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Aliases for PSMB5 Gene

Aliases for PSMB5 Gene

  • Proteasome Subunit Beta 5 2 3
  • Proteasome (Prosome, Macropain) Subunit, Beta Type, 5 2 3
  • Multicatalytic Endopeptidase Complex Epsilon Chain 3 4
  • Proteasome Epsilon Chain 3 4
  • Macropain Epsilon Chain 3 4
  • Proteasome Subunit MB1 3 4
  • Proteasome Subunit X 3 4
  • Proteasome Chain 6 3 4
  • EC 3.4.25.1 4 63
  • LMPX 3 4
  • MB1 3 4
  • X 3 4
  • PSX Large Multifunctional Protease X 3
  • Proteasome Subunit, Beta Type, 5 3
  • Proteasome Catalytic Subunit 3 3
  • Proteasome Beta 5 Subunit 3

External Ids for PSMB5 Gene

Previous GeneCards Identifiers for PSMB5 Gene

  • GC14M020867
  • GC14M017282
  • GC14M021475
  • GC14M021485
  • GC14M022564
  • GC14M023495
  • GC14M003612
  • GC14M023485

Summaries for PSMB5 Gene

Entrez Gene Summary for PSMB5 Gene

  • The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit in the proteasome. This catalytic subunit is not present in the immunoproteasome and is replaced by catalytic subunit 3i (proteasome beta 8 subunit). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]

GeneCards Summary for PSMB5 Gene

PSMB5 (Proteasome Subunit Beta 5) is a Protein Coding gene. Among its related pathways are Immune System and Signaling by GPCR. GO annotations related to this gene include peptidase activity and threonine-type endopeptidase activity. An important paralog of this gene is PSMB11.

UniProtKB/Swiss-Prot for PSMB5 Gene

  • The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This unit is responsible of the chymotrypsin-like activity of the proteasome and is one of the principal target of the proteasome inhibitor bortezomib. May catalyze basal processing of intracellular antigens. Plays a role in the protection against oxidative damage through the Nrf2-ARE pathway (By similarity).

Gene Wiki entry for PSMB5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMB5 Gene

Genomics for PSMB5 Gene

Regulatory Elements for PSMB5 Gene

Genomic Location for PSMB5 Gene

Chromosome:
14
Start:
23,016,543 bp from pter
End:
23,035,230 bp from pter
Size:
18,688 bases
Orientation:
Minus strand

Genomic View for PSMB5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PSMB5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMB5 Gene

Proteins for PSMB5 Gene

  • Protein details for PSMB5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P28074-PSB5_HUMAN
    Recommended name:
    Proteasome subunit beta type-5
    Protein Accession:
    P28074
    Secondary Accessions:
    • B2R4N9
    • B4DUM9
    • D3DS43
    • E9PAV2
    • Q16242
    • Q6PEW2
    • Q7Z3B5
    • Q86T01
    • Q9TNN9

    Protein attributes for PSMB5 Gene

    Size:
    263 amino acids
    Molecular mass:
    28480 Da
    Quaternary structure:
    • The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. This subunit can be displaced by the equivalent immune-specific subunit PSMB8. Directly interacts with POMP. Interacts with HIV-1 TAT protein. Interacts with ABCB1 and TAP1.
    SequenceCaution:
    • Sequence=AAP35423.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA06097.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAD97956.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PSMB5 Gene

    Alternative splice isoforms for PSMB5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSMB5 Gene

Proteomics data for PSMB5 Gene at MOPED

Selected DME Specific Peptides for PSMB5 Gene

Post-translational modifications for PSMB5 Gene

  • Ubiquitination at Lys 91 and Lys 92
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PSMB5 (PSMB5)

Domains & Families for PSMB5 Gene

Gene Families for PSMB5 Gene

Suggested Antigen Peptide Sequences for PSMB5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P28074

UniProtKB/Swiss-Prot:

PSB5_HUMAN :
  • Belongs to the peptidase T1B family.
Family:
  • Belongs to the peptidase T1B family.
genes like me logo Genes that share domains with PSMB5: view

Function for PSMB5 Gene

Molecular function for PSMB5 Gene

GENATLAS Biochemistry:
multicatalytic proteinase complex (20S) proteasome (prosome,macropain) component,beta,subunit MB-1/X,22.9kDa
UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage of peptide bonds with very broad specificity
UniProtKB/Swiss-Prot Function:
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This unit is responsible of the chymotrypsin-like activity of the proteasome and is one of the principal target of the proteasome inhibitor bortezomib. May catalyze basal processing of intracellular antigens. Plays a role in the protection against oxidative damage through the Nrf2-ARE pathway (By similarity).
UniProtKB/Swiss-Prot Induction:
Down-regulated by IFNG/IFN-gamma (at protein level). Induced in breast cancer tissue. Up-regulated by sulforaphane in breast cancer cells.

Enzyme Numbers (IUBMB) for PSMB5 Gene

Gene Ontology (GO) - Molecular Function for PSMB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IBA --
GO:0004298 threonine-type endopeptidase activity IEA --
GO:0005515 protein binding IPI 14733938
GO:0008233 peptidase activity --
genes like me logo Genes that share ontologies with PSMB5: view
genes like me logo Genes that share phenotypes with PSMB5: view

Animal Model Products

miRNA for PSMB5 Gene

miRTarBase miRNAs that target PSMB5

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PSMB5

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for PSMB5 Gene

Localization for PSMB5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMB5 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSMB5 Gene COMPARTMENTS Subcellular localization image for PSMB5 gene
Compartment Confidence
extracellular 5
nucleus 5
cytoskeleton 4
cytosol 4

Gene Ontology (GO) - Cellular Components for PSMB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IDA 17323924
GO:0005634 nucleus IDA 21630459
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA --
GO:0005813 centrosome IDA --
genes like me logo Genes that share ontologies with PSMB5: view

Pathways & Interactions for PSMB5 Gene

SuperPathways for PSMB5 Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
2 Interleukin receptor SHC signaling
3 Chks in Checkpoint Regulation
4 Infectious disease
.53
5 Immune System
genes like me logo Genes that share pathways with PSMB5: view

Gene Ontology (GO) - Biological Process for PSMB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0000278 mitotic cell cycle TAS --
genes like me logo Genes that share ontologies with PSMB5: view

No data available for SIGNOR curated interactions for PSMB5 Gene

Drugs & Compounds for PSMB5 Gene

(13) Drugs for PSMB5 Gene - From: ApexBio, DrugBank, DGIdb, and FDA Approved Drugs

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Experimental, Investigational Pharma inhibitor, other, Target, antagonist Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 758
carfilzomib Approved Pharma other, Inhibitor, Target Other, 20S Proteasome Inhibitor 0
Kyprolis Approved July 2012 Pharma 0
Velcade Approved May 2003 Pharma 0
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE Experimental Pharma Target 0
genes like me logo Genes that share compounds with PSMB5: view

Transcripts for PSMB5 Gene

Unigene Clusters for PSMB5 Gene

Proteasome (prosome, macropain) subunit, beta type, 5:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PSMB5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSMB5 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b
SP1: - -
SP2: - - -
SP3: -
SP4:

Relevant External Links for PSMB5 Gene

GeneLoc Exon Structure for
PSMB5
ECgene alternative splicing isoforms for
PSMB5

Expression for PSMB5 Gene

mRNA expression in normal human tissues for PSMB5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PSMB5 Gene

This gene is overexpressed in Liver, secretome (12.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PSMB5 Gene



SOURCE GeneReport for Unigene cluster for PSMB5 Gene Hs.422990

genes like me logo Genes that share expression patterns with PSMB5: view

Protein tissue co-expression partners for PSMB5 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PSMB5 Gene

Orthologs for PSMB5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMB5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PSMB5 35
  • 92.24 (n)
  • 96.18 (a)
PSMB5 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PSMB5 35
  • 91.76 (n)
  • 96.2 (a)
PSMB5 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Psmb5 35
  • 88.67 (n)
  • 94.59 (a)
Psmb5 16
Psmb5 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Psmb5 35
  • 88.47 (n)
  • 93.54 (a)
oppossum
(Monodelphis domestica)
Mammalia PSMB5 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PSMB5 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PSMB5 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PSMB5 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia psmb5 35
  • 75.16 (n)
  • 89.62 (a)
zebrafish
(Danio rerio)
Actinopterygii psmb5 35
  • 67.7 (n)
  • 73.26 (a)
psmb5 36
  • 69 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11284 35
fruit fly
(Drosophila melanogaster)
Insecta CG9868 37
  • 57 (a)
Prosbgr5 37
  • 63 (a)
Prosbeta5 35
  • 63.86 (n)
  • 60.62 (a)
CG31742 36
  • 40 (a)
ManyToMany
Prosbeta5 36
  • 50 (a)
ManyToMany
Prosbeta5R 36
  • 40 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010718 35
  • 60.55 (n)
  • 63.32 (a)
worm
(Caenorhabditis elegans)
Secernentea pbs-5 35
  • 52.4 (n)
  • 49.25 (a)
pbs-5 36
  • 37 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRE2 36
  • 51 (a)
OneToMany
PRE2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G26340 35
  • 59.32 (n)
  • 61.22 (a)
rice
(Oryza sativa)
Liliopsida Os06g0153800 35
  • 63.24 (n)
  • 68.63 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1918 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8465 36
  • 62 (a)
OneToMany
Species with no ortholog for PSMB5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PSMB5 Gene

ENSEMBL:
Gene Tree for PSMB5 (if available)
TreeFam:
Gene Tree for PSMB5 (if available)

Paralogs for PSMB5 Gene

Paralogs for PSMB5 Gene

(4) SIMAP similar genes for PSMB5 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for PSMB5 Gene

genes like me logo Genes that share paralogs with PSMB5: view

Variants for PSMB5 Gene

Sequence variations from dbSNP and Humsavar for PSMB5 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs12043 -- 23,026,265(-) ATGAC(A/C)TGGAA missense, reference, utr-variant-3-prime, intron-variant
rs941717 -- 23,025,778(+) TCCCT(C/T)CCACT downstream-variant-500B, intron-variant
rs941718 -- 23,025,839(+) AAAGA(C/T)GCAAC downstream-variant-500B, intron-variant
rs2230087 -- 23,026,034(-) AATAC(A/G)GACAC utr-variant-3-prime, intron-variant
rs2331829 -- 23,032,290(+) aaata(C/T)aaaat intron-variant

Variation tolerance for PSMB5 Gene

Residual Variation Intolerance Score: 41.55% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.73; 57.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PSMB5 Gene

HapMap Linkage Disequilibrium report
PSMB5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PSMB5 Gene

Disorders for PSMB5 Gene

Relevant External Links for PSMB5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSMB5
genes like me logo Genes that share disorders with PSMB5: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSMB5 Gene

Publications for PSMB5 Gene

  1. Relationship between HLA class I antigen processing machinery component expression and the clinicopathologic characteristics of bladder carcinomas. (PMID: 19756593) Cathro H.P. … Frierson H.F. (Cancer Immunol. Immunother. 2010) 23 67
  2. Down-regulation of proteasomal subunit MB1 is an independent predictor of improved survival in ovarian cancer. (PMID: 19243813) Leffers N. … Nijman H.W. (Gynecol. Oncol. 2009) 23 67
  3. Upregulation of antigen-processing machinery components at mRNA level in acute lymphoblastic leukemia cells after CD40 stimulation. (PMID: 17285277) LuczyA8ski W. … Krawczuk-Rybak M. (Ann. Hematol. 2007) 23 67
  4. Structure and functions of the 20S and 26S proteasomes. (PMID: 8811196) Coux O. … Goldberg A.L. (Annu. Rev. Biochem. 1996) 2 67
  5. cDNA cloning and interferon gamma down-regulation of proteasomal subunits X and Y. (PMID: 8066462) Akiyama K.-Y. … Ichihara A. (Science 1994) 2 67

Products for PSMB5 Gene

Sources for PSMB5 Gene

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