Aliases for SLC12A9 Gene
Aliases for SLC12A9 Gene
External Ids for SLC12A9 Gene
- HGNC: 17435
- Entrez Gene: 56996
- Ensembl: ENSG00000146828
- OMIM: 616861
- UniProtKB: Q9BXP2
Previous GeneCards Identifiers for SLC12A9 Gene
- GC07P100047
- GC07P100061
- GC07P100095
- GC07P100290
- GC07P100424
- GC07P095080
Summaries for SLC12A9 Gene
GeneCards Summary for SLC12A9 Gene
SLC12A9 (Solute Carrier Family 12 Member 9) is a Protein Coding gene. GO annotations related to this gene include cation:chloride symporter activity. An important paralog of this gene is SLC12A2.
UniProtKB/Swiss-Prot for SLC12A9 Gene
-
May be an inhibitor of SLC12A1. Seems to correspond to a subunit of a multimeric transport system and thus, additional subunits may be required for its function.
No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC12A9 Gene
Genomics for SLC12A9 Gene
Regulatory Elements for SLC12A9 Gene
Enhancers for SLC12A9 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around SLC12A9 on UCSC Golden Path with GeneCards custom track
Promoters for SLC12A9 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around SLC12A9 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the SLC12A9 gene promoter:
Regulatory Element Products
Genomic Location for SLC12A9 Gene
- Chromosome:
- 7
- Start:
- 100,826,820 bp from pter
- End:
- 100,867,012 bp from pter
- Size:
- 40,193 bases
- Orientation:
- Plus strand
Genomic View for SLC12A9 Gene
Genes around SLC12A9 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7q22.1 by Ensembl
- 7q22 by Entrez Gene
- 7q22 by HGNC
SLC12A9 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SLC12A9 Gene
Proteins for SLC12A9 Gene
-
Protein details for SLC12A9 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9BXP2-S12A9_HUMAN
- Recommended name:
- Solute carrier family 12 member 9
- Protein Accession:
- Q9BXP2
- B7Z740
- D6W5X0
- D6W5X2
- F5H8C2
- Q9BWL2
- Q9BXP1
- Q9BYI0
- Q9NQR5
Protein attributes for SLC12A9 Gene
- Size:
- 914 amino acids
- Molecular mass:
- 96110 Da
- Quaternary structure:
-
- Interacts with SLC12A1.
Protein Expression for SLC12A9 Gene
Post-translational modifications for SLC12A9 Gene
Other Protein References for SLC12A9 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Search GeneTex for Antibodies for SLC12A9
-
Santa Cruz Biotechnology (SCBT) Antibodies for SLC12A9
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for SLC12A9
- Origene Custom Protein Services for SLC12A9
- Novus Biologicals lysates for SLC12A9
- Search GeneTex for Proteins for SLC12A9
Assay Products
No data available for DME Specific Peptides for SLC12A9 Gene
Domains & Families for SLC12A9 Gene
Gene Families for SLC12A9 Gene
- HGNC:
- IUPHAR :
Protein Domains for SLC12A9 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for SLC12A9 Gene
Graphical View of Domain Structure for InterPro Entry
Q9BXP2- Family:
-
- Belongs to the SLC12A transporter family.
Function for SLC12A9 Gene
Molecular function for SLC12A9 Gene
- UniProtKB/Swiss-Prot Function:
- May be an inhibitor of SLC12A1. Seems to correspond to a subunit of a multimeric transport system and thus, additional subunits may be required for its function.
Phenotypes for SLC12A9 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for SLC12A9 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SLC12A9 gene
- Search ViGene Biosciences for SLC12A9
CRISPR Products
-
OriGene CRISPR knockouts for SLC12A9
-
Santa Cruz Biotechnology (SCBT) CRISPR for SLC12A9
- GenScript: Design CRISPR guide RNA sequences for SLC12A9
miRNA for SLC12A9 Gene
- miRTarBase miRNAs that target SLC12A9
miRNA Products
- Search ViGene Biosciences for SLC12A9
Clone Products
- OriGene clones in human for SLC12A9
- OriGene ORF clones in human,mouse,rat for SLC12A9
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for SLC12A9 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for SLC12A9 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SLC12A9 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC12A9 Gene
Localization for SLC12A9 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SLC12A9 Gene
- Cell membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0070062 | extracellular exosome | IDA | 19056867 |
Pathways & Interactions for SLC12A9 Gene
More details on SuperPathways for SLC12A9
No Data Available
Interacting Proteins for SLC12A9 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006810 | transport | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for SLC12A9 Gene
Transcripts for SLC12A9 Gene
mRNA/cDNA for SLC12A9 Gene
- (9) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (142) Selected AceView cDNA sequences:
- (15) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for SLC12A9 Gene
CRISPR Products
-
OriGene CRISPR knockouts for SLC12A9
-
Santa Cruz Biotechnology (SCBT) CRISPR for SLC12A9
- GenScript: Design CRISPR guide RNA sequences for SLC12A9
miRNA Products
- Search ViGene Biosciences for SLC12A9
Clone Products
- OriGene clones in human for SLC12A9
- OriGene ORF clones in human,mouse,rat for SLC12A9
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | - | - | - |
| ExUns: | 15 | ^ | 16 | ^ | 17 |
|---|---|---|---|---|---|
| SP1: | - | ||||
| SP2: | |||||
| SP3: | - | ||||
| SP4: | - | ||||
| SP5: | |||||
| SP6: | |||||
| SP7: | |||||
| SP8: | |||||
| SP9: | |||||
| SP10: | |||||
| SP11: | |||||
| SP12: | |||||
| SP13: |
Expression for SLC12A9 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
mRNA differential expression in normal tissues according to GTEx for SLC12A9 Gene
This gene is overexpressed in Whole Blood (x15.4).
This gene is overexpressed in Monocytes (26.5), Heart (6.5), Peripheral blood mononuclear cells (6.2), and Placenta (6.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC12A9 Gene
SOURCE GeneReport for Unigene cluster for SLC12A9 Gene Hs.521087
mRNA Expression by UniProt/SwissProt for SLC12A9 Gene
Q9BXP2-S12A9_HUMAN
Tissue specificity:
Highly expressed in placenta, brain and kidney. Lower expression in lung, liver and heart.
Primer Products
-
OriGene qPCR primer pairs for SLC12A9
Orthologs for SLC12A9 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | SLC12A9 35 |
|
||
| SLC12A9 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | SLC12A9 35 |
|
||
| SLC12A9 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Slc12a9 35 |
|
||
| Slc12a9 16 |
|
||||
| Slc12a9 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | SLC12A9 35 |
|
||
| SLC12A9 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Slc12a9 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | SLC12A9 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | SLC12A9 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | SLC12A9 35 |
|
||
| SLC12A9 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | SLC12A9 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100498108 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | slc12a9 35 |
|
||
| slc12a9 36 |
|
OneToOne | |||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.1845 35 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP010249 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG10413 35 |
|
||
| CG10413 36 |
|
OneToOne | |||
| worm (Caenorhabditis elegans) |
Secernentea | T04B8.5 35 |
|
||
| T04B8.5 36 |
|
OneToOne | |||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AFL025C 35 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F10549g 35 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | VHC1 35 |
|
||
| -- 36 |
|
OneToMany | |||
| VHC1 38 |
|
|
|||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU03784 35 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | can1 35 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 36 |
|
OneToOne |
- Species with no ortholog for SLC12A9:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for SLC12A9 Gene
Paralogs for SLC12A9 Gene
(10) SIMAP similar genes for SLC12A9 Gene using alignment to 7 proteins:
Variants for SLC12A9 Gene
| SNP ID | Clin | Chr 07 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs892718 | -- | 100,859,360(+) | GAGGG(G/T)GGGTA | intron-variant | |
| rs7782299 | -- | 100,858,541(+) | gctac(A/G)atggt | intron-variant, upstream-variant-2KB | |
| rs7784933 | -- | 100,863,943(+) | GTGTC(A/G)TCAAG | intron-variant | |
| rs7785074 | -- | 100,833,920(+) | agagc(A/G)agact | upstream-variant-2KB | |
| rs34012126 | -- | 100,855,834(+) | TCGGG(-/G)CCGGT | intron-variant, reference, frameshift-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2734888 | CNV | Deletion | 23290073 |
| dgv2119e1 | CNV | Complex | 17122850 |
| dgv7402n71 | CNV | Loss | 21882294 |
| dgv7403n71 | CNV | Loss | 21882294 |
| nsv831073 | CNV | Loss | 17160897 |
| nsv5870 | CNV | Insertion | 18451855 |
Residual Variation Intolerance Score:
6.71% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.83;
34.38% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SLC12A9 Gene
Disorders for SLC12A9 Gene
Relevant External Links for SLC12A9
No disorders were found for SLC12A9 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC12A9 Gene
Publications for SLC12A9 Gene
- Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5. (PMID: 11239002) Wilson M.D. … Koop B.F. (Nucleic Acids Res. 2001) 2 3 4 67
- Cloning and functional characterization of a cation-Cl-cotransporter- interacting protein. (PMID: 10871601) Caron L. … Isenring P. (J. Biol. Chem. 2000) 2 3
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
- A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
- Physiology of SLC12 transporters: lessons from inherited human genetic mutations and genetically engineered mouse knockouts. (PMID: 23325410) Gagnon K.B. … Delpire E. (Am. J. Physiol., Cell Physiol. 2013) 3
Products for SLC12A9 Gene
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- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for SLC12A9
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- Origene siRNA, shRNA, mouse_rna, rat_shrna, and RNAi products in human, mouse, rat for SLC12A9
- Browse OriGene Inhibitory RNA Products For SLC12A9
- OriGene qPCR primer pairs for SLC12A9
- OriGene CRISPR knockouts for SLC12A9
- OriGene clones in human for SLC12A9
- OriGene ORF clones in human,mouse,rat for SLC12A9
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: Next-day shipping cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for SLC12A9
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- GenScript Custom overexpressing Cell Line Services for SLC12A9
- GenScript: Design CRISPR guide RNA sequences for SLC12A9
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for SLC12A9
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ViGene Biosciences adenoviral particle packaged cDNA for SLC12A9 gene
- ViGene Biosciences lentiviral particle packaged cDNA for SLC12A9 gene
- ViGene Biosciences lentiviral particle packaged cDNA for SLC12A9 gene
- ViGene Biosciences ready-to-package AAV shRNAs for SLC12A9 gene
- ViGene Biosciences ready-to-package AAV shRNAs for SLC12A9 gene
- ViGene Biosciences ready-to-package AAV shRNAs for SLC12A9 gene
- Search ViGene Biosciences for SLC12A9
- Search ViGene Biosciences for SLC12A9
- Santa Cruz Biotechnology (SCBT) Antibodies for SLC12A9
- Search Santa Cruz Biotechnology (SCBT) for SLC12A9 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for SLC12A9
Sources for SLC12A9 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
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- (18) KEGG
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- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
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- (62) miRBase
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- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
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- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
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- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
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- (107) COMPARTMENTS
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