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Aliases for AGTRAP Gene

Aliases for AGTRAP Gene

  • Angiotensin II Receptor Associated Protein 2 3
  • Angiotensin II Receptor-Associated Protein 3 5
  • AT1 Receptor-Associated Protein 3 4
  • ATRAP 3 4
  • Angiotensin II, Type I Receptor-Associated Protein 3
  • ATI Receptor-Associated Protein 3

External Ids for AGTRAP Gene

Previous GeneCards Identifiers for AGTRAP Gene

  • GC00U990804
  • GC01P011639
  • GC01P011405
  • GC01P011505
  • GC01P011730
  • GC01P011796
  • GC01P010950

Summaries for AGTRAP Gene

Entrez Gene Summary for AGTRAP Gene

  • This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for AGTRAP Gene

AGTRAP (Angiotensin II Receptor Associated Protein) is a Protein Coding gene. GO annotations related to this gene include angiotensin type II receptor activity.

UniProtKB/Swiss-Prot for AGTRAP Gene

  • Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity.

Gene Wiki entry for AGTRAP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGTRAP Gene

Genomics for AGTRAP Gene

Regulatory Elements for AGTRAP Gene

Enhancers for AGTRAP Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around AGTRAP on UCSC Golden Path with GeneCards custom track

Promoters for AGTRAP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around AGTRAP on UCSC Golden Path with GeneCards custom track

Genomic Location for AGTRAP Gene

Chromosome:
1
Start:
11,735,474 bp from pter
End:
11,754,802 bp from pter
Size:
19,329 bases
Orientation:
Plus strand

Genomic View for AGTRAP Gene

Genes around AGTRAP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AGTRAP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AGTRAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGTRAP Gene

Proteins for AGTRAP Gene

  • Protein details for AGTRAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6RW13-ATRAP_HUMAN
    Recommended name:
    Type-1 angiotensin II receptor-associated protein
    Protein Accession:
    Q6RW13
    Secondary Accessions:
    • A8MVQ5
    • Q5SNV4
    • Q5SNV5
    • Q96AC0
    • Q96PL4
    • Q9NRW9

    Protein attributes for AGTRAP Gene

    Size:
    159 amino acids
    Molecular mass:
    17419 Da
    Quaternary structure:
    • Interacts with RACK1, and with the C-terminal region of AGTR1.
    SequenceCaution:
    • Sequence=CAI15876.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for AGTRAP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AGTRAP Gene

Proteomics data for AGTRAP Gene at MOPED

Post-translational modifications for AGTRAP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for AGTRAP Gene

Domains & Families for AGTRAP Gene

Protein Domains for AGTRAP Gene

Suggested Antigen Peptide Sequences for AGTRAP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with AGTRAP: view

No data available for Gene Families and UniProtKB/Swiss-Prot for AGTRAP Gene

Function for AGTRAP Gene

Molecular function for AGTRAP Gene

UniProtKB/Swiss-Prot Function:
Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity.
genes like me logo Genes that share phenotypes with AGTRAP: view

Animal Model Products

miRNA for AGTRAP Gene

miRTarBase miRNAs that target AGTRAP

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AGTRAP Gene

Localization for AGTRAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for AGTRAP Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Present in perinuclear vesicular membranes, Endoplasmic reticulum, Golgi and endocytic vesicles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AGTRAP Gene COMPARTMENTS Subcellular localization image for AGTRAP gene
Compartment Confidence
nucleus 5
plasma membrane 4
endoplasmic reticulum 3
golgi apparatus 3
cytosol 2
extracellular 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for AGTRAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with AGTRAP: view

Pathways & Interactions for AGTRAP Gene

SuperPathways for AGTRAP Gene

No Data Available

Gene Ontology (GO) - Biological Process for AGTRAP Gene

None

No data available for Pathways by source and SIGNOR curated interactions for AGTRAP Gene

Drugs & Compounds for AGTRAP Gene

(13) Drugs for AGTRAP Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Azilsartan medoxomil Approved Pharma Angiotensin II receptor type 1 antagonist 0
Irbesartan Approved, Investigational Pharma Antagonist Angiotensin II inhibitor 99
Angiotensin (1-7) Pharma Vasoconstriction peptide hormone 0
Angiotensin 1/2 (1-5) Pharma Vasoconstrictor 0
Angiotensin 1/2 (1-6) Pharma Vasoconstrictor 0

(12) ApexBio Compounds for AGTRAP Gene

Compound Action Cas Number
Angiotensin (1-7) Vasoconstriction peptide hormone 51833-78-4
Angiotensin 1/2 (1-5) Vasoconstrictor 58442-64-1
Angiotensin 1/2 (1-6) Vasoconstrictor 47896-63-9
Angiotensin 1/2 + A (2 - 8) 51833-76-2
Angiotensin III (human, mouse) Aldosterone stimulator 13602-53-4
AVE 0991 Agonist of angiotensin-(1-7) receptor 304462-19-9
Azilsartan 147403-03-0
Azilsartan Medoxomil Angiotensin II receptor type 1 antagonist 863031-21-4
Eprosartan Mesylate 144143-96-4
Irbesartan Angiotensin II inhibitor 138402-11-6
PD123319 Angiotensin AT2 receptor antagonist 130663-39-7
Tranilast Angiogenesis inhibitor 53902-12-8
genes like me logo Genes that share compounds with AGTRAP: view

Transcripts for AGTRAP Gene

Unigene Clusters for AGTRAP Gene

Angiotensin II receptor-associated protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AGTRAP Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g · 6h
SP1: -
SP2: - - - -
SP3: - - -
SP4: - - - - -
SP5: - - - -
SP6: -
SP7: - - - - - -
SP8:
SP9: - - - - - -

Relevant External Links for AGTRAP Gene

GeneLoc Exon Structure for
AGTRAP
ECgene alternative splicing isoforms for
AGTRAP

Expression for AGTRAP Gene

mRNA expression in normal human tissues for AGTRAP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AGTRAP Gene

This gene is overexpressed in Whole Blood (x17.8).

Protein differential expression in normal tissues from HIPED for AGTRAP Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.9), Monocytes (11.9), NK cells (7.2), and Gallbladder (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for AGTRAP Gene



SOURCE GeneReport for Unigene cluster for AGTRAP Gene Hs.464438

mRNA Expression by UniProt/SwissProt for AGTRAP Gene

Q6RW13-ATRAP_HUMAN
Tissue specificity: Ubiquitous but more abundant in kidney, heart, pancreas and thyroid.
genes like me logo Genes that share expression patterns with AGTRAP: view

Protein tissue co-expression partners for AGTRAP Gene

Primer Products

Orthologs for AGTRAP Gene

This gene was present in the common ancestor of chordates.

Orthologs for AGTRAP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AGTRAP 35
  • 82.21 (n)
  • 75.68 (a)
AGTRAP 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AGTRAP 35
  • 83.22 (n)
  • 75.5 (a)
AGTRAP 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Agtrap 35
  • 81.97 (n)
  • 77.36 (a)
Agtrap 16
Agtrap 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia AGTRAP 35
  • 99.79 (n)
  • 99.37 (a)
rat
(Rattus norvegicus)
Mammalia Agtrap 35
  • 81.97 (n)
  • 75.47 (a)
oppossum
(Monodelphis domestica)
Mammalia AGTRAP 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 47 (a)
OneToMany
-- 36
  • 47 (a)
OneToMany
chicken
(Gallus gallus)
Aves AGTRAP 35
  • 66.67 (n)
  • 64.54 (a)
AGTRAP 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia agtrap 35
  • 60.42 (n)
  • 59.72 (a)
zebrafish
(Danio rerio)
Actinopterygii agtrap 35
  • 61.22 (n)
  • 56.6 (a)
agtrap 36
  • 52 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10899 35
Species with no ortholog for AGTRAP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AGTRAP Gene

ENSEMBL:
Gene Tree for AGTRAP (if available)
TreeFam:
Gene Tree for AGTRAP (if available)

Paralogs for AGTRAP Gene

No data available for Paralogs for AGTRAP Gene

Variants for AGTRAP Gene

Sequence variations from dbSNP and Humsavar for AGTRAP Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs17875960 - 11,750,140(+) GCCCG(C/T)AGATC reference, missense, utr-variant-3-prime
rs8617 -- 11,750,448(-) TAGGA(A/G)GTAAA utr-variant-3-prime
rs12955 -- 11,750,435(-) GAGAC(A/C)CTGGT utr-variant-3-prime
rs14962 -- 11,750,574(-) CAGGG(A/C)TTCCA utr-variant-3-prime
rs1128055 -- 11,750,614(+) GCAGT(C/T)TGGCA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for AGTRAP Gene

Variant ID Type Subtype PubMed ID
nsv832758 CNV Loss 17160897
nsv871014 CNV Gain 21882294
dgv140n71 CNV Loss 21882294
nsv508880 CNV Insertion 20534489
nsv871919 CNV Loss 21882294
nsv870510 CNV Gain 21882294
nsv871561 CNV Gain 21882294

Variation tolerance for AGTRAP Gene

Residual Variation Intolerance Score: 82.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.46; 9.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AGTRAP Gene

HapMap Linkage Disequilibrium report
AGTRAP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AGTRAP Gene

Disorders for AGTRAP Gene

Relevant External Links for AGTRAP

Genetic Association Database (GAD)
AGTRAP
Human Genome Epidemiology (HuGE) Navigator
AGTRAP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AGTRAP

No disorders were found for AGTRAP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AGTRAP Gene

Publications for AGTRAP Gene

  1. Identification and characterization of AGTRAP, a human homolog of murine angiotensin II receptor-associated protein (Agtrap). (PMID: 11733189) Wang W. … Mao Y. (Int. J. Biochem. Cell Biol. 2002) 2 3 4 23 67
  2. ATRAP, novel AT1 receptor associated protein, enhances internalization of AT1 receptor and inhibits vascular smooth muscle cell growth. (PMID: 11162453) Cui T. … Horiuchi M. (Biochem. Biophys. Res. Commun. 2000) 3 23
  3. A role for AT1 receptor-associated proteins in blood pressure regulation. (PMID: 25562590) Castrop H. (Curr Opin Pharmacol 2015) 3
  4. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for AGTRAP Gene

Sources for AGTRAP Gene

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