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Aliases for SLC39A10 Gene

Aliases for SLC39A10 Gene

  • Solute Carrier Family 39 Member 10 2 3 4 5
  • Solute Carrier Family 39 (Metal Ion Transporter), Member 10 2 3
  • Solute Carrier Family 39 (Zinc Transporter), Member 10 2 3
  • Zrt- And Irt-Like Protein 10 3 4
  • ZIP-10 3 4
  • Zinc Transporter ZIP10 3
  • KIAA1265 4
  • LZT-Hs2 3
  • ZIP10 4

External Ids for SLC39A10 Gene

Previous GeneCards Identifiers for SLC39A10 Gene

  • GC00U912989
  • GC02P196724
  • GC02P196347
  • GC02P196229
  • GC02P196440
  • GC02P188374

Summaries for SLC39A10 Gene

Entrez Gene Summary for SLC39A10 Gene

  • Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A10 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC39A10 Gene

SLC39A10 (Solute Carrier Family 39 Member 10) is a Protein Coding gene. Among its related pathways are Metal ion SLC transporters and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include metal ion transmembrane transporter activity. An important paralog of this gene is SLC39A6.

UniProtKB/Swiss-Prot for SLC39A10 Gene

  • May act as a zinc-influx transporter.

Gene Wiki entry for SLC39A10 Gene

Additional gene information for SLC39A10 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC39A10 Gene

Genomics for SLC39A10 Gene

Regulatory Elements for SLC39A10 Gene

Enhancers for SLC39A10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H195647 1.6 FANTOM5 Ensembl ENCODE dbSUPER 22.6 +74.0 74040 4 PKNOX1 BMI1 EBF1 ZNF316 ZNF207 ATF7 ZSCAN29 RUNX3 IKZF2 NR2F1 SLC39A10 LINC01827 DNAH7 LOC101927482 ENSG00000272211 GC02P195660 AHCYP5
GH02H195655 1.8 FANTOM5 ENCODE dbSUPER 15.3 +82.2 82193 5 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 DNAH7 SLC39A10 RNU6-169P LINC01827 LOC100420572 STK17B GC02P195660 AHCYP5
GH02H195531 1.5 FANTOM5 ENCODE dbSUPER 11.7 -41.3 -41327 5 HDGF PKNOX1 TCF12 GATA2 FOS ATF7 RUNX3 ZNF592 NBN HMBOX1 RNU6-169P LINC01827 SLC39A10 DNAH7 LOC100420572 LINC01825
GH02H195612 1.5 FANTOM5 Ensembl ENCODE 10.8 +37.8 37764 3 HDAC1 ATF1 ARNT ZEB1 CHAMP1 RFX5 TCF12 GATA2 SCRT2 RCOR1 SLC39A10 LINC01827 DNAH7 LINC01825 AHCYP5 LOC101927482 GC02P195660
GH02H195661 1 Ensembl dbSUPER 10.6 +86.3 86324 1 ATF1 TBL1XR1 TAL1 CHAMP1 TCF12 CC2D1A GATA2 POLR2A NCOR1 TRIM24 DNAH7 LOC100420572 LINC01827 SLC39A10 GC02P195660 RNU6-915P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC39A10 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC39A10 Gene

Chromosome:
2
Start:
195,575,977 bp from pter
End:
195,737,702 bp from pter
Size:
161,726 bases
Orientation:
Plus strand

Genomic View for SLC39A10 Gene

Genes around SLC39A10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC39A10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC39A10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC39A10 Gene

Proteins for SLC39A10 Gene

  • Protein details for SLC39A10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULF5-S39AA_HUMAN
    Recommended name:
    Zinc transporter ZIP10
    Protein Accession:
    Q9ULF5
    Secondary Accessions:
    • A8K5C6
    • B4DGU0
    • Q3MJA4
    • Q68CR5
    • Q6DKH6
    • Q9Y3Z1

    Protein attributes for SLC39A10 Gene

    Size:
    831 amino acids
    Molecular mass:
    94132 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • High levels of expression are correlated with invasiveness in several breast cancer lines.
    SequenceCaution:
    • Sequence=BAA86579.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB43393.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC39A10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC39A10 Gene

Post-translational modifications for SLC39A10 Gene

  • Ubiquitination at Lys50, Lys66, and isoforms=2533
  • Glycosylation at isoforms=139, Asn198, isoforms=210, Asn218, Thr248, and Asn339
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC39A10 Gene

Domains & Families for SLC39A10 Gene

Gene Families for SLC39A10 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins
  • Transporters

Protein Domains for SLC39A10 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9ULF5

UniProtKB/Swiss-Prot:

S39AA_HUMAN :
  • Belongs to the ZIP transporter (TC 2.A.5) family.
Family:
  • Belongs to the ZIP transporter (TC 2.A.5) family.
genes like me logo Genes that share domains with SLC39A10: view

Function for SLC39A10 Gene

Molecular function for SLC39A10 Gene

UniProtKB/Swiss-Prot Function:
May act as a zinc-influx transporter.

Phenotypes From GWAS Catalog for SLC39A10 Gene

Gene Ontology (GO) - Molecular Function for SLC39A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005385 zinc ion transmembrane transporter activity IBA --
GO:0046873 metal ion transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC39A10: view
genes like me logo Genes that share phenotypes with SLC39A10: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC39A10

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SLC39A10
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC39A10 Gene

Localization for SLC39A10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC39A10 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC39A10 gene
Compartment Confidence
plasma membrane 5
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC39A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC39A10: view

Pathways & Interactions for SLC39A10 Gene

genes like me logo Genes that share pathways with SLC39A10: view

Gene Ontology (GO) - Biological Process for SLC39A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002903 negative regulation of B cell apoptotic process IEA --
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006829 zinc II ion transport IEA --
GO:0006882 cellular zinc ion homeostasis IBA --
genes like me logo Genes that share ontologies with SLC39A10: view

No data available for SIGNOR curated interactions for SLC39A10 Gene

Drugs & Compounds for SLC39A10 Gene

No Compound Related Data Available

Transcripts for SLC39A10 Gene

Unigene Clusters for SLC39A10 Gene

Solute carrier family 39 (zinc transporter), member 10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SLC39A10
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SLC39A10 Gene

No ASD Table

Relevant External Links for SLC39A10 Gene

GeneLoc Exon Structure for
SLC39A10
ECgene alternative splicing isoforms for
SLC39A10

Expression for SLC39A10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC39A10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC39A10 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.9) and Brain - Anterior cingulate cortex (BA24) (x4.6).

Protein differential expression in normal tissues from HIPED for SLC39A10 Gene

This gene is overexpressed in Fetal Brain (21.6), Amniocyte (21.2), and Plasma (14.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC39A10 Gene



Protein tissue co-expression partners for SLC39A10 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC39A10 Gene:

SLC39A10

SOURCE GeneReport for Unigene cluster for SLC39A10 Gene:

Hs.650158

Evidence on tissue expression from TISSUES for SLC39A10 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with SLC39A10: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC39A10 Gene

Orthologs for SLC39A10 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC39A10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC39A10 33 34
  • 99.8 (n)
dog
(Canis familiaris)
Mammalia SLC39A10 34
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC39A10 33 34
  • 93.94 (n)
mouse
(Mus musculus)
Mammalia Slc39a10 33 16 34
  • 86.6 (n)
rat
(Rattus norvegicus)
Mammalia Slc39a10 33
  • 85.56 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC39A10 34
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC39A10 33
  • 74.18 (n)
-- 34
  • 67 (a)
OneToMany
-- 34
  • 50 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia SLC39A10 34
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493171 33
  • 64.8 (n)
Str.9023 33
zebrafish
(Danio rerio)
Actinopterygii slc39a10 33 34
  • 62.08 (n)
zgc63552 33
fruit fly
(Drosophila melanogaster)
Insecta foi 34
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 46 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.192 33
Species where no ortholog for SLC39A10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC39A10 Gene

ENSEMBL:
Gene Tree for SLC39A10 (if available)
TreeFam:
Gene Tree for SLC39A10 (if available)

Paralogs for SLC39A10 Gene

(2) SIMAP similar genes for SLC39A10 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with SLC39A10: view

Variants for SLC39A10 Gene

Sequence variations from dbSNP and Humsavar for SLC39A10 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000055529 -- 195,635,958(+) GATAC(A/G)AAATC intron-variant
rs1000056204 -- 195,688,254(+) AATGA(A/C)TTGTG intron-variant
rs1000071643 -- 195,584,655(+) GAGAC(C/G)TCTTC intron-variant
rs1000087578 -- 195,645,398(+) ACTTA(C/T)TCTCA intron-variant
rs1000090687 -- 195,605,015(+) TTTTT(C/G)ATAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC39A10 Gene

Variant ID Type Subtype PubMed ID
esv3593872 CNV loss 21293372
nsv1127791 CNV deletion 24896259
nsv3094 CNV deletion 18451855
nsv515614 CNV loss 19592680
nsv820131 CNV loss 19587683
nsv834501 CNV gain 17160897
nsv834503 CNV loss 17160897
nsv999936 CNV gain 25217958

Variation tolerance for SLC39A10 Gene

Residual Variation Intolerance Score: 6.45% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.10; 51.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC39A10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC39A10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC39A10 Gene

Disorders for SLC39A10 Gene

Relevant External Links for SLC39A10

Genetic Association Database (GAD)
SLC39A10
Human Genome Epidemiology (HuGE) Navigator
SLC39A10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC39A10

No disorders were found for SLC39A10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC39A10 Gene

Publications for SLC39A10 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  2. Polymorphisms in mitochondrial genes and prostate cancer risk. (PMID: 19064571) Wang L … Thibodeau SN (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008) 3 45 60
  3. The LZT proteins; the LIV-1 subfamily of zinc transporters. (PMID: 12659941) Taylor KM … Nicholson RI (Biochimica et biophysica acta 2003) 2 3 60
  4. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for SLC39A10 Gene

Sources for SLC39A10 Gene

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