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Aliases for PYY Gene

Aliases for PYY Gene

  • Peptide YY 2 3 5
  • Peptide Tyrosine Tyrosine 3 4
  • Prepro-PYY 2 3
  • PYY-I 3 4
  • PYY1 3

External Ids for PYY Gene

Previous GeneCards Identifiers for PYY Gene

  • GC17M041772
  • GC17M044207
  • GC17M042040
  • GC17M042505
  • GC17M039385
  • GC17M037794

Summaries for PYY Gene

Entrez Gene Summary for PYY Gene

  • This gene encodes a member of the neuropeptide Y (NPY) family of peptides. The encoded preproprotein is proteolytically processed to generate two alternative peptide products that differ in length by three amino acids. These peptides, secreted by endocrine cells in the gut, exhibit different binding affinities for each of the neuropeptide Y receptors. Binding of the encoded peptides to these receptors mediates regulation of pancreatic secretion, gut mobility and energy homeostasis. Rare variations in this gene could increase susceptibility to obesity and elevated serum levels of the encoded peptides may be associated with anorexia nervosa. [provided by RefSeq, Feb 2016]

GeneCards Summary for PYY Gene

PYY (Peptide YY) is a Protein Coding gene. Diseases associated with PYY include Obesity, Pyy-Related and Anorexia Nervosa. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. GO annotations related to this gene include hormone activity and neuropeptide hormone activity. An important paralog of this gene is NPY.

UniProtKB/Swiss-Prot for PYY Gene

  • This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility.

Gene Wiki entry for PYY Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PYY Gene

Genomics for PYY Gene

Regulatory Elements for PYY Gene

Enhancers for PYY Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PYY on UCSC Golden Path with GeneCards custom track

Genomic Location for PYY Gene

43,952,733 bp from pter
44,024,260 bp from pter
71,528 bases
Minus strand

Genomic View for PYY Gene

Genes around PYY on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PYY Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PYY Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PYY Gene

Proteins for PYY Gene

  • Protein details for PYY Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Peptide YY
    Protein Accession:
    Secondary Accessions:
    • Q5U5Q6
    • Q6FGH8

    Protein attributes for PYY Gene

    97 amino acids
    Molecular mass:
    11145 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PYY Gene

    Alternative splice isoforms for PYY Gene


neXtProt entry for PYY Gene

Proteomics data for PYY Gene at MOPED

Post-translational modifications for PYY Gene

  • The peptide YY form is cleaved at Pro-30 by the prolyl endopeptidase FAP (seprase) activity (in vitro) to generate peptide YY(3-36).

Other Protein References for PYY Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for PYY Gene

Domains & Families for PYY Gene

Gene Families for PYY Gene

Protein Domains for PYY Gene

Suggested Antigen Peptide Sequences for PYY Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NPY family.
  • Belongs to the NPY family.
genes like me logo Genes that share domains with PYY: view

Function for PYY Gene

Molecular function for PYY Gene

GENATLAS Biochemistry:
peptide YY,gut hormone,inhibiting exocrine pancreatic secretion
UniProtKB/Swiss-Prot Function:
This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility.
genes like me logo Genes that share phenotypes with PYY: view

Animal Models for PYY Gene

MGI Knock Outs for PYY:

Animal Model Products

  • Taconic Biosciences Mouse Models for PYY

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PYY Gene

Localization for PYY Gene

Subcellular locations from UniProtKB/Swiss-Prot for PYY Gene


Subcellular locations from

Jensen Localization Image for PYY Gene COMPARTMENTS Subcellular localization image for PYY gene
Compartment Confidence
extracellular 5
cytosol 3
nucleus 3
plasma membrane 2
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for PYY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
genes like me logo Genes that share ontologies with PYY: view

Pathways & Interactions for PYY Gene

genes like me logo Genes that share pathways with PYY: view

SIGNOR curated interactions for PYY Gene


Gene Ontology (GO) - Biological Process for PYY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization TAS 7493937
GO:0007186 G-protein coupled receptor signaling pathway TAS 7592911
GO:0007631 feeding behavior TAS 10698177
GO:0008283 cell proliferation TAS 10488139
GO:0032098 regulation of appetite IBA --
genes like me logo Genes that share ontologies with PYY: view

Drugs & Compounds for PYY Gene

(72) Drugs for PYY Gene - From: ClinicalTrials and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hydrocortisone Approved Pharma Agonist 594
Insulin Detemir Approved Pharma 190
Insulin Glargine Approved Pharma 499
Methyltestosterone Approved Pharma 519
Testosterone Approved, Investigational Pharma Endogenous androgen receptor agonist 519

(26) Additional Compounds for PYY Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PYY: view

Transcripts for PYY Gene

mRNA/cDNA for PYY Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PYY Gene

Peptide YY:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PYY Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b

Relevant External Links for PYY Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PYY Gene

mRNA expression in normal human tissues for PYY Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PYY Gene

This gene is overexpressed in Colon - Transverse (x31.7), Small Intestine - Terminal Ileum (x13.7), and Colon - Sigmoid (x4.0).

Protein differential expression in normal tissues from HIPED for PYY Gene

This gene is overexpressed in Colon (42.1) and Rectum (26.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PYY Gene

SOURCE GeneReport for Unigene cluster for PYY Gene Hs.169249

genes like me logo Genes that share expression patterns with PYY: view

Protein tissue co-expression partners for PYY Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for PYY Gene

Orthologs for PYY Gene

This gene was present in the common ancestor of chordates.

Orthologs for PYY Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PYY 35
  • 80.76 (n)
  • 72.16 (a)
PYY 36
  • 70 (a)
(Canis familiaris)
Mammalia PYY 35
  • 84.54 (n)
  • 77.32 (a)
PYY 36
  • 74 (a)
(Mus musculus)
Mammalia Pyy 35
  • 77.32 (n)
  • 72.16 (a)
Pyy 16
Pyy 36
  • 70 (a)
(Pan troglodytes)
Mammalia PYY 35
  • 96.91 (n)
  • 96.91 (a)
PYY 36
  • 93 (a)
(Rattus norvegicus)
Mammalia Pyy 35
  • 80.07 (n)
  • 74.23 (a)
(Monodelphis domestica)
Mammalia PYY 36
  • 62 (a)
(Ornithorhynchus anatinus)
Mammalia PYY 36
  • 54 (a)
(Gallus gallus)
Aves PPY 36
  • 34 (a)
(Anolis carolinensis)
Reptilia PYY 36
  • 50 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pyy 35
  • 53.33 (n)
  • 56.67 (a)
(Danio rerio)
Actinopterygii pyya 35
  • 58.42 (n)
  • 49.48 (a)
pyyb 36
  • 41 (a)
Species with no ortholog for PYY:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PYY Gene

Gene Tree for PYY (if available)
Gene Tree for PYY (if available)

Paralogs for PYY Gene

Paralogs for PYY Gene

(4) SIMAP similar genes for PYY Gene using alignment to 1 proteins: Pseudogenes for PYY Gene

genes like me logo Genes that share paralogs with PYY: view

Variants for PYY Gene

Sequence variations from dbSNP and Humsavar for PYY Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1058046 - 43,953,163(-) GGACA(C/G)GCTTC reference, missense
rs229969 - 43,953,375(-) CTCCC(C/G)GCGAA reference, missense
rs465407 - 43,952,967(-) GCCCA(A/C/G)ACCTG reference, missense
rs149420 -- 43,958,007(-) TCCTA(A/G)AGCGA utr-variant-5-prime
rs149421 -- 43,959,014(-) CACTT(A/C)TAGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PYY Gene

Variant ID Type Subtype PubMed ID
nsv833454 CNV Loss 17160897
nsv112219 CNV Insertion 16902084
esv2675215 CNV Deletion 23128226

Variation tolerance for PYY Gene

Residual Variation Intolerance Score: 52.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.27; 40.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PYY Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PYY Gene

Disorders for PYY Gene

MalaCards: The human disease database

(20) MalaCards diseases for PYY Gene - From: GeneTests, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
obesity, pyy-related
anorexia nervosa
  • anorexia nervosa, susceptibility to
bulimia nervosa
  • hyperorexia nervosa
short bowel syndrome
  • acquired short bowel syndrome
lymphocytic colitis
  • colitis, lymphocytic
- elite association - COSMIC cancer census association via MalaCards
Search PYY in MalaCards View complete list of genes associated with diseases

Relevant External Links for PYY

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PYY: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PYY Gene

Publications for PYY Gene

  1. Single nucleotide polymorphisms in the neuropeptide Y2 receptor (NPY2R) gene and association with severe obesity in French white subjects. (PMID: 17235527) Siddiq A. … Froguel P. (Diabetologia 2007) 3 48 67
  2. Peptide YY levels across pubertal stages and associations with growth hormone. (PMID: 20375207) Lloyd B. … Misra M. (J. Clin. Endocrinol. Metab. 2010) 3 23
  3. Influence of resistance and aerobic exercise on hunger, circulating levels of acylated ghrelin, and peptide YY in healthy males. (PMID: 18987287) Broom D.R. … Stensel D.J. (Am. J. Physiol. Regul. Integr. Comp. Physiol. 2009) 3 23
  4. Long-term exercise training in overweight adolescents improves plasma peptide YY and resistin. (PMID: 19247279) Jones T.E. … Hickner R.C. (Obesity (Silver Spring) 2009) 3 23
  5. Peptide YY in adolescent athletes with amenorrhea, eumenorrheic athletes and non-athletic controls. (PMID: 19344792) Russell M. … Misra M. (Bone 2009) 3 23

Products for PYY Gene

Sources for PYY Gene