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Aliases for TCIM Gene

Aliases for TCIM Gene

  • Transcriptional And Immune Response Regulator 2 3
  • C8orf4 3 4 5
  • Chromosome 8 Open Reading Frame 4 2 5
  • Thyroid Cancer Protein 1 3 4
  • Human Thyroid Cancer 1 2 3
  • TC-1 3 4
  • TC1 3 4
  • Protein C8orf4 3

External Ids for TCIM Gene

Previous HGNC Symbols for TCIM Gene

  • C8orf4

Summaries for TCIM Gene

Entrez Gene Summary for TCIM Gene

  • This gene encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes. The encoded protein may also play a role in the NF-kappaB and ERK1/2 signaling pathways. Expression of this gene may play a role in the proliferation of several types of cancer including thyroid cancer, breast cancer and hematological malignancies. [provided by RefSeq, Nov 2011]

GeneCards Summary for TCIM Gene

TCIM (Transcriptional And Immune Response Regulator) is a Protein Coding gene. Diseases associated with TCIM include Thyroid Cancer.

UniProtKB/Swiss-Prot for TCIM Gene

  • Seems to be involved in the regulation of cell growth an differentiation, may play different and opposite roles depending on the tissue or cell type. May enhance the WNT-CTNNB1 pathway by relieving antagonistic activity of CBY1 (PubMed:16424001, PubMed:16730711). Enhances the proliferation of follicular dendritic cells (PubMed:16730711). Plays a role in the mitogen-activated MAPK2/3 signaling pathway, positively regulates G1-to-S-phase transition of the cell cycle (PubMed:18959821). In endothelial cells, enhances key inflammatory mediators and inflammatory response through the modulation of NF-kappaB transcriptional regulatory activity (PubMed:19684084). Involved in the regulation of heat shock response, seems to play a positive feedback with HSF1 to modulate heat-shock downstream gene expression (PubMed:17603013). Plays a role in the regulation of hematopoiesis even if the mechanisms are unknown (By similarity). In cancers such as thyroid or lung cancer, it has been described as promoter of cell proliferation, G1-to-S-phase transition and inhibitor of apoptosis (PubMed:15087392, PubMed:24941347). However, it negatively regulates self-renewal of liver cancer cells via suppresion of NOTCH2 signaling (PubMed:25985737).

Gene Wiki entry for TCIM Gene

Additional gene information for TCIM Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCIM Gene

Genomics for TCIM Gene

Regulatory Elements for TCIM Gene

Enhancers for TCIM Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08H040170 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.5 +20.7 20734 7 PKNOX1 FOXA2 ATF1 MLX SIN3A YY1 SLC30A9 ELK1 FOS SP5 TCIM ENSG00000253939 LOC100420944 IDO1 ENSG00000254143 LOC105379387
GH08H040198 1.5 FANTOM5 Ensembl ENCODE 11.2 +47.0 46996 4 FOXA2 ARID4B SIN3A BRCA1 YY1 ZNF143 FOS ATF7 DEK ZC3H11A TCIM LOC100420944 ENSG00000253939 ENSG00000254143 LOC105379387
GH08H040098 1.3 FANTOM5 Ensembl ENCODE 12.4 -54.0 -53994 2 TBP PKNOX1 TAL1 SIN3A GATA3 POLR2A FOS MAFK NFE2L2 CEBPB TCIM ENSG00000254143 ZMAT4 LOC105379385 GC08P040016
GH08H040118 1.4 FANTOM5 Ensembl ENCODE 10.8 -34.2 -34211 2 ELF3 SOX13 FOXA2 SAP130 JUN SIN3A ZNF644 RAD21 POLR2A HNF4G TCIM IDO1 LOC105379386
GH08H040152 1.8 FANTOM5 Ensembl ENCODE dbSUPER 7 +2.8 2835 7 FOXA2 ATF1 SIN3A DMAP1 BRCA1 YY1 DEK PAF1 REST PPARG TCIM GC08M040152 ENSG00000254143
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TCIM on UCSC Golden Path with GeneCards custom track

Promoters for TCIM Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000223842 1245 2601 TBP ATF1 SIN3A DMAP1 RAD21 DNMT3B ZSCAN9 RFX5 YY1 CREM

Genomic Location for TCIM Gene

Chromosome:
8
Start:
40,153,455 bp from pter
End:
40,155,308 bp from pter
Size:
1,854 bases
Orientation:
Plus strand

Genomic View for TCIM Gene

Genes around TCIM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCIM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCIM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCIM Gene

Proteins for TCIM Gene

  • Protein details for TCIM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NR00-CH004_HUMAN
    Recommended name:
    Protein C8orf4
    Protein Accession:
    Q9NR00

    Protein attributes for TCIM Gene

    Size:
    106 amino acids
    Molecular mass:
    12337 Da
    Quaternary structure:
    • Monomer. Interacts with NOTCH2 (via ANK repeats), the interaction inhibits the nuclear translocation of NOTCH2 N2ICD (PubMed:25985737). Interacts (C-terminus) with CBY1 (C-terminus), C8orf4 competes with CTNNB1 for the interaction with CBY1 (PubMed:16424001).

neXtProt entry for TCIM Gene

Post-translational modifications for TCIM Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TCIM Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TCIM Gene

Domains & Families for TCIM Gene

Gene Families for TCIM Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TCIM Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TCIM Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TCIM: view

No data available for UniProtKB/Swiss-Prot for TCIM Gene

Function for TCIM Gene

Molecular function for TCIM Gene

UniProtKB/Swiss-Prot Function:
Seems to be involved in the regulation of cell growth an differentiation, may play different and opposite roles depending on the tissue or cell type. May enhance the WNT-CTNNB1 pathway by relieving antagonistic activity of CBY1 (PubMed:16424001, PubMed:16730711). Enhances the proliferation of follicular dendritic cells (PubMed:16730711). Plays a role in the mitogen-activated MAPK2/3 signaling pathway, positively regulates G1-to-S-phase transition of the cell cycle (PubMed:18959821). In endothelial cells, enhances key inflammatory mediators and inflammatory response through the modulation of NF-kappaB transcriptional regulatory activity (PubMed:19684084). Involved in the regulation of heat shock response, seems to play a positive feedback with HSF1 to modulate heat-shock downstream gene expression (PubMed:17603013). Plays a role in the regulation of hematopoiesis even if the mechanisms are unknown (By similarity). In cancers such as thyroid or lung cancer, it has been described as promoter of cell proliferation, G1-to-S-phase transition and inhibitor of apoptosis (PubMed:15087392, PubMed:24941347). However, it negatively regulates self-renewal of liver cancer cells via suppresion of NOTCH2 signaling (PubMed:25985737).
UniProtKB/Swiss-Prot Induction:
Induced by proinflammatory cytokines such as TNF and IL1B, via NF-kappaB signaling (PubMed:16730711, PubMed:19684084). Induced by cellular stresses such as heat shock, TPA, lipopolysaccahride and UV (PubMed:17603013). Induced by mitogens such as thrombin (PubMed:18959821).

Phenotypes From GWAS Catalog for TCIM Gene

Gene Ontology (GO) - Molecular Function for TCIM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005112 Notch binding IPI 25985737
GO:0005515 protein binding IPI 16424001
genes like me logo Genes that share ontologies with TCIM: view
genes like me logo Genes that share phenotypes with TCIM: view

Animal Models for TCIM Gene

MGI Knock Outs for TCIM:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TCIM
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TCIM Gene

Localization for TCIM Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCIM Gene

Cytoplasm. Nucleus, nucleolus. Nucleus speckle. Nucleus. Note=Localizes in nucleus speckles in presence of CBY1 (PubMed:16424001). Translocates to the nucleus upon cellular stress such as H(2)O(2) (PubMed:17603013). {ECO:0000269 PubMed:16424001, ECO:0000269 PubMed:17603013}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCIM gene
Compartment Confidence
nucleus 5
plasma membrane 4
cytosol 4
mitochondrion 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TCIM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA 15087392
GO:0005634 nucleus IEA,IDA 16424001
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA,IEA 16424001
GO:0005737 cytoplasm IDA,IEA 16424001
genes like me logo Genes that share ontologies with TCIM: view

Pathways & Interactions for TCIM Gene

No Data Available

Interacting Proteins for TCIM Gene

Gene Ontology (GO) - Biological Process for TCIM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002264 endothelial cell activation involved in immune response IDA 19684084
GO:0006915 apoptotic process IEA --
GO:0010739 positive regulation of protein kinase A signaling IDA 15087392
GO:0034605 cellular response to heat IDA 17603013
GO:0042346 positive regulation of NF-kappaB import into nucleus IDA 19684084
genes like me logo Genes that share ontologies with TCIM: view

No data available for Pathways by source and SIGNOR curated interactions for TCIM Gene

Drugs & Compounds for TCIM Gene

No Compound Related Data Available

Transcripts for TCIM Gene

mRNA/cDNA for TCIM Gene

(1) REFSEQ mRNAs :
(205) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TCIM
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TCIM Gene

No ASD Table

Relevant External Links for TCIM Gene

GeneLoc Exon Structure for
TCIM
ECgene alternative splicing isoforms for
TCIM

Expression for TCIM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of TCIM Gene:

TCIM

mRNA Expression by UniProt/SwissProt for TCIM Gene:

Q9NR00-CH004_HUMAN
Tissue specificity: Ubiquitous. Expressed in thyroid papillary carcinoma. Expressed in liver, expression levels decrease in hepatocellular carcinoma (PubMed:25985737). Slightly detected in normal lung, its expression is highly induced in lung cancer cells (at protein level) (PubMed:24941347).

Evidence on tissue expression from TISSUES for TCIM Gene

  • Lung(4.4)
  • Liver(2.7)
genes like me logo Genes that share expression patterns with TCIM: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TCIM Gene

Orthologs for TCIM Gene

This gene was present in the common ancestor of chordates.

Orthologs for TCIM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C8H8orf4 33
  • 99.69 (n)
C8orf4 34
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C8orf4 34
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C16H8orf4 33
  • 89.94 (n)
C8orf4 34
  • 77 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C27H8orf4 33 34
  • 89.62 (n)
mouse
(Mus musculus)
Mammalia 1810011O10Rik 33 16 34
  • 87.74 (n)
rat
(Rattus norvegicus)
Mammalia LOC684871 33
  • 86.79 (n)
oppossum
(Monodelphis domestica)
Mammalia C8orf4 34
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves C8orf4 34
  • 76 (a)
OneToOne
C8ORF4 33
  • 75.47 (n)
lizard
(Anolis carolinensis)
Reptilia C8orf4 34
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c8orf4 33
  • 69.15 (n)
Str.10371 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.15208 33
zebrafish
(Danio rerio)
Actinopterygii zgc:110340 33
  • 64.79 (n)
C5H8orf4 (2 of 2) 34
  • 51 (a)
OneToMany
C8orf4 (1 of 2) 34
  • 43 (a)
OneToMany
Species where no ortholog for TCIM was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TCIM Gene

ENSEMBL:
Gene Tree for TCIM (if available)
TreeFam:
Gene Tree for TCIM (if available)

Paralogs for TCIM Gene

No data available for Paralogs for TCIM Gene

Variants for TCIM Gene

Sequence variations from dbSNP and Humsavar for TCIM Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000097855 -- 40,155,633(+) TGTGT(G/T)TGTGT intron-variant, downstream-variant-500B
rs1000400009 -- 40,152,942(+) GTCAT(A/G)TCAGC intron-variant, upstream-variant-2KB
rs1000771184 -- 40,152,743(+) TCATT(C/T)TGGGC intron-variant, upstream-variant-2KB
rs1001369872 -- 40,152,536(+) CGGAC(C/G)AGGCG intron-variant, upstream-variant-2KB
rs1001655472 -- 40,152,109(+) CCTCT(C/G)CTTCC intron-variant, upstream-variant-2KB

Variation tolerance for TCIM Gene

Residual Variation Intolerance Score: 49.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.28; 6.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TCIM Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TCIM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TCIM Gene

Disorders for TCIM Gene

MalaCards: The human disease database

(1) MalaCards diseases for TCIM Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
thyroid cancer
  • malignant neoplasm of thyroid gland
- elite association - COSMIC cancer census association via MalaCards
Search TCIM in MalaCards View complete list of genes associated with diseases

Relevant External Links for TCIM

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TCIM
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TCIM
genes like me logo Genes that share disorders with TCIM: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TCIM Gene

Publications for TCIM Gene

  1. TC1 (C8orf4) is involved in ERK1/2 pathway-regulated G(1)- to S-phase transition. (PMID: 18959821) Wang YD … Zhou Q (BMB reports 2008) 3 4 22 60
  2. TC1 (C8orf4) is upregulated by cellular stress and mediates heat shock response. (PMID: 17603013) Park J … Lee I (Biochemical and biophysical research communications 2007) 3 4 22 60
  3. Cloning of TC-1 (C8orf4), a novel gene found to be overexpressed in thyroid cancer. (PMID: 11056052) Chua EL … Dong Q (Genomics 2000) 2 3 4 60
  4. C8orf4 negatively regulates self-renewal of liver cancer stem cells via suppression of NOTCH2 signalling. (PMID: 25985737) Zhu P … Fan Z (Nature communications 2015) 3 4 60
  5. TC-1 overexpression promotes cell proliferation in human non-small cell lung cancer that can be inhibited by PD173074. (PMID: 24941347) Lei J … Wang X (PloS one 2014) 3 4 60

Products for TCIM Gene

Sources for TCIM Gene

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