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Aliases for ADAMTS9 Gene

Aliases for ADAMTS9 Gene

  • ADAM Metallopeptidase With Thrombospondin Type 1 Motif 9 2 3 5
  • A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin Type 1 Motif, 9 2
  • EC 3.4.24.14 63
  • EC 3.4.24.82 63
  • EC 3.4.24.- 4
  • ADAM-TS 9 4
  • ADAM-TS9 4
  • ADAMTS-9 4
  • KIAA1312 4

External Ids for ADAMTS9 Gene

Previous GeneCards Identifiers for ADAMTS9 Gene

  • GC03M063400
  • GC03M063939
  • GC03M064356
  • GC03M064458
  • GC03M064476

Summaries for ADAMTS9 Gene

Entrez Gene Summary for ADAMTS9 Gene

  • This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. Members of the ADAMTS family have been implicated in the cleavage of proteoglycans, the control of organ shape during development, and the inhibition of angiogenesis. This gene is localized to chromosome 3p14.3-p14.2, an area known to be lost in hereditary renal tumors. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Jan 2016]

GeneCards Summary for ADAMTS9 Gene

ADAMTS9 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 9) is a Protein Coding gene. Among its related pathways are O-glycosylation of TSR domain-containing proteins and Degradation of the extracellular matrix. GO annotations related to this gene include metalloendopeptidase activity and endopeptidase activity. An important paralog of this gene is ADAMTS20.

UniProtKB/Swiss-Prot for ADAMTS9 Gene

  • Cleaves the large aggregating proteoglycans, aggrecan and versican. Has a protease-independent function in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos.

Gene Wiki entry for ADAMTS9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAMTS9 Gene

Genomics for ADAMTS9 Gene

Regulatory Elements for ADAMTS9 Gene

Enhancers for ADAMTS9 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ADAMTS9 on UCSC Golden Path with GeneCards custom track

Promoters for ADAMTS9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ADAMTS9 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADAMTS9 Gene

Chromosome:
3
Start:
64,515,654 bp from pter
End:
64,688,000 bp from pter
Size:
172,347 bases
Orientation:
Minus strand

Genomic View for ADAMTS9 Gene

Genes around ADAMTS9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAMTS9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAMTS9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAMTS9 Gene

Proteins for ADAMTS9 Gene

  • Protein details for ADAMTS9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2N4-ATS9_HUMAN
    Recommended name:
    A disintegrin and metalloproteinase with thrombospondin motifs 9
    Protein Accession:
    Q9P2N4
    Secondary Accessions:
    • A1L4L0
    • B7ZVX9
    • B9ZVN0
    • Q9NR29

    Protein attributes for ADAMTS9 Gene

    Size:
    1935 amino acids
    Molecular mass:
    216491 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ADAMTS9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADAMTS9 Gene

Proteomics data for ADAMTS9 Gene at MOPED

Selected DME Specific Peptides for ADAMTS9 Gene

Post-translational modifications for ADAMTS9 Gene

  • Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).
  • The precursor is cleaved by a furin endopeptidase.
  • Glycosylation at Asn 112, Asn 135, Asn 271, Asn 749, Asn 840, Asn 1213, Asn 1267, Asn 1788, and Asn 1806
  • Modification sites at PhosphoSitePlus

Other Protein References for ADAMTS9 Gene

Antibody Products

Domains & Families for ADAMTS9 Gene

Gene Families for ADAMTS9 Gene

Suggested Antigen Peptide Sequences for ADAMTS9 Gene

Graphical View of Domain Structure for InterPro Entry

Q9P2N4

UniProtKB/Swiss-Prot:

ATS9_HUMAN :
  • The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.
Domain:
  • The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.
  • The ancillary domains, including the TSRs domain, are required for specific extracellular localization and for its versicanase and aggrecanase activities.
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • The GON domain mediates protease-independent function in ER to Golgi transport.
  • Contains 1 disintegrin domain.
  • Contains 1 GON domain.
  • Contains 1 peptidase M12B domain.
  • Contains 15 TSP type-1 domains.
genes like me logo Genes that share domains with ADAMTS9: view

Function for ADAMTS9 Gene

Molecular function for ADAMTS9 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Cleaves aggrecan at the 1838-Glu- -Ala-1839 site and versican at the 1428-Glu- -Ala-1429 site.
UniProtKB/Swiss-Prot Function:
Cleaves the large aggregating proteoglycans, aggrecan and versican. Has a protease-independent function in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos.

Enzyme Numbers (IUBMB) for ADAMTS9 Gene

Gene Ontology (GO) - Molecular Function for ADAMTS9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
genes like me logo Genes that share ontologies with ADAMTS9: view
genes like me logo Genes that share phenotypes with ADAMTS9: view

Animal Models for ADAMTS9 Gene

MGI Knock Outs for ADAMTS9:

Animal Model Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADAMTS9 Gene

Localization for ADAMTS9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAMTS9 Gene

Secreted, extracellular space, extracellular matrix. Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADAMTS9 Gene COMPARTMENTS Subcellular localization image for ADAMTS9 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 3
plasma membrane 2
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ADAMTS9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0031012 colocalizes_with extracellular matrix IEA,ISS 22261194
genes like me logo Genes that share ontologies with ADAMTS9: view

Pathways & Interactions for ADAMTS9 Gene

genes like me logo Genes that share pathways with ADAMTS9: view

Interacting Proteins for ADAMTS9 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000418735%0d%0a9606.ENSP00000446121%0d%0a
Selected Interacting proteins: ENSP00000418735 for ADAMTS9 Gene via STRING

Symbol External ID(s) Details
LIMS1

Gene Ontology (GO) - Biological Process for ADAMTS9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA,IDA 12514189
GO:0006516 glycoprotein catabolic process TAS 10936055
GO:0007275 multicellular organism development TAS 10936055
GO:0045636 positive regulation of melanocyte differentiation IEA --
genes like me logo Genes that share ontologies with ADAMTS9: view

No data available for SIGNOR curated interactions for ADAMTS9 Gene

Drugs & Compounds for ADAMTS9 Gene

No Compound Related Data Available

Transcripts for ADAMTS9 Gene

Unigene Clusters for ADAMTS9 Gene

ADAM metallopeptidase with thrombospondin type 1 motif, 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADAMTS9 Gene

No ASD Table

Relevant External Links for ADAMTS9 Gene

GeneLoc Exon Structure for
ADAMTS9
ECgene alternative splicing isoforms for
ADAMTS9

Expression for ADAMTS9 Gene

mRNA expression in normal human tissues for ADAMTS9 Gene

Protein differential expression in normal tissues from HIPED for ADAMTS9 Gene

This gene is overexpressed in Pancreas (36.5) and Heart (32.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADAMTS9 Gene



SOURCE GeneReport for Unigene cluster for ADAMTS9 Gene Hs.656071

mRNA Expression by UniProt/SwissProt for ADAMTS9 Gene

Q9P2N4-ATS9_HUMAN
Tissue specificity: Highly expressed in all fetal tissues. Expressed in a number of adult tissues with highest expression in heart, placenta and skeletal muscle.
genes like me logo Genes that share expression patterns with ADAMTS9: view

Protein tissue co-expression partners for ADAMTS9 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ADAMTS9 Gene

Orthologs for ADAMTS9 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADAMTS9 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ADAMTS9 35
  • 90.23 (n)
  • 92.04 (a)
ADAMTS9 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADAMTS9 35
  • 90.67 (n)
  • 92.85 (a)
ADAMTS9 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adamts9 35
  • 86.41 (n)
  • 89.99 (a)
Adamts9 16
Adamts9 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ADAMTS9 35
  • 99.45 (n)
  • 99.64 (a)
ADAMTS9 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adamts9 35
  • 86.27 (n)
  • 87.95 (a)
oppossum
(Monodelphis domestica)
Mammalia ADAMTS9 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADAMTS9 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADAMTS9 35
  • 73.7 (n)
  • 76.87 (a)
ADAMTS9 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADAMTS9 36
  • 74 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii adamts9 35
  • 66.1 (n)
  • 68.45 (a)
adamts9 36
  • 67 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6107 37
  • 34 (a)
worm
(Caenorhabditis elegans)
Secernentea gon-1 35
  • 49.88 (n)
  • 41.21 (a)
Species with no ortholog for ADAMTS9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ADAMTS9 Gene

ENSEMBL:
Gene Tree for ADAMTS9 (if available)
TreeFam:
Gene Tree for ADAMTS9 (if available)

Paralogs for ADAMTS9 Gene

genes like me logo Genes that share paralogs with ADAMTS9: view

Variants for ADAMTS9 Gene

Sequence variations from dbSNP and Humsavar for ADAMTS9 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_047081 -, -
rs17071010 - 64,551,026(+) CACCT(C/T)GCGGT nc-transcript-variant, reference, missense
rs6787633 - 64,546,800(+) GGGCA(C/G/T)TCCCT nc-transcript-variant, reference, missense
rs17070967 - 64,541,599(+) CCTCC(C/T)TGCAA nc-transcript-variant, reference, missense
rs3796381 - 64,541,336(-) TCTCC(A/C/G)AGGTT nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ADAMTS9 Gene

Variant ID Type Subtype PubMed ID
dgv289n21 CNV Gain 19592680
dgv809n67 CNV Gain 20364138
esv259785 OTHER Complex 20981092
esv259423 OTHER Complex 20981092
esv28694 CNV Gain 19812545
nsv834718 CNV Gain 17160897
esv272472 CNV Insertion 20981092

Variation tolerance for ADAMTS9 Gene

Residual Variation Intolerance Score: 2.52% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.51; 82.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADAMTS9 Gene

HapMap Linkage Disequilibrium report
ADAMTS9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAMTS9 Gene

Disorders for ADAMTS9 Gene

Relevant External Links for ADAMTS9

Genetic Association Database (GAD)
ADAMTS9
Human Genome Epidemiology (HuGE) Navigator
ADAMTS9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADAMTS9

No disorders were found for ADAMTS9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADAMTS9 Gene

Publications for ADAMTS9 Gene

  1. ADAMTS 9, a novel member of the ADAM-TS/Metallospondin gene family. (PMID: 10936055) Clark M.E. … Maki R.A. (Genomics 2000) 2 3 4 67
  2. High-resolution melting analysis of ADAMTS9 methylation levels in gastric, colorectal, and pancreatic cancers. (PMID: 19963134) Zhang C. … Wan J. (Cancer Genet. Cytogenet. 2010) 3 23
  3. ADAMTS9 is a cell-autonomously acting, anti-angiogenic metalloprotease expressed by microvascular endothelial cells. (PMID: 20093484) Koo B.H. … Apte S.S. (Am. J. Pathol. 2010) 3 23
  4. ADAMTS9 activation by interleukin 1 beta via NFATc1 in OUMS-27 chondrosarcoma cells and in human chondrocytes. (PMID: 19052845) Yaykasli K.O. … Ninomiya Y. (Mol. Cell. Biochem. 2009) 3 23
  5. Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1. (PMID: 12514189) Somerville R.P. … Apte S.S. (J. Biol. Chem. 2003) 3 23

Products for ADAMTS9 Gene

Sources for ADAMTS9 Gene

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