Aliases for CHRNA10 Gene
External Ids for CHRNA10 Gene
Previous GeneCards Identifiers for CHRNA10 Gene
GeneCards Summary for CHRNA10 Gene
CHRNA10 (Cholinergic Receptor, Nicotinic, Alpha 10 (Neuronal)) is a Protein Coding gene. Among its related pathways are CREB Pathway and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include receptor binding and acetylcholine-activated cation-selective channel activity. An important paralog of this gene is HTR3A.
UniProtKB/Swiss-Prot for CHRNA10 Gene
Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma.