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Aliases for WRNIP1 Gene

Aliases for WRNIP1 Gene

  • Werner Helicase Interacting Protein 1 2 3
  • WHIP 3 4 6
  • Werner Helicase-Interacting Protein 1 3 4
  • Putative Helicase RUVBL 3
  • ATPase WRNIP1 3
  • EC 4
  • BA420G6.2 3
  • EC 3.6.1 63

External Ids for WRNIP1 Gene

Previous GeneCards Identifiers for WRNIP1 Gene

  • GC06P002755
  • GC06P002710

Summaries for WRNIP1 Gene

Entrez Gene Summary for WRNIP1 Gene

  • Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein. This protein has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus. It has sequence similarity to replication factor C family proteins and is conserved from E. coli to human. This protein likely accumulates at sites of DNA damage by interacting with polyubiquinated proteins and also binds to DNA polymerase delta and increases the initiation frequency of DNA polymerase delta-mediated DNA synthesis. This protein also interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been isolated for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for WRNIP1 Gene

WRNIP1 (Werner Helicase Interacting Protein 1) is a Protein Coding gene. Diseases associated with WRNIP1 include posterior myocardial infarction and mitral valve insufficiency. GO annotations related to this gene include identical protein binding and ATPase activity.

UniProtKB/Swiss-Prot for WRNIP1 Gene

  • Functions as a modulator for initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. Has an intrinsic ATPase activity that functions as a sensor of DNA damage or of arrested replication forks and regulates the extent of DNA synthesis.

Gene Wiki entry for WRNIP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WRNIP1 Gene

Genomics for WRNIP1 Gene

Regulatory Elements for WRNIP1 Gene

Genomic Location for WRNIP1 Gene

2,765,341 bp from pter
2,786,952 bp from pter
21,612 bases
Plus strand

Genomic View for WRNIP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WRNIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WRNIP1 Gene

Proteins for WRNIP1 Gene

  • Protein details for WRNIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ATPase WRNIP1
    Protein Accession:
    Secondary Accessions:
    • B2RDB0
    • Q53EP6
    • Q59ET8
    • Q5W0E2
    • Q5W0E4
    • Q8WV26
    • Q9H681
    • Q9NRJ6

    Protein attributes for WRNIP1 Gene

    665 amino acids
    Molecular mass:
    72133 Da
    Quaternary structure:
    • Homooligomer; most likely an octamer. Interacts with POLD1, POLD2 and POLD4. Interacts with the N-terminal domain of WRN. Interacts (via UBZ-type zinc finger) with polyubiquitin.
    • Sequence=AAF80563.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15383.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for WRNIP1 Gene

    Alternative splice isoforms for WRNIP1 Gene


neXtProt entry for WRNIP1 Gene

Proteomics data for WRNIP1 Gene at MOPED

Selected DME Specific Peptides for WRNIP1 Gene

Post-translational modifications for WRNIP1 Gene

  • Sumoylated with SUMO1 and SUMO2/3.
  • Ubiquitination at Lys81, Lys141, Lys225, Lys286, Lys301, Lys310, Lys316, Lys322, Lys335, Lys482, Lys508, Lys601, Lys627, Lys636, and Lys661
  • Modification sites at PhosphoSitePlus

Other Protein References for WRNIP1 Gene

Antibody Products

Domains for WRNIP1 Gene

Gene Families for WRNIP1 Gene

  • AATP :ATPases / AAA-type

Suggested Antigen Peptide Sequences for WRNIP1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q96S55
  • Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.
  • Contains 1 UBZ-type zinc finger.
genes like me logo Genes that share domains with WRNIP1: view

Function for WRNIP1 Gene

Molecular function for WRNIP1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
Functions as a modulator for initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. Has an intrinsic ATPase activity that functions as a sensor of DNA damage or of arrested replication forks and regulates the extent of DNA synthesis.

Enzyme Numbers (IUBMB) for WRNIP1 Gene

Gene Ontology (GO) - Molecular Function for WRNIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 15670210
GO:0005524 ATP binding IEA --
GO:0009378 four-way junction helicase activity --
GO:0016887 ATPase activity IMP 15670210
genes like me logo Genes that share ontologies with WRNIP1: view

Phenotypes for WRNIP1 Gene

GenomeRNAi human phenotypes for WRNIP1:
genes like me logo Genes that share phenotypes with WRNIP1: view

Animal Model Products

CRISPR Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for WRNIP1 Gene

Localization for WRNIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WRNIP1 Gene

Nucleus. Note=Colocalizes with WRN in granular structures in the nucleus. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for WRNIP1 Gene COMPARTMENTS Subcellular localization image for WRNIP1 gene
Compartment Confidence
nucleus 5
mitochondrion 4
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for WRNIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0016020 membrane IDA 19946888
GO:0048471 perinuclear region of cytoplasm IDA 17888034
genes like me logo Genes that share ontologies with WRNIP1: view

Pathways for WRNIP1 Gene

SuperPathways for WRNIP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WRNIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000731 DNA synthesis involved in DNA repair IDA 15670210
GO:0006200 obsolete ATP catabolic process --
GO:0006260 DNA replication IEA --
GO:0006281 DNA repair --
GO:0006310 DNA recombination --
genes like me logo Genes that share ontologies with WRNIP1: view

No data available for Pathways by source for WRNIP1 Gene

Transcripts for WRNIP1 Gene

Unigene Clusters for WRNIP1 Gene

Werner helicase interacting protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WRNIP1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WRNIP1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1: - - -
SP2: - - - -
SP3: -
SP4: -
SP5: -
SP6: - - - - - -

Relevant External Links for WRNIP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WRNIP1 Gene

mRNA expression in normal human tissues for WRNIP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for WRNIP1 Gene

This gene is overexpressed in Lymph node (11.1), Peripheral blood mononuclear cells (8.0), and Placenta (7.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for WRNIP1 Gene

SOURCE GeneReport for Unigene cluster for WRNIP1 Gene Hs.236828

mRNA Expression by UniProt/SwissProt for WRNIP1 Gene

Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expressions with WRNIP1: view

Expression partners for WRNIP1 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for WRNIP1 Gene

Orthologs for WRNIP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WRNIP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia WRNIP1 35
  • 82.55 (n)
  • 86.52 (a)
  • 84 (a)
(Canis familiaris)
Mammalia WRNIP1 35
  • 91.61 (n)
  • 97.53 (a)
  • 94 (a)
(Mus musculus)
Mammalia Wrnip1 35
  • 89.19 (n)
  • 95.45 (a)
Wrnip1 16
Wrnip1 36
  • 72 (a)
(Pan troglodytes)
Mammalia WRNIP1 35
  • 99 (n)
  • 99.55 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Wrnip1 35
  • 87.83 (n)
  • 95.15 (a)
(Monodelphis domestica)
Mammalia WRNIP1 36
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia WRNIP1 36
  • 81 (a)
(Gallus gallus)
Aves WRNIP1 35
  • 74.03 (n)
  • 78.99 (a)
  • 64 (a)
(Anolis carolinensis)
Reptilia WRNIP1 36
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10820 35
wrnip1 35
  • 66.74 (n)
  • 74.26 (a)
(Danio rerio)
Actinopterygii Dr.16690 35
wrnip1 35
  • 68.13 (n)
  • 75.29 (a)
wrnip1 36
  • 61 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL183W 35
  • 53.17 (n)
  • 49.14 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D19360g 35
  • 50.6 (n)
  • 49.88 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MGS1 35
  • 51.12 (n)
  • 49.04 (a)
MGS1 36
  • 36 (a)
MGS1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G24290 35
  • 55.42 (n)
  • 54.03 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08706 35
  • 52.97 (n)
  • 51.1 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC26H5.02c 35
  • 52.92 (n)
  • 51.5 (a)
Species with no ortholog for WRNIP1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WRNIP1 Gene

Gene Tree for WRNIP1 (if available)
Gene Tree for WRNIP1 (if available)

Paralogs for WRNIP1 Gene

No data available for Paralogs for WRNIP1 Gene

Variants for WRNIP1 Gene

Sequence variations from dbSNP and Humsavar for WRNIP1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs8912 -- 2,785,425(+) AGGTG(A/G)AGGCG utr-variant-3-prime
rs15217 -- 2,785,441(-) TTATT(C/T)GAAAG utr-variant-3-prime
rs160658 -- 2,768,971(+) ACTTA(C/T)GAGCT intron-variant
rs160659 -- 2,769,404(+) CTTAG(A/G)GATTT intron-variant
rs160660 -- 2,770,970(+) TGAGT(A/T)CCACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WRNIP1 Gene

Variant ID Type Subtype PubMed ID
nsv883389 CNV Gain 21882294
nsv883393 CNV Gain 21882294
nsv883395 CNV Gain 21882294
esv273277 CNV Insertion 20981092
esv271458 CNV Insertion 20981092
esv1193325 CNV Insertion 17803354

Relevant External Links for WRNIP1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WRNIP1 Gene

Disorders for WRNIP1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for WRNIP1 Gene in MalaCards »

(2) Diseases for WRNIP1 Gene including...

Relevant External Links for WRNIP1

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with WRNIP1: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for WRNIP1 Gene

Publications for WRNIP1 Gene

  1. A novel protein interacts with the Werner's syndrome gene product physically and functionally. (PMID: 11301316) Kawabe Y. … Enomoto T. (J. Biol. Chem. 2001) 2 3 4 23
  2. Human Werner helicase interacting protein 1 (WRNIP1) functions as a novel modulator for DNA polymerase delta. (PMID: 15670210) Tsurimoto T. … Enomoto T. (Genes Cells 2005) 3 4 23
  3. Fibroblast growth factor receptor 1 oncogene partner as a novel prognostic biomarker and therapeutic target for lung cancer. (PMID: 17888034) Mano Y. … Daigo Y. (Cancer Sci. 2007) 3 23
  4. Conjugation of complex polyubiquitin chains to WRNIP1. (PMID: 18613717) Bish R.A. … Myers M.P. (J. Proteome Res. 2008) 3 23
  5. Human Wrnip1 is localized in replication factories in a ubiquitin-binding zinc finger-dependent manner. (PMID: 18842586) Crosetto N. … Dikic I. (J. Biol. Chem. 2008) 3 23

Products for WRNIP1 Gene

Sources for WRNIP1 Gene

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