Aliases for CHRNA10 Gene
External Ids for CHRNA10 Gene
Previous GeneCards Identifiers for CHRNA10 Gene
GeneCards Summary for CHRNA10 Gene
CHRNA10 (Cholinergic Receptor, Nicotinic, Alpha 10 (Neuronal)) is a Protein Coding gene. Diseases associated with CHRNA10 include nicotine dependence, protection against. Among its related pathways are CREB Pathway and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include receptor binding and extracellular ligand-gated ion channel activity. An important paralog of this gene is HTR3A.
UniProtKB/Swiss-Prot for CHRNA10 Gene
Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma.