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Aliases for MEPE Gene

Aliases for MEPE Gene

  • Matrix Extracellular Phosphoglycoprotein 2 3
  • Matrix, Extracellular Phosphoglycoprotein With ASARM Motif (Bone) 2 3
  • Osteoblast/Osteocyte Factor 45 3 4
  • OF45 3 4

External Ids for MEPE Gene

Summaries for MEPE Gene

Entrez Gene Summary for MEPE Gene

  • This gene encodes a secreted calcium-binding phosphoprotein that belongs to the small integrin-binding ligand, N-linked glycoprotein (SIBLING) family of proteins. Members of this family are components of the extracellular matrix of bone and dentin and regulate bone mineralization. Deficiency of a similar protein in mouse results in increased bone mass. Mice lacking this gene are resistant to aging-related trabecular bone loss. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

GeneCards Summary for MEPE Gene

MEPE (Matrix Extracellular Phosphoglycoprotein) is a Protein Coding gene. Diseases associated with MEPE include oncogenic osteomalacia and hypophosphatemic rickets, autosomal dominant. Among its related pathways are ERK Signaling and ERK Signaling. GO annotations related to this gene include extracellular matrix structural constituent.

UniProtKB/Swiss-Prot for MEPE Gene

  • Promotes renal phosphate excretion and modulates mineralization.

Gene Wiki entry for MEPE Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEPE Gene

Genomics for MEPE Gene

Genomic Location for MEPE Gene

Start:
87,821,411 bp from pter
End:
87,846,817 bp from pter
Size:
25,407 bases
Orientation:
Plus strand

Genomic View for MEPE Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MEPE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEPE Gene

Regulatory Elements for MEPE Gene

Proteins for MEPE Gene

  • Protein details for MEPE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQ76-MEPE_HUMAN
    Recommended name:
    Matrix extracellular phosphoglycoprotein
    Protein Accession:
    Q9NQ76
    Secondary Accessions:
    • A1A4X9
    • A8MTA3
    • D2CFR4
    • F5H5C5

    Protein attributes for MEPE Gene

    Size:
    525 amino acids
    Molecular mass:
    58419 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MEPE Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MEPE Gene

Proteomics data for MEPE Gene at MOPED

Post-translational modifications for MEPE Gene

  • Phosphorylated (in vitro) by FAM20C in the extracellular medium at sites within the S-x-E/pS motif.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn477 and Asn478

No data available for DME Specific Peptides for MEPE Gene

Domains for MEPE Gene

Protein Domains for MEPE Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with MEPE: view

No data available for Gene Families and UniProtKB/Swiss-Prot for MEPE Gene

Function for MEPE Gene

Molecular function for MEPE Gene

UniProtKB/Swiss-Prot Function: Promotes renal phosphate excretion and modulates mineralization.

Gene Ontology (GO) - Molecular Function for MEPE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005201 extracellular matrix structural constituent TAS 10945470
GO:0005515 protein binding IPI 17474147
genes like me logo Genes that share ontologies with MEPE: view

Phenotypes for MEPE Gene

genes like me logo Genes that share phenotypes with MEPE: view

Animal Models for MEPE Gene

MGI Knock Outs for MEPE:

miRNA for MEPE Gene

miRTarBase miRNAs that target MEPE

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for MEPE Gene

Localization for MEPE Gene

Subcellular locations from UniProtKB/Swiss-Prot for MEPE Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MEPE Gene COMPARTMENTS Subcellular localization image for MEPE gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 2
cytosol 1
golgi apparatus 1
lysosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MEPE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix IEA --
genes like me logo Genes that share ontologies with MEPE: view

Pathways for MEPE Gene

genes like me logo Genes that share pathways with MEPE: view

Pathways by source for MEPE Gene

Gene Ontology (GO) - Biological Process for MEPE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development TAS 10945470
GO:0030502 negative regulation of bone mineralization IEA --
GO:0031214 biomineral tissue development IEA --
GO:0046850 regulation of bone remodeling IEA --
genes like me logo Genes that share ontologies with MEPE: view

Compounds for MEPE Gene

(1) Novoseek inferred chemical compound relationships for MEPE Gene

Compound -log(P) Hits PubMed IDs
calcitriol 46.9 1
genes like me logo Genes that share compounds with MEPE: view

Transcripts for MEPE Gene

mRNA/cDNA for MEPE Gene

(7) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MEPE Gene

Matrix extracellular phosphoglycoprotein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MEPE Gene

No ASD Table

Relevant External Links for MEPE Gene

GeneLoc Exon Structure for
MEPE
ECgene alternative splicing isoforms for
MEPE

Expression for MEPE Gene

mRNA expression in normal human tissues for MEPE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MEPE Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (14.3), Brain - Frontal Cortex (BA9) (11.7), Brain - Cortex (8.4), Brain - Amygdala (6.0), and Brain - Hippocampus (5.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MEPE Gene

SOURCE GeneReport for Unigene cluster for MEPE Gene Hs.676357

mRNA Expression by UniProt/SwissProt for MEPE Gene

Q9NQ76-MEPE_HUMAN
Tissue specificity: Expressed by osteoblasts. Secreted from oncogenic hypophosphataemic tumors
genes like me logo Genes that share expressions with MEPE: view

Orthologs for MEPE Gene

This gene was present in the common ancestor of mammals.

Orthologs for MEPE Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MEPE 36
  • 99.2 (n)
  • 98.2 (a)
MEPE 37
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MEPE 36
  • 78.92 (n)
  • 65.86 (a)
MEPE 37
  • 64 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MEPE 36
  • 83.1 (n)
  • 71.52 (a)
mouse
(Mus musculus)
Mammalia Mepe 36
  • 67.81 (n)
  • 52.12 (a)
Mepe 16
Mepe 37
  • 51 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MEPE 37
  • 35 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mepe 36
  • 67.93 (n)
  • 50.54 (a)
Species with no ortholog for MEPE:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MEPE Gene

ENSEMBL:
Gene Tree for MEPE (if available)
TreeFam:
Gene Tree for MEPE (if available)

Paralogs for MEPE Gene

No data available for Paralogs for MEPE Gene

Variants for MEPE Gene

Sequence variations from dbSNP and Humsavar for MEPE Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs727420 -- 87,829,584(+) GCTCT(A/T)TAACT intron-variant
rs727421 -- 87,829,748(+) TCTTC(A/C)ATTTA intron-variant
rs990862 -- 87,836,661(+) CTTGA(C/T)GATAA intron-variant
rs1381966 -- 87,835,826(+) CAAGT(C/T)GGCCA intron-variant
rs1463113 -- 87,827,404(+) ACATG(A/G)AATTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MEPE Gene

Variant ID Type Subtype PubMed ID
nsv822637 CNV Gain 20364138
dgv94n17 CNV Loss 16327808
esv275333 CNV Gain+Loss 21479260

Relevant External Links for MEPE Gene

HapMap Linkage Disequilibrium report
MEPE

Disorders for MEPE Gene

(8) Novoseek inferred disease relationships for MEPE Gene

Disease -log(P) Hits PubMed IDs
rickets hypophosphatemic 90.9 4
osteomalacia 86.5 18
hypophosphatemic rickets, autosomal dominant 83.7 1
hypophosphatemia 81.7 3
rickets 63.8 2

Relevant External Links for MEPE

Genetic Association Database (GAD)
MEPE
Human Genome Epidemiology (HuGE) Navigator
MEPE
genes like me logo Genes that share disorders with MEPE: view

No data available for UniProtKB/Swiss-Prot for MEPE Gene

Publications for MEPE Gene

  1. MEPE, a new gene expressed in bone marrow and tumors causing osteomalacia. (PMID: 10945470) Rowe P.S.N. … Oudet C.L. (Genomics 2000) 2 3 4 23
  2. Mepe, the gene encoding a tumor-secreted protein in oncogenic hypophosphatemic osteomalacia, is expressed in bone. (PMID: 11414762) Argiro L. … Ecarot B. (Genomics 2001) 3 4 23
  3. MEPE/OF45, a new dentin/bone matrix protein and candidate gene for dentin diseases mapping to chromosome 4q21. (PMID: 12489176) MacDougall M. … Dong J. (Connect. Tissue Res. 2002) 3 23
  4. FGF23, PHEX, and MEPE regulation of phosphate homeostasis and skeletal mineralization. (PMID: 12791601) Quarles L.D. (Am. J. Physiol. Endocrinol. Metab. 2003) 3 23
  5. Matrix extracellular phosphoglycoprotein (MEPE) is highly expressed in osteocytes in human bone. (PMID: 15108058) Nampei A. … Yoshikawa H. (J. Bone Miner. Metab. 2004) 3 23

Products for MEPE Gene

Sources for MEPE Gene

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