Aliases for SLC12A9 Gene
Aliases for SLC12A9 Gene
External Ids for SLC12A9 Gene
- HGNC: 17435
- Entrez Gene: 56996
- Ensembl: ENSG00000146828
- OMIM: 616861
- UniProtKB: Q9BXP2
Previous GeneCards Identifiers for SLC12A9 Gene
- GC07P100047
- GC07P100061
- GC07P100095
- GC07P100290
- GC07P100424
- GC07P095080
Summaries for SLC12A9 Gene
GeneCards Summary for SLC12A9 Gene
SLC12A9 (Solute Carrier Family 12 Member 9) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include cation:chloride symporter activity. An important paralog of this gene is SLC12A2.
UniProtKB/Swiss-Prot for SLC12A9 Gene
-
May be an inhibitor of SLC12A1. Seems to correspond to a subunit of a multimeric transport system and thus, additional subunits may be required for its function.
Additional gene information for SLC12A9 Gene
- Monarch Initiative
- Search for SLC12A9 at DataMed
- Search for SLC12A9 at HumanCyc
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC12A9 Gene
Genomics for SLC12A9 Gene
GeneHancer (GH) Regulatory Elements for SLC12A9 Gene
Regulatory Element Products
Genomic Locations for SLC12A9 Gene
- chr7:100,826,820-100,867,012
- (GRCh38/hg38)
- Size:
- 40,193 bases
- Orientation:
- Plus strand
- chr7:100,424,442-100,464,634
- (GRCh37/hg19)
Genomic View for SLC12A9 Gene
- Cytogenetic band:
-
- 7q22.1 by Ensembl
- 7q22.1 by Entrez Gene
- 7q22.1 by HGNC


RefSeq DNA sequence for SLC12A9 Gene
Proteins for SLC12A9 Gene
-
Protein details for SLC12A9 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9BXP2-S12A9_HUMAN
- Recommended name:
- Solute carrier family 12 member 9
- Protein Accession:
- Q9BXP2
- B7Z740
- D6W5X0
- D6W5X2
- F5H8C2
- Q9BWL2
- Q9BXP1
- Q9BYI0
- Q9NQR5
Protein attributes for SLC12A9 Gene
- Size:
- 914 amino acids
- Molecular mass:
- 96110 Da
- Quaternary structure:
-
- Interacts with SLC12A1.
Protein Expression for SLC12A9 Gene
Post-translational modifications for SLC12A9 Gene
Other Protein References for SLC12A9 Gene
Antibody Products
- Search GeneTex for Antibodies for SLC12A9
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for SLC12A9
- Origene Custom Protein Services for SLC12A9
- Novus Biologicals lysates for SLC12A9
- Search GeneTex for Proteins for SLC12A9
Assay Products
No data available for DME Specific Peptides for SLC12A9 Gene
Domains & Families for SLC12A9 Gene
Gene Families for SLC12A9 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
- Transporters
Protein Domains for SLC12A9 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for SLC12A9 Gene
Graphical View of Domain Structure for InterPro Entry
Q9BXP2- Family:
-
- Belongs to the SLC12A transporter family.
Function for SLC12A9 Gene
Molecular function for SLC12A9 Gene
- UniProtKB/Swiss-Prot Function:
- May be an inhibitor of SLC12A1. Seems to correspond to a subunit of a multimeric transport system and thus, additional subunits may be required for its function.
Phenotypes From GWAS Catalog for SLC12A9 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0015377 | cation:chloride symporter activity | TAS | 10871601 |
GO:0015379 | potassium:chloride symporter activity | IBA | -- |
GO:0022820 | potassium ion symporter activity | IBA | -- |
Phenotypes for SLC12A9 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for SLC12A9 gene
-
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CRISPR Products
-
OriGene CRISPR knockouts for SLC12A9
- genomics-online: gRNA clones - Search results for 88 available SLC12A9 gene related products
- Overview of 88 available SLC12A9 gene related products
- Applied Biological Materials CRISPR for SLC12A9
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SLC12A9
- GenScript: Design CRISPR guide RNA sequences for SLC12A9
miRNA for SLC12A9 Gene
- miRTarBase miRNAs that target SLC12A9
miRNA Products
- Search ViGene Biosciences for SLC12A9
Inhibitory RNA Products
- Origene RNAi and shrna products in human, mouse, rat for SLC12A9
- Browse OriGene Inhibitory RNA Products For SLC12A9
- genomics-online: shRNA clones - Search results for 88 available SLC12A9 gene related products
- Overview of 88 available SLC12A9 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for SLC12A9 gene
Clone Products
- Sino Biological Human cDNA Clone for SLC12A9
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for SLC12A9
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SLC12A9
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for SLC12A9
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for SLC12A9
-
ViGene Biosciences adenoviral particle packaged cDNA for SLC12A9 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for SLC12A9 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SLC12A9 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC12A9 Gene
Localization for SLC12A9 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SLC12A9 Gene
- Cell membrane; Multi-pass membrane protein.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | IEA | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | TAS,IEA | -- |
GO:0070062 | extracellular exosome | IDA,HDA | 19056867 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC12A9 Gene
Pathways & Interactions for SLC12A9 Gene
Interacting Proteins for SLC12A9 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006810 | transport | IEA | -- |
GO:0006811 | ion transport | IEA | -- |
GO:0055085 | transmembrane transport | IEA | -- |
GO:0071805 | potassium ion transmembrane transport | IEA | -- |
GO:1902476 | chloride transmembrane transport | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for SLC12A9 Gene
Transcripts for SLC12A9 Gene
mRNA/cDNA for SLC12A9 Gene
- (8) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (142) Selected AceView cDNA sequences:
- (15) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for SLC12A9 Gene
CRISPR Products
-
OriGene CRISPR knockouts for SLC12A9
- genomics-online: gRNA clones - Search results for 88 available SLC12A9 gene related products
- Overview of 88 available SLC12A9 gene related products
- Applied Biological Materials CRISPR for SLC12A9
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SLC12A9
- GenScript: Design CRISPR guide RNA sequences for SLC12A9
miRNA Products
- Search ViGene Biosciences for SLC12A9
Inhibitory RNA Products
- Origene RNAi and shrna products in human, mouse, rat for SLC12A9
- Browse OriGene Inhibitory RNA Products For SLC12A9
- genomics-online: shRNA clones - Search results for 88 available SLC12A9 gene related products
- Overview of 88 available SLC12A9 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for SLC12A9 gene
Clone Products
- Sino Biological Human cDNA Clone for SLC12A9
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for SLC12A9
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SLC12A9
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for SLC12A9
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP7: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP9: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP11: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP12: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP13: | - | - | - | - | - | - |
ExUns: | 15 | ^ | 16 | ^ | 17 |
---|---|---|---|---|---|
SP1: | - | ||||
SP2: | |||||
SP3: | - | ||||
SP4: | - | ||||
SP5: | |||||
SP6: | |||||
SP7: | |||||
SP8: | |||||
SP9: | |||||
SP10: | |||||
SP11: | |||||
SP12: | |||||
SP13: |
Expression for SLC12A9 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
mRNA differential expression in normal tissues according to GTEx for SLC12A9 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC12A9 Gene
NURSA nuclear receptor signaling pathways regulating expression of SLC12A9 Gene:
SLC12A9SOURCE GeneReport for Unigene cluster for SLC12A9 Gene:
Hs.521087mRNA Expression by UniProt/SwissProt for SLC12A9 Gene:
Q9BXP2-S12A9_HUMANEvidence on tissue expression from TISSUES for SLC12A9 Gene
- Heart(4.1)
Primer Products
-
OriGene qPCR primer pairs for SLC12A9
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC12A9 Gene
Orthologs for SLC12A9 Gene
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | SLC12A9 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | SLC12A9 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | SLC12A9 33 34 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | SLC12A9 34 |
|
OneToOne | |
mouse (Mus musculus) |
Mammalia | Slc12a9 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Slc12a9 33 |
|
||
platypus (Ornithorhynchus anatinus) |
Mammalia | SLC12A9 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | SLC12A9 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | SLC12A9 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100498108 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | slc12a9 33 34 |
|
||
rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.1845 33 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | CG10413 33 34 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP010249 33 |
|
||
worm (Caenorhabditis elegans) |
Secernentea | T04B8.5 33 34 |
|
||
A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AFL025C 33 |
|
||
K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F10549g 33 |
|
||
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | VHC1 33 36 |
|
||
-- 34 |
|
OneToMany | |||
bread mold (Neurospora crassa) |
Ascomycetes | NCU03784 33 |
|
||
sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne | |
fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | can1 33 |
|
- Species where no ortholog for SLC12A9 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for SLC12A9 Gene
Paralogs for SLC12A9 Gene
(10) SIMAP similar genes for SLC12A9 Gene using alignment to 7 proteins:
Variants for SLC12A9 Gene
SNP ID | Clin | Chr 07 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000093956 | -- | 100,853,576(+) | A/T | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
rs1000549709 | -- | 100,859,890(+) | T/C | 5_prime_UTR_variant, coding_sequence_variant, missense_variant | |
rs1000616346 | -- | 100,858,669(+) | A/C | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
rs1000627721 | -- | 100,865,441(+) | G/A | 3_prime_UTR_variant, intron_variant | |
rs1000705298 | -- | 100,867,323(+) | G/C | downstream_transcript_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2734888 | CNV | deletion | 23290073 |
esv2759547 | CNV | gain+loss | 17122850 |
nsv1020837 | CNV | loss | 25217958 |
nsv5870 | CNV | insertion | 18451855 |
nsv607965 | CNV | loss | 21841781 |
nsv607966 | CNV | loss | 21841781 |
nsv831073 | CNV | loss | 17160897 |
Additional Variant Information for SLC12A9 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SLC12A9
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC12A9 Gene
Disorders for SLC12A9 Gene
Additional Disease Information for SLC12A9
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for SLC12A9 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC12A9 Gene
Publications for SLC12A9 Gene
- Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5. (PMID: 11239002) Wilson MD … Koop BF (Nucleic acids research 2001) 2 3 4 58
- Cloning and functional characterization of a cation-Cl- cotransporter-interacting protein. (PMID: 10871601) Caron L … Isenring P (The Journal of biological chemistry 2000) 2 3 4 58
- Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. (PMID: 21347282) Lettre G … Boerwinkle E (PLoS genetics 2011) 3 44 58
- Genome-wide association analysis identifies multiple loci related to resting heart rate. (PMID: 20639392) Eijgelsheim M … O'Donnell CJ (Human molecular genetics 2010) 3 44 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
Products for SLC12A9 Gene
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- OriGene qPCR primer pairs for SLC12A9
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- GenScript: Design CRISPR guide RNA sequences for SLC12A9
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- CloneReady with Over 120,000 Genes
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- Novus Biologicals lysates for SLC12A9
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies at Cloud-Clone Corp.
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- Cloud-Clone Corp. primary cells service
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for SLC12A9
- VectorBuilder custom plasmid, inducible vectors for SLC12A9
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SLC12A9
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneTex for Antibodies for SLC12A9
- Search GeneTex for Proteins for SLC12A9
- ViGene Biosciences adenoviral particle packaged cDNA for SLC12A9 gene
- ViGene Biosciences lentiviral particle packaged cDNA for SLC12A9 gene
- ViGene Biosciences ready-to-package AAV shRNAs for SLC12A9 gene
- Search ViGene Biosciences for SLC12A9
- Horizon Cell Lines for SLC12A9
- genomics-online: cdna clones - Search results for 88 available SLC12A9 gene related products
- Overview of 88 available SLC12A9 gene related products
- orf clones - Search results for 88 available SLC12A9 gene related products
- Overview of 88 available SLC12A9 gene related products
- genomics-online: gRNA clones - Search results for 88 available SLC12A9 gene related products
- Overview of 88 available SLC12A9 gene related products
- genomics-online: primer clones - Search results for 88 available SLC12A9 gene related products
- Overview of 88 available SLC12A9 gene related products
- genomics-online: shRNA clones - Search results for 88 available SLC12A9 gene related products
- Overview of 88 available SLC12A9 gene related products
Sources for SLC12A9 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
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