Aliases for PYY Gene
External Ids for PYY Gene
- HGNC: 9748
- Entrez Gene: 5697
- Ensembl: ENSG00000131096
- OMIM: 600781
- UniProtKB: P10082
Previous GeneCards Identifiers for PYY Gene
- GC17M041772
- GC17M044207
- GC17M042040
- GC17M042505
- GC17M039385
- GC17M037794
Summaries for PYY Gene
-
This gene encodes a member of the neuropeptide Y (NPY) family of peptides. The encoded preproprotein is proteolytically processed to generate two alternative peptide products that differ in length by three amino acids. These peptides, secreted by endocrine cells in the gut, exhibit different binding affinities for each of the neuropeptide Y receptors. Binding of the encoded peptides to these receptors mediates regulation of pancreatic secretion, gut mobility and energy homeostasis. Rare variations in this gene could increase susceptibility to obesity and elevated serum levels of the encoded peptides may be associated with anorexia nervosa. [provided by RefSeq, Feb 2016]
GeneCards Summary for PYY Gene
PYY (Peptide YY) is a Protein Coding gene. Diseases associated with PYY include Obesity, Pyy-Related and Anorexia Nervosa. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. GO annotations related to this gene include hormone activity and neuropeptide hormone activity. An important paralog of this gene is NPY.
UniProtKB/Swiss-Prot for PYY Gene
-
This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility.
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PYY Gene
Genomics for PYY Gene
Regulatory Elements for PYY Gene
Enhancers for PYY Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around PYY on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the PYY gene promoter:
Regulatory Element Products
Genomic Location for PYY Gene
- Chromosome:
- 17
- Start:
- 43,952,733 bp from pter
- End:
- 44,024,260 bp from pter
- Size:
- 71,528 bases
- Orientation:
- Minus strand
Genomic View for PYY Gene
Genes around PYY on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q21.31 by Ensembl
- 17q21.1 by Entrez Gene
- 17q21.1 by HGNC
PYY Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PYY Gene
Proteins for PYY Gene
-
Protein details for PYY Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P10082-PYY_HUMAN
- Recommended name:
- Peptide YY
- Protein Accession:
- P10082
- Q5U5Q6
- Q6FGH8
Protein attributes for PYY Gene
- Size:
- 97 amino acids
- Molecular mass:
- 11145 Da
- Quaternary structure:
- No Data Available
Protein Expression for PYY Gene
Post-translational modifications for PYY Gene
- The peptide YY form is cleaved at Pro-30 by the prolyl endopeptidase FAP (seprase) activity (in vitro) to generate peptide YY(3-36).
Other Protein References for PYY Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for PYY
-
Custom Antibody ServicesOriGene Antibodies for PYY
- Novus Biologicals Antibodies for PYY
- Abcam antibodies for Peptide YY
-
Cloud-Clone Corp. Antibodies for PYY
- Invitrogen Antibodies for PYY
- GeneTex PYY antibody for PYY
-
Santa Cruz Biotechnology (SCBT) Antibodies for PYY
Protein Products
-
OriGene Purified Proteins for PYY
- Search Origene for MassSpec and Protein Over-expression Lysates for PYY
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-
Cloud-Clone Corp. Proteins for PYY
- GeneTex Peptide YY Protein (GTX110638-pro) for PYY
- Abcam proteins for Peptide YY
Assay Products
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- Enzo Life Sciences assays for PYY
-
Cloud-Clone Corp Assay Kits for PYY
No data available for DME Specific Peptides for PYY Gene
Domains & Families for PYY Gene
Gene Families for PYY Gene
- HGNC:
Protein Domains for PYY Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for PYY Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P10082- Family:
-
- Belongs to the NPY family.
Function for PYY Gene
Molecular function for PYY Gene
- GENATLAS Biochemistry:
- peptide YY,gut hormone,inhibiting exocrine pancreatic secretion
- UniProtKB/Swiss-Prot Function:
- This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility.
Phenotypes for PYY Gene
- MGI mutant phenotypes for PYY:
- inferred from 5 alleles
- GenomeRNAi human phenotypes for PYY:
Animal Model Products
-
Taconic Biosciences Mouse Models for PYY
-
ViGene Biosciences lentiviral particle packaged cDNA for PYY gene
- Search ViGene Biosciences for PYY
CRISPR Products
-
OriGene CRISPR knockouts for PYY
-
Santa Cruz Biotechnology (SCBT) CRISPR for PYY
- GenScript: Design CRISPR guide RNA sequences for PYY
miRNA Products
- Search ViGene Biosciences for PYY
Clone Products
- OriGene clones in human for PYY
- OriGene ORF clones in human,mouse,rat for PYY
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for PYY gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PYY gene
- Search ViGene Biosciences for PYY
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PYY Gene
Localization for PYY Gene
Subcellular locations from UniProtKB/Swiss-Prot for PYY Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| cytosol | 3 |
| nucleus | 3 |
| plasma membrane | 2 |
| lysosome | 1 |
| peroxisome | 1 |
| vacuole | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA,TAS | -- |
Pathways & Interactions for PYY Gene
More details on SuperPathways for PYY| Superpath | Contained pathways | ||
|---|---|---|---|
| 1 | Peptide ligand-binding receptors | ||
| 2 | Signaling by GPCR | ||
| 3 | Sympathetic Nerve Pathway (Neuroeffector Junction) |
Pathways by source for PYY Gene
7 Reactome pathways for PYY Gene
1 PharmGKB pathway for PYY Gene
Interacting Proteins for PYY Gene
Selected Interacting proteins:
P10082-PYY_HUMAN
ENSP00000353198
for PYY Gene via
MINT
STRING
I2D
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007010 | cytoskeleton organization | TAS | 7493937 |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | 7592911 |
| GO:0007631 | feeding behavior | TAS | 10698177 |
| GO:0008283 | cell proliferation | TAS | 10488139 |
| GO:0032098 | regulation of appetite | IBA | -- |
Drugs & Compounds for PYY Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Hydrocortisone | Approved | Pharma | Agonist | 594 | ||
| Insulin Detemir | Approved | Pharma | 190 | |||
| Insulin Glargine | Approved | Pharma | 499 | |||
| Methyltestosterone | Approved | Pharma | 519 | |||
| Testosterone | Approved, Investigational | Pharma | Endogenous androgen receptor agonist | 519 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for PYY Gene
mRNA/cDNA for PYY Gene
- (2) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (12) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for PYY
-
Santa Cruz Biotechnology (SCBT) CRISPR for PYY
- GenScript: Design CRISPR guide RNA sequences for PYY
miRNA Products
- Search ViGene Biosciences for PYY
Clone Products
- OriGene clones in human for PYY
- OriGene ORF clones in human,mouse,rat for PYY
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||
| SP2: |
Expression for PYY Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Pancreas (Endocrine System)
- Endocrine Progenitor Cells Dorsal Pancreatic Bud
- Bipotent Endocrine/Duct Progenitor Cells Dorsal Pancreatic Bud
- Endocrine Progenitor Cells Ventral Pancreatic Bud
- Bipotent Endocrine/Duct Progenitor Cells Ventral Pancreatic Bud
-
Epithelial Cells
- Endocrine Progenitor Cells Dorsal Pancreatic Bud
- Bipotent Endocrine/Duct Progenitor Cells Dorsal Pancreatic Bud
- Endocrine Progenitor Cells Ventral Pancreatic Bud
- Bipotent Endocrine/Duct Progenitor Cells Ventral Pancreatic Bud
-
Gut Tube (Gastrointestinal Tract)
- Foregut Endoderm Cells Foregut
- Foregut
- Brain (Nervous System)
- Intestine (Gastrointestinal Tract)
- Endoderm (Gastrulation Derivatives)
-
Colon (Gastrointestinal Tract)
mRNA differential expression in normal tissues according to GTEx for PYY Gene
This gene is overexpressed in Colon - Transverse (x31.7), Small Intestine - Terminal Ileum (x13.7), and Colon - Sigmoid (x4.0).
This gene is overexpressed in Colon (42.1) and Rectum (26.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PYY Gene
SOURCE GeneReport for Unigene cluster for PYY Gene Hs.169249
- Elite partner
Primer Products
-
OriGene qPCR primer pairs and template standards for PYY
-
OriGene qPCR primer pairs for PYY
No data available for mRNA Expression by UniProt/SwissProt for PYY Gene
Orthologs for PYY Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | PYY 35 |
|
||
| PYY 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | PYY 35 |
|
||
| PYY 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Pyy 35 |
|
||
| Pyy 16 |
|
||||
| Pyy 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | PYY 35 |
|
||
| PYY 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Pyy 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | PYY 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | PYY 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | PPY 36 |
|
ManyToMany | |
| lizard (Anolis carolinensis) |
Reptilia | PYY 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | pyy 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | pyya 35 |
|
||
| pyyb 36 |
|
OneToOne |
- Species with no ortholog for PYY:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for PYY Gene
Pseudogenes.org Pseudogenes for PYY Gene
Variants for PYY Gene
| SNP ID | Clin | Chr 17 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1058046 | - | 43,953,163(-) | GGACA(C/G)GCTTC | reference, missense | |
| rs229969 | - | 43,953,375(-) | CTCCC(C/G)GCGAA | reference, missense | |
| rs465407 | - | 43,952,967(-) | GCCCA(A/C/G)ACCTG | reference, missense | |
| rs149420 | -- | 43,958,007(-) | TCCTA(A/G)AGCGA | utr-variant-5-prime | |
| rs149421 | -- | 43,959,014(-) | CACTT(A/C)TAGAT | intron-variant |
Residual Variation Intolerance Score:
52.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.27;
40.71% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for PYY Gene
- Human Gene Mutation Database (HGMD)
- PYY
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PYY Gene
Disorders for PYY Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| obesity, pyy-related |
|
|
| anorexia nervosa |
|
|
| bulimia nervosa |
|
|
| short bowel syndrome |
|
|
| lymphocytic colitis |
|
|
Search PYY in MalaCards
View complete list of genes associated with diseases
Relevant External Links for PYY
No data available for UniProtKB/Swiss-Prot and Genatlas for PYY Gene
Publications for PYY Gene
- Single nucleotide polymorphisms in the neuropeptide Y2 receptor (NPY2R) gene and association with severe obesity in French white subjects. (PMID: 17235527) Siddiq A. … Froguel P. (Diabetologia 2007) 3 48 67
- Peptide YY levels across pubertal stages and associations with growth hormone. (PMID: 20375207) Lloyd B. … Misra M. (J. Clin. Endocrinol. Metab. 2010) 3 23
- Influence of resistance and aerobic exercise on hunger, circulating levels of acylated ghrelin, and peptide YY in healthy males. (PMID: 18987287) Broom D.R. … Stensel D.J. (Am. J. Physiol. Regul. Integr. Comp. Physiol. 2009) 3 23
- Long-term exercise training in overweight adolescents improves plasma peptide YY and resistin. (PMID: 19247279) Jones T.E. … Hickner R.C. (Obesity (Silver Spring) 2009) 3 23
- Peptide YY in adolescent athletes with amenorrhea, eumenorrheic athletes and non-athletic controls. (PMID: 19344792) Russell M. … Misra M. (Bone 2009) 3 23
Products for PYY Gene
- Browse R&D Systems for Antibodies
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- Browse R&D Systems for biochemical assays
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- OriGene qPCR primer pairs for PYY
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- Novus Biologicals proteins and lysates for PYY
- Novus Biologicals
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- Abcam antibodies for Peptide YY
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- Search for Assays for PYY at Abcam
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- Search knockout validated antibodies
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- Cloud-Clone Corp. Antibodies for PYY
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- Taconic Biosciences Mouse Models for PYY
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- Humanized Mice
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- ViGene Biosciences lentiviral particle packaged cDNA for PYY gene
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- Santa Cruz Biotechnology (SCBT) Antibodies for PYY
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Sources for PYY Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon