Free for academic non-profit institutions. Other users need a Commercial license

Aliases for AKR1B10 Gene

Aliases for AKR1B10 Gene

  • Aldo-Keto Reductase Family 1, Member B10 (Aldose Reductase) 2 3
  • Aldose Reductase-Related Protein 2 3 4
  • Small Intestine Reductase 2 3 4
  • Aldose Reductase-Like Peptide 2 3
  • Aldose Reductase-Like 1 2 3
  • SI Reductase 3 4
  • AKR1B11 3 4
  • ARL-1 3 4
  • HARP 3 4
  • ARL1 3 6
  • ARP 3 4
  • Aldo-Keto Reductase Family 1, Member B11 (Aldose Reductase-Like) 3
  • Aldo-Keto Reductase Family 1 Member B10 3
  • Member B11 (Aldose Reductase-Like) 2
  • Aldo-Keto Reductase Family 1 2
  • Aldose Reductase-Like 4
  • EC 1.1.1.21 64
  • EC 1.1.1.- 4
  • EC 1.1.1 64
  • AKR1B12 3
  • ALDRLn 3
  • HIS 3
  • HSI 3

External Ids for AKR1B10 Gene

Previous Symbols for AKR1B10 Gene

  • AKR1B11

Summaries for AKR1B10 Gene

Entrez Gene Summary for AKR1B10 Gene

  • This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for AKR1B10 Gene

AKR1B10 (Aldo-Keto Reductase Family 1, Member B10 (Aldose Reductase)) is a Protein Coding gene. Diseases associated with AKR1B10 include hepatocellular carcinoma. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include aldo-keto reductase (NADP) activity and indanol dehydrogenase activity. An important paralog of this gene is AKR1B1.

UniProtKB/Swiss-Prot for AKR1B10 Gene

  • Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs.

Gene Wiki entry for AKR1B10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AKR1B10 Gene

Genomics for AKR1B10 Gene

Genomic Location for AKR1B10 Gene

Start:
134,527,592 bp from pter
End:
134,541,414 bp from pter
Size:
13,823 bases
Orientation:
Plus strand

Genomic View for AKR1B10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AKR1B10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AKR1B10 Gene

Regulatory Elements for AKR1B10 Gene

Proteins for AKR1B10 Gene

  • Protein details for AKR1B10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60218-AK1BA_HUMAN
    Recommended name:
    Aldo-keto reductase family 1 member B10
    Protein Accession:
    O60218
    Secondary Accessions:
    • A4D1P1
    • O75890
    • Q6FHF3
    • Q8IWZ1

    Protein attributes for AKR1B10 Gene

    Size:
    316 amino acids
    Molecular mass:
    36020 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for AKR1B10 Gene

neXtProt entry for AKR1B10 Gene

Proteomics data for AKR1B10 Gene at MOPED

Post-translational modifications for AKR1B10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AKR1B10 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for AKR1B10 Gene

Gene Families for AKR1B10 Gene

HGNC:
  • AKR :Aldo-keto reductases

Protein Domains for AKR1B10 Gene

UniProtKB/Swiss-Prot:

AK1BA_HUMAN
Family:
  • Belongs to the aldo/keto reductase family.:
    • O60218
genes like me logo Genes that share domains with AKR1B10: view

Function for AKR1B10 Gene

Molecular function for AKR1B10 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=600 uM for D,L-glyceraldehyde {ECO:0000269 PubMed:18087047}; KM=0.6 uM for all-trans-retinaldehyde {ECO:0000269 PubMed:18087047}; KM=0.7 uM for 9-cis-retinaldehyde {ECO:0000269 PubMed:18087047};
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by tolrestat.
UniProtKB/Swiss-Prot Function: Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs.

Enzyme Numbers (IUBMB) for AKR1B10 Gene

Gene Ontology (GO) - Molecular Function for AKR1B10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001758 retinal dehydrogenase activity IDA 21851338
GO:0004033 aldo-keto reductase (NADP) activity TAS 9565553
GO:0005515 protein binding IPI 18056116
GO:0045550 geranylgeranyl reductase activity IDA 21187079
GO:0047718 indanol dehydrogenase activity IDA 20837989
genes like me logo Genes that share ontologies with AKR1B10: view

Phenotypes for AKR1B10 Gene

GenomeRNAi human phenotypes for AKR1B10:
genes like me logo Genes that share phenotypes with AKR1B10: view

miRNA for AKR1B10 Gene

miRTarBase miRNAs that target AKR1B10

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for AKR1B10 Gene

Localization for AKR1B10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AKR1B10 Gene

Lysosome. Secreted. Note=Secreted through a lysosome-mediated non-classical pathway.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AKR1B10 Gene COMPARTMENTS Subcellular localization image for AKR1B10 gene
Compartment Confidence
extracellular 5
lysosome 5
vacuole 5
cytosol 4
mitochondrion 2
nucleus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for AKR1B10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IEA --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with AKR1B10: view

Pathways for AKR1B10 Gene

genes like me logo Genes that share pathways with AKR1B10: view

Gene Ontology (GO) - Biological Process for AKR1B10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process TAS --
GO:0006081 cellular aldehyde metabolic process TAS 9565553
GO:0007586 digestion TAS 9565553
GO:0007603 phototransduction, visible light TAS --
GO:0008202 steroid metabolic process TAS 9565553
genes like me logo Genes that share ontologies with AKR1B10: view

Compounds for AKR1B10 Gene

(3) Drugbank Compounds for AKR1B10 Gene

(1) Novoseek inferred chemical compound relationships for AKR1B10 Gene

Compound -log(P) Hits PubMed IDs
aldose 87.2 25
genes like me logo Genes that share compounds with AKR1B10: view

Transcripts for AKR1B10 Gene

Unigene Clusters for AKR1B10 Gene

Aldo-keto reductase family 1, member B10 (aldose reductase):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AKR1B10 Gene

No ASD Table

Relevant External Links for AKR1B10 Gene

GeneLoc Exon Structure for
AKR1B10
ECgene alternative splicing isoforms for
AKR1B10

Expression for AKR1B10 Gene

mRNA expression in normal human tissues for AKR1B10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AKR1B10 Gene

This gene is overexpressed in Stomach (15.4), Esophagus - Mucosa (10.4), Vagina (5.6), Colon - Transverse (4.4), and Bladder (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AKR1B10 Gene

SOURCE GeneReport for Unigene cluster for AKR1B10 Gene Hs.116724

mRNA Expression by UniProt/SwissProt for AKR1B10 Gene

O60218-AK1BA_HUMAN
Tissue specificity: Found in many tissues. Highly expressed in small intestine, colon and adrenal gland
genes like me logo Genes that share expressions with AKR1B10: view

Orthologs for AKR1B10 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AKR1B10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AKR1B10 36
  • 99.05 (n)
  • 99.05 (a)
AKR1B10 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 79 (a)
OneToMany
AKR1B10 36
  • 83.98 (n)
  • 79.68 (a)
mouse
(Mus musculus)
Mammalia Akr1b10 37
  • 83 (a)
ManyToMany
Akr1b7 37
  • 80 (a)
ManyToMany
Akr1b8 36
  • 81.43 (n)
  • 82.28 (a)
Akr1b8 16
Akr1b8 37
  • 82 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Akr1b8 36
  • 81.43 (n)
  • 81.65 (a)
chicken
(Gallus gallus)
Aves AKR1B10 36
  • 71.9 (n)
  • 69.87 (a)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-180p18.9 37
  • 66 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6084 36
  • 62.37 (n)
  • 60.97 (a)
CG6084 37
  • 54 (a)
OneToMany
CG6084 38
  • 61 (a)
CG10638 38
  • 42 (a)
CG6083 38
  • 47 (a)
BcDNA:GH10614 38
  • 42 (a)
CG9436 38
  • 38 (a)
CG2767 38
  • 42 (a)
CG12766 38
  • 47 (a)
worm
(Caenorhabditis elegans)
Secernentea T08H10.1 38
  • 46 (a)
C07D8.6 38
  • 40 (a)
Y39G8B.1b 38
  • 45 (a)
C01G5.5 38
  • 30 (a)
F53F1.2 38
  • 35 (a)
ZC443.1 38
  • 35 (a)
Y39G8B.2 38
  • 34 (a)
F53F1.3 38
  • 35 (a)
C35D10.6 38
  • 32 (a)
Y39G8B.1a 38
  • 44 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL107C 36
  • 50.29 (n)
  • 40.89 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARA1 39
GRE3 36
  • 49.14 (n)
  • 43.99 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E21627g 36
  • 50.06 (n)
  • 45.73 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G21250 36
  • 48.62 (n)
  • 43.45 (a)
rice
(Oryza sativa)
Liliopsida Os02g0123500 36
  • 49.94 (n)
  • 42.56 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08384 36
  • 52.61 (n)
  • 43.54 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1520 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 50 (a)
OneToMany
Species with no ortholog for AKR1B10:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for AKR1B10 Gene

ENSEMBL:
Gene Tree for AKR1B10 (if available)
TreeFam:
Gene Tree for AKR1B10 (if available)

Paralogs for AKR1B10 Gene

Paralogs for AKR1B10 Gene

Selected SIMAP similar genes for AKR1B10 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for AKR1B10 Gene

genes like me logo Genes that share paralogs with AKR1B10: view

Variants for AKR1B10 Gene

Sequence variations from dbSNP and Humsavar for AKR1B10 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs697534 -- 134,526,253(+) ggcac(C/G)atctt upstream-variant-2KB
rs697535 -- 134,525,864(+) ctttc(A/G)tgatt upstream-variant-2KB
rs697536 -- 134,525,835(+) actgc(C/G)tgtcc upstream-variant-2KB
rs706159 -- 134,536,942(-) ACCTG(C/T)CCACT intron-variant, downstream-variant-500B
rs706160 -- 134,535,845(+) TTCTG(A/G)GCAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AKR1B10 Gene

Variant ID Type Subtype PubMed ID
nsv889222 CNV Gain 21882294
esv2669756 CNV Deletion 23128226
dgv430n21 CNV Loss 19592680
esv2735180 CNV Deletion 23290073
dgv1240e199 CNV Deletion 23128226

Relevant External Links for AKR1B10 Gene

HapMap Linkage Disequilibrium report
AKR1B10

Disorders for AKR1B10 Gene

(1) MalaCards Diseases for AKR1B10 Gene

Search for AKR1B10 Gene in MalaCards »

(1) Novoseek inferred disease relationships for AKR1B10 Gene

Disease -log(P) Hits PubMed IDs
hepatocellular carcinoma 33.8 6

Relevant External Links for AKR1B10

Genetic Association Database (GAD)
AKR1B10
Human Genome Epidemiology (HuGE) Navigator
AKR1B10
genes like me logo Genes that share disorders with AKR1B10: view

No data available for UniProtKB/Swiss-Prot for AKR1B10 Gene

Publications for AKR1B10 Gene

  1. Identification and characterization of a novel human aldose reductase-like gene. (PMID: 9565553) Cao D. … Chung S.S.M. (J. Biol. Chem. 1998) 2 3 4 23
  2. Sequence and expression levels in human tissues of a new member of the aldo-keto reductase family. (PMID: 9765596) Hyndman D.J. … Flynn T.G. (Biochim. Biophys. Acta 1998) 2 3 4 23
  3. Aldo-keto reductase family 1 B10 gene silencing results in growth inhibition of colorectal cancer cells: Implication for cancer intervention. (PMID: 17597105) Yan R. … Cao D. (Int. J. Cancer 2007) 3 23
  4. Aldo-keto reductase family 1 B10 affects fatty acid synthesis by regulating the stability of acetyl-CoA carboxylase-alpha in breast cancer cells. (PMID: 18056116) Ma J. … Cao D. (J. Biol. Chem. 2008) 3 23
  5. Structure and promoter characterization of aldo-keto reductase family 1 B10 gene. (PMID: 19236911) Liu Z. … Cao D. (Gene 2009) 3 23

Products for AKR1B10 Gene

Sources for AKR1B10 Gene

Back to Top

Content