Aliases for BACH1 Gene
External Ids for BACH1 Gene
Previous GeneCards Identifiers for BACH1 Gene
This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These BTB/POZ domains facilitate protein-protein interactions and formation of homo- and/or hetero-oligomers. When this encoded protein forms a heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE) and transcription is repressed. Multiple alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, May 2009]
GeneCards Summary for BACH1 Gene
BACH1 (BTB Domain And CNC Homolog 1) is a Protein Coding gene. Among its related pathways are Integrated Breast Cancer Pathway and Integrated Cancer Pathway. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and heme binding. An important paralog of this gene is BACH2.
UniProtKB/Swiss-Prot for BACH1 Gene
Transcriptional regulator that acts as repressor or activator. Binds, in vitro, to NF-E2 binding sites. Play important roles in coordinating transcription activation and repression by MAFK.