Aliases for ADAMTS9 Gene
Aliases for ADAMTS9 Gene
External Ids for ADAMTS9 Gene
- HGNC: 13202
- Entrez Gene: 56999
- Ensembl: ENSG00000163638
- OMIM: 605421
- UniProtKB: Q9P2N4
Previous GeneCards Identifiers for ADAMTS9 Gene
- GC03M063400
- GC03M063939
- GC03M064356
- GC03M064458
- GC03M064476
Summaries for ADAMTS9 Gene
-
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. Members of the ADAMTS family have been implicated in the cleavage of proteoglycans, the control of organ shape during development, and the inhibition of angiogenesis. This gene is localized to chromosome 3p14.3-p14.2, an area known to be lost in hereditary renal tumors. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Jan 2016]
GeneCards Summary for ADAMTS9 Gene
ADAMTS9 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 9) is a Protein Coding gene. Among its related pathways are Degradation of the extracellular matrix and O-glycosylation of TSR domain-containing proteins. GO annotations related to this gene include metalloendopeptidase activity and endopeptidase activity. An important paralog of this gene is ADAMTS20.
UniProtKB/Swiss-Prot for ADAMTS9 Gene
-
Cleaves the large aggregating proteoglycans, aggrecan and versican. Has a protease-independent function in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAMTS9 Gene
Genomics for ADAMTS9 Gene
Regulatory Elements for ADAMTS9 Gene
Enhancers for ADAMTS9 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH03G064684 | 1.5 | FANTOM5 ENCODE dbSUPER | 20.3 | +1.2 | 1239 | 5.4 | PKNOX1 FOXA2 ARNT SIN3A FEZF1 GLI4 ZNF121 GLIS2 KLF7 FOS | ADAMTS9 ADAMTS9-AS2 |
| GH03G064665 | 1 | Ensembl ENCODE dbSUPER | 21.4 | +21.9 | 21870 | 1.2 | CTCF ETV6 NR3C1 NR2F2 | ADAMTS9 ADAMTS9-AS2 GC03P064578 GC03P064577 |
| GH03G064650 | 1 | Ensembl ENCODE | 11 | +37.1 | 37121 | 1.7 | CTCF PKNOX1 JUN FEZF1 ZIC2 ZBTB40 CTBP1 FOXK2 SCRT2 ETV6 | ADAMTS9 ADAMTS9-AS2 GC03P064578 GC03P064577 |
| GH03G064594 | 0.8 | Ensembl ENCODE | 10 | +92.4 | 92415 | 1.4 | JUN MAX FOS RAD21 NR2F2 | ADAMTS9-AS1 ADAMTS9 GC03P064577 GC03P064578 ADAMTS9-AS2 |
| GH03G064642 | 0.6 | ENCODE | 10.6 | +44.9 | 44941 | 0.2 | KLF17 ZIC2 ZSCAN16 ZNF341 WT1 TRIM28 TCF7L2 SP7 | ADAMTS9 ADAMTS9-AS2 GC03P064577 GC03P064578 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around ADAMTS9 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the ADAMTS9 gene promoter:
Regulatory Element Products
Genomic Location for ADAMTS9 Gene
- Chromosome:
- 3
- Start:
- 64,515,654 bp from pter
- End:
- 64,688,000 bp from pter
- Size:
- 172,347 bases
- Orientation:
- Minus strand
Genomic View for ADAMTS9 Gene
Genes around ADAMTS9 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3p14.1 by Ensembl
- 3p14.1 by Entrez Gene
- 3p14.1 by HGNC
ADAMTS9 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ADAMTS9 Gene
Proteins for ADAMTS9 Gene
-
Protein details for ADAMTS9 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9P2N4-ATS9_HUMAN
- Recommended name:
- A disintegrin and metalloproteinase with thrombospondin motifs 9
- Protein Accession:
- Q9P2N4
- A1L4L0
- B7ZVX9
- B9ZVN0
- Q9NR29
Protein attributes for ADAMTS9 Gene
- Size:
- 1935 amino acids
- Molecular mass:
- 216491 Da
- Cofactor:
- Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Quaternary structure:
- No Data Available
Protein Expression for ADAMTS9 Gene
Selected DME Specific Peptides for ADAMTS9 Gene
- Q9P2N4:
-
- VCGGDNS
- DKCGVCGG
- AHELGHVF
Post-translational modifications for ADAMTS9 Gene
- Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).
- The precursor is cleaved by a furin endopeptidase.
- Glycosylation at posLast=112112, posLast=135135, Asn271, posLast=749749, Asn840, Asn1213, Asn1267, Asn1788, and Asn1806
- Modification sites at PhosphoSitePlus
Other Protein References for ADAMTS9 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
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Assay Products
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Domains & Families for ADAMTS9 Gene
Gene Families for ADAMTS9 Gene
Protein Domains for ADAMTS9 Gene
Suggested Antigen Peptide Sequences for ADAMTS9 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9P2N4UniProtKB/Swiss-Prot:
ATS9_HUMAN :- The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.
- Domain:
-
- The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.
- The ancillary domains, including the TSRs domain, are required for specific extracellular localization and for its versicanase and aggrecanase activities.
- The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
- The GON domain mediates protease-independent function in ER to Golgi transport.
Function for ADAMTS9 Gene
Molecular function for ADAMTS9 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- Cleaves aggrecan at the 1838-Glu- -Ala-1839 site and versican at the 1428-Glu- -Ala-1429 site.
- UniProtKB/Swiss-Prot Function:
- Cleaves the large aggregating proteoglycans, aggrecan and versican. Has a protease-independent function in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos.
Enzyme Numbers (IUBMB) for ADAMTS9 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004222 | metalloendopeptidase activity | IEA | -- |
| GO:0008233 | peptidase activity | IEA | -- |
| GO:0008237 | metallopeptidase activity | IEA,IDA | 12514189 |
| GO:0008270 | zinc ion binding | IEA | -- |
| GO:0016787 | hydrolase activity | IEA | -- |
Phenotypes for ADAMTS9 Gene
- MGI mutant phenotypes for ADAMTS9:
-
inferred from 4 alleles
- mortality/aging
- normal phenotype
- growth/size/body region phenotype
- immune system phenotype
- nervous system phenotype
- cardiovascular system phenotype
- digestive/alimentary phenotype
- reproductive system phenotype
- endocrine/exocrine gland phenotype
- vision/eye phenotype
- integument phenotype
- limbs/digits/tail phenotype
- embryo phenotype
- pigmentation phenotype
- craniofacial phenotype
- GenomeRNAi human phenotypes for ADAMTS9:
-
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Increased shRNA abundance (Z-score > 2)
- Dynamic nuclei (hole, folded or small irregular)
- Strongly decreased CFP-tsO45G cell surface transport
- Decreased shRNA abundance (Z-score < -2)
- Increased cilium length after serum starvation
Animal Models for ADAMTS9 Gene
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- Search ViGene Biosciences for ADAMTS9
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-
Santa Cruz Biotechnology (SCBT) CRISPR for ADAMTS9
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miRNA for ADAMTS9 Gene
- miRTarBase miRNAs that target ADAMTS9
-
- hsa-mir-29a-3p (MIRT005668)
- hsa-mir-183-3p (MIRT545136)
- hsa-mir-3613-3p (MIRT545137)
- hsa-mir-7-2-3p (MIRT545138)
- hsa-mir-5688 (MIRT545139)
- hsa-mir-7-1-3p (MIRT545140)
- hsa-mir-495-3p (MIRT545141)
- hsa-mir-3609 (MIRT545142)
- hsa-mir-548ah-5p (MIRT545143)
- hsa-mir-548t-5p (MIRT545144)
- hsa-mir-548az-5p (MIRT545145)
- hsa-mir-297 (MIRT707536)
- hsa-mir-3924 (MIRT707537)
- hsa-mir-190a-3p (MIRT707538)
- hsa-mir-3941 (MIRT707539)
- hsa-mir-223-5p (MIRT707540)
- hsa-mir-567 (MIRT707541)
- hsa-mir-511-3p (MIRT707542)
- hsa-mir-5011-5p (MIRT707543)
- hsa-mir-4789-3p (MIRT707544)
- hsa-mir-603 (MIRT707545)
- hsa-mir-362-3p (MIRT707546)
- hsa-mir-329-3p (MIRT707547)
- hsa-mir-8485 (MIRT707548)
miRNA Products
- Search ViGene Biosciences for ADAMTS9
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for ADAMTS9
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for ADAMTS9
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ViGene Biosciences adenoviral particle packaged cDNA for ADAMTS9 gene
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Flow Cytometry Products
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADAMTS9 Gene
Localization for ADAMTS9 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ADAMTS9 Gene
- Secreted, extracellular space, extracellular matrix. Endoplasmic reticulum.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| endoplasmic reticulum | 3 |
| plasma membrane | 2 |
| peroxisome | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005578 | proteinaceous extracellular matrix | IDA | 12514189 |
| GO:0005615 | extracellular space | IEA | -- |
| GO:0005783 | endoplasmic reticulum | IEA | -- |
| GO:0009986 | cell surface | IEA | -- |
Pathways & Interactions for ADAMTS9 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | O-glycosylation of TSR domain-containing proteins | ||
| 2 | Degradation of the extracellular matrix | ||
| 3 | Diseases of glycosylation | ||
| 4 | Metabolism of proteins | ||
| 5 | HIV Life Cycle |
.45
|
|
Pathways by source for ADAMTS9 Gene
Interacting Proteins for ADAMTS9 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006508 | proteolysis | IEA,IDA | 12514189 |
| GO:0006516 | glycoprotein catabolic process | TAS | 10936055 |
| GO:0006810 | transport | IEA | -- |
| GO:0007275 | multicellular organism development | TAS | 10936055 |
| GO:0015031 | protein transport | IEA | -- |
No data available for SIGNOR curated interactions for ADAMTS9 Gene
Transcripts for ADAMTS9 Gene
mRNA/cDNA for ADAMTS9 Gene
- (2) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (117) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ADAMTS9 Gene
CRISPR Products
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OriGene CRISPR knockouts for ADAMTS9
-
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miRNA Products
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Inhibitory RNA Products
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Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for ADAMTS9 Gene
This gene is overexpressed in Pancreas (36.5) and Heart (32.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ADAMTS9 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of ADAMTS9 Gene:
ADAMTS9SOURCE GeneReport for Unigene cluster for ADAMTS9 Gene:
Hs.656071mRNA Expression by UniProt/SwissProt for ADAMTS9 Gene:
Q9P2N4-ATS9_HUMAN
Tissue specificity:
Highly expressed in all fetal tissues. Expressed in a number of adult tissues with highest expression in heart, placenta and skeletal muscle.
Evidence on tissue expression from TISSUES for ADAMTS9 Gene
- Nervous system(4.4)
Primer Products
-
OriGene qPCR primer pairs for ADAMTS9
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADAMTS9 Gene
Orthologs for ADAMTS9 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ADAMTS9 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | ADAMTS9 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | ADAMTS9 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Adamts9 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Adamts9 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ADAMTS9 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | ADAMTS9 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ADAMTS9 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | ADAMTS9 35 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | adamts9 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG6107 36 |
|
|
|
| worm (Caenorhabditis elegans) |
Secernentea | gon-1 34 |
|
- Species where no ortholog for ADAMTS9 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Paralogs for ADAMTS9 Gene
Paralogs for ADAMTS9 Gene
(12) SIMAP similar genes for ADAMTS9 Gene using alignment to 3 proteins:
Variants for ADAMTS9 Gene
| SNP ID | Clin | Chr 03 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000002276 | -- | 64,681,927(+) | TTAGA(G/T)AGCCT | intron-variant | |
| rs1000028209 | -- | 64,640,368(+) | GCTTT(A/G)CCAAT | intron-variant | |
| rs1000048023 | -- | 64,605,999(+) | ATTGC(C/T)AAATG | intron-variant | |
| rs1000050823 | -- | 64,568,031(+) | TCAGT(A/G)CAGTC | intron-variant | |
| rs1000052612 | -- | 64,670,785(+) | TTAGA(C/T)TTTAG | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv2709e59 | CNV | duplication | 20981092 |
| dgv2710e59 | CNV | tandem duplication | 20981092 |
| dgv289n21 | CNV | gain | 19592680 |
| dgv809n67 | CNV | gain | 20364138 |
| esv28694 | CNV | gain | 19812545 |
| esv3326518 | CNV | insertion | 20981092 |
| esv3596407 | CNV | gain | 21293372 |
| esv3596408 | CNV | gain | 21293372 |
| nsv1014598 | CNV | gain | 25217958 |
| nsv834718 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
2.52% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.51;
82.26% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for ADAMTS9 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ADAMTS9
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAMTS9 Gene
Disorders for ADAMTS9 Gene
Relevant External Links for ADAMTS9
No disorders were found for ADAMTS9 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADAMTS9 Gene
Publications for ADAMTS9 Gene
- Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1. (PMID: 12514189) Somerville R.P. … Apte S.S. (J. Biol. Chem. 2003) 3 4 22 64
- ADAMTS 9, a novel member of the ADAM-TS/Metallospondin gene family. (PMID: 10936055) Clark M.E. … Maki R.A. (Genomics 2000) 2 3 4 64
- Identification of a novel ADAMTS9/GON-1 function for protein transport from the ER to the Golgi. (PMID: 22419820) Yoshina S. … Mitani S. (Mol. Biol. Cell 2012) 3 4 64
- Genome-wide association analysis of age-at-onset in Alzheimer's disease. (PMID: 22005931) Kamboh M.I. … Lopez O.L. (Mol. Psychiatry 2012) 3 46 64
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
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- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ADAMTS9
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for ADAMTS9 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer