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Aliases for MFF Gene

Aliases for MFF Gene

  • Mitochondrial Fission Factor 2 3 5
  • C2orf33 3 4
  • Chromosome 2 Open Reading Frame 33 2
  • GL004 3

External Ids for MFF Gene

Previous HGNC Symbols for MFF Gene

  • C2orf33

Previous GeneCards Identifiers for MFF Gene

  • GC02P227899
  • GC02P228189
  • GC02P220036

Summaries for MFF Gene

Entrez Gene Summary for MFF Gene

  • This is a nuclear gene encoding a protein that functions in mitochondrial and peroxisomal fission. The encoded protein recruits dynamin-1-like protein (DNM1L) to mitochondria. There are multiple pseudogenes for this gene on chromosomes 1, 5, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]

GeneCards Summary for MFF Gene

MFF (Mitochondrial Fission Factor) is a Protein Coding gene. Diseases associated with MFF include elephantiasis and sclerosing keratitis. GO annotations related to this gene include protein homodimerization activity.

UniProtKB/Swiss-Prot for MFF Gene

  • Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles.

Gene Wiki entry for MFF Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MFF Gene

Genomics for MFF Gene

Regulatory Elements for MFF Gene

Promoters for MFF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MFF on UCSC Golden Path with GeneCards custom track

Genomic Location for MFF Gene

Chromosome:
2
Start:
227,325,151 bp from pter
End:
227,357,836 bp from pter
Size:
32,686 bases
Orientation:
Plus strand

Genomic View for MFF Gene

Genes around MFF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MFF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MFF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MFF Gene

Proteins for MFF Gene

  • Protein details for MFF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZY8-MFF_HUMAN
    Recommended name:
    Mitochondrial fission factor
    Protein Accession:
    Q9GZY8
    Secondary Accessions:
    • Q567U1
    • Q658R6
    • Q9BVZ1
    • Q9H690
    • Q9NRG8

    Protein attributes for MFF Gene

    Size:
    342 amino acids
    Molecular mass:
    38465 Da
    Quaternary structure:
    • Homodimer. Interacts with DNM1L (By similarity).

    Alternative splice isoforms for MFF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MFF Gene

Proteomics data for MFF Gene at MOPED

Post-translational modifications for MFF Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MFF (MFF)
  • Cell Signaling Technology (CST) Antibodies for MFF (MFF)

No data available for DME Specific Peptides for MFF Gene

Domains & Families for MFF Gene

Protein Domains for MFF Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MFF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9GZY8

UniProtKB/Swiss-Prot:

MFF_HUMAN :
  • Belongs to the Tango11 family.
Family:
  • Belongs to the Tango11 family.
genes like me logo Genes that share domains with MFF: view

No data available for Gene Families for MFF Gene

Function for MFF Gene

Molecular function for MFF Gene

UniProtKB/Swiss-Prot Function:
Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles.
genes like me logo Genes that share phenotypes with MFF: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MFF Gene

Localization for MFF Gene

Subcellular locations from UniProtKB/Swiss-Prot for MFF Gene

Mitochondrion outer membrane; Single-pass type IV membrane protein. Peroxisome. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MFF Gene COMPARTMENTS Subcellular localization image for MFF gene
Compartment Confidence
mitochondrion 5
peroxisome 5
cytosol 2
nucleus 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for MFF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005777 peroxisome IDA 18353969
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MFF: view

Pathways & Interactions for MFF Gene

SuperPathways for MFF Gene

No Data Available

Interacting Proteins for MFF Gene

Gene Ontology (GO) - Biological Process for MFF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000266 mitochondrial fission ISS --
GO:0006626 protein targeting to mitochondrion IMP 21149567
GO:0008053 mitochondrial fusion IMP 23921378
GO:0051260 protein homooligomerization IDA 18353969
GO:0070584 mitochondrion morphogenesis IMP 21149567
genes like me logo Genes that share ontologies with MFF: view

No data available for Pathways by source and SIGNOR curated interactions for MFF Gene

Drugs & Compounds for MFF Gene

No Compound Related Data Available

Transcripts for MFF Gene

Unigene Clusters for MFF Gene

Mitochondrial fission factor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MFF Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^
SP1: - - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - -
SP5: -
SP6: - - - -
SP7: - - - - - - - - - - - - -
SP8: - -
SP9:
SP10:
SP11:
SP12: - - -
SP13: - - - - - - - - - -
SP14: - - - -
SP15: - -
SP16: -

ExUns: 11 ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c · 14d · 14e · 14f
SP1: -
SP2:
SP3: - -
SP4:
SP5:
SP6: -
SP7: - -
SP8:
SP9:
SP10:
SP11: -
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for MFF Gene

GeneLoc Exon Structure for
MFF
ECgene alternative splicing isoforms for
MFF

Expression for MFF Gene

mRNA expression in normal human tissues for MFF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MFF Gene

This gene is overexpressed in Peripheral blood mononuclear cells (16.8) and Testis (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MFF Gene



SOURCE GeneReport for Unigene cluster for MFF Gene Hs.471528

mRNA Expression by UniProt/SwissProt for MFF Gene

Q9GZY8-MFF_HUMAN
Tissue specificity: Highly expressed in heart, kidney, liver, brain, muscle, and stomach.
genes like me logo Genes that share expression patterns with MFF: view

Protein tissue co-expression partners for MFF Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MFF Gene

Orthologs for MFF Gene

This gene was present in the common ancestor of chordates.

Orthologs for MFF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MFF 35
  • 99.71 (n)
  • 99.42 (a)
MFF 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC102556337 35
  • 91.23 (n)
  • 92.98 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 88 (a)
OneToMany
MFF 36
  • 94 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia MFF 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mff 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MFF 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves MFF 35
  • 81.71 (n)
  • 84.45 (a)
MFF 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MFF 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.2181 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.31432 35
zebrafish
(Danio rerio)
Actinopterygii mff 35
  • 62.69 (n)
  • 62.96 (a)
zgc66022 35
mff 36
  • 57 (a)
OneToMany
MFF (1 of 2) 36
  • 57 (a)
OneToMany
Species with no ortholog for MFF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MFF Gene

ENSEMBL:
Gene Tree for MFF (if available)
TreeFam:
Gene Tree for MFF (if available)

Paralogs for MFF Gene

genes like me logo Genes that share paralogs with MFF: view

No data available for Paralogs for MFF Gene

Variants for MFF Gene

Sequence variations from dbSNP and Humsavar for MFF Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_036028 A colorectal cancer sample
rs3211097 - 227,329,764(+) CAAGC(A/T)GTGAC intron-variant, reference, missense, utr-variant-5-prime
rs3211098 - 227,329,765(+) AAGCA(G/T)TGACA intron-variant, reference, missense, utr-variant-5-prime
rs1994 -- 227,328,169(-) GATCT(C/T)AAACT intron-variant, upstream-variant-2KB
rs2708 -- 227,357,050(+) CCATT(A/C/G/T)CTCTT nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MFF Gene

Variant ID Type Subtype PubMed ID
esv2721554 CNV Deletion 23290073
esv2721555 CNV Deletion 23290073
esv2721556 CNV Deletion 23290073
esv2721557 CNV Deletion 23290073
esv2721558 CNV Deletion 23290073

Variation tolerance for MFF Gene

Residual Variation Intolerance Score: 57.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.87; 95.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MFF Gene

HapMap Linkage Disequilibrium report
MFF
Human Gene Mutation Database (HGMD)
MFF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MFF Gene

Disorders for MFF Gene

MalaCards: The human disease database

(10) MalaCards diseases for MFF Gene - From: DISEASES

Disorder Aliases PubMed IDs
elephantiasis
  • elephantiasis nos
sclerosing keratitis
  • sclerokeratitis
loiasis
  • african eye worm
anterior scleritis
deep keratitis
- elite association - COSMIC cancer census association via MalaCards
Search MFF in MalaCards View complete list of genes associated with diseases

Relevant External Links for MFF

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MFF
genes like me logo Genes that share disorders with MFF: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MFF Gene

Publications for MFF Gene

  1. The novel tail-anchored membrane protein Mff controls mitochondrial and peroxisomal fission in mammalian cells. (PMID: 18353969) Gandre-Babbe S. … van der Bliek A.M. (Mol. Biol. Cell 2008) 2 3 4 67
  2. miR-27 regulates mitochondrial networks by directly targeting the mitochondrial fission factor. (PMID: 25431021) Tak H. … Lee E.K. (Exp. Mol. Med. 2014) 3
  3. Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission. (PMID: 23283981) LosA^n O.C. … Chan D.C. (Mol. Biol. Cell 2013) 3
  4. 14-3-3 proteins sequester a pool of soluble TRIM32 ubiquitin ligase to repress autoubiquitylation and cytoplasmic body formation. (PMID: 23444366) Ichimura T. … Hachiya N. (J. Cell. Sci. 2013) 3
  5. Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission. (PMID: 23530241) Koirala S. … Shaw J.M. (Proc. Natl. Acad. Sci. U.S.A. 2013) 3

Products for MFF Gene

Sources for MFF Gene

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