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Aliases for DDX24 Gene

Aliases for DDX24 Gene

  • DEAD-Box Helicase 24 2 3 5
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 24 2
  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 24 2
  • DEAD (Asp-Glu-Ala-Asp) Box Helicase 24 2
  • DEAD Box Protein 24 4
  • EC 4
  • EC 3.6.1 61

External Ids for DDX24 Gene

Previous GeneCards Identifiers for DDX24 Gene

  • GC14M092024
  • GC14M088333
  • GC14M092507
  • GC14M093587
  • GC14M094517
  • GC14M074697

Summaries for DDX24 Gene

Entrez Gene Summary for DDX24 Gene

  • DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. [provided by RefSeq, Jul 2008]

GeneCards Summary for DDX24 Gene

DDX24 (DEAD-Box Helicase 24) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and ATP-dependent RNA helicase activity.

UniProtKB/Swiss-Prot for DDX24 Gene

  • ATP-dependent RNA helicase.

Gene Wiki entry for DDX24 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX24 Gene

Genomics for DDX24 Gene

Regulatory Elements for DDX24 Gene

Enhancers for DDX24 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G094056 0.9 ENCODE 23.8 +22.6 22620 4.4 FOXA2 ATF1 MLX ARID4B ZNF48 YY1 ZNF121 TBX21 MIER3 RFX3 DDX24 IFI27L1 IFI27 PPP4R4 IFI27L2 GC14M094051 GC14M094050 PIR58882
GH14G094025 1.1 ENCODE 17.1 +53.2 53230 4.1 PKNOX1 FOXA2 ARID4B SIN3A ZNF2 ZBTB7B ZNF207 ZNF548 FOS PAF1 DDX24 C14orf48 ASB2 IFI27L2 IFI27L1 IFI27 OTUB2 GC14M094051 GC14M094050
GH14G094036 1 Ensembl ENCODE 17.7 +44.5 44545 0.6 HDGF CTCF WRNIP1 ARID4B ZIC2 ZNF644 ZNF48 RAD21 TEAD3 CTBP1 DDX24 IFI27L1 IFI27L2 IFI27 GC14M094050 GC14M094051 OTUB2
GH14G094065 1.2 Ensembl ENCODE 14.7 +15.0 14982 1.6 FOXA2 NFIB ZNF133 KLF17 ZNF195 FEZF1 BMI1 ZNF2 RARA GLIS2 DDX24 IFI27 PIR58882 GC14M094050 GC14M094051
GH14G094079 1.1 ENCODE 14.4 +0.3 256 3.3 PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 FOS DDX24 IFI27 PPP4R4 IFI27L1 PIR58882
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DDX24 on UCSC Golden Path with GeneCards custom track

Promoters for DDX24 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for DDX24 Gene

94,048,291 bp from pter
94,081,245 bp from pter
32,955 bases
Minus strand

Genomic View for DDX24 Gene

Genes around DDX24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDX24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDX24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX24 Gene

Proteins for DDX24 Gene

  • Protein details for DDX24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ATP-dependent RNA helicase DDX24
    Protein Accession:
    Secondary Accessions:
    • E7EMJ4
    • Q4V9L5

    Protein attributes for DDX24 Gene

    859 amino acids
    Molecular mass:
    96332 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DDX24 Gene


neXtProt entry for DDX24 Gene

Selected DME Specific Peptides for DDX24 Gene


Post-translational modifications for DDX24 Gene

  • Ubiquitination at isoforms=195, Lys429, Lys541, and isoforms=2601
  • Modification sites at PhosphoSitePlus

Other Protein References for DDX24 Gene

Domains & Families for DDX24 Gene

Gene Families for DDX24 Gene

Suggested Antigen Peptide Sequences for DDX24 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the DEAD box helicase family. DDX24/MAK5 subfamily.
  • Belongs to the DEAD box helicase family. DDX24/MAK5 subfamily.
genes like me logo Genes that share domains with DDX24: view

Function for DDX24 Gene

Molecular function for DDX24 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
ATP-dependent RNA helicase.

Enzyme Numbers (IUBMB) for DDX24 Gene

Gene Ontology (GO) - Molecular Function for DDX24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IDA,IEA 22658674
GO:0003724 RNA helicase activity NAS 10936056
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0004386 helicase activity IEA --
genes like me logo Genes that share ontologies with DDX24: view
genes like me logo Genes that share phenotypes with DDX24: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DDX24

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DDX24 Gene

Localization for DDX24 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DDX24 gene
Compartment Confidence
nucleus 5
cytosol 3
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for DDX24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with DDX24: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DDX24 Gene

Pathways & Interactions for DDX24 Gene

SuperPathways for DDX24 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DDX24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010501 RNA secondary structure unwinding IBA --
GO:0016070 RNA metabolic process NAS 10936056
genes like me logo Genes that share ontologies with DDX24: view

No data available for Pathways by source and SIGNOR curated interactions for DDX24 Gene

Drugs & Compounds for DDX24 Gene

(3) Drugs for DDX24 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for DDX24 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with DDX24: view

Transcripts for DDX24 Gene

Unigene Clusters for DDX24 Gene

DEAD (Asp-Glu-Ala-Asp) box polypeptide 24:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DDX24 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c
SP1: - -
SP2: - -
SP4: - -
SP6: -
SP7: -

Relevant External Links for DDX24 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DDX24 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DDX24 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DDX24 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (26.7) and Tlymphocyte (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DDX24 Gene

Protein tissue co-expression partners for DDX24 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DDX24 Gene:


SOURCE GeneReport for Unigene cluster for DDX24 Gene:


mRNA Expression by UniProt/SwissProt for DDX24 Gene:

Tissue specificity: Ubiquitous. Most abundant in heart and brain, but with lowest levels in thymus and small intestine.

Evidence on tissue expression from TISSUES for DDX24 Gene

  • Nervous system(4.9)
  • Liver(4.8)
  • Intestine(4.6)
  • Lung(4)
  • Pancreas(3.6)
  • Skin(3.5)
  • Kidney(3.1)
  • Eye(2.9)
  • Stomach(2.9)
  • Heart(2.5)
  • Spleen(2.2)
genes like me logo Genes that share expression patterns with DDX24: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DDX24 Gene

Orthologs for DDX24 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DDX24 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DDX24 34 35
  • 99.26 (n)
(Bos Taurus)
Mammalia DDX24 34 35
  • 86.76 (n)
(Canis familiaris)
Mammalia DDX24 34 35
  • 85.56 (n)
(Rattus norvegicus)
Mammalia Ddx24 34
  • 82.25 (n)
(Mus musculus)
Mammalia Ddx24 34 16 35
  • 81.75 (n)
(Monodelphis domestica)
Mammalia DDX24 35
  • 62 (a)
(Ornithorhynchus anatinus)
Mammalia DDX24 35
  • 60 (a)
(Gallus gallus)
Aves DDX24 34 35
  • 63.01 (n)
(Anolis carolinensis)
Reptilia DDX24 35
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx24 34
  • 60.35 (n)
Str.14965 34
African clawed frog
(Xenopus laevis)
Amphibia LOC398446 34
(Danio rerio)
Actinopterygii LOC553462 34
  • 62.3 (n)
ddx24 35
  • 48 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2533 34
fruit fly
(Drosophila melanogaster)
Insecta CG9143 36 34 35
  • 57.41 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010702 34
  • 51.33 (n)
(Caenorhabditis elegans)
Secernentea F55F8.2 34 35
  • 50.53 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MAK5 35 37
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3498 35
  • 41 (a)
Species where no ortholog for DDX24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DDX24 Gene

Gene Tree for DDX24 (if available)
Gene Tree for DDX24 (if available)

Paralogs for DDX24 Gene

(4) SIMAP similar genes for DDX24 Gene using alignment to 3 proteins: Pseudogenes for DDX24 Gene

genes like me logo Genes that share paralogs with DDX24: view

No data available for Paralogs for DDX24 Gene

Variants for DDX24 Gene

Sequence variations from dbSNP and Humsavar for DDX24 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000081904 -- 94,074,053(+) AAAAA(A/G)AAAAG intron-variant
rs1000147075 -- 94,075,352(+) CCACA(C/T)CTATA intron-variant
rs1000176612 -- 94,058,424(+) ACATA(C/T)CCAAT intron-variant
rs1000202291 -- 94,068,628(+) CCTCA(A/G)TAAAT intron-variant
rs1000250016 -- 94,079,754(+) TGAAA(A/G)GGAGA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DDX24 Gene

Variant ID Type Subtype PubMed ID
esv34067 CNV loss 18971310
esv3581391 CNV loss 25503493
esv3635373 CNV gain 21293372

Variation tolerance for DDX24 Gene

Residual Variation Intolerance Score: 80.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.05; 60.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DDX24 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDX24 Gene

Disorders for DDX24 Gene

Relevant External Links for DDX24

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DDX24 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DDX24 Gene

Publications for DDX24 Gene

  1. Cloning and characterization of human DDX24 and mouse Ddx24, two novel putative DEAD-box proteins, and mapping DDX24 to human chromosome 14q32. (PMID: 10936056) Zhao Y. … Zhao S. (Genomics 2000) 2 3 4 64
  2. The requirement of the DEAD-box protein DDX24 for the packaging of human immunodeficiency virus type 1 RNA. (PMID: 18289627) Ma J. … Liang C. (Virology 2008) 2 3 64
  3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4 64
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for DDX24 Gene

Sources for DDX24 Gene

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