with PTGDR include asthma 1 and rosacea. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and prostaglandin D receptor activity. An important paralog of this gene is TBXA2R.

UniProtKB/Swiss-Prot for PTGDR Gene

  • Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity).

Tocris Summary for PTGDR Gene

  • Prostanoid receptors are activated by the endogenous ligands prostaglandin (PG) D2, PGE2, PGF2alpha, PGH2, prostacyclin (PGI2) and thromboxane A2. Cyclooxygenase (COX) converts arachidonic acid to PGH2, from which the other prostaglandins are synthesized.

Gene Wiki entry for PTGDR Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTGDR Gene

Genomics for PTGDR Gene

Regulatory Elements for PTGDR Gene

Promoters for PTGDR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PTGDR on UCSC Golden Path with GeneCards custom track

Genomic Location for PTGDR Gene

Chromosome:
14
Start:
52,267,256 bp from pter
End:
52,276,724 bp from pter
Size:
9,469 bases
Orientation:
Plus strand

Genomic View for PTGDR Gene

Genes around PTGDR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTGDR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTGDR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTGDR Gene

Proteins for PTGDR Gene

  • Protein details for PTGDR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13258-PD2R_HUMAN
    Recommended name:
    Prostaglandin D2 receptor
    Protein Accession:
    Q13258
    Secondary Accessions:
    • G3V5L3
    • Q13250
    • Q13251
    • Q1ZZ52

    Protein attributes for PTGDR Gene

    Size:
    359 amino acids
    Molecular mass:
    40271 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PTGDR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTGDR Gene

Proteomics data for PTGDR Gene at MOPED

Post-translational modifications for PTGDR Gene

  • Glycosylation at Asn 10, Asn 90, and Asn 297
  • Modification sites at PhosphoSitePlus

Other Protein References for PTGDR Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for PTGDR Gene

Domains & Families for PTGDR Gene

Gene Families for PTGDR Gene

Protein Domains for PTGDR Gene

Suggested Antigen Peptide Sequences for PTGDR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13258

UniProtKB/Swiss-Prot:

PD2R_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with PTGDR: view

Function for PTGDR Gene

Molecular function for PTGDR Gene

UniProtKB/Swiss-Prot Function:
Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity).

Gene Ontology (GO) - Molecular Function for PTGDR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004956 prostaglandin D receptor activity NAS 7642548
genes like me logo Genes that share ontologies with PTGDR: view
genes like me logo Genes that share phenotypes with PTGDR: view

Animal Models for PTGDR Gene

MGI Knock Outs for PTGDR:

Animal Model Products

  • Taconic Biosciences Mouse Models for PTGDR

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTGDR Gene

Localization for PTGDR Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTGDR Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTGDR Gene COMPARTMENTS Subcellular localization image for PTGDR gene
Compartment Confidence
plasma membrane 5
nucleus 2
cytosol 1
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for PTGDR Gene

Pathways & Interactions for PTGDR Gene

genes like me logo Genes that share pathways with PTGDR: view

Gene Ontology (GO) - Biological Process for PTGDR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA,NAS 7642548
GO:0071799 cellular response to prostaglandin D stimulus IEA --
genes like me logo Genes that share ontologies with PTGDR: view

No data available for SIGNOR curated interactions for PTGDR Gene

Drugs & Compounds for PTGDR Gene

(36) Drugs for PTGDR Gene - From: IUPHAR, DGIdb, Tocris, HMDB, Novoseek, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Iloprost Approved, Investigational Pharma Full agonist, Agonist, agonist Others, Prostacyclin (PGI2) analog 74
Nedocromil Approved Pharma Target, unknown 5
Dinoprostone Approved Pharma Major endogenous prostanoid 74
cyclic amp Experimental Pharma 0
Prostaglandin D2 Experimental Pharma 0

(15) Additional Compounds for PTGDR Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
15-deoxy-Delta<sup>12,14</sup>-PGJ<sub>2</sub>
Full agonist, Agonist
Delta<sup>12</sup>-PGJ<sub>2</sub>
Full agonist, Agonist
PGF<sub>2alpha</sub>
Full agonist, Agonist
(+-)-Cloprostenol sodium salt
55028-72-3
U 46619
56985-40-1
genes like me logo Genes that share compounds with PTGDR: view

Transcripts for PTGDR Gene

mRNA/cDNA for PTGDR Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PTGDR Gene

Prostaglandin D2 receptor (DP):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PTGDR Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1:
SP2: -

Relevant External Links for PTGDR Gene

GeneLoc Exon Structure for
PTGDR
ECgene alternative splicing isoforms for
PTGDR

Expression for PTGDR Gene

mRNA expression in normal human tissues for PTGDR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTGDR Gene

This gene is overexpressed in Colon - Transverse (x8.6), Whole Blood (x7.0), and Spleen (x4.4).

Protein differential expression in normal tissues from HIPED for PTGDR Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PTGDR Gene



SOURCE GeneReport for Unigene cluster for PTGDR Gene Hs.306831

mRNA Expression by UniProt/SwissProt for PTGDR Gene

Q13258-PD2R_HUMAN
Tissue specificity: Expressed in retinal choroid, ciliary epithelium, longitudinal and circular ciliary muscles, iris, small intestine and platelet membranes.
genes like me logo Genes that share expression patterns with PTGDR: view

Protein tissue co-expression partners for PTGDR Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for PTGDR Gene

This gene was present in the common ancestor of chordates.

Orthologs for PTGDR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTGDR 35
  • 99.34 (n)
  • 98.57 (a)
PTGDR 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PTGDR 36
  • 80 (a)
OneToOne
PTGDR 35
  • 84.49 (n)
  • 79.94 (a)
dog
(Canis familiaris)
Mammalia PTGDR 35
  • 85.77 (n)
  • 82.87 (a)
PTGDR 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptgdr 16
Ptgdr 36
  • 73 (a)
OneToOne
Ptgdr 35
  • 78.06 (n)
  • 74.36 (a)
rat
(Rattus norvegicus)
Mammalia Ptgdrl 35
  • 78.25 (n)
  • 77.21 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ptgdr 35
  • 56.72 (n)
  • 55.81 (a)
zebrafish
(Danio rerio)
Actinopterygii ptger4c 36
  • 22 (a)
ManyToMany
Species with no ortholog for PTGDR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PTGDR Gene

ENSEMBL:
Gene Tree for PTGDR (if available)
TreeFam:
Gene Tree for PTGDR (if available)

Paralogs for PTGDR Gene

Paralogs for PTGDR Gene

(3) SIMAP similar genes for PTGDR Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PTGDR: view

Variants for PTGDR Gene

Sequence variations from dbSNP and Humsavar for PTGDR Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs41311442 - 52,267,833(+) TCTAC(A/C/T)GCTGC reference, missense
rs41312504 - 52,274,786(+) CTCTG(A/C)AGAAG reference, missense, utr-variant-3-prime
rs41312444 - 52,268,407(+) GCTGG(A/G)GTACT reference, missense
rs41312506 - 52,274,879(+) ATTTC(A/G)GATAT reference, missense, utr-variant-3-prime
rs802986 -- 52,275,996(-) ACCGT(C/G)TCCAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PTGDR Gene

Variant ID Type Subtype PubMed ID
nsv832795 CNV Gain 17160897
nsv819552 CNV Gain 19587683

Variation tolerance for PTGDR Gene

Residual Variation Intolerance Score: 71.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.12; 51.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTGDR Gene

HapMap Linkage Disequilibrium report
PTGDR
Human Gene Mutation Database (HGMD)
PTGDR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTGDR Gene

Disorders for PTGDR Gene

MalaCards: The human disease database

(7) MalaCards diseases for PTGDR Gene - From: OMIM, ClinVar, GeneTests, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
asthma 1
  • asthma, susceptibility to, 1
rosacea
  • acne rosacea
asthma
  • asthma, protection against
atopic dermatitis
  • allergic eczema
anemia of prematurity
- elite association - COSMIC cancer census association via MalaCards
Search PTGDR in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

PD2R_HUMAN
  • Asthma-related traits 1 (ASRT1) [MIM:607277]: Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis. {ECO:0000269 PubMed:15496624}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for PTGDR

Genetic Association Database (GAD)
PTGDR
Human Genome Epidemiology (HuGE) Navigator
PTGDR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTGDR
genes like me logo Genes that share disorders with PTGDR: view

No data available for Genatlas for PTGDR Gene

Publications for PTGDR Gene

  1. Role of prostanoid DP receptor variants in susceptibility to asthma. (PMID: 15496624) Oguma T. … Lilly C.M. (N. Engl. J. Med. 2004) 3 4 23 48 67
  2. Molecular cloning and characterization of the human prostanoid DP receptor. (PMID: 7642548) Boie Y. … Abramovitz M. (J. Biol. Chem. 1995) 2 3 23
  3. Prostanoid DP receptor (PTGDR) variants in mothers with post-coital associated preterm births: preliminary observations. (PMID: 19710676) Grisaru-Granovsky S. … Schimmel M.S. (J Perinatol 2010) 3 23
  4. Mast cell-derived prostaglandin D2 controls hyaluronan synthesis in human orbital fibroblasts via DP1 activation: implications for thyroid eye disease. (PMID: 20308056) Guo N. … Phipps R.P. (J. Biol. Chem. 2010) 3 23
  5. Expression and characterization of PGD2 receptors in chronic rhinosinusitis: modulation of DP and CRTH2 by PGD2. (PMID: 18802357) Yamamoto M. … Nishizaki K. (Int. Arch. Allergy Immunol. 2009) 3 23

Products for PTGDR Gene

Sources for PTGDR Gene

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