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Aliases for PAK6 Gene

Aliases for PAK6 Gene

  • P21 Protein (Cdc42/Rac)-Activated Kinase 6 2 3
  • P21(CDKN1A)-Activated Kinase 6 2 3
  • EC 2.7.11.1 4 64
  • PAK5 3 4
  • Serine/Threonine-Protein Kinase PAK 6 3
  • P21-Activated Kinase 6 4
  • EC 2.7.11 64
  • PAK-5 4
  • PAK-6 4

External Ids for PAK6 Gene

Summaries for PAK6 Gene

Entrez Gene Summary for PAK6 Gene

  • This gene encodes a member of a family of p21-stimulated serine/threonine protein kinases, which contain an amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. These kinases function in a number of cellular processes, including cytoskeleton rearrangement, apoptosis, and the mitogen-activated protein (MAP) kinase signaling pathway. The protein encoded by this gene interacts with androgen receptor (AR) and translocates to the nucleus, where it is involved in transcriptional regulation. Changes in expression of this gene have been linked to prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]

GeneCards Summary for PAK6 Gene

PAK6 (P21 Protein (Cdc42/Rac)-Activated Kinase 6) is a Protein Coding gene. Diseases associated with PAK6 include prostate cancer and la crosse encephalitis. Among its related pathways are RhoGDI Pathway and Ras signaling pathway. GO annotations related to this gene include protein serine/threonine kinase activity.

UniProtKB/Swiss-Prot for PAK6 Gene

  • Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD.

Gene Wiki entry for PAK6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PAK6 Gene

Genomics for PAK6 Gene

Genomic Location for PAK6 Gene

Start:
40,217,428 bp from pter
End:
40,277,487 bp from pter
Size:
60,060 bases
Orientation:
Plus strand

Genomic View for PAK6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PAK6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAK6 Gene

Regulatory Elements for PAK6 Gene

Proteins for PAK6 Gene

  • Protein details for PAK6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQU5-PAK6_HUMAN
    Recommended name:
    Serine/threonine-protein kinase PAK 6
    Protein Accession:
    Q9NQU5
    Secondary Accessions:
    • A8K2G2
    • B3KYB0
    • G5E9R2

    Protein attributes for PAK6 Gene

    Size:
    681 amino acids
    Molecular mass:
    74869 Da
    Quaternary structure:
    • Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1 (By similarity). Interacts with the androgen receptor AR and the estrogen receptor ESR1. Interacts with IQGAP1 and PPM1B.

    Three dimensional structures from OCA and Proteopedia for PAK6 Gene

    Alternative splice isoforms for PAK6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PAK6 Gene

Proteomics data for PAK6 Gene at MOPED

Post-translational modifications for PAK6 Gene

  • Autophosphorylated. Phosphorylated by MAP2K6//MAPKK6, leading to PAK6 activation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PAK6 Gene

Domains for PAK6 Gene

Gene Families for PAK6 Gene

UniProtKB/Swiss-Prot:

PAK6_HUMAN
Domain:
  • Contains 1 CRIB domain.:
    • Q9NQU5
  • Contains 1 protein kinase domain.:
    • Q9NQU5
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.:
    • Q9NQU5
genes like me logo Genes that share domains with PAK6: view

Function for PAK6 Gene

Molecular function for PAK6 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot Function: Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD.

Enzyme Numbers (IUBMB) for PAK6 Gene

Gene Ontology (GO) - Molecular Function for PAK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity --
GO:0004702 receptor signaling protein serine/threonine kinase activity IBA --
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 24510904
genes like me logo Genes that share ontologies with PAK6: view
genes like me logo Genes that share phenotypes with PAK6: view

Animal Models for PAK6 Gene

MGI Knock Outs for PAK6:

miRNA for PAK6 Gene

miRTarBase miRNAs that target PAK6

No data available for Transcription Factor Targeting and HOMER Transcription for PAK6 Gene

Localization for PAK6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PAK6 Gene

Cytoplasm. Nucleus. Note=Cotranslocates into nucleus with AR in response to androgen induction.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PAK6 Gene COMPARTMENTS Subcellular localization image for PAK6 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for PAK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with PAK6: view

Pathways for PAK6 Gene

genes like me logo Genes that share pathways with PAK6: view

Pathways by source for PAK6 Gene

Interacting Proteins for PAK6 Gene

Gene Ontology (GO) - Biological Process for PAK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 NOT mitotic cell cycle IBA --
GO:0006355 regulation of transcription, DNA-templated TAS 20070256
GO:0006468 protein phosphorylation IEA --
GO:0006915 apoptotic process TAS 20070256
GO:0007010 cytoskeleton organization TAS 20070256
genes like me logo Genes that share ontologies with PAK6: view

Compounds for PAK6 Gene

(3) HMDB Compounds for PAK6 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Guanosine triphosphate
  • 5'-GTP
86-01-1

(4) Novoseek inferred chemical compound relationships for PAK6 Gene

Compound -log(P) Hits PubMed IDs
threonine 61.4 3
serine 54.4 3
testosterone 24.5 3
steroid 21.5 1
genes like me logo Genes that share compounds with PAK6: view

Transcripts for PAK6 Gene

Unigene Clusters for PAK6 Gene

P21 protein (Cdc42/Rac)-activated kinase 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PAK6 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a ·
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - - - - - -
SP4: - - - - -
SP5:
SP6: - - - - - -
SP7: -
SP8: -
SP9: -
SP10:
SP11:

ExUns: 16b · 16c ^ 17
SP1:
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for PAK6 Gene

GeneLoc Exon Structure for
PAK6
ECgene alternative splicing isoforms for
PAK6

Expression for PAK6 Gene

mRNA expression in normal human tissues for PAK6 Gene

mRNA differential expression in normal tissues according to GTEx for PAK6 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (5.2), Brain - Cortex (5.1), and Brain - Frontal Cortex (BA9) (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for PAK6 Gene

SOURCE GeneReport for Unigene cluster for PAK6 Gene Hs.732375

mRNA Expression by UniProt/SwissProt for PAK6 Gene

Q9NQU5-PAK6_HUMAN
Tissue specificity: Selectively expressed in brain and testis, with lower levels in multiple tissues including prostate and breast.
genes like me logo Genes that share expressions with PAK6: view

Orthologs for PAK6 Gene

This gene was present in the common ancestor of animals.

Orthologs for PAK6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PAK6 36
  • 99.56 (n)
  • 99.41 (a)
cow
(Bos Taurus)
Mammalia PAK6 36
  • 91.73 (n)
  • 93.39 (a)
dog
(Canis familiaris)
Mammalia PAK6 36
  • 92.02 (n)
  • 94.42 (a)
mouse
(Mus musculus)
Mammalia Pak6 36
  • 88.79 (n)
  • 92.66 (a)
Pak6 16
rat
(Rattus norvegicus)
Mammalia Pak6 36
  • 87.86 (n)
  • 92.95 (a)
chicken
(Gallus gallus)
Aves PAK6 36
  • 75.09 (n)
  • 78.21 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pak6 36
  • 63.55 (n)
  • 66.38 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100536197 36
  • 68.83 (n)
  • 69.46 (a)
fruit fly
(Drosophila melanogaster)
Insecta mbt 38
  • 73 (a)
worm
(Caenorhabditis elegans)
Secernentea C45B11.1b 38
  • 45 (a)
C45B11.1a 38
  • 45 (a)
Species with no ortholog for PAK6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PAK6 Gene

ENSEMBL:
Gene Tree for PAK6 (if available)
TreeFam:
Gene Tree for PAK6 (if available)

Paralogs for PAK6 Gene

genes like me logo Genes that share paralogs with PAK6: view

No data available for Paralogs for PAK6 Gene

Variants for PAK6 Gene

Sequence variations from dbSNP and Humsavar for PAK6 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs731497 -- 40,262,864(-) AACAA(A/G)TAACT intron-variant
rs748556 -- 40,266,543(+) GTGTA(A/G)GGACA intron-variant
rs900055 -- 40,240,383(-) CACAC(C/T)GGGGC intron-variant
rs900056 -- 40,239,625(-) CACAC(A/G)GGCAG intron-variant, utr-variant-5-prime, upstream-variant-2KB
rs936214 -- 40,273,504(-) GGGAG(C/T)GTGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PAK6 Gene

Variant ID Type Subtype PubMed ID
nsv904095 CNV Loss 21882294
nsv471240 CNV Loss 18288195
esv34145 CNV Loss 18971310
dgv2359n71 CNV Loss 21882294
nsv510660 CNV Loss 20534489
nsv517541 CNV Loss 19592680
nsv904098 CNV Loss 21882294
nsv457118 CNV Loss 19166990

Relevant External Links for PAK6 Gene

HapMap Linkage Disequilibrium report
PAK6

Disorders for PAK6 Gene

(1) University of Copenhagen DISEASES for PAK6 Gene

Relevant External Links for PAK6

Genetic Association Database (GAD)
PAK6
Human Genome Epidemiology (HuGE) Navigator
PAK6
genes like me logo Genes that share disorders with PAK6: view

No data available for UniProtKB/Swiss-Prot for PAK6 Gene

Publications for PAK6 Gene

  1. Androgen receptor specifically interacts with a novel p21-activated kinase, PAK6. (PMID: 11278661) Yang F. … Sun Z. (J. Biol. Chem. 2001) 2 3 4 23
  2. AR and ER interaction with a p21-activated kinase (PAK6). (PMID: 11773441) Lee S.R. … Balk S.P. (Mol. Endocrinol. 2002) 3 4 23
  3. Mechanism of p21-activated kinase 6-mediated inhibition of androgen receptor signaling. (PMID: 14573606) Schrantz N. … Bokoch G.M. (J. Biol. Chem. 2004) 3 4 23
  4. Activation of p21-activated kinase 6 by MAP kinase kinase 6 and p38 MAP kinase. (PMID: 15550393) Kaur R. … Lu M.L. (J. Biol. Chem. 2005) 3 4 23
  5. Inhibition of p21-activated kinase 6 (PAK6) increases radiosensitivity of prostate cancer cells. (PMID: 20054820) Zhang M. … Chakravarti A. (Prostate 2010) 3 4 23

Products for PAK6 Gene

  • Addgene plasmids for PAK6

Sources for PAK6 Gene

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