Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MFF Gene

Aliases for MFF Gene

  • Mitochondrial Fission Factor 2 3
  • C2orf33 3 4 6
  • Chromosome 2 Open Reading Frame 33 2
  • GL004 3

External Ids for MFF Gene

Previous Symbols for MFF Gene

  • C2orf33

Summaries for MFF Gene

Entrez Gene Summary for MFF Gene

  • This is a nuclear gene encoding a protein that functions in mitochondrial and peroxisomal fission. The encoded protein recruits dynamin-1-like protein (DNM1L) to mitochondria. There are multiple pseudogenes for this gene on chromosomes 1, 5, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]

GeneCards Summary for MFF Gene

MFF (Mitochondrial Fission Factor) is a Protein Coding gene. Diseases associated with MFF include sclerosing keratitis and intestinal volvulus. GO annotations related to this gene include protein homodimerization activity.

UniProtKB/Swiss-Prot for MFF Gene

  • Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles.

Gene Wiki entry for MFF Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MFF Gene

Genomics for MFF Gene

Genomic Location for MFF Gene

Start:
227,325,151 bp from pter
End:
227,357,836 bp from pter
Size:
32,686 bases
Orientation:
Plus strand

Genomic View for MFF Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MFF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MFF Gene

Regulatory Elements for MFF Gene

Proteins for MFF Gene

  • Protein details for MFF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZY8-MFF_HUMAN
    Recommended name:
    Mitochondrial fission factor
    Protein Accession:
    Q9GZY8
    Secondary Accessions:
    • Q567U1
    • Q658R6
    • Q9BVZ1
    • Q9H690
    • Q9NRG8

    Protein attributes for MFF Gene

    Size:
    342 amino acids
    Molecular mass:
    38465 Da
    Quaternary structure:
    • Homodimer. Interacts with DNM1L (By similarity).

    Alternative splice isoforms for MFF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MFF Gene

Proteomics data for MFF Gene at MOPED

Post-translational modifications for MFF Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MFF Gene

Domains for MFF Gene

Protein Domains for MFF Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

MFF_HUMAN
Family:
  • Belongs to the Tango11 family.:
    • Q9GZY8
genes like me logo Genes that share domains with MFF: view

No data available for Gene Families for MFF Gene

Function for MFF Gene

Molecular function for MFF Gene

UniProtKB/Swiss-Prot Function: Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles.

Gene Ontology (GO) - Molecular Function for MFF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21149567
GO:0042803 protein homodimerization activity IDA 23530241
genes like me logo Genes that share ontologies with MFF: view

Phenotypes for MFF Gene

MGI mutant phenotypes for MFF:
inferred from 1 alleles
GenomeRNAi human phenotypes for MFF:
genes like me logo Genes that share phenotypes with MFF: view

miRNA for MFF Gene

miRTarBase miRNAs that target MFF

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MFF Gene

Localization for MFF Gene

Subcellular locations from UniProtKB/Swiss-Prot for MFF Gene

Mitochondrion outer membrane; Single-pass type IV membrane protein. Peroxisome. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MFF Gene COMPARTMENTS Subcellular localization image for MFF gene
Compartment Confidence
mitochondrion 5
peroxisome 5
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for MFF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005741 mitochondrial outer membrane IDA 21149567
GO:0005777 peroxisome IDA 18353969
GO:0008021 synaptic vesicle IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with MFF: view

Pathways for MFF Gene

SuperPathways for MFF Gene

No Data Available

Interacting Proteins for MFF Gene

Gene Ontology (GO) - Biological Process for MFF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000266 mitochondrial fission ISS --
GO:0001836 release of cytochrome c from mitochondria IMP 18353969
GO:0006626 protein targeting to mitochondrion IMP 21149567
GO:0008053 mitochondrial fusion IMP 23921378
GO:0010821 regulation of mitochondrion organization IMP 18353969
genes like me logo Genes that share ontologies with MFF: view

No data available for Pathways by source for MFF Gene

Transcripts for MFF Gene

Unigene Clusters for MFF Gene

Mitochondrial fission factor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MFF Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^
SP1: - - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - -
SP5: -
SP6: - - - -
SP7: - - - - - - - - - - - - -
SP8: - -
SP9:
SP10:
SP11:
SP12: - - -
SP13: - - - - - - - - - -
SP14: - - - -
SP15: - -
SP16: -

ExUns: 11 ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c · 14d · 14e · 14f
SP1: -
SP2:
SP3: - -
SP4:
SP5:
SP6: -
SP7: - -
SP8:
SP9:
SP10:
SP11: -
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for MFF Gene

GeneLoc Exon Structure for
MFF
ECgene alternative splicing isoforms for
MFF

Expression for MFF Gene

mRNA expression in normal human tissues for MFF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MFF Gene

SOURCE GeneReport for Unigene cluster for MFF Gene Hs.471528

mRNA Expression by UniProt/SwissProt for MFF Gene

Q9GZY8-MFF_HUMAN
Tissue specificity: Highly expressed in heart, kidney, liver, brain, muscle, and stomach.
genes like me logo Genes that share expressions with MFF: view

Orthologs for MFF Gene

This gene was present in the common ancestor of chordates.

Orthologs for MFF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MFF 36
  • 99.71 (n)
  • 99.42 (a)
MFF 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 88 (a)
OneToMany
MFF 37
  • 94 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Mff 16
Mff 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MFF 37
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MFF 37
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC102556337 36
  • 91.23 (n)
  • 92.98 (a)
chicken
(Gallus gallus)
Aves MFF 36
  • 81.71 (n)
  • 84.45 (a)
MFF 37
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MFF 37
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.31432 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.2181 36
zebrafish
(Danio rerio)
Actinopterygii mff 36
  • 62.69 (n)
  • 62.96 (a)
mff 37
  • 57 (a)
OneToMany
MFF (1 of 2) 37
  • 57 (a)
OneToMany
zgc66022 36
Species with no ortholog for MFF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MFF Gene

ENSEMBL:
Gene Tree for MFF (if available)
TreeFam:
Gene Tree for MFF (if available)

Paralogs for MFF Gene

genes like me logo Genes that share paralogs with MFF: view

No data available for Paralogs for MFF Gene

Variants for MFF Gene

Sequence variations from dbSNP and Humsavar for MFF Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1994 -- 227,328,169(-) GATCT(C/T)AAACT intron-variant, upstream-variant-2KB
rs2708 -- 227,357,050(-) CCATT(C/T)CTCTT reference, missense, nc-transcript-variant
rs4844 -- 227,357,009(+) CGTCT(A/G)CAACT reference, synonymous-codon, nc-transcript-variant
rs8222 -- 227,357,577(-) ACTTT(C/G)AAAGT utr-variant-3-prime, nc-transcript-variant
rs14579 -- 227,357,064(-) AATTG(A/T)ATACA missense, reference, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for MFF Gene

Variant ID Type Subtype PubMed ID
esv2721554 CNV Deletion 23290073
esv2721555 CNV Deletion 23290073
esv2721556 CNV Deletion 23290073
esv2721557 CNV Deletion 23290073
esv2721558 CNV Deletion 23290073

Relevant External Links for MFF Gene

HapMap Linkage Disequilibrium report
MFF
Human Gene Mutation Database (HGMD)
MFF

Disorders for MFF Gene

(5) University of Copenhagen DISEASES for MFF Gene

genes like me logo Genes that share disorders with MFF: view

No data available for UniProtKB/Swiss-Prot for MFF Gene

Publications for MFF Gene

  1. The novel tail-anchored membrane protein Mff controls mitochondrial and peroxisomal fission in mammalian cells. (PMID: 18353969) Gandre-Babbe S. … van der Bliek A.M. (Mol. Biol. Cell 2008) 2 3 4
  2. Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission. (PMID: 23530241) Koirala S. … Shaw J.M. (Proc. Natl. Acad. Sci. U.S.A. 2013) 3 4
  3. MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and are specific for mitochondrial fission. (PMID: 23921378) Palmer C.S. … Ryan M.T. (J. Biol. Chem. 2013) 3 4
  4. miR-27 regulates mitochondrial networks by directly targeting the mitochondrial fission factor. (PMID: 25431021) Tak H. … Lee E.K. (Exp. Mol. Med. 2014) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4

Products for MFF Gene

Sources for MFF Gene

Back to Top

Content