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Aliases for PLSCR3 Gene

Aliases for PLSCR3 Gene

  • Phospholipid Scramblase 3 2 3
  • Ca(2+)-Dependent Phospholipid Scramblase 3 4
  • PL Scramblase 3 4

External Ids for PLSCR3 Gene

Summaries for PLSCR3 Gene

GeneCards Summary for PLSCR3 Gene

PLSCR3 (Phospholipid Scramblase 3) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and calcium-dependent protein binding. An important paralog of this gene is PLSCR4.

UniProtKB/Swiss-Prot for PLSCR3 Gene

  • May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. Seems to play a role in apoptosis, through translocation of cardiolipin from the inner to the outer mitochondrial membrane which promotes BID recruitment and enhances tBid-induced mitochondrial damages.

Gene Wiki entry for PLSCR3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLSCR3 Gene

Genomics for PLSCR3 Gene

Genomic Location for PLSCR3 Gene

Start:
7,389,727 bp from pter
End:
7,394,843 bp from pter
Size:
5,117 bases
Orientation:
Minus strand

Genomic View for PLSCR3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PLSCR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLSCR3 Gene

Regulatory Elements for PLSCR3 Gene

Proteins for PLSCR3 Gene

  • Protein details for PLSCR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRY6-PLS3_HUMAN
    Recommended name:
    Phospholipid scramblase 3
    Protein Accession:
    Q9NRY6
    Secondary Accessions:
    • A8K252
    • Q567U0
    • Q8NBW6
    • Q96F13

    Protein attributes for PLSCR3 Gene

    Size:
    295 amino acids
    Molecular mass:
    31648 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Interacts with PDCD6 in a calcium-dependent manner.

neXtProt entry for PLSCR3 Gene

Proteomics data for PLSCR3 Gene at MOPED

Post-translational modifications for PLSCR3 Gene

  • Phosphorylation at Thr-21 by PKC/PRKCD upon apoptotic stimuli enhances flip-flop activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PLSCR3 Gene

Domains for PLSCR3 Gene

Protein Domains for PLSCR3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for PLSCR3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NRY6

UniProtKB/Swiss-Prot:

PLS3_HUMAN
Domain:
  • The N-terminal proline-rich domain (PRD) is required for phospholipid scramblase activity.:
    • Q9NRY6
Family:
  • Belongs to the phospholipid scramblase family.:
    • Q9NRY6
genes like me logo Genes that share domains with PLSCR3: view

No data available for Gene Families for PLSCR3 Gene

Function for PLSCR3 Gene

Molecular function for PLSCR3 Gene

UniProtKB/Swiss-Prot Function: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. Seems to play a role in apoptosis, through translocation of cardiolipin from the inner to the outer mitochondrial membrane which promotes BID recruitment and enhances tBid-induced mitochondrial damages.

Gene Ontology (GO) - Molecular Function for PLSCR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding NAS 10930526
GO:0005515 protein binding IPI 16189514
GO:0017124 SH3 domain binding IEA --
GO:0017128 phospholipid scramblase activity NAS 10930526
GO:0048306 calcium-dependent protein binding IPI 18256029
genes like me logo Genes that share ontologies with PLSCR3: view
genes like me logo Genes that share phenotypes with PLSCR3: view

Animal Models for PLSCR3 Gene

MGI Knock Outs for PLSCR3:

miRNA for PLSCR3 Gene

miRTarBase miRNAs that target PLSCR3

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PLSCR3 Gene

Localization for PLSCR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLSCR3 Gene

Mitochondrion membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLSCR3 Gene COMPARTMENTS Subcellular localization image for PLSCR3 gene
Compartment Confidence
mitochondrion 5
plasma membrane 5
cytosol 2
extracellular 2
nucleus 2

Gene Ontology (GO) - Cellular Components for PLSCR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005886 plasma membrane NAS 10930526
GO:0016021 integral component of membrane IEA --
GO:0031966 mitochondrial membrane IEA --
genes like me logo Genes that share ontologies with PLSCR3: view

Pathways for PLSCR3 Gene

SuperPathways for PLSCR3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PLSCR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0017121 phospholipid scrambling NAS 10930526
GO:0042593 glucose homeostasis IEA --
GO:0042632 cholesterol homeostasis IEA --
GO:0071222 cellular response to lipopolysaccharide IEA --
genes like me logo Genes that share ontologies with PLSCR3: view

No data available for Pathways by source for PLSCR3 Gene

Compounds for PLSCR3 Gene

(2714) HMDB Compounds for PLSCR3 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
PC(14:0/14:0)
  • Phosphatidylcholine(14:0/14:0)
Not Available
PC(14:0/14:1(9Z))
  • Phosphatidylcholine(14:0/14:1)
Not Available
PC(14:0/15:0)
  • GPCho(14:0/15:0)
Not Available
PC(14:0/16:0)
  • GPCho(30:0)
Not Available

(4) Novoseek inferred chemical compound relationships for PLSCR3 Gene

Compound -log(P) Hits PubMed IDs
n-benzyladriamycin-14-valerate 96.3 1
cardiolipin 82.3 3
phospholipid 68.9 14
lipid 21.1 1
genes like me logo Genes that share compounds with PLSCR3: view

Transcripts for PLSCR3 Gene

Unigene Clusters for PLSCR3 Gene

Phospholipid scramblase 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLSCR3 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e · 8f ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12a · 12b ·
SP1: - - - - -
SP2: - -
SP3: - -
SP4: - - - -
SP5: - - -
SP6: - - - - -
SP7: - - - - - - -
SP8: - - - - - - -
SP9: - - - -
SP10: - - - - -
SP11: - - - -
SP12: -
SP13: - - - - - - - -
SP14: - - - - - - -
SP15: - -
SP16:
SP17: - - - - - - - - -
SP18: - - -
SP19: - - - - - - -
SP20: - - - - -
SP21: - - -
SP22: -
SP23: - - -
SP24: -
SP25: -
SP26:

ExUns: 12c ^ 13a · 13b ^ 14a · 14b · 14c ^ 15a · 15b ^ 16a · 16b · 16c ^ 17
SP1: -
SP2: -
SP3: -
SP4: - -
SP5:
SP6: -
SP7: - -
SP8: - -
SP9: - -
SP10: -
SP11: -
SP12: - -
SP13:
SP14: -
SP15: -
SP16: - - -
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23: - -
SP24:
SP25:
SP26:

Relevant External Links for PLSCR3 Gene

GeneLoc Exon Structure for
PLSCR3
ECgene alternative splicing isoforms for
PLSCR3

Expression for PLSCR3 Gene

mRNA expression in normal human tissues for PLSCR3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PLSCR3 Gene

SOURCE GeneReport for Unigene cluster for PLSCR3 Gene Hs.534591

mRNA Expression by UniProt/SwissProt for PLSCR3 Gene

Q9NRY6-PLS3_HUMAN
Tissue specificity: Expressed in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, uterus, small intestine and peripheral blood lymphocytes. Not detected in testis, brain and liver
genes like me logo Genes that share expressions with PLSCR3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PLSCR3 Gene

Orthologs for PLSCR3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLSCR3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLSCR3 35
  • 99.55 (n)
  • 99.32 (a)
TMEM256-PLSCR3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PLSCR3 35
  • 90.28 (n)
  • 94.92 (a)
PLSCR3 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLSCR3 35
  • 88.89 (n)
  • 90.58 (a)
TMEM256-PLSCR3 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Plscr3 35
  • 86.44 (n)
  • 93.22 (a)
Plscr3 16
Plscr3 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM256-PLSCR3 36
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM256-PLSCR3 36
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Plscr3 35
  • 87.12 (n)
  • 92.2 (a)
lizard
(Anolis carolinensis)
Reptilia TMEM256-PLSCR3 36
  • 46 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.2011 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4717 35
zebrafish
(Danio rerio)
Actinopterygii CR848032.2 36
  • 23 (a)
OneToMany
plscr3a 36
  • 48 (a)
OneToMany
plscr3b 36
  • 45 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta scramb1 36
  • 32 (a)
ManyToMany
scramb2 35
  • 52.4 (n)
  • 45.12 (a)
scramb2 36
  • 40 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea scrm-3 36
  • 34 (a)
ManyToMany
ZK1053.5 37
  • 40 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2436 36
  • 53 (a)
OneToMany
Species with no ortholog for PLSCR3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PLSCR3 Gene

ENSEMBL:
Gene Tree for PLSCR3 (if available)
TreeFam:
Gene Tree for PLSCR3 (if available)

Paralogs for PLSCR3 Gene

Paralogs for PLSCR3 Gene

Selected SIMAP similar genes for PLSCR3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PLSCR3: view

Variants for PLSCR3 Gene

Sequence variations from dbSNP and Humsavar for PLSCR3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
VAR_015568 -

Structural Variations from Database of Genomic Variants (DGV) for PLSCR3 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV Deletion 17116639
nsv457659 CNV Loss 19166990
nsv907644 CNV Loss 21882294
nsv523672 CNV Loss 19592680
nsv907645 CNV Loss 21882294
nsv470575 CNV Loss 18288195
dgv3054n71 CNV Loss 21882294
dgv3055n71 CNV Loss 21882294
esv1007381 CNV Deletion 20482838

Relevant External Links for PLSCR3 Gene

HapMap Linkage Disequilibrium report
PLSCR3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLSCR3 Gene

Disorders for PLSCR3 Gene

Relevant External Links for PLSCR3

Genetic Association Database (GAD)
PLSCR3
genes like me logo Genes that share disorders with PLSCR3: view

No data available for UniProtKB/Swiss-Prot for PLSCR3 Gene

Publications for PLSCR3 Gene

  1. Phosphorylation of mitochondrial phospholipid scramblase 3 by protein kinase C-delta induces its activation and facilitates mitochondrial targeting of tBid. (PMID: 17226776) He Y. … Lee R.M. (J. Cell. Biochem. 2007) 3 4 23
  2. Identification of Alix-type and non-Alix-type ALG-2-binding sites in human phospholipid scramblase 3: differential binding to an alternatively spliced isoform and amino acid-substituted mutants. (PMID: 18256029) Shibata H. … Maki M. (J. Biol. Chem. 2008) 3 4 23
  3. Identification of three new members of the phospholipid scramblase gene family. (PMID: 10930526) Wiedmer T. … Sims P.J. (Biochim. Biophys. Acta 2000) 2 3 4
  4. Phospholipid scramblase-3 regulates cardiolipin de novo biosynthesis and its resynthesis in growing HeLa cells. (PMID: 16939411) Van Q. … Hatch G.M. (Biochem. J. 2007) 3 23
  5. Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induced mitochondrial pathway to apoptosis and caspase activation is potentiated by phospholipid scramblase-3. (PMID: 18491232) Ndebele K. … Khosravi-Far R. (Apoptosis 2008) 3 23

Products for PLSCR3 Gene

Sources for PLSCR3 Gene

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