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Aliases for SLC44A2 Gene

Aliases for SLC44A2 Gene

  • Solute Carrier Family 44 (Choline Transporter), Member 2 2 3
  • CTL2 3 4 6
  • Choline Transporter-Like Protein 2 3
  • Solute Carrier Family 44, Member 2 3
  • Solute Carrier Family 44 Member 2 4
  • PP1292 3

External Ids for SLC44A2 Gene

Previous GeneCards Identifiers for SLC44A2 Gene

  • GC19P010713
  • GC19P010290

Summaries for SLC44A2 Gene

GeneCards Summary for SLC44A2 Gene

SLC44A2 (Solute Carrier Family 44 (Choline Transporter), Member 2) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include signal transducer activity and choline transmembrane transporter activity. An important paralog of this gene is SLC44A1.

UniProtKB/Swiss-Prot for SLC44A2 Gene

  • Isoform 1, but not isoform 3, exhibits some choline transporter activity.

Gene Wiki entry for SLC44A2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC44A2 Gene

Genomics for SLC44A2 Gene

Regulatory Elements for SLC44A2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC44A2 Gene

Start:
10,602,445 bp from pter
End:
10,644,559 bp from pter
Size:
42,115 bases
Orientation:
Plus strand

Genomic View for SLC44A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC44A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC44A2 Gene

Proteins for SLC44A2 Gene

  • Protein details for SLC44A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWA5-CTL2_HUMAN
    Recommended name:
    Choline transporter-like protein 2
    Protein Accession:
    Q8IWA5
    Secondary Accessions:
    • B2RBB1
    • B3KNH3
    • B4DFJ0
    • F2Q9D7
    • Q658V1
    • Q658Z2
    • Q6PJV7
    • Q8N2F0
    • Q9NY68

    Protein attributes for SLC44A2 Gene

    Size:
    706 amino acids
    Molecular mass:
    80124 Da
    Quaternary structure:
    • Interacts with COCH.
    SequenceCaution:
    • Sequence=BAC11662.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC44A2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC44A2 Gene

Proteomics data for SLC44A2 Gene at MOPED

Post-translational modifications for SLC44A2 Gene

  • Glycosylation at Asn187, Asn200, and Asn417
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for SLC44A2 Gene

Domains for SLC44A2 Gene

Gene Families for SLC44A2 Gene

Protein Domains for SLC44A2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC44A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IWA5

UniProtKB/Swiss-Prot:

CTL2_HUMAN :
  • Q8IWA5
Family:
  • Belongs to the CTL (choline transporter-like) family.
genes like me logo Genes that share domains with SLC44A2: view

Function for SLC44A2 Gene

Molecular function for SLC44A2 Gene

UniProtKB/Swiss-Prot Function: Isoform 1, but not isoform 3, exhibits some choline transporter activity.

Gene Ontology (GO) - Molecular Function for SLC44A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IMP 12761501
GO:0005515 protein binding --
GO:0015220 choline transmembrane transporter activity TAS 10677542
genes like me logo Genes that share ontologies with SLC44A2: view

Animal Model Products

CRISPR Products

miRNA for SLC44A2 Gene

miRTarBase miRNAs that target SLC44A2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC44A2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC44A2 Gene

Localization for SLC44A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC44A2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC44A2 Gene COMPARTMENTS Subcellular localization image for SLC44A2 gene
Compartment Confidence
plasma membrane 4
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for SLC44A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IDA 17897319
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane TAS 10677542
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with SLC44A2: view

Pathways for SLC44A2 Gene

genes like me logo Genes that share pathways with SLC44A2: view

Interacting Proteins for SLC44A2 Gene

Gene Ontology (GO) - Biological Process for SLC44A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process TAS --
GO:0006656 phosphatidylcholine biosynthetic process TAS --
GO:0007165 signal transduction IMP 12761501
GO:0015871 choline transport TAS 10677542
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IMP 12761501
genes like me logo Genes that share ontologies with SLC44A2: view

Compounds for SLC44A2 Gene

(1) HMDB Compounds for SLC44A2 Gene

Compound Synonyms Cas Number PubMed IDs
Choline
  • (2-Hydroxyethyl)trimethyl ammonium
62-49-7

(1) Drugbank Compounds for SLC44A2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Choline
  • Bilineurine
62-49-7 transporter substrate

(1) Novoseek inferred chemical compound relationships for SLC44A2 Gene

Compound -log(P) Hits PubMed IDs
choline 67.2 13
genes like me logo Genes that share compounds with SLC44A2: view

Transcripts for SLC44A2 Gene

Unigene Clusters for SLC44A2 Gene

Solute carrier family 44, member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC44A2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SLC44A2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC44A2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15a · 15b ^ 16a · 16b · 16c ·
SP1: - - -
SP2: - - - - -
SP3: - - -
SP4: - - -
SP5:
SP6:
SP7: - - - - - - - - - - - - - - - - - - -
SP8:
SP9: -
SP10: -
SP11:

ExUns: 16d · 16e ^ 17a · 17b · 17c ^ 18a · 18b · 18c ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24a · 24b
SP1: - -
SP2: - -
SP3: - - - -
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for SLC44A2 Gene

GeneLoc Exon Structure for
SLC44A2
ECgene alternative splicing isoforms for
SLC44A2

Expression for SLC44A2 Gene

mRNA expression in normal human tissues for SLC44A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC44A2 Gene

This gene is overexpressed in Whole Blood (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SLC44A2 Gene

SOURCE GeneReport for Unigene cluster for SLC44A2 Gene Hs.534560

mRNA Expression by UniProt/SwissProt for SLC44A2 Gene

Q8IWA5-CTL2_HUMAN
Tissue specificity: Present in supporting cells of the inner ear (at protein level). Only isoform 3 is expressed in inner ear vestibular tissue.
genes like me logo Genes that share expressions with SLC44A2: view

In Situ Assay Products

Orthologs for SLC44A2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC44A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC44A2 35
  • 99.76 (n)
  • 99.72 (a)
SLC44A2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC44A2 35
  • 87.77 (n)
  • 90.04 (a)
SLC44A2 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC44A2 35
  • 89.73 (n)
  • 93.89 (a)
SLC44A2 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc44a2 35
  • 84.78 (n)
  • 90.47 (a)
Slc44a2 16
Slc44a2 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC44A2 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC44A2 36
  • 56 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc44a2 35
  • 84.95 (n)
  • 91.31 (a)
chicken
(Gallus gallus)
Aves SLC44A2 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC44A2 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc44a2 35
  • 72.68 (n)
  • 76.99 (a)
Str.7588 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10852 35
zebrafish
(Danio rerio)
Actinopterygii sbcb39 35
slc44a2 35
  • 69.24 (n)
  • 70.16 (a)
slc44a2 36
  • 67 (a)
OneToMany
SLC44A2 (1 of 2) 36
  • 63 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG11880 36
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea chtl-1 36
  • 35 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PNS1 36
  • 19 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G15380 35
  • 42.49 (n)
  • 27 (a)
rice
(Oryza sativa)
Liliopsida Os04g0681600 35
  • 43.59 (n)
  • 28.83 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12838 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
OneToMany
Species with no ortholog for SLC44A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC44A2 Gene

ENSEMBL:
Gene Tree for SLC44A2 (if available)
TreeFam:
Gene Tree for SLC44A2 (if available)

Paralogs for SLC44A2 Gene

Paralogs for SLC44A2 Gene

Selected SIMAP similar genes for SLC44A2 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with SLC44A2: view

Variants for SLC44A2 Gene

Sequence variations from dbSNP and Humsavar for SLC44A2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs10948 -- 10,644,229(+) ATGAT(G/T)TCAGG utr-variant-3-prime
rs892078 -- 10,612,343(-) CCAGG(A/C)TGAAG intron-variant
rs892079 -- 10,612,278(-) cctcc(C/T)gcctc intron-variant
rs1036230 -- 10,629,334(-) tgcca(C/T)tgcac intron-variant
rs1053007 -- 10,643,724(+) ACCAC(A/C/G/T)GGAAG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SLC44A2 Gene

Variant ID Type Subtype PubMed ID
nsv833744 CNV Loss 17160897
nsv911042 CNV Loss 21882294
nsv833745 CNV Loss 17160897
nsv911046 CNV Loss 21882294
nsv911047 CNV Loss 21882294
nsv911048 CNV Loss 21882294

Relevant External Links for SLC44A2 Gene

HapMap Linkage Disequilibrium report
SLC44A2
Human Gene Mutation Database (HGMD)
SLC44A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC44A2 Gene

Disorders for SLC44A2 Gene

Relevant External Links for SLC44A2

Human Genome Epidemiology (HuGE) Navigator
SLC44A2
genes like me logo Genes that share disorders with SLC44A2: view

No data available for UniProtKB/Swiss-Prot for SLC44A2 Gene

Publications for SLC44A2 Gene

  1. Identification and characterization of choline transporter-like protein 2, an inner ear glycoprotein of 68 and 72 kDa that is the target of antibody-induced hearing loss. (PMID: 14973250) Nair T.S. … Carey T.E. (J. Neurosci. 2004) 3 4 23
  2. Cochlin isoforms and their interaction with CTL2 (SLC44A2) in the inner ear. (PMID: 17926100) Kommareddi P.K. … Carey T.E. (J. Assoc. Res. Otolaryngol. 2007) 3 4 23
  3. An electric lobe suppressor for a yeast choline transport mutation belongs to a new family of transporter-like proteins. (PMID: 10677542) O'Regan S. … Meunier F.-M. (Proc. Natl. Acad. Sci. U.S.A. 2000) 2 3 4
  4. Isoforms, expression, glycosylation, and tissue distribution of CTL2/SLC44A2. (PMID: 20665236) Kommareddi P.K. … Carey T.E. (Protein J. 2010) 3 4
  5. Characterization of the human neutrophil alloantigen-3a. (PMID: 20037594) Greinacher A. … Bux J. (Nat. Med. 2010) 3 23

Products for SLC44A2 Gene

Sources for SLC44A2 Gene

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