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Aliases for INTS12 Gene

Aliases for INTS12 Gene

  • Integrator Complex Subunit 12 2 3
  • PHD Finger Protein 22 2 3 4
  • INT12 3 4 6
  • Hypothetical Nuclear Factor SBBI22 2 3
  • PHF22 3 4
  • SBBI22 3

External Ids for INTS12 Gene

Previous Symbols for INTS12 Gene

  • PHF22

Summaries for INTS12 Gene

Entrez Gene Summary for INTS12 Gene

  • INTS12 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]

GeneCards Summary for INTS12 Gene

INTS12 (Integrator Complex Subunit 12) is a Protein Coding gene.

UniProtKB/Swiss-Prot for INTS12 Gene

  • Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes

Gene Wiki entry for INTS12 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INTS12 Gene

Genomics for INTS12 Gene

Genomic Location for INTS12 Gene

Start:
105,682,627 bp from pter
End:
105,895,986 bp from pter
Size:
213,360 bases
Orientation:
Minus strand

Genomic View for INTS12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for INTS12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INTS12 Gene

Regulatory Elements for INTS12 Gene

Proteins for INTS12 Gene

  • Protein details for INTS12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96CB8-INT12_HUMAN
    Recommended name:
    Integrator complex subunit 12
    Protein Accession:
    Q96CB8
    Secondary Accessions:
    • B2RC48
    • Q3B6Z3
    • Q9HD71

    Protein attributes for INTS12 Gene

    Size:
    462 amino acids
    Molecular mass:
    48808 Da
    Quaternary structure:
    • Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12.
    SequenceCaution:
    • Sequence=AAF99604.1; Type=Frameshift; Positions=439; Evidence={ECO:0000305};

neXtProt entry for INTS12 Gene

Proteomics data for INTS12 Gene at MOPED

Post-translational modifications for INTS12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for INTS12 Gene

Domains for INTS12 Gene

Gene Families for INTS12 Gene

HGNC:
  • PHF :Zinc fingers, PHD-type

UniProtKB/Swiss-Prot:

INT12_HUMAN
Similarity:
  • Contains 1 PHD-type zinc finger.:
    • Q96CB8
genes like me logo Genes that share domains with INTS12: view

Function for INTS12 Gene

Molecular function for INTS12 Gene

UniProtKB/Swiss-Prot Function: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes

Gene Ontology (GO) - Molecular Function for INTS12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16239144
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with INTS12: view

Phenotypes for INTS12 Gene

MGI mutant phenotypes for INTS12:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with INTS12: view

miRNA for INTS12 Gene

miRTarBase miRNAs that target INTS12

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for INTS12 Gene

Localization for INTS12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for INTS12 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for INTS12 Gene COMPARTMENTS Subcellular localization image for INTS12 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for INTS12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032039 integrator complex IDA 16239144
genes like me logo Genes that share ontologies with INTS12: view

Pathways for INTS12 Gene

SuperPathways for INTS12 Gene

No Data Available

Gene Ontology (GO) - Biological Process for INTS12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016180 snRNA processing IDA 16239144
genes like me logo Genes that share ontologies with INTS12: view

No data available for Pathways by source for INTS12 Gene

Transcripts for INTS12 Gene

Unigene Clusters for INTS12 Gene

Integrator complex subunit 12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for INTS12 Gene

No ASD Table

Relevant External Links for INTS12 Gene

GeneLoc Exon Structure for
INTS12
ECgene alternative splicing isoforms for
INTS12

Expression for INTS12 Gene

mRNA expression in normal human tissues for INTS12 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for INTS12 Gene

SOURCE GeneReport for Unigene cluster for INTS12 Gene Hs.480454

genes like me logo Genes that share expressions with INTS12: view

Orthologs for INTS12 Gene

This gene was present in the common ancestor of animals.

Orthologs for INTS12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia INTS12 36
  • 99.64 (n)
  • 99.57 (a)
INTS12 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia INTS12 36
  • 91.5 (n)
  • 91.8 (a)
INTS12 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia INTS12 36
  • 92.24 (n)
  • 93.57 (a)
INTS12 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ints12 36
  • 88.15 (n)
  • 91.33 (a)
Ints12 16
Ints12 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia INTS12 37
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia INTS12 37
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ints12 36
  • 86.37 (n)
  • 90.67 (a)
chicken
(Gallus gallus)
Aves INTS12 36
  • 74.31 (n)
  • 77.9 (a)
INTS12 37
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia INTS12 37
  • 79 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.13619 36
tropical clawed frog
(Silurana tropicalis)
Amphibia ints12 36
  • 64.36 (n)
  • 65.4 (a)
zebrafish
(Danio rerio)
Actinopterygii ints12 37
  • 60 (a)
OneToMany
ints12 37
  • 60 (a)
OneToMany
LOC100334713 36
  • 59.7 (n)
  • 63.6 (a)
fruit fly
(Drosophila melanogaster)
Insecta IntS12 37
  • 27 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5374 37
  • 42 (a)
OneToOne
Species with no ortholog for INTS12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for INTS12 Gene

ENSEMBL:
Gene Tree for INTS12 (if available)
TreeFam:
Gene Tree for INTS12 (if available)

Paralogs for INTS12 Gene

No data available for Paralogs for INTS12 Gene

Variants for INTS12 Gene

Sequence variations from dbSNP and Humsavar for INTS12 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs4069 -- 105,683,206(-) GGTCC(C/T)CAACA frameshift-variant, reference
rs1374529 -- 105,697,412(-) CCTCA(C/G)AGGTA intron-variant
rs3213950 -- 105,700,012(+) GCAAA(C/T)GCCTG utr-variant-5-prime
rs3796924 -- 105,688,603(+) TCATT(C/G)CAAAA intron-variant
rs3796925 -- 105,701,651(+) TTTAA(A/G)TTCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for INTS12 Gene

Variant ID Type Subtype PubMed ID
nsv879699 CNV Gain 21882294

Relevant External Links for INTS12 Gene

HapMap Linkage Disequilibrium report
INTS12

Disorders for INTS12 Gene

(1) Novoseek inferred disease relationships for INTS12 Gene

Disease -log(P) Hits PubMed IDs
adenocarcinoma 9.61 2

Relevant External Links for INTS12

Genetic Association Database (GAD)
INTS12
Human Genome Epidemiology (HuGE) Navigator
INTS12
genes like me logo Genes that share disorders with INTS12: view

No data available for UniProtKB/Swiss-Prot for INTS12 Gene

Publications for INTS12 Gene

  1. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. (PMID: 16239144) Baillat D. … Shiekhattar R. (Cell 2005) 2 3 4
  2. Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function. (PMID: 20010835) Hancock D.B. … London S.J. (Nat. Genet. 2010) 3 49
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PMID: 20332099) Kalsi G. … Riley B.P. (Hum. Mol. Genet. 2010) 3 49
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for INTS12 Gene

  • antibodies-online peptides for INTS12
  • antibodies-online antibodies for INTS12
  • antibodies-online kits for INTS12

Sources for INTS12 Gene

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