Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DDX24 Gene

Aliases for DDX24 Gene

  • DEAD (Asp-Glu-Ala-Asp) Box Helicase 24 2 3
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 24 2
  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 24 2
  • DEAD Box Protein 24 4
  • EC 3.6.4.13 4
  • EC 3.6.1 63

External Ids for DDX24 Gene

Previous GeneCards Identifiers for DDX24 Gene

  • GC14M092024
  • GC14M088333
  • GC14M092507
  • GC14M093587
  • GC14M094517
  • GC14M074697

Summaries for DDX24 Gene

Entrez Gene Summary for DDX24 Gene

  • DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. [provided by RefSeq, Jul 2008]

GeneCards Summary for DDX24 Gene

DDX24 (DEAD (Asp-Glu-Ala-Asp) Box Helicase 24) is a Protein Coding gene. GO annotations related to this gene include RNA binding and RNA helicase activity.

UniProtKB/Swiss-Prot for DDX24 Gene

  • ATP-dependent RNA helicase.

Gene Wiki entry for DDX24 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX24 Gene

Genomics for DDX24 Gene

Regulatory Elements for DDX24 Gene

Genomic Location for DDX24 Gene

Start:
94,048,291 bp from pter
End:
94,081,245 bp from pter
Size:
32,955 bases
Orientation:
Minus strand

Genomic View for DDX24 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DDX24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX24 Gene

Proteins for DDX24 Gene

  • Protein details for DDX24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZR7-DDX24_HUMAN
    Recommended name:
    ATP-dependent RNA helicase DDX24
    Protein Accession:
    Q9GZR7
    Secondary Accessions:
    • E7EMJ4
    • Q4V9L5

    Protein attributes for DDX24 Gene

    Size:
    859 amino acids
    Molecular mass:
    96332 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DDX24 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DDX24 Gene

Proteomics data for DDX24 Gene at MOPED

Post-translational modifications for DDX24 Gene

  • Ubiquitination at Lys195, Lys429, Lys541, and Lys601
  • Modification sites at PhosphoSitePlus

Other Protein References for DDX24 Gene

Domains for DDX24 Gene

Gene Families for DDX24 Gene

HGNC:
  • DDX :DEAD-boxes

Suggested Antigen Peptide Sequences for DDX24 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9GZR7

UniProtKB/Swiss-Prot:

DDX24_HUMAN :
  • Q9GZR7
Domain:
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
Family:
  • Belongs to the DEAD box helicase family. DDX24/MAK5 subfamily.
genes like me logo Genes that share domains with DDX24: view

Function for DDX24 Gene

Molecular function for DDX24 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O = ADP + phosphate
UniProtKB/Swiss-Prot Function: ATP-dependent RNA helicase.

Enzyme Numbers (IUBMB) for DDX24 Gene

Gene Ontology (GO) - Molecular Function for DDX24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003724 RNA helicase activity NAS 10936056
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0005524 ATP binding IEA --
GO:0008026 ATP-dependent helicase activity --
genes like me logo Genes that share ontologies with DDX24: view
genes like me logo Genes that share phenotypes with DDX24: view

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for DDX24 Gene

Localization for DDX24 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DDX24 Gene COMPARTMENTS Subcellular localization image for DDX24 gene
Compartment Confidence
nucleus 4
cytosol 3

Gene Ontology (GO) - Cellular Components for DDX24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IBA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with DDX24: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DDX24 Gene

Pathways for DDX24 Gene

SuperPathways for DDX24 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DDX24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0010501 RNA secondary structure unwinding IBA --
GO:0016070 RNA metabolic process NAS 10936056
genes like me logo Genes that share ontologies with DDX24: view

No data available for Pathways by source for DDX24 Gene

Transcripts for DDX24 Gene

Unigene Clusters for DDX24 Gene

DEAD (Asp-Glu-Ala-Asp) box polypeptide 24:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DDX24 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c
SP1: - -
SP2: - -
SP3:
SP4: - -
SP5:
SP6: -
SP7: -
SP8:

Relevant External Links for DDX24 Gene

GeneLoc Exon Structure for
DDX24
ECgene alternative splicing isoforms for
DDX24

Expression for DDX24 Gene

mRNA expression in normal human tissues for DDX24 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DDX24 Gene

SOURCE GeneReport for Unigene cluster for DDX24 Gene Hs.510328

mRNA Expression by UniProt/SwissProt for DDX24 Gene

Q9GZR7-DDX24_HUMAN
Tissue specificity: Ubiquitous. Most abundant in heart and brain, but with lowest levels in thymus and small intestine
genes like me logo Genes that share expressions with DDX24: view

No data available for mRNA differential expression in normal tissues for DDX24 Gene

Orthologs for DDX24 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DDX24 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DDX24 35
  • 99.26 (n)
  • 99.07 (a)
DDX24 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DDX24 35
  • 86.76 (n)
  • 84.23 (a)
DDX24 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DDX24 35
  • 85.56 (n)
  • 84.62 (a)
DDX24 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ddx24 35
  • 81.75 (n)
  • 79.6 (a)
Ddx24 16
Ddx24 36
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DDX24 36
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DDX24 36
  • 60 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ddx24 35
  • 82.25 (n)
  • 81.23 (a)
chicken
(Gallus gallus)
Aves DDX24 35
  • 63.01 (n)
  • 62.4 (a)
DDX24 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DDX24 36
  • 59 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398446 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx24 35
  • 60.35 (n)
  • 58.51 (a)
Str.14965 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2533 35
zebrafish
(Danio rerio)
Actinopterygii ddx24 36
  • 48 (a)
OneToOne
LOC553462 35
  • 62.3 (n)
  • 61.07 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010702 35
  • 51.33 (n)
  • 44.73 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9143 35
  • 57.41 (n)
  • 50.99 (a)
CG9143 36
  • 37 (a)
OneToOne
CG9143 37
  • 48 (a)
worm
(Caenorhabditis elegans)
Secernentea F55F8.2 35
  • 50.53 (n)
  • 44.34 (a)
F55F8.2 36
  • 36 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MAK5 36
  • 29 (a)
OneToOne
MAK5 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3498 36
  • 41 (a)
OneToOne
Species with no ortholog for DDX24:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DDX24 Gene

ENSEMBL:
Gene Tree for DDX24 (if available)
TreeFam:
Gene Tree for DDX24 (if available)

Paralogs for DDX24 Gene

Selected SIMAP similar genes for DDX24 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for DDX24 Gene

genes like me logo Genes that share paralogs with DDX24: view

No data available for Paralogs for DDX24 Gene

Variants for DDX24 Gene

Sequence variations from dbSNP and Humsavar for DDX24 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1644 -- 94,056,186(-) CTGTA(C/T)CACAG intron-variant
rs7291 -- 94,051,187(+) GACCA(C/G)GGCAG utr-variant-3-prime
rs9816 -- 94,060,478(-) CTCAC(A/C)CTGGT synonymous-codon, reference
rs1056810 -- 94,057,870(-) GTGGC(A/G)GCTCG reference, synonymous-codon
rs1950342 -- 94,067,411(+) ATATT(G/T)GGAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DDX24 Gene

Variant ID Type Subtype PubMed ID
esv34067 CNV Loss 18971310

Relevant External Links for DDX24 Gene

HapMap Linkage Disequilibrium report
DDX24
Human Gene Mutation Database (HGMD)
DDX24

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDX24 Gene

Disorders for DDX24 Gene

Relevant External Links for DDX24

Human Genome Epidemiology (HuGE) Navigator
DDX24
genes like me logo Genes that share disorders with DDX24: view

No data available for UniProtKB/Swiss-Prot for DDX24 Gene

Publications for DDX24 Gene

  1. Cloning and characterization of human DDX24 and mouse Ddx24, two novel putative DEAD-box proteins, and mapping DDX24 to human chromosome 14q32. (PMID: 10936056) Zhao Y. … Zhao S. (Genomics 2000) 2 3 4
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for DDX24 Gene

Sources for DDX24 Gene

Back to Top

Content