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Aliases for C8orf4 Gene

Aliases for C8orf4 Gene

  • Chromosome 8 Open Reading Frame 4 2 3
  • TC1 3 4 6
  • Thyroid Cancer Protein 1 3 4
  • Human Thyroid Cancer 1 2 3
  • TC-1 3 4
  • Uncharacterized Protein C8orf4 3

External Ids for C8orf4 Gene

Previous GeneCards Identifiers for C8orf4 Gene

  • GC08P039461
  • GC08P040040
  • GC08P039751
  • GC08P040028
  • GC08P038544
  • GC08P040010

Summaries for C8orf4 Gene

Entrez Gene Summary for C8orf4 Gene

  • This gene encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes. The encoded protein may also play a role in the NF-kappaB and ERK1/2 signaling pathways. Expression of this gene may play a role in the proliferation of several types of cancer including thyroid cancer, breast cancer and hematological malignancies. [provided by RefSeq, Nov 2011]

GeneCards Summary for C8orf4 Gene

C8orf4 (Chromosome 8 Open Reading Frame 4) is a Protein Coding gene. Diseases associated with C8orf4 include thyroid cancer and breast cancer.

UniProtKB/Swiss-Prot for C8orf4 Gene

  • May decrease apoptosis.

Gene Wiki entry for C8orf4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C8orf4 Gene

Genomics for C8orf4 Gene

Genomic Location for C8orf4 Gene

40,153,455 bp from pter
40,155,308 bp from pter
1,854 bases
Plus strand

Genomic View for C8orf4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C8orf4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C8orf4 Gene

No data available for Regulatory Elements for C8orf4 Gene

Proteins for C8orf4 Gene

  • Protein details for C8orf4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C8orf4
    Protein Accession:
    Secondary Accessions:

    Protein attributes for C8orf4 Gene

    106 amino acids
    Molecular mass:
    12337 Da
    Quaternary structure:
    • Monomer.

neXtProt entry for C8orf4 Gene

Proteomics data for C8orf4 Gene at MOPED

Post-translational modifications for C8orf4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C8orf4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for C8orf4

No data available for DME Specific Peptides for C8orf4 Gene

Domains for C8orf4 Gene

Protein Domains for C8orf4 Gene

Suggested Antigen Peptide Sequences for C8orf4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C8orf4: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C8orf4 Gene

Function for C8orf4 Gene

Molecular function for C8orf4 Gene

UniProtKB/Swiss-Prot Function:
May decrease apoptosis.

Phenotypes for C8orf4 Gene

GenomeRNAi human phenotypes for C8orf4:
genes like me logo Genes that share phenotypes with C8orf4: view

Animal Model Products

CRISPR Products

miRNA for C8orf4 Gene

miRTarBase miRNAs that target C8orf4

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for C8orf4 Gene

Localization for C8orf4 Gene

Subcellular locations from

Jensen Localization Image for C8orf4 Gene COMPARTMENTS Subcellular localization image for C8orf4 gene
Compartment Confidence
mitochondrion 3
nucleus 2
cytosol 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C8orf4 Gene

Pathways for C8orf4 Gene

SuperPathways for C8orf4 Gene

No Data Available

Interacting Proteins for C8orf4 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000319914 for C8orf4 Gene via STRING

Gene Ontology (GO) - Biological Process for C8orf4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with C8orf4: view

No data available for Pathways by source for C8orf4 Gene

Transcripts for C8orf4 Gene

mRNA/cDNA for C8orf4 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(205) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C8orf4 Gene

Chromosome 8 open reading frame 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C8orf4 Gene

No ASD Table

Relevant External Links for C8orf4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C8orf4 Gene

mRNA expression in normal human tissues for C8orf4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C8orf4 Gene

This gene is overexpressed in Liver (6.0) and Lung (4.4).

Protein differential expression in normal tissues for C8orf4 Gene

This gene is overexpressed in Salivary gland (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for C8orf4 Gene

SOURCE GeneReport for Unigene cluster for C8orf4 Gene Hs.591849

mRNA Expression by UniProt/SwissProt for C8orf4 Gene

Tissue specificity: Ubiquitous. Expressed in thyroid papillary carcinoma.
genes like me logo Genes that share expressions with C8orf4: view

Expression partners for C8orf4 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

Orthologs for C8orf4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C8orf4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C27H8orf4 35
  • 89.62 (n)
  • 92.45 (a)
C27H8orf4 36
  • 92 (a)
(Canis familiaris)
Mammalia C16H8orf4 35
  • 89.94 (n)
  • 90.57 (a)
C8orf4 36
  • 77 (a)
(Mus musculus)
Mammalia 1810011O10Rik 35
  • 87.74 (n)
  • 91.51 (a)
1810011O10Rik 16
1810011O10Rik 36
  • 92 (a)
(Pan troglodytes)
Mammalia C8H8orf4 35
  • 99.69 (n)
  • 99.06 (a)
C8orf4 36
  • 98 (a)
(Rattus norvegicus)
Mammalia LOC100910163 35
  • 86.79 (n)
  • 91.51 (a)
(Monodelphis domestica)
Mammalia C8orf4 36
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia C8orf4 36
  • 91 (a)
(Gallus gallus)
Aves C8ORF4 35
  • 75.47 (n)
  • 76.42 (a)
C8orf4 36
  • 76 (a)
(Anolis carolinensis)
Reptilia C8orf4 36
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia c8orf4 35
  • 69.15 (n)
  • 72.34 (a)
Str.10371 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.15208 35
(Danio rerio)
Actinopterygii zgc:110340 35
  • 64.79 (n)
  • 60.67 (a)
C5H8orf4 (2 of 2) 36
  • 51 (a)
C8orf4 (1 of 2) 36
  • 43 (a)
Species with no ortholog for C8orf4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C8orf4 Gene

Gene Tree for C8orf4 (if available)
Gene Tree for C8orf4 (if available)

Paralogs for C8orf4 Gene

No data available for Paralogs for C8orf4 Gene

Variants for C8orf4 Gene

Sequence variations from dbSNP and Humsavar for C8orf4 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs10199 -- 40,154,544(+) TGTAA(A/G)AGGTT utr-variant-3-prime
rs10353 -- 40,153,668(-) TGATT(A/C)TTGGT reference, stop-gained
rs1046868 -- 40,154,574(+) GTTGC(A/C)CAAAA utr-variant-3-prime
rs1129246 -- 40,153,570(+) CATGT(C/T)CACGT reference, missense
rs1383605 -- 40,152,734(-) GAACG(A/T)GGTGA upstream-variant-2KB

Relevant External Links for C8orf4 Gene

HapMap Linkage Disequilibrium report

PCR Panel Products

  • Copy Number PCR Panels: for C8orf4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for C8orf4 Gene

Disorders for C8orf4 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for C8orf4 Gene in MalaCards »

(2) Diseases for C8orf4 Gene

Relevant External Links for C8orf4

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with C8orf4: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for C8orf4 Gene

Publications for C8orf4 Gene

  1. Cloning of TC-1 (C8orf4), a novel gene found to be overexpressed in thyroid cancer. (PMID: 11056052) Chua E.L. … Dong Q. (Genomics 2000) 2 3 4
  2. TC1 (C8orf4) is involved in ERK1/2 pathway-regulated G(1)- to S-phase transition. (PMID: 18959821) Wang Y.D. … Zhou Q. (BMB Rep 2008) 3 23
  3. TC1 (C8orf4) is upregulated by cellular stress and mediates heat shock response. (PMID: 17603013) Park J. … Lee I. (Biochem. Biophys. Res. Commun. 2007) 3 23
  4. TC-1 is a novel tumorigenic and natively disordered protein associated with thyroid cancer. (PMID: 15087392) Sunde M. … Death A.K. (Cancer Res. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for C8orf4 Gene

Sources for C8orf4 Gene

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