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PYY Gene(Protein Coding)

Peptide YY

GCID:
GC17M043952
GIFtS:
61
Genes Participants
UDN Logo

Aliases for PYY Gene

Aliases for PYY Gene

  • Peptide YY 2 3 5
  • Peptide Tyrosine Tyrosine 3 4
  • Prepro-PYY 2 3
  • PYY-I 3 4
  • PYY1 3

External Ids for PYY Gene

Previous GeneCards Identifiers for PYY Gene

  • GC17M041772
  • GC17M044207
  • GC17M042040
  • GC17M042505
  • GC17M039385
  • GC17M037794

Summaries for PYY Gene

Entrez Gene Summary for PYY Gene

  • This gene encodes a member of the neuropeptide Y (NPY) family of peptides. The encoded preproprotein is proteolytically processed to generate two alternative peptide products that differ in length by three amino acids. These peptides, secreted by endocrine cells in the gut, exhibit different binding affinities for each of the neuropeptide Y receptors. Binding of the encoded peptides to these receptors mediates regulation of pancreatic secretion, gut mobility and energy homeostasis. Rare variations in this gene could increase susceptibility to obesity and elevated serum levels of the encoded peptides may be associated with anorexia nervosa. [provided by RefSeq, Feb 2016]

GeneCards Summary for PYY Gene

PYY (Peptide YY) is a Protein Coding gene. Diseases associated with PYY include Obesity, Pyy-Related and Anorexia Nervosa. Among its related pathways are Peptide ligand-binding receptors and Sympathetic Nerve Pathway (Neuroeffector Junction). GO annotations related to this gene include hormone activity and neuropeptide hormone activity. An important paralog of this gene is NPY.

UniProtKB/Swiss-Prot for PYY Gene

  • This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility.

Gene Wiki entry for PYY Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PYY Gene

Genomics for PYY Gene

Products:

  1. Regulatory Element

Regulatory Elements for PYY Gene

Enhancers for PYY Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G044094 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.7 -72.6 -72644 4.1 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 ZNF263 ASB16 G6PC3 TMEM101 ASB16-AS1 LSM12 RNU6-131P C17orf53 HDAC5 ENSG00000221044 PYY
GH17G044101 1.7 Ensembl ENCODE dbSUPER 10.7 -83.4 -83395 12.5 CREB3L1 MLX ZFP64 DMAP1 YBX1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 ASB16-AS1 ASB16 NAGS G6PC3 HMGN1P29 LINC00910 C17orf53 DHX8 LSM12 RNU6-131P
GH17G043926 1.3 FANTOM5 Ensembl ENCODE 11.1 +96.1 96053 2.8 SOX13 TFAP4 SUZ12 FEZF1 ZNF121 PRDM10 EZH2 GATAD2A SOX5 NRF1 LSM12 C17orf105 MPP2 NAGS PYY ENSG00000221044 CD300LG LOC102724183 LINC01976
GH17G043878 1.2 Ensembl ENCODE 10.9 +145.5 145540 1.1 HDGF SIN3A ZNF2 ZNF48 GLIS2 ZNF143 ZNF263 REST GLIS1 WT1 MPP2 CD300LG MPP3 NAGS PYY ENSG00000221044 GC17P043880
GH17G043871 0.8 Ensembl ENCODE 11 +150.8 150818 3.4 CTCF IRF2 IKZF1 IRF1 MAFK MPP2 CD300LG MPP3 NAGS PYY ENSG00000221044 MEOX1 MIR2117 RNU6-406P DUSP3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PYY on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the PYY gene promoter:

Genomic Location for PYY Gene

Chromosome:
17
Start:
43,952,733 bp from pter
End:
44,024,260 bp from pter
Size:
71,528 bases
Orientation:
Minus strand

Genomic View for PYY Gene

Genes around PYY on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PYY Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PYY Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for PYY Gene

Proteins for PYY Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for PYY Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10082-PYY_HUMAN
    Recommended name:
    Peptide YY
    Protein Accession:
    P10082
    Secondary Accessions:
    • Q5U5Q6
    • Q6FGH8

    Protein attributes for PYY Gene

    Size:
    97 amino acids
    Molecular mass:
    11145 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PYY Gene

    Alternative splice isoforms for PYY Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PYY Gene

Protein Expression for PYY Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for PYY Gene

  • The peptide YY form is cleaved at Pro-30 by the prolyl endopeptidase FAP (seprase) activity (in vitro) to generate peptide YY(3-36).

Other Protein References for PYY Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for PYY Gene

Domains & Families for PYY Gene

Gene Families for PYY Gene

HGNC:

Protein Domains for PYY Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for PYY Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P10082

UniProtKB/Swiss-Prot:

PYY_HUMAN :
  • Belongs to the NPY family.
Family:
  • Belongs to the NPY family.
genes like me logo Genes that share domains with PYY: view

Function for PYY Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for PYY Gene

GENATLAS Biochemistry:
peptide YY,gut hormone,inhibiting exocrine pancreatic secretion
UniProtKB/Swiss-Prot Function:
This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility.

Gene Ontology (GO) - Molecular Function for PYY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding IBA --
GO:0005179 hormone activity TAS 10698177
GO:0005184 neuropeptide hormone activity IBA --
GO:0005515 protein binding IPI 23597562
genes like me logo Genes that share ontologies with PYY: view
genes like me logo Genes that share phenotypes with PYY: view

Animal Models for PYY Gene

MGI Knock Outs for PYY:

Animal Model Products

  • Taconic Biosciences Mouse Models for PYY

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PYY Gene

Localization for PYY Gene

Subcellular locations from UniProtKB/Swiss-Prot for PYY Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PYY gene
Compartment Confidence
extracellular 5
nucleus 3
cytosol 3
plasma membrane 2
peroxisome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for PYY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with PYY: view

Pathways & Interactions for PYY Gene

genes like me logo Genes that share pathways with PYY: view

SIGNOR curated interactions for PYY Gene

Activates:

Gene Ontology (GO) - Biological Process for PYY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006928 movement of cell or subcellular component TAS 10488139
GO:0007010 cytoskeleton organization TAS 7493937
GO:0007186 G-protein coupled receptor signaling pathway TAS 7592911
GO:0007218 neuropeptide signaling pathway IBA --
GO:0007267 cell-cell signaling TAS 7493937
genes like me logo Genes that share ontologies with PYY: view

Drugs & Compounds for PYY Gene

Products:

  1. Drug

(82) Drugs for PYY Gene - From: ClinicalTrials and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hydrocortisone Approved, Vet_approved Pharma Agonist Adrenal glucocorticoid; immunosuppressant 667
Insulin Detemir Approved Pharma 195
Insulin Glargine Approved Pharma 528
Methyltestosterone Approved Pharma 563
Testosterone Approved, Investigational Pharma Endogenous androgen receptor agonist 563

(24) Additional Compounds for PYY Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PYY: view

Transcripts for PYY Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for PYY Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PYY Gene

Peptide YY:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PYY Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b
SP1:
SP2:

Relevant External Links for PYY Gene

GeneLoc Exon Structure for
PYY
ECgene alternative splicing isoforms for
PYY

Expression for PYY Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PYY Gene

mRNA expression in normal human tissues for PYY Gene
mRNA expression by BioGPS for PYY GenemRNA expression by GTEx for PYY Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PYY Gene

This gene is overexpressed in Colon - Transverse (x31.7), Small Intestine - Terminal Ileum (x13.7), and Colon - Sigmoid (x4.0).

Protein differential expression in normal tissues from HIPED for PYY Gene

This gene is overexpressed in Colon (42.1) and Rectum (26.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PYY Gene



Protein tissue co-expression partners for PYY Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PYY Gene:

PYY

SOURCE GeneReport for Unigene cluster for PYY Gene:

Hs.169249

Evidence on tissue expression from TISSUES for PYY Gene

  • Intestine(4.7)
  • Nervous system(4.5)
  • Stomach(2.7)
  • Blood(2.5)
  • Pancreas(2.3)
genes like me logo Genes that share expression patterns with PYY: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PYY Gene

Orthologs for PYY Gene

This gene was present in the common ancestor of chordates.

Orthologs for PYY Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia PYY 34 35
  • 96.91 (n)
dog
(Canis familiaris)
 Mammalia PYY 34 35
  • 84.54 (n)
cow
(Bos Taurus)
 Mammalia PYY 34 35
  • 80.76 (n)
rat
(Rattus norvegicus)
 Mammalia Pyy 34
  • 80.07 (n)
mouse
(Mus musculus)
 Mammalia Pyy 34 16 35
  • 77.32 (n)
oppossum
(Monodelphis domestica)
 Mammalia PYY 35
  • 62 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia PYY 35
  • 54 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves PPY 35
  • 34 (a)
 ManyToMany
lizard
(Anolis carolinensis)
 Reptilia PYY 35
  • 50 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia pyy 34
  • 53.33 (n)
zebrafish
(Danio rerio)
 Actinopterygii pyya 34
  • 58.42 (n)
pyyb 35
  • 41 (a)
 OneToOne
Species where no ortholog for PYY was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PYY Gene

ENSEMBL:
Gene Tree for PYY (if available)
TreeFam:
Gene Tree for PYY (if available)

Paralogs for PYY Gene

Paralogs for PYY Gene

(4) SIMAP similar genes for PYY Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for PYY Gene

genes like me logo Genes that share paralogs with PYY: view

Variants for PYY Gene

Sequence variations from dbSNP and Humsavar for PYY Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs104894604 Pathogenic 44,006,584(+) CGAGT(A/G)GGTGA intron-variant, reference, stop-gained
rs104894605 Pathogenic 44,007,611(+) CATTC(C/T)GACCA intron-variant, reference, missense
rs104894606 Pathogenic 44,007,772(+) ATCCC(C/G/T)GGTAG intron-variant, reference, missense
rs104894607 Pathogenic 44,007,621(+) ATGGA(A/C/G)CCCGT intron-variant, reference, synonymous-codon, missense
rs121912591 Pathogenic 44,006,157(+) TGACC(A/G)CGTCG intron-variant, upstream-variant-2KB, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PYY Gene

Variant ID Type Subtype PubMed ID
esv2675215 CNV deletion 23128226
nsv112219 CNV insertion 16902084
nsv1125242 CNV deletion 24896259
nsv1129188 CNV insertion 24896259
nsv1142218 CNV tandem duplication 24896259
nsv1146669 OTHER inversion 26484159
nsv1152253 CNV insertion 26484159
nsv833454 CNV loss 17160897

Variation tolerance for PYY Gene

Residual Variation Intolerance Score: 52.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.27; 40.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PYY Gene

Human Gene Mutation Database (HGMD)
PYY
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PYY

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PYY Gene

Disorders for PYY Gene

MalaCards: The human disease database

(21) MalaCards diseases for PYY Gene - From: GeneTests, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
obesity, pyy-related
anorexia nervosa
  • bulimia nervosa
bulimia nervosa
  • hyperorexia nervosa
short bowel syndrome
  • acquired short bowel syndrome
eating disorder
  • eating disorders
- elite association - COSMIC cancer census association via MalaCards
Search PYY in MalaCards View complete list of genes associated with diseases

Relevant External Links for PYY

Genetic Association Database (GAD)
PYY
Human Genome Epidemiology (HuGE) Navigator
PYY
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PYY
genes like me logo Genes that share disorders with PYY: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PYY Gene

Publications for PYY Gene

  1. Association study of 182 candidate genes in anorexia nervosa. (PMID: 20468064) Pinheiro A.P. … Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 46 64
  2. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PMID: 20602615) RuaA+o G. … Wu A.H. (Pharmacogenomics 2010) 3 46 64
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  4. Peptide YY levels across pubertal stages and associations with growth hormone. (PMID: 20375207) Lloyd B. … Misra M. (J. Clin. Endocrinol. Metab. 2010) 3 22 64
  5. Candidate molecular pathway genes related to appetite regulatory neural network, adipocyte homeostasis and obesity: results from the CARDIA Study. (PMID: 20642810) Friedlander Y. … Siscovick D.S. (Ann. Hum. Genet. 2010) 3 46 64

Products for PYY Gene

Sources for PYY Gene

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