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Aliases for BBX Gene

Aliases for BBX Gene

  • Bobby Sox Homolog (Drosophila) 2 3 5
  • HMG Box-Containing Protein 2 3 4
  • X 001 Protein 2 3
  • HBP2 3 4
  • Ag Recognized By Treg Cells 1 3
  • Bobby Sox Homolog 4
  • HSPC339 3
  • MDS001 3
  • ARTC1 3

External Ids for BBX Gene

Previous GeneCards Identifiers for BBX Gene

  • GC03P103845
  • GC03P106769
  • GC03P108523
  • GC03P108562
  • GC03P108724
  • GC03P107241
  • GC03P104615

Summaries for BBX Gene

GeneCards Summary for BBX Gene

BBX (Bobby Sox Homolog (Drosophila)) is a Protein Coding gene. An important paralog of this gene is CIC.

UniProtKB/Swiss-Prot for BBX Gene

  • Transcription factor that is necessary for cell cycle progression from G1 to S phase.

Gene Wiki entry for BBX Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BBX Gene

Genomics for BBX Gene

Regulatory Elements for BBX Gene

Promoters for BBX Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BBX on UCSC Golden Path with GeneCards custom track

Genomic Location for BBX Gene

Chromosome:
3
Start:
107,522,936 bp from pter
End:
107,811,329 bp from pter
Size:
288,394 bases
Orientation:
Plus strand

Genomic View for BBX Gene

Genes around BBX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BBX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BBX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BBX Gene

Proteins for BBX Gene

  • Protein details for BBX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WY36-BBX_HUMAN
    Recommended name:
    HMG box transcription factor BBX
    Protein Accession:
    Q8WY36
    Secondary Accessions:
    • A2RRM7
    • Q2TAJ1
    • Q7L3J8
    • Q7LBY8
    • Q8NDB0
    • Q8WY35
    • Q9H0J6

    Protein attributes for BBX Gene

    Size:
    941 amino acids
    Molecular mass:
    105130 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI10904.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for BBX Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BBX Gene

Proteomics data for BBX Gene at MOPED

Post-translational modifications for BBX Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for BBX Gene

Domains & Families for BBX Gene

Protein Domains for BBX Gene

Suggested Antigen Peptide Sequences for BBX Gene

Graphical View of Domain Structure for InterPro Entry

Q8WY36

UniProtKB/Swiss-Prot:

BBX_HUMAN :
  • Contains 1 HMG box DNA-binding domain.
Domain:
  • Contains 1 HMG box DNA-binding domain.
genes like me logo Genes that share domains with BBX: view

No data available for Gene Families for BBX Gene

Function for BBX Gene

Molecular function for BBX Gene

UniProtKB/Swiss-Prot Function:
Transcription factor that is necessary for cell cycle progression from G1 to S phase.
genes like me logo Genes that share phenotypes with BBX: view

Animal Models for BBX Gene

MGI Knock Outs for BBX:
  • Bbx tm1a(EUCOMM)Wtsi

Animal Model Products

miRNA for BBX Gene

miRTarBase miRNAs that target BBX

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BBX Gene

Localization for BBX Gene

Subcellular locations from UniProtKB/Swiss-Prot for BBX Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BBX Gene COMPARTMENTS Subcellular localization image for BBX gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for BBX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with BBX: view

Pathways & Interactions for BBX Gene

SuperPathways for BBX Gene

No Data Available

Interacting Proteins for BBX Gene

Gene Ontology (GO) - Biological Process for BBX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0060348 bone development IEA --
genes like me logo Genes that share ontologies with BBX: view

No data available for Pathways by source and SIGNOR curated interactions for BBX Gene

Drugs & Compounds for BBX Gene

No Compound Related Data Available

Transcripts for BBX Gene

Unigene Clusters for BBX Gene

Bobby sox homolog (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BBX Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
SP1: -
SP2:
SP3: -
SP4:

Relevant External Links for BBX Gene

GeneLoc Exon Structure for
BBX
ECgene alternative splicing isoforms for
BBX

Expression for BBX Gene

mRNA expression in normal human tissues for BBX Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BBX Gene

This gene is overexpressed in Peripheral blood mononuclear cells (24.0), Lung (14.8), Blymphocyte (13.3), and Heart (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for BBX Gene



SOURCE GeneReport for Unigene cluster for BBX Gene Hs.124366

genes like me logo Genes that share expression patterns with BBX: view

Protein tissue co-expression partners for BBX Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for BBX Gene

Orthologs for BBX Gene

This gene was present in the common ancestor of animals.

Orthologs for BBX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BBX 36
  • 99 (a)
OneToOne
BBX 35
  • 99.54 (n)
  • 99.47 (a)
cow
(Bos Taurus)
Mammalia BBX 36
  • 93 (a)
OneToOne
BBX 35
  • 92.88 (n)
  • 93.41 (a)
dog
(Canis familiaris)
Mammalia BBX 35
  • 93.48 (n)
  • 94.26 (a)
BBX 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bbx 16
Bbx 35
  • 88.31 (n)
  • 87.98 (a)
Bbx 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BBX 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BBX 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bbx 35
  • 87.19 (n)
  • 87 (a)
chicken
(Gallus gallus)
Aves BBX 35
  • 75.51 (n)
  • 73.7 (a)
BBX 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BBX 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bbx 35
  • 65.3 (n)
  • 60.36 (a)
zebrafish
(Danio rerio)
Actinopterygii BBX 36
  • 48 (a)
OneToOne
LOC100005540 35
  • 60.52 (n)
  • 60.47 (a)
fruit fly
(Drosophila melanogaster)
Insecta bbx 36
  • 8 (a)
ManyToMany
cic 36
  • 6 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea gei-3 36
  • 8 (a)
OneToMany
Species with no ortholog for BBX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BBX Gene

ENSEMBL:
Gene Tree for BBX (if available)
TreeFam:
Gene Tree for BBX (if available)

Paralogs for BBX Gene

Paralogs for BBX Gene

genes like me logo Genes that share paralogs with BBX: view

Variants for BBX Gene

Sequence variations from dbSNP and Humsavar for BBX Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs59781647 - 107,773,447(+) CAGAA(A/C/T)CATTG intron-variant, reference, missense
rs23534 -- 107,670,239(-) ATTTG(A/G)TAGAA intron-variant
rs167923 -- 107,662,596(-) ATTCA(A/G)AATGC intron-variant
rs191313 -- 107,666,027(+) GGAAT(C/T)GCTAA intron-variant
rs496718 -- 107,586,907(-) tggac(A/T)tggtg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BBX Gene

Variant ID Type Subtype PubMed ID
nsv829654 CNV Gain 17160897
esv2673634 CNV Deletion 23128226
nsv877321 CNV Loss 21882294
esv2670666 CNV Deletion 23128226
nsv829655 CNV Gain 17160897
esv2656585 CNV Deletion 23128226
esv27545 CNV Loss 19812545

Variation tolerance for BBX Gene

Residual Variation Intolerance Score: 50.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.94; 79.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BBX Gene

HapMap Linkage Disequilibrium report
BBX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BBX Gene

Disorders for BBX Gene

Relevant External Links for BBX

Genetic Association Database (GAD)
BBX
Human Genome Epidemiology (HuGE) Navigator
BBX
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BBX

No disorders were found for BBX Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BBX Gene

Publications for BBX Gene

  1. HBP2: a new mammalian protein that complements the fission yeast MBF transcription complex. (PMID: 11680820) Sanchez-Diaz A. … Moreno S. (Curr. Genet. 2001) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry. (PMID: 24332808) Marechal A. … Zou L. (Mol. Cell 2014) 3
  4. The functional interactome landscape of the human histone deacetylase family. (PMID: 23752268) Joshi P. … Cristea I.M. (Mol. Syst. Biol. 2013) 3
  5. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PMID: 22939624) Taipale M. … Lindquist S. (Cell 2012) 3

Products for BBX Gene

Sources for BBX Gene

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