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Aliases for CCNL1 Gene

Aliases for CCNL1 Gene

  • Cyclin L1 2 3
  • Cyclin-L 3 4
  • Cyclin L Ania-6a 3
  • Cyclin L Gamma 3
  • PRO1073 3
  • Ania-6a 3
  • ANIA6A 3
  • BM-001 3

External Ids for CCNL1 Gene

Previous GeneCards Identifiers for CCNL1 Gene

  • GC03M157812
  • GC03M158147
  • GC03M158186
  • GC03M158348
  • GC03M156864
  • GC03M154261

Summaries for CCNL1 Gene

GeneCards Summary for CCNL1 Gene

CCNL1 (Cyclin L1) is a Protein Coding gene. Diseases associated with CCNL1 include squamous cell carcinoma, head and neck. GO annotations related to this gene include protein kinase binding. An important paralog of this gene is CCNT1.

UniProtKB/Swiss-Prot for CCNL1 Gene

  • Transcriptional regulator which participates in regulating the pre-mRNA splicing process. Seems to be involved in the regulation of RNA polymerase II (pol II). Functions in association with cyclin-dependent kinases (CDKs) and has a role in the second step of splicing. May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC). Inhibited by the CDK-specific inhibitor p21.

Gene Wiki entry for CCNL1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCNL1 Gene

Genomics for CCNL1 Gene

Regulatory Elements for CCNL1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CCNL1 Gene

Chromosome:
3
Start:
157,146,364 bp from pter
End:
157,160,760 bp from pter
Size:
14,397 bases
Orientation:
Minus strand

Genomic View for CCNL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCNL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNL1 Gene

Proteins for CCNL1 Gene

  • Protein details for CCNL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UK58-CCNL1_HUMAN
    Recommended name:
    Cyclin-L1
    Protein Accession:
    Q9UK58
    Secondary Accessions:
    • B3KMY3
    • Q6NVY9
    • Q6UWS7
    • Q8NI48
    • Q96QT0
    • Q9NZF3

    Protein attributes for CCNL1 Gene

    Size:
    526 amino acids
    Molecular mass:
    59634 Da
    Quaternary structure:
    • Interacts with POLR2A via its hyperphosphorylated C-terminal domain (CTD) (By similarity). Interacts with CDK11A, CDK11B, CDK12, CDK13 and SFRS2.
    Miscellaneous:
    • CCNL1 is amplified in several HNSCC. May play a critical role in the formation of loco-regional metastases and an unfavorable clinical outcome of HNSCC
    SequenceCaution:
    • Sequence=AAF64257.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=AAQ89026.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

    Alternative splice isoforms for CCNL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCNL1 Gene

Proteomics data for CCNL1 Gene at MOPED

Post-translational modifications for CCNL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for CCNL1 Gene

Domains & Families for CCNL1 Gene

Gene Families for CCNL1 Gene

Protein Domains for CCNL1 Gene

Suggested Antigen Peptide Sequences for CCNL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UK58

UniProtKB/Swiss-Prot:

CCNL1_HUMAN :
  • Contains a RS region (arginine-serine dipeptide repeat) within the C-terminal domain which is the hallmark of the SR family of splicing factors. This region probably plays a role in protein-protein interactions.
  • Belongs to the cyclin family. Cyclin L subfamily.
Domain:
  • Contains a RS region (arginine-serine dipeptide repeat) within the C-terminal domain which is the hallmark of the SR family of splicing factors. This region probably plays a role in protein-protein interactions.
Family:
  • Belongs to the cyclin family. Cyclin L subfamily.
genes like me logo Genes that share domains with CCNL1: view

Function for CCNL1 Gene

Molecular function for CCNL1 Gene

GENATLAS Biochemistry:
cyclin like 1,most likely member of a new family of cyclins,with homology to mouse cyclin G
UniProtKB/Swiss-Prot Function:
Transcriptional regulator which participates in regulating the pre-mRNA splicing process. Seems to be involved in the regulation of RNA polymerase II (pol II). Functions in association with cyclin-dependent kinases (CDKs) and has a role in the second step of splicing. May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC). Inhibited by the CDK-specific inhibitor p21.

Gene Ontology (GO) - Molecular Function for CCNL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity IBA --
GO:0019901 protein kinase binding IEA --
genes like me logo Genes that share ontologies with CCNL1: view
genes like me logo Genes that share phenotypes with CCNL1: view

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCNL1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for CCNL1 Gene

Localization for CCNL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCNL1 Gene

Nucleus speckle. Note=More specifically found in nuclear intrachromatin granules clusters (IGC), also called nuclear speckles, which are storage compartments for nuclear proteins involved in mRNA processing. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCNL1 Gene COMPARTMENTS Subcellular localization image for CCNL1 gene
Compartment Confidence
nucleus 5
mitochondrion 2

Gene Ontology (GO) - Cellular Components for CCNL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000307 cyclin-dependent protein kinase holoenzyme complex IBA --
GO:0005634 nucleus IDA 17494991
GO:0016607 nuclear speck IEA --
genes like me logo Genes that share ontologies with CCNL1: view

Pathways & Interactions for CCNL1 Gene

SuperPathways for CCNL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCNL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006396 RNA processing IEA --
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity IBA --
genes like me logo Genes that share ontologies with CCNL1: view

No data available for Pathways by source and SIGNOR curated interactions for CCNL1 Gene

Drugs & Compounds for CCNL1 Gene

No Compound Related Data Available

Transcripts for CCNL1 Gene

Unigene Clusters for CCNL1 Gene

Cyclin L1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCNL1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCNL1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ·
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - - - - -
SP5:
SP6: - - - - -
SP7: - - -
SP8: - -
SP9: - - - - -
SP10:
SP11: - -
SP12: - - -
SP13: - - -
SP14:
SP15: -
SP16: - - - -
SP17:
SP18: - - -

ExUns: 11d ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b · 14c ^ 15
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - - - - -
SP5: - - -
SP6: -
SP7:
SP8:
SP9:
SP10: - -
SP11:
SP12:
SP13:
SP14: - -
SP15:
SP16:
SP17: -
SP18:

Relevant External Links for CCNL1 Gene

GeneLoc Exon Structure for
CCNL1
ECgene alternative splicing isoforms for
CCNL1

Expression for CCNL1 Gene

mRNA expression in normal human tissues for CCNL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CCNL1 Gene

This gene is overexpressed in Heart (46.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CCNL1 Gene



SOURCE GeneReport for Unigene cluster for CCNL1 Gene Hs.4859

mRNA Expression by UniProt/SwissProt for CCNL1 Gene

Q9UK58-CCNL1_HUMAN
Tissue specificity: Ubiquitous with higher level in thymus. Overexpression in primary tumors of head and neck squamous cell carcinomas (HNSCC).
genes like me logo Genes that share expression patterns with CCNL1: view

Protein tissue co-expression partners for CCNL1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CCNL1 Gene

Orthologs for CCNL1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCNL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CCNL1 35
  • 95.31 (n)
  • 98.48 (a)
CCNL1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccnl1 35
  • 93.09 (n)
  • 98.15 (a)
Ccnl1 16
Ccnl1 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CCNL1 35
  • 99.81 (n)
  • 100 (a)
CCNL1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccnl1 35
  • 93.03 (n)
  • 97.34 (a)
dog
(Canis familiaris)
Mammalia CCNL1 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCNL1 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCNL1 36
  • 94 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCNL1 35
  • 81.77 (n)
  • 93.66 (a)
CCNL1 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCNL1 36
  • 78 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ccnl1a 35
  • 70.36 (n)
  • 82.75 (a)
Dr.28373 35
ccnl1a 36
  • 76 (a)
OneToMany
ccnl1b 36
  • 66 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13166 35
fruit fly
(Drosophila melanogaster)
Insecta CG16903 36
  • 43 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cyl-1 36
  • 36 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSN8 36
  • 20 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os.1541 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11553 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
OneToMany
Species with no ortholog for CCNL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CCNL1 Gene

ENSEMBL:
Gene Tree for CCNL1 (if available)
TreeFam:
Gene Tree for CCNL1 (if available)

Paralogs for CCNL1 Gene

Paralogs for CCNL1 Gene

(2) SIMAP similar genes for CCNL1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CCNL1: view

Variants for CCNL1 Gene

Sequence variations from dbSNP and Humsavar for CCNL1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs8925 -- 157,150,661(+) ATATA(C/T)TTCTG intron-variant, utr-variant-3-prime
rs3202590 -- 157,154,317(-) ATCTA(A/G)GAATG intron-variant
rs3202591 -- 157,154,260(-) AAGCC(C/T)AATTC intron-variant
rs4371471 -- 157,161,308(+) TTTCA(A/G)AAAGA upstream-variant-2KB
rs4680342 -- 157,155,431(+) AAAAT(C/G)CCAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCNL1 Gene

Variant ID Type Subtype PubMed ID
nsv829766 CNV Gain 17160897
nsv520331 CNV Loss 19592680
nsv819788 CNV Loss 19587683
esv2660786 CNV Deletion 23128226

Variation tolerance for CCNL1 Gene

Residual Variation Intolerance Score: 29.81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCNL1 Gene

HapMap Linkage Disequilibrium report
CCNL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCNL1 Gene

Disorders for CCNL1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CCNL1 Gene - From: DISEASES and NovoSeek

Disorder Aliases PubMed IDs
squamous cell carcinoma, head and neck
  • squamous cell carcinoma, head and neck, somatic
- elite association
Search CCNL1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CCNL1

Human Genome Epidemiology (HuGE) Navigator
CCNL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCNL1
genes like me logo Genes that share disorders with CCNL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCNL1 Gene

Publications for CCNL1 Gene

  1. Characterization of cyclin L1 and L2 interactions with CDK11 and splicing factors: influence of cyclin L isoforms on splice site selection. (PMID: 18216018) Loyer P. … Lahti J.M. (J. Biol. Chem. 2008) 23 67
  2. CDK13/CDC2L5 interacts with L-type cyclins and regulates alternative splicing. (PMID: 17261272) Chen H.H. … Fann M.J. (Biochem. Biophys. Res. Commun. 2007) 23 67
  3. Characterization of cyclin L1 as an immobile component of the splicing factor compartment. (PMID: 17494991) Herrmann A. … Becker W. (FASEB J. 2007) 23 67
  4. Identification and characterization of the CDK12/cyclin L1 complex involved in alternative splicing regulation. (PMID: 16537916) Chen H.H. … Fann M.J. (Mol. Cell. Biol. 2006) 23 67
  5. Cyclin L1 (CCNL1) gene alterations in human head and neck squamous cell carcinoma. (PMID: 16598186) Muller D. … Abecassis J. (Br. J. Cancer 2006) 23 67

Products for CCNL1 Gene

Sources for CCNL1 Gene

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