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Aliases for SPRYD7 Gene

Aliases for SPRYD7 Gene

  • SPRY Domain Containing 7 2 3 5
  • Chronic Lymphocytic Leukemia Deletion Region Gene 6 Protein 3 4
  • CLL Deletion Region Gene 6 Protein 3 4
  • C13orf1 3 4
  • CLLD6 3 4
  • Chromosome 13 Open Reading Frame 1 2

External Ids for SPRYD7 Gene

Previous HGNC Symbols for SPRYD7 Gene

  • C13orf1

Previous GeneCards Identifiers for SPRYD7 Gene

  • GC13M050487

Summaries for SPRYD7 Gene

GeneCards Summary for SPRYD7 Gene

SPRYD7 (SPRY Domain Containing 7) is a Protein Coding gene. Diseases associated with SPRYD7 include Chronic Lymphocytic Leukemia.

Gene Wiki entry for SPRYD7 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPRYD7 Gene

Genomics for SPRYD7 Gene

Regulatory Elements for SPRYD7 Gene

Enhancers for SPRYD7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SPRYD7 on UCSC Golden Path with GeneCards custom track

Promoters for SPRYD7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SPRYD7 on UCSC Golden Path with GeneCards custom track

Genomic Location for SPRYD7 Gene

49,912,702 bp from pter
49,995,962 bp from pter
83,261 bases
Minus strand

Genomic View for SPRYD7 Gene

Genes around SPRYD7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPRYD7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPRYD7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPRYD7 Gene

Proteins for SPRYD7 Gene

  • Protein details for SPRYD7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SPRY domain-containing protein 7
    Protein Accession:
    Secondary Accessions:
    • A8K3G1
    • O60648
    • Q8TBG8
    • Q96T69

    Protein attributes for SPRYD7 Gene

    196 amino acids
    Molecular mass:
    21666 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAC09363.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for SPRYD7 Gene


neXtProt entry for SPRYD7 Gene

Proteomics data for SPRYD7 Gene at MOPED

Post-translational modifications for SPRYD7 Gene

  • Ubiquitination at Lys 85
  • Modification sites at PhosphoSitePlus

Other Protein References for SPRYD7 Gene

No data available for DME Specific Peptides for SPRYD7 Gene

Domains & Families for SPRYD7 Gene

Protein Domains for SPRYD7 Gene


Suggested Antigen Peptide Sequences for SPRYD7 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 B30.2/SPRY domain.
  • Contains 1 B30.2/SPRY domain.
genes like me logo Genes that share domains with SPRYD7: view

No data available for Gene Families for SPRYD7 Gene

Function for SPRYD7 Gene

genes like me logo Genes that share phenotypes with SPRYD7: view

Animal Model Products

CRISPR Products

miRNA for SPRYD7 Gene

miRTarBase miRNAs that target SPRYD7

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPRYD7 Gene

Localization for SPRYD7 Gene

Subcellular locations from

Jensen Localization Image for SPRYD7 Gene COMPARTMENTS Subcellular localization image for SPRYD7 gene
Compartment Confidence
cytosol 3
extracellular 2
nucleus 2
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SPRYD7 Gene

Pathways & Interactions for SPRYD7 Gene

SuperPathways for SPRYD7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SPRYD7 Gene


No data available for Pathways by source and SIGNOR curated interactions for SPRYD7 Gene

Drugs & Compounds for SPRYD7 Gene

No Compound Related Data Available

Transcripts for SPRYD7 Gene

Unigene Clusters for SPRYD7 Gene

SPRY domain containing 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPRYD7 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d
SP2: - -
SP3: - - -
SP4: -

Relevant External Links for SPRYD7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPRYD7 Gene

mRNA expression in normal human tissues for SPRYD7 Gene

Protein differential expression in normal tissues from HIPED for SPRYD7 Gene

This gene is overexpressed in Placenta (13.2) and Bone (13.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SPRYD7 Gene

SOURCE GeneReport for Unigene cluster for SPRYD7 Gene Hs.44235

genes like me logo Genes that share expression patterns with SPRYD7: view

Protein tissue co-expression partners for SPRYD7 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SPRYD7 Gene

Orthologs for SPRYD7 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPRYD7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SPRYD7 35
  • 94.05 (n)
  • 98.47 (a)
  • 98 (a)
(Canis familiaris)
Mammalia SPRYD7 35
  • 94.2 (n)
  • 98.76 (a)
  • 87 (a)
(Mus musculus)
Mammalia Spryd7 35
  • 90.48 (n)
  • 98.47 (a)
Spryd7 16
Spryd7 36
  • 98 (a)
(Pan troglodytes)
Mammalia SPRYD7 35
  • 99.66 (n)
  • 99.49 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Spryd7 35
  • 90.48 (n)
  • 98.47 (a)
(Monodelphis domestica)
Mammalia SPRYD7 36
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia SPRYD7 36
  • 94 (a)
(Gallus gallus)
Aves SPRYD7 35
  • 82.99 (n)
  • 95.41 (a)
  • 95 (a)
(Anolis carolinensis)
Reptilia SPRYD7 36
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia spryd7 35
  • 80.28 (n)
  • 93.72 (a)
Str.11085 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.24473 35
(Danio rerio)
Actinopterygii Dr.13478 35
spryd7a 35
  • 74.49 (n)
  • 82.14 (a)
spryd7a 36
  • 82 (a)
spryd7b 36
  • 85 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001349 35
  • 51.66 (n)
  • 53.4 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7785 35
  • 53.68 (n)
  • 49.47 (a)
CG7785 36
  • 36 (a)
(Caenorhabditis elegans)
Secernentea F18H3.1 35
  • 54.69 (n)
  • 47.31 (a)
F18H3.1 36
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
Species with no ortholog for SPRYD7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SPRYD7 Gene

Gene Tree for SPRYD7 (if available)
Gene Tree for SPRYD7 (if available)

Paralogs for SPRYD7 Gene Pseudogenes for SPRYD7 Gene

genes like me logo Genes that share paralogs with SPRYD7: view

No data available for Paralogs for SPRYD7 Gene

Variants for SPRYD7 Gene

Sequence variations from dbSNP and Humsavar for SPRYD7 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs732729 -- 49,939,399(-) TGCTT(A/T)TGACT intron-variant
rs1063181 -- 49,936,265(-) CTAGG(C/G)ACGGC intron-variant, nc-transcript-variant, utr-variant-5-prime
rs1063183 -- 49,914,947(-) GATGC(C/T)GTCTA nc-transcript-variant, utr-variant-3-prime
rs1609571 -- 49,914,719(-) GGGTG(G/T)GTGTT nc-transcript-variant, utr-variant-3-prime
rs1807033 -- 49,938,728(+) TTTGC(C/T)TTAAC intron-variant

Variation tolerance for SPRYD7 Gene

Residual Variation Intolerance Score: 37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.03; 0.62% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for SPRYD7 Gene

Disorders for SPRYD7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SPRYD7 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
chronic lymphocytic leukemia
  • cll
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SPRYD7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SPRYD7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SPRYD7 Gene

Publications for SPRYD7 Gene

  1. Cloning and characterization of CLLD6, CLLD7, and CLLD8, novel candidate genes for leukemogenesis at chromosome 13q14, a region commonly deleted in B-cell chronic lymphocytic leukemia. (PMID: 11306461) Mabuchi H. … Croce C.M. (Cancer Res. 2001) 2 3 4 67
  2. [Transcription map of the 13q14 region, frequently deleted in B-cell chronic lymphocytic leukemia patients]. (PMID: 11771308) Tiazhelova T.V. … Baranova A.V. (Genetika 2001) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. (PMID: 22053931) Oshikawa K. … Nakayama K.I. (J. Proteome Res. 2012) 3

Products for SPRYD7 Gene

Sources for SPRYD7 Gene